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31. 发明申请

WO1998001565A1 PROCESS FOR PRODUCING ICOSAPENTAENOIC ACID BY GENETIC RECOMBINATION 审中-公开
标题翻译：通过遗传重组生产聚氧乙烯酸的方法
公开(公告)号：WO1998001565A1
公开(公告)日：1998-01-15
申请号：PCT/JP1997002371
申请日：1997-07-09
申请人： SAGAMI CHEMICAL RESEARCH CENTER
发明人： SAGAMI CHEMICAL RESEARCH CENTER , YAZAWA, Kazunaga , YAMADA, Akiko , KONDO, Kiyosi , KATO, Seishi
IPC分类号： C12N15/52
CPC分类号： C12P7/6427 , C12N15/52 , C12P7/6472
摘要： An advantageous process for producing icosapentaenoic acid (EPA) useful as medicine, pesticide, food, feed and the like by obtaining a gene coding for a group of biosynthetases for EPA from a microorganism, preparing a plasmid by connecting the gene to a vector, transforming Escherichia coli by using the plasmid, and culturing the transformant.
摘要翻译：通过从微生物获得一组编码EPA的生物合成酶的基因，通过将该基因连接到载体上来制备质粒来制备用作药物，农药，食品，饲料等的二十碳五烯酸（EPA）的有利方法，通过使用该质粒的大肠杆菌，并培养转化体。

32. 发明申请

WO1997047581A1 PROCESS FOR THE PREPARATION OF HALOMETHYLATED 2-PHENYLPROPIONIC ACID DERIVATIVES 审中-公开
标题翻译：制备2-甲基丙酸衍生物的方法
公开(公告)号：WO1997047581A1
公开(公告)日：1997-12-18
申请号：PCT/JP1997002035
申请日：1997-06-12
申请人： KYOWA HAKKO KOGYO CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER , FUKUDA, Yukitoshi , CHUJO, Iwao , FUCHIKAMI, Takamasa , HIROSAWA, Chitaru , WAKASA, Noriko
发明人： KYOWA HAKKO KOGYO CO., LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07C57/58
CPC分类号： C07C67/38 , C07C69/65
摘要： A process for the preparation of halomethylated 2-phenylpropionic acid derivatives of general formula (III) (wherein X is halogeno; and R is hydrogen or lower alkyl) characterized by reacting a halomethylated styrene of general formula (I) (wherein X is as defined above) with carbon monoxide and a compound of general formula (II): R-OH (wherein R is as defined above) in the presence of a palladium catalyst.
摘要翻译：制备通式（III）的卤代甲基化2-苯基丙酸衍生物（其中X为卤素; R为氢或低级烷基）的方法，其特征在于使通式（I）的卤代甲基化苯乙烯（其中X如所定义）（II）的化合物：R-OH（其中R如上定义）在钯催化剂存在下进行。

33. 发明申请

WO1997035581A1 INTERLEUKIN-6 PRODUCTION INHIBITOR 审中-公开
标题翻译：白细胞介素-6生产抑制剂
公开(公告)号：WO1997035581A1
公开(公告)日：1997-10-02
申请号：PCT/JP1997001018
申请日：1997-03-26
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TSUJI, Tomoko , YAMAGUCHI, Kohji , YADA, Mika , UEMURA, Daisuke , YAMADA, Kaoru
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： A61K31/55
CPC分类号： C07D498/22
摘要： An interleukin-6 production inhibitor and bone resorption inhibitor containing as the active ingredient zoanthamines or salts thereof obtained from coelenterates by extraction and purification. The inhibitors are efficacious as remedies for autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosus, remedies for bacterial infections, remedies for septic shock accompanying bacterial infections, remedies for viral infections, remedies for cancers including multiple myeloma, cancerous metastasis inhibitor, cancerous cachexia ameliorant, remedies for inflammatory diseases including mesangial nephritis, inhibitor for inflammation after organ extirpation, and also osteoporosis remedy.
摘要翻译：一种白细胞介素-6产生抑制剂和骨吸收抑制剂，其通过提取和纯化作为活性成分含有由其肠道动物获得的佐安胺或其盐。抑制剂作为自身免疫性疾病包括类风湿性关节炎和系统性红斑狼疮的补救措施，细菌感染的补救措施，伴随细菌感染的败血性休克的补救措施，病毒感染的补救措施，包括多发性骨髓瘤的癌症的治疗剂，癌性转移抑制剂，癌性恶病质改善剂，炎症性疾病包括肾小球肾炎，器官消除后炎症抑制剂以及骨质疏松症的补救措施。

34. 发明申请

WO1997030110A1 MODEL SKIN MEMBRANE 审中-公开
标题翻译：型号皮肤膜
公开(公告)号：WO1997030110A1
公开(公告)日：1997-08-21
申请号：PCT/JP1997000314
申请日：1997-02-07
申请人： SAGAMI CHEMICAL RESEARCH CENTER , NAGASE, Yu , AOYAGI, Takao , MORIMOTO, Yasunori , SUGIBAYASHI, Kenji , NATSUME, Hideshi
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C08J05/18
CPC分类号： C08F290/06 , A61L27/16 , A61L27/18 , A61F2/10 , C08L33/08 , C08L83/04
摘要： A cross-linked polymer obtained by mixing monomer compounds respectively represented by general formulae (I), (II), and (III) in amounts of 40 to 70 wt.%, 20 to 55 wt.%, and 5 to 40 wt.%, respectively, polymerizing the mixture and simultaneously forming the same into a film, and then treating the resultant polymer to replace the hydroxyl-protective groups represented by A in the formula with hydrogen atoms, and an artificial model skin membrane which comprises the cross-linked polymer and is similar to the human skin in permeability to various drugs.
摘要翻译：通过将分别由通式（I），（II）和（III）表示的单体化合物以40至70重量％，20至55重量％和5至40重量％的量混合而获得的交联聚合物。％，分别将混合物聚合并同时形成薄膜，然后处理所得聚合物以用氢原子代替式中的A表示的羟基保护基，以及包含交联剂的人造模型皮肤膜，并且与各种药物的渗透性类似于人皮肤。

35. 发明申请

WO1996028401A1 PROCESS FOR PRODUCING UNSATURATED ORGANIC COMPOUNDS 审中-公开
标题翻译：生产不饱和有机化合物的方法
公开(公告)号：WO1996028401A1
公开(公告)日：1996-09-19
申请号：PCT/JP1996000570
申请日：1996-03-08
申请人： SAGAMI CHEMICAL RESEARCH CENTER , HATANAKA, Yasuo , HAGIWARA, Emiko , GOUDA, Ken-ichi , HIYAMA, Tamejiro
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07B37/04
CPC分类号： C07D213/30 , C07B37/04 , C07C17/263 , C07C45/68 , C07C67/343 , C07C253/30 , C07D213/06 , C07D213/26 , C07D213/73 , C07D213/75 , C07F7/083 , C09K19/12 , C09K19/3444 , C07C22/08 , C07C25/18 , C07C49/782 , C07C49/84 , C07C49/794 , C07C69/76
摘要： A process whereby organic compounds, such as biaryls or alkenylallenes, which are useful as functional organic materials such as liquid crystals, drugs or pesticides can be efficiently synthesized in a short step. This process comprises reacting organic halosilanes with organic halides in the presence of a base or in the presence of a catalyst of a transition metal of the group (10) having a trialkylphosphine ligand and a fluoride to thereby give unsaturated organic compounds represented by the following general formula: R -R , wherein R represents optionally substituted aryl, optionally substituted alkenyl or optionally substituted alkyl; and R represents optionally substituted aryl, optionally substituted 1-alkenyl or optionally substituted 2-alkenyl.
摘要翻译：可以在短时间内有效地合成可用作液晶，药物或农药等功能性有机材料的有机化合物如联芳基或烯基亚苯基的方法。该方法包括在碱的存在下或在具有三烷基膦配体和氟化物的基团（10）的过渡金属的催化剂存在下使有机卤代硅烷与有机卤化物反应，由此得到由以下通式表示的不饱和有机化合物式R 1 -R 3，其中R 1表示任选取代的芳基，任选取代的烯基或任选取代的烷基; R 2表示任选取代的芳基，任选取代的1-烯基或任选取代的2-链烯基。

36. 发明申请

WO1996026930A1 PROCESS FOR THE PREPARATION OF 3-(SUBSTITUTED PHENYL)-5-ALKYLIDENE-1,3-OXAZOLIDINE-2,4-DIONE DERIVATIVES 审中-公开
标题翻译：制备3-（取代的苯基）-5-甲氧基-1,3-氧杂环丁烷-2,4-二酮衍生物的方法
公开(公告)号：WO1996026930A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000430
申请日：1996-02-26
申请人： SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD. , HIRAI, Kenji , MASUDA, Katsuyuki , YANO, Tomoyuki , OHNO, Ryuta , MATUKAWA, Tomoko , IMAI, Kiyomi , OKANO, Natsuko , YOSHII, Tomoko , MOURI, Takehito
发明人： SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07D263/44
CPC分类号： C07D263/44 , C07C67/31 , C07C69/708
摘要： An industrial process for efficiently preparing a 3-(substituted phenyl)-5-isopropylidene-1,3-oxazolidine-2,4-dione derivative having a potent herbicidal activity without using phosgene or the like. More precisely, a process for preparing a 3-(substituted phenyl)-5-alkylidene-1,3-oxazolidine-2,3-dione derivative of general formula (III) by reacting an N-(substituted phenyl)carbamate of general formula (I) with a 2-hydroxy-3-alkenoate of general formula (II) or a 3-alkoxy-2-hydroxyalkanoate of general formula (IV), wherein Ar is substituted phenyl; R is C1-C6 alkyl; R and R are each independently hydrogen or C1-C12 alkyl; and R and R are each independently C1-C6 alkyl.
摘要翻译：用于有效地制备具有强效除草活性而不使用光气等的3-（取代苯基）-5-异亚丙基-1,3-恶唑烷-2,4-二酮衍生物的工业方法。更精确地说，通过使通式（III）的N-（取代苯基）氨基甲酸酯与通式（III）的N-（取代苯基）-5-亚烷基-1,3-恶唑烷-2,3-二酮衍生物（I）与通式（II）的2-羟基-3-烯酸酯或通式（IV）的3-烷氧基-2-羟基链烷酸酯，其中Ar是取代的苯基; R 1是C 1 -C 6烷基; R 2和R 3各自独立地为氢或C 1 -C 12烷基; R 4和R 5各自独立地为C 1 -C 6烷基。

37. 发明申请

WO1996021735A1 GENES CODING FOR BIOSYNTHETIC ENZYME GROUP FOR ICOSAPENTAENOIC ACID AND PROCESS FOR PRODUCING ICOSAPENTAENOIC ACID 审中-公开
标题翻译：用于生产乙酸的生物合成酶组的基因编码及其生产途径的方法
公开(公告)号：WO1996021735A1
公开(公告)日：1996-07-18
申请号：PCT/JP1996000030
申请日：1996-01-12
申请人： SAGAMI CHEMICAL RESEARCH CENTER
发明人： SAGAMI CHEMICAL RESEARCH CENTER , YAZAWA, Kazunaga , YAMADA, Akiko , KONDO, Kiyosi , KATO, Seishi
IPC分类号： C12N15/52
CPC分类号： C12P7/6427 , C12N15/52 , C12P7/6436 , C12P7/6472
摘要： An advantageous process for producing icosapentaenoic acid (EPA) useful as medicines, agricultural chemicals, food, feeds, and so forth, which comprises obtaining from microorganisms a gene coding for the biosynthetic enzyme group for EPA, connecting the gene and a vector to prepare a plasmid, transforming Escherichia coli with the plasmid, and culturing the transformant.
摘要翻译：用于生产用作药物，农药，食品，饲料等的二十碳五烯酸（EPA）的有利方法，其包括从微生物获得编码EPA生物合成酶基团的基因，连接基因和载体以制备质粒，用质粒转化大肠杆菌，并培养转化体。

38. 发明申请

WO1995011898A1 CONDENSED PYRIDINE TYPE MEVALONOLACTONE INTERMEDIATE AND PROCESS FOR ITS PRODUCTION 审中-公开
标题翻译：浓缩吡啶类中间体及其制备方法
公开(公告)号：WO1995011898A1
公开(公告)日：1995-05-04
申请号：PCT/JP1993001551
申请日：1993-10-27
申请人： NISSAN CHEMICAL INDUSTRIES LTD. , SAGAMI CHEMICAL RESEARCH CENTER , HIYAMA, Tamejiro , MINAMI, Tatsuya , YANAGAWA, Yoshinobu , OHARA, Yoshio
发明人： NISSAN CHEMICAL INDUSTRIES LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07D471/04 , C07D495/04 , C07F9/60 , Y02P20/55
摘要： The present invention provides a synthetic condensed pyridine type mevalonolactone intermediate of formula (1), wherein Z is (a) or (b), each of R and R is a hydroxyl-protecting group, and R is methyl, ethyl, propyl, isopropyl, tert-butyl, tetrahydropyranyl, allyl, benzyl, triphenylmethyl, trimethylsilyl or tert-butyldimethylsilyl. The intermediate is useful for producing a 7-position substituted (E, 3R, 5S)-3,5-dihydroxy-6-heptenoic acid or its 1,5-lactone or its enantiomer which has an activity as an HMG-CoA reductase inhibitor and which is useful as a hypercholesterolemia therapeutic agent.
摘要翻译：本发明提供式（1）的合成缩合吡啶型甲羟戊酸内酯，其中Z为（a）或（b），R 9a和R 9b各自为羟基保护基，R 10为甲基，乙基，丙基，异丙基，叔丁基，四氢吡喃基，烯丙基，苄基，三苯基甲基，三甲基甲硅烷基或叔丁基二甲基甲硅烷基。该中间体可用于制备具有作为HMG-CoA还原酶抑制剂活性的7-位取代的（E，3R，5S）-3,5-二羟基-6-庚烯酸或其1,5-内酯或其对映异构体并且其可用作高胆固醇血症治疗剂。

39. 发明申请

WO1995010509A1 4-IMINOOXAZOLIDIN-2-ONE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译： 4-IMINOOXAZOLIDIN-2-ONE衍生物，其制备方法和含有它们的除草剂作为活性成分
公开(公告)号：WO1995010509A1
公开(公告)日：1995-04-20
申请号：PCT/JP1994001683
申请日：1994-10-07
申请人： SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD. , HIRAI, Kenji , MATSUKAWA, Tomoko , YANO, Tomoyuki , MASUDA, Katsuyuki , YOSHII, Tomoko , MOURI, Takehito , UGAI, Sadayuki , YAMADA, Osamu
发明人： SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07D263/48
CPC分类号： C07D263/48 , A01N43/76
摘要： A 4-iminooxazolidin-2-one derivative represented by general formula (1) (wherein X represents hydrogen or halogen; X represents hydrogen, halogen or alkyloxy; and X represents hydrogen, halogen, alkyloxy, cycloalkyloxy or alkynyloxy); a process for producing the above compound by the reaction of an aryl isocyanate represented by general formula (2) with methacrolein cyanohydrin in the presence of a base; a herbicide containing the above compound as the active ingredient; and a process for producing an oxazolidinedione derivative useful as a herbicide by hydrolyzing the above compound.
摘要翻译：由通式（1）表示的4-亚氨基恶唑烷-2-酮衍生物（其中X 1表示氢或卤素; X 2表示氢，卤素或烷氧基; X 3表示氢，卤素，烷氧基，环烷氧基或炔氧基）; 通过在碱存在下通过通式（2）表示的异氰酸酯与异丁烯醛氰醇反应制备上述化合物的方法; 含有上述化合物作为活性成分的除草剂; 以及通过水解上述化合物制备可用作除草剂的恶唑烷二酮衍生物的方法。

40. 发明申请

WO1994024180A1 COPOLYMER HAVING LIQUID CRYSTAL GROUP IN THE SIDE CHAIN 审中-公开
标题翻译：具有侧链中的液晶组合物的共聚物
公开(公告)号：WO1994024180A1
公开(公告)日：1994-10-27
申请号：PCT/JP1994000539
申请日：1994-03-31
申请人： SAGAMI CHEMICAL RESEARCH CENTER , NAGASE, Yu , AKIYAMA, Eiichi , TAKAMURA, Yuriko
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C08F299/08
CPC分类号： C08F230/08 , C09K19/408
摘要： A copolymer having a polyacrylate skeleton as the main chain and a liquid crystal group in the side chain, which copolymer has a number-average molecular weight of 1,000 or above and is composed of repeating acrylate units (I) each having a liquid crystal group bonded thereto by means of an ester linkage via an alkylene chain and repeating acrylate units (II) each having a liquid crystal group bonded thereto by means of an ester linkage via an alkylene chain having a siloxane linkage in a molar ratio of the units (I) to the units (II) of 95/5 to 20/80. This copolymer is a side-chain type of polymer liquid crystal which exhibits liquid crystallinity at a comparatively low temperature, i.e., around room temperature, and is useful as the material of large-area display elements that are driven at low temperature, optical shutters, light-modulating glass, and so forth.
摘要翻译：以聚丙烯酸酯骨架为主链和侧链中的液晶基团的共聚物，该共聚物的数均分子量为1000以上，由具有液晶基团的重复丙烯酸酯单元（I）组成的共聚物通过亚烷基链的酯键和具有通过酯键键合的液晶基团的丙烯酸酯单元（II）通过具有硅氧烷键的亚烷基链以单位（I）的摩尔比重复，到95/5至20/80的单位（II）。该共聚物是侧链型聚合物液晶，其在比较低的温度即室温附近呈现液晶性，并且可用作在低温下驱动的大面积显示元件的材料，光学快门，光调制玻璃等。

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