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31. 发明授权

US5451424A Anti-infective and antithrombogenic medical articles and method for their preparation 失效
公开(公告)号：US5451424A
公开(公告)日：1995-09-19
申请号：US980984
申请日：1992-11-24
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61L27/34 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A01N1/02 , A61M25/00
CPC分类号： A61L29/06 , A61L29/085 , A61L29/16 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61M2025/0056
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.

32. 发明授权

US5151231A Method for making liquid crystalline tube having a point 失效
标题翻译：制造具有点的液晶管的方法
公开(公告)号：US5151231A
公开(公告)日：1992-09-29
申请号：US765782
申请日：1991-09-26
申请人： James M. Lambert , Donald D. Solomon
发明人： James M. Lambert , Donald D. Solomon
IPC分类号： A61L29/04 , A61L29/14 , A61M25/00 , C08G63/60
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/14 , C08G63/60 , C08G63/605 , B29C2045/0098
摘要： A catheter assembly includes a tubing portion and a needle portion, at least one of which is a thermoplastic liquid crystalline polymer. The tubing and needle may be integral or unitary. The invention includes a method to make the assembly in which a melt of the liquid crystalline polymer is shear thinned by passing through an orifice such as an extrusion die to make tubing. The shear thinned melt may be directed into a mold having a point to make a liquid crystalline needle.
摘要翻译：导管组件包括管部分和针部分，其中至少一个是热塑性液晶聚合物。管道和针头可以是整体的或整体的。本发明包括一种制造组合件的方法，其中液晶聚合物的熔体通过诸如挤出模头的孔口被剪切变薄以制成管材。剪切稀化的熔体可以被引导到具有点的模具中以形成液晶针。

33. 发明授权

US5013306A Anti-infective and antithrombogenic medical articles and method for their preparation 失效
标题翻译：抗感染和抗血栓形成的医疗用品及其制备方法
公开(公告)号：US5013306A
公开(公告)日：1991-05-07
申请号：US497780
申请日：1990-03-21
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61L27/34 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/06 , A61M2025/0056
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
摘要翻译：抗感染性医疗用品具有遍及整个聚氨酯基层的氯己定，并且可以在基层上具有涂层。涂层可以是氯己定渗透到表面中，或者它可以是层压到基底层上的抗生素，抗血栓形成剂或聚合物表面层。本发明包括一种制备该制品的方法，其中通过双螺杆混合制备聚合物和氯己定的均匀熔体，并将该熔体挤出以得到具有体积分布的氯己定的医用制品。

34. 发明授权

US4999210A Anti-infective and antithrombogenic medical articles and method for their preparation 失效
标题翻译：抗感染和抗血栓形成的医疗用品及其制备方法
公开(公告)号：US4999210A
公开(公告)日：1991-03-12
申请号：US449382
申请日：1989-12-07
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61L27/34 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/16 , A61L29/06 , A61L29/085 , A61L2300/104 , A61L2300/206 , A61L2300/406 , A61L2300/42 , A61L2300/608 , A61M2025/0056 , Y10S514/822 , Y10S524/916
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine, an antibiotic, or an antithrombogenic agent permeated into the surface or it may be a polymeric surface layer having bulk distributed chlorhexidine laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine. The article may then be laminated by dipping into a solution of chlorhexidine and a substantially hydrophilic polymer in a solvent.
摘要翻译：抗感染性医疗用品具有遍及整个聚氨酯基层的氯己定，并且可以在基层上具有涂层。涂层可以是氯己定，抗生素或渗透到表面中的抗血栓形成剂，或者它可以是层叠在基底层上的体积分散的氯己定的聚合物表面层。本发明包括一种制备该制品的方法，其中通过双螺杆混合制备聚合物和氯己定的均匀熔体，并将该熔体挤出以得到具有体积分布的氯己定的医用制品。然后可以通过在溶剂中浸入氯己定和基本亲水性聚合物的溶液中来层压该制品。

35. 发明授权

US4948860A Melt processable polyurethaneurea copolymers and method for their preparation 失效
标题翻译：熔融加工聚氨酯脲共聚物及其制备方法
公开(公告)号：US4948860A
公开(公告)日：1990-08-14
申请号：US345800
申请日：1989-05-01
申请人： Donald D. Solomon , Anthony J. Walder , Can B. Hu
发明人： Donald D. Solomon , Anthony J. Walder , Can B. Hu
IPC分类号： C08G18/32 , C08G18/10 , C08G18/61 , C08G18/65 , C08G18/66 , C08G18/76
CPC分类号： C08G18/7671 , C08G18/10 , C08G18/61 , C08G18/6685
摘要： Melt processable polyurethaneureas are prepared from a diisocyanate, a macroglycol, a diol chain extender and a diamine chain extender. Water may be included as a reactant, and the polymer may contain an additive such as a radiopaque material. The invention includes a one-pot bulk polymerization method for preparation of the polymers.

36. 发明授权

US4600652A Permanently bonded antithrombogenic polyurethane surface 失效
公开(公告)号：US4600652A
公开(公告)日：1986-07-15
申请号：US718664
申请日：1985-04-01
申请人： Donald D. Solomon , Charles W. McGary , Vincent J. Pascarella
发明人： Donald D. Solomon , Charles W. McGary , Vincent J. Pascarella
IPC分类号： C08G18/00 , A61L33/00 , A61L33/10 , B32B27/40 , C08G18/08 , C08G18/83 , C08G18/84 , B32B27/00
CPC分类号： C08G18/84 , A61L33/0023 , A61L33/0029 , C08G18/0814 , Y10T428/31554
摘要： An antithrombogenic polyurethane polymer being bound to a support substrate wherein the antithrombogenic agent is reacted through an aldehyde group with an amine functionality of a polyurethane-urea to form the covalently bonded antithrombogenic material.

37. 发明授权

US08419713B1 Carrier assembly with caps for medical connectors 有权
标题翻译：带医疗连接器盖的承载器组件
公开(公告)号：US08419713B1
公开(公告)日：2013-04-16
申请号：US13564122
申请日：2012-08-01
申请人： Donald D. Solomon , James Paul Kennedy
发明人： Donald D. Solomon , James Paul Kennedy
IPC分类号： A61M39/00
CPC分类号： A61M39/10 , A61M5/002 , A61M39/162 , A61M39/165 , A61M39/20 , A61M2209/06
摘要： An assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. A distinct sealing tab includes a cover portion that sealingly covers the openable end of a corresponding one of the caps and includes an overhang portion that overhangs the openable end thereof. The overhang portion is dimensioned to include a tether of sufficient length that a tip of the tether overlaps an adjacent portion of the carrier. The tip is affixed to the carrier, so that the corresponding one of the caps is tethered to the carrier by such sealing tab.
摘要翻译：用于安装医疗连接器帽的组件包括由一片材料形成并具有孔阵列的载体。组件还包括多个医疗连接器帽。每个盖子插入阵列的一个孔中。组件还包括多个密封片。不同的密封片包括盖部分，其密封地覆盖相应的一个盖子的可打开端部，并且包括突出部分，该突出部分伸出其可打开的端部。突出部分的尺寸被设计成包括足够长度的系绳，使得系绳的尖端与载体的相邻部分重叠。尖端被固定到载体上，使得相应的一个盖通过这种密封片系在载体上。

38. 发明授权

US06210379B1 Needle assembly having an elongated blunting device which allows for venting of air 有权
标题翻译：针组件具有允许排出空气的细长钝化装置
公开(公告)号：US06210379B1
公开(公告)日：2001-04-03
申请号：US09452848
申请日：1999-12-02
申请人： Donald D. Solomon , Joseph J. Chang , Phil D. Schmidt
发明人： Donald D. Solomon , Joseph J. Chang , Phil D. Schmidt
IPC分类号： A61M500
CPC分类号： A61M25/0643 , A61B5/15003 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150641 , A61B5/1535 , A61M25/065 , A61M25/0693 , A61M2005/3212
摘要： The invention generally relates to a needle assembly of the kind having a needle, an elongate blunting device, a shifting member, and a flash chamber. The needle is of the kind that has a needle proximal end, a sharp needle distal end and a needle canula extending therethrough. The elongate blunting device is at least partially located within the needle canula. The elongate blunting device is of the kind that has a blunting device proximal end, a blunting device distal end, and a blunting device blood flow passage therethrough through which blood can flow from the blunting device distal end to the blunting device proximal end. The shifting member can be actuated to move relative to the needle and, upon movement relative to the needle, causes movement to the elongate blunting device from a retracted position wherein the blunting device distal end is retracted into the needle canula so that the sharp needle distal end can penetrate the body, to an extended position wherein the blunting device distal end extends out of the needle canula so as to prevent the sharp needle distal end from penetrating the body. The flash chamber is of the kind that has an internal volume which in communication with the blunting device blood flow passage so that the blood can flow from the blunting device blood flow passage into the internal volume. The flash chamber is at least partially made of a material through which blood can be seen when located in the internal volume.
摘要翻译：本发明一般涉及一种具有针头，细长钝化装置，移动构件和闪光室的针组件。针是具有针近端，尖针头端和穿过其中的针头套的针。细长钝化装置至少部分地位于针槽内。细长钝化装置是具有钝器件近端，钝器装置远端以及穿过其的平坦化装置血流通道的类型，血液可以通过该血流通道从平坦化装置远端流到平稳装置近端。移动构件可以被致动以相对于针移动，并且在相对于针运动时，使其从缩回位置移动到细长的钝化装置，其中平坦化装置的远端缩回到针管中，使得尖锐的针远端端部可以穿透身体到达延伸位置，其中平坦化装置远端从针头套管延伸出来，以防止尖锐的针头远端穿透身体。闪光室具有与平坦化装置血流通道连通的内部容积，使得血液可以从平坦化装置血流通道流入内部容积。闪光室至少部分地由当位于内部体积中时可以看到血液的材料制成。

39. 发明授权

US5322659A Method for rendering a substrate surface antithrombogenic and/or anti-infective 失效
标题翻译：用于使底物表面抗血栓形成和/或抗感染的方法
公开(公告)号：US5322659A
公开(公告)日：1994-06-21
申请号：US586115
申请日：1990-09-21
申请人： Anthony J. Walder , Donald D. Solomon , Gregory J. Mann
发明人： Anthony J. Walder , Donald D. Solomon , Gregory J. Mann
IPC分类号： A61L27/54 , A61L29/16 , A61L33/00 , B29C47/06 , B32B37/00
CPC分类号： A61L33/0041 , A61L27/54 , A61L29/16 , A61L33/0023 , B29C47/0016 , B29C47/0023 , B29C47/065 , A61L2300/404 , A61L2300/406 , A61L2300/42 , A61L2300/45 , B29C47/0026 , B29C47/06 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2027/06 , B29K2033/04 , B29K2067/00 , B29K2075/00 , B29K2077/00 , B29K2105/0011 , B29K2995/0092 , B29K2995/0093 , B29L2023/22
摘要： A method to render a medical article antithrombogenic and/or anti-infective includes coextruding a base polymer with a hydrophilic laminating polymer having dispersed therein a quarternary salt complexing agent and steeping the extruded article in an aqueous solution of an antithrombogenic and/or anti-infective reagent whereby the reagent is absorbed along with water by the hydrophilic polymer and reacts with the complexing agent.
摘要翻译：使医疗制品抗血栓形成和/或抗感染的方法包括将基础聚合物与其中分散有季盐络合剂的亲水层压聚合物共挤出，并将挤出制品浸入抗血栓形成和/或抗感染的水溶液中试剂，其中试剂与水一起被亲水性聚合物吸收并与络合剂反应。

40. 发明授权

US5165952A Anti-infective and antithrombogenic medical articles and method for their preparation 失效
标题翻译：抗感染和抗血栓形成的医疗用品及其制备方法
公开(公告)号：US5165952A
公开(公告)日：1992-11-24
申请号：US586171
申请日：1990-09-21
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61L27/34 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/06 , A61L29/085 , A61L29/16 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61M2025/0056
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
摘要翻译：抗感染性医疗用品具有遍及整个聚氨酯基层的氯己定，并且可以在基层上具有涂层。涂层可以是氯己定渗透到表面中，或者它可以是层压到基底层上的抗生素，抗血栓形成剂或聚合物表面层。本发明包括一种制备该制品的方法，其中通过双螺杆混合制备聚合物和氯己定的均匀熔体，并将该熔体挤出以得到具有体积分布的氯己定的医用制品。

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