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31. 发明授权

US07217921B2 Method and apparatus for FAIMS for in-line analysis of multiple samples 失效
标题翻译：用于FAIMS在线分析多种样品的方法和装置
公开(公告)号：US07217921B2
公开(公告)日：2007-05-15
申请号：US11040303
申请日：2005-01-21
申请人： Roger Guevremont , Ragnar Dworschak
发明人： Roger Guevremont , Ragnar Dworschak
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/0413 , H01J49/0418
摘要： A method of separating ions includes providing a FAIMS analyzer region including an ion inlet orifice for providing ions thereto, and providing a sample holder along a side of the ion inlet orifice that is opposite the FAIMS analyzer. A sample material is applied to the sample holder such that sample material is disposed about first and second points along the sample holder, a distance between the first and second points being greater than a maximum dimension of the ion inlet orifice. The first point is aligned with the ion inlet orifice, and the sample material disposed about the first point is irradiated with laser light of a predetermined wavelength. Next, the sample holder is moved relative to the ion inlet so as to align the second point with the ion inlet orifice, and the sample material disposed about the second point is irradiated with laser light of a predetermined wavelength.
摘要翻译：分离离子的方法包括提供包括用于提供离子的离子入口孔的FAIMS分析器区域，并且沿着与FAIMS分析仪相对的离子入口孔的一侧提供样品保持器。将样品材料施加到样品保持器，使得样品材料围绕样品保持器围绕第一和第二点设置，第一和第二点之间的距离大于离子入口孔的最大尺寸。第一点与离子入口孔对准，并且围绕第一点设置的样品材料用预定波长的激光照射。接下来，样品保持器相对于离子入口移动，以使第二点与离子入口孔对齐，并且围绕第二点设置的样品材料用预定波长的激光照射。

32. 发明授权

US07045778B2 Apparatus and method for establishing a temperature gradient within a FAIMS analyzer region 有权
标题翻译：在FAIMS分析仪区域内建立温度梯度的装置和方法
公开(公告)号：US07045778B2
公开(公告)日：2006-05-16
申请号：US11038099
申请日：2005-01-21
申请人： Roger Guevremont , Edward Masionis , David Barnett
发明人： Roger Guevremont , Edward Masionis , David Barnett
IPC分类号： H01J49/28 , H01J49/40
CPC分类号： G01N27/624
摘要： A method of separating ions includes providing a FAIMS analyzer region for separating ions, and establishing a temperature gradient across the FAIMS analyzer region to controllably affect ion focusing in the FAIMS analyzer region.
摘要翻译：分离离子的方法包括提供用于分离离子的FAIMS分析器区域，并且在FAIMS分析仪区域上建立温度梯度以可控地影响FAIMS分析仪区域中的离子聚焦。

33. 发明授权

US07026612B2 FAIMS apparatus and method using carrier gases that contain a trace amount of a dopant species 有权
标题翻译：使用含有微量掺杂剂种类的载气的FAIMS装置和方法
公开(公告)号：US07026612B2
公开(公告)日：2006-04-11
申请号：US10503713
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett , Barbara Ells
发明人： Roger Guevremont , Randy Purves , David Barnett , Barbara Ells
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/04
摘要： Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus. A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector.
摘要翻译：公开了一种用于改善通过FAIMS装置的分析器区域传输的与感兴趣的离子相关的峰值分离和信号强度中的至少一个的方法和装置。根据本发明的方法包括将包含感兴趣的离子的离子引入到FAIMS的分析器区域中的步骤。除了空气之外的掺杂载气的流动也通过分析器区域提供。掺杂的载气包括载气和痕量的预定掺杂气体，所选择的预定掺杂剂气体相对于峰值分离和信号来改善峰值分离和与感兴趣的离子相关的信号强度中的至少一个仅在载气存在下与感兴趣的离子有关的强度。感兴趣的离子在掺杂的载气的存在下选择性地透过分析器区域，并在检测器处检测。

34. 发明授权

US07005633B2 Method and apparatus for desolvating ions for introduction into a FAIMS analyzer region 有权
标题翻译：用于脱离离子以引入FAIMS分析仪区域的方法和装置
公开(公告)号：US07005633B2
公开(公告)日：2006-02-28
申请号：US10503659
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , G01N21/3504
摘要： Disclosed are an apparatus and a method for separating ions produced at an electrospray ionization source, based upon the high field mobility properties of the ions. An apparatus according to the instant invention includes a high field asymmetric waveform ion mobility spectrometer (FAIMS) having an analyzer region defined by a space between an inner electrode (32) and an outer electrode (34). In particular, the outer electrode includes an ion inlet (38) for introducing ions into a first portion of analyzer region and an ion outlet (56) for extracting ions from a second portion of the analyzer region. The FAIMS is characterized in that a gas-directing conduit (48) is provided through at least a portion of the inner electrode. In particular, the gas-directing conduit includes an opening at a first end thereof for supporting fluid communication between the gas-directing conduit and the first portion of the analyzer region. The gas-directing conduit is adapted at a second end thereof opposite the first end for supporting fluid communication between a gas source and the gas-directing conduit. The opening is orientated relative to the ion inlet such that gas provided through the gas-directing conduit flows partially outwardly from the analyzer region through the ion inlet, so as to desolvate the ions produced at an ionization source (42, 45) as they are introduced into the analyzer region.
摘要翻译：公开了基于离子的高场迁移率特性分离在电喷雾离子源产生的离子的装置和方法。根据本发明的装置包括具有由内电极（32）和外电极（34）之间的空间限定的分析器区域的高场不对称波形离子迁移谱仪（FAIMS）。特别地，外部电极包括用于将离子引入分析器区域的第一部分的离子入口（38）和用于从分析器区域的第二部分提取离子的离子出口（56）。 FAIMS的特征在于，通过内部电极的至少一部分提供导气导管（48）。特别地，导气导管包括在其第一端处的开口，用于支撑气体导向导管和分析器区域的第一部分之间的流体连通。气体导向管道在其与第一端相对的第二端处适配，以支撑气体源和气体导向管道之间的流体连通。开口相对于离子入口定向，使得通过导气导管提供的气体通过离子入口部分地从分析器区域向外流动，从而使离子化物质（42,45）产生的离子原样脱水引入分析仪区域。

35. 发明申请

US20060038121A1 Method and quadrupole apparatus for separating ions in the gas-phase 有权
标题翻译：用于分离气相中离子的方法和四极杆装置
公开(公告)号：US20060038121A1
公开(公告)日：2006-02-23
申请号：US10529304
申请日：2003-09-23
申请人： Roger Guevremont
发明人： Roger Guevremont
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/063
摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) including a set of spaced-apart parallel rods, the space between the parallel rods having first and second ends and defining an analyzer region. The apparatus includes an electrical controller for electrically coupling to the set of parallel rods, for applying at least an rf-voltage between the parallel rods of the set of parallel rods in a first operating mode and for applying a combination of an asymmetric waveform voltage and a direct current voltage between the parallel rods of the set of parallel rods in a second operating mode.
摘要翻译：公开了一种包括一组间隔开的平行杆的高场非对称波形离子迁移谱仪（FAIMS），平行杆之间的空间具有第一和第二端并限定分析器区域。该装置包括用于电耦合到该组平行杆的电控制器，用于在第一操作模式中在该组平行杆的平行杆之间施加至少一个rf电压，并且用于施加非对称波形电压和在第二操作模式下，该组平行杆的平行杆之间的直流电压。

36. 发明申请

US20060038119A1 Faims apparatus and method for separating ions 失效
标题翻译： Faims仪器和分离离子的方法
公开(公告)号：US20060038119A1
公开(公告)日：2006-02-23
申请号：US10529308
申请日：2003-08-28
申请人： Roger Guevremont , Lucien Potvin
发明人： Roger Guevremont , Lucien Potvin
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： H01J49/42
摘要： A method of controlling an asymmetric waveform that is generated as a combination of a plurality of sinusoidal waves, including two sinusoidal waves having a frequency that differs by a factor of two. The method includes the steps of sampling the generated asymmetric waveform to obtain a set of data points that is indicative of the generated asymmetric waveform. Each data point of the set of data points normalized. The method further includes the steps of determining at least a value relating to the normalized data points, of comparing the determined at least a value to template data relating to an ideal asymmetric waveform, and of effecting a change to the generated asymmetric waveform in dependence upon the comparison.
摘要翻译：一种控制作为多个正弦波的组合产生的非对称波形的方法，包括具有两倍的频率的两个正弦波。该方法包括以下步骤：对生成的非对称波形进行采样以获得指示所生成的不对称波形的一组数据点。数据点集合中的每个数据点被归一化。该方法还包括以下步骤：至少确定与归一化数据点相关的值，将所确定的至少一个值与与理想非对称波形相关的模板数据进行比较，以及根据所产生的不对称波形进行改变比较。

37. 发明授权

US06770875B1 Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer 有权
标题翻译：用于溶解和聚焦离子以引入质谱仪的装置和方法
公开(公告)号：US06770875B1
公开(公告)日：2004-08-03
申请号：US09762239
申请日：2001-06-28
申请人： Roger Guevremont , Randy Purves
发明人： Roger Guevremont , Randy Purves
IPC分类号： H01J4904
CPC分类号： G01N27/624 , B01D59/46 , B01D59/48 , H01J49/004 , H01J49/044
摘要： This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry (FAIMS), for introduction into a mass spectrometer. The ion focussing, trapping and desolvating effects of FAIMS, as identified by the inventors, provides high ion transmission efficiency and high sensitivity for the detection of ions. An apparatus comprising an ESI source, a FAIMS device and a mass spectrometer provides a way of desolvating and selectively transmitting highly solvated ions for introduction into a mass spectrometer for analysis.
摘要翻译：本发明提供了一种基于高场非对称波形离子淌度光谱法（FAIMS）的离子聚焦原理，通过电喷雾离子化（ESI）产生的离子来去离子并选择性地透射和聚焦离子的设备和方法，用于引入质谱仪。如本发明人所确定的，FAIMS的离子聚焦，捕获和脱溶剂效应为离子的检测提供了高离子传输效率和高灵敏度。包括ESI源，FAIMS装置和质谱仪的装置提供了一种解吸和选择性地透射高度溶剂化的离子以引入质谱仪进行分析的方法。

38. 发明授权

US07358504B2 FAIMS apparatus and method for separating ions 失效
标题翻译： FAIMS仪器和分离离子的方法
公开(公告)号：US07358504B2
公开(公告)日：2008-04-15
申请号：US10529306
申请日：2003-07-10
申请人： Roger Guevremont
发明人： Roger Guevremont
IPC分类号： H01J49/42
CPC分类号： G01N27/624
摘要： Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) for separating ions, and a method therefore. The FAIMS includes an electrode stack (24) having a length and comprising a plurality of electrodes (26, 28). Each electrode of the electrode stack is spaced apart from an adjacent electrode in a direction along the length of the electrode stack, and each electrode of the electrode stack has an edge that defines a portion of an edge of the electrode stack. At least an electrode (22) is spaced apart from the edge of the electrode stack in a direction approximately transverse to the length of the electrode stack, the space between the at least an electrode and the edge of the electrode stack defines an analytical gap (20) for allowing ions to propagate therebetween. Ions are separated as they move through an electric field within the analytical gap resulting from the application of an asymmetric waveform voltage to alternate electrodes of the electrode stack and application of a direct current voltage to at least some of the electrodes of the electrode stack and to the at least an electrode.
摘要翻译：公开了用于分离离子的高场非对称波形离子迁移谱仪（FAIMS），因此公开了一种方法。 FAIMS包括具有长度并包括多个电极（26,28）的电极堆叠（24）。电极堆叠的每个电极在沿着电极堆叠的长度的方向上与相邻电极间隔开，并且电极堆叠的每个电极具有限定电极堆叠的边缘的一部分的边缘。至少电极（22）在大致横向于电极堆叠长度的方向上与电极堆叠的边缘间隔开，至少电极和电极堆叠边缘之间的空间限定分析间隙（ 20），用于允许离子在其间传播。当分离间隙中的电场移动时，由于将非对称波形电压施加到电极堆叠的交替电极并且将直流电压施加到电极堆叠的至少一些电极并且向所述至少一个电极。

39. 发明授权

US07135674B2 Method and apparatus for FAIMS with a laser-based ionization source 失效
标题翻译：用于具有基于激光的电离源的FAIMS的方法和装置
公开(公告)号：US07135674B2
公开(公告)日：2006-11-14
申请号：US11038144
申请日：2005-01-21
申请人： Roger Guevremont , Ragnar Dworschak , Richard A. Yost , Christopher Karl Hilton , Michael William Belford
发明人： Roger Guevremont , Ragnar Dworschak , Richard A. Yost , Christopher Karl Hilton , Michael William Belford
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： G01N27/624 , H01J49/0413 , H01J49/0418
摘要： A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.
摘要翻译：分离离子的方法包括将样品材料的斑点施加到靶板。目标板安装成与FAIMS分析仪区域的离子入口孔流体连通并且在FAIMS分析仪区域的外部。使用设置在FAIMS分析仪区域外部的激光源，用预定波长的光照射靶板，选择预定波长的光以影响施加到靶板的样品材料，以产生离子的样品材料。样品材料的离子通过离子入口孔沿着靶板和FAIMS分析器区域之间的离子流动路径引导。气体的流动与离子流动路径逆流并且通过目标板。通过目标板的气体流动有助于离子去离子化，并将中性分子引导离开FAIMS分析仪区域。

40. 发明授权

US07034289B2 Segmented side-to-side FAIMS 失效
标题翻译：分段的侧向FAIMS
公开(公告)号：US07034289B2
公开(公告)日：2006-04-25
申请号：US10503714
申请日：2003-02-07
申请人： Roger Guevremont , Randy Purves , David Barnett
发明人： Roger Guevremont , Randy Purves , David Barnett
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/624 , G01N21/03 , G01N21/35 , G01N21/3504 , G01N21/65 , Y10T436/105831 , Y10T436/24
摘要： Provided is a side-to-side high field asymmetric waveform ion mobility spectrometer (FAIMS) including a generally cylindrically-shaped inner electrode having a length. Encircling the inner electrode is a generally cylindrically-shaped outer electrode assembly comprising at least first and second and third outer electrode segments. Each of the outer electrode segments has a channel extending therethrough and open at opposite ends thereof. In an assembled condition, the second outer electrode segment is disposed intermediate the first and third outer electrode segments in an end-to-end arrangement, each one of the first and second and third electrode segments overlapping a different portion of the length of the inner electrode. An electrical contact is provided on at least one of the inner electrode and the second outer electrode segment for receiving a first direct current voltage between the inner electrode and the second outer electrode segment, and for applying an asymmetric waveform voltage to the at least one of the inner electrode and the second outer electrode segment. The second outer electrode segment is maintained at a different potential relative to the first and third outer electrode segments, such that a potential gradient is formed in a direction along the length of the inner electrode.
摘要翻译：提供了一种包括具有长度的大致圆柱形的内部电极的侧对侧高场非对称波形离子迁移谱仪（FAIMS）。围绕内部电极是大致圆柱形的外部电极组件，其包括至少第一和第二和第三外部电极段。每个外部电极段具有穿过其延伸并在其相对端处开口的通道。在组装状态下，第二外部电极段以端对端布置设置在第一和第三外部电极段的中间，第一和第二和第三电极段中的每一个与内部电极段的长度的不同部分重叠电极。在内部电极和第二外部电极段中的至少一个上提供电接触，用于接收内部电极和第二外部电极段之间的第一直流电压，并且将不对称波形电压施加到至少一个内电极和第二外电极段。第二外部电极段相对于第一和第三外部电极段保持在不同的电势，使得在沿着内部电极的长度的方向上形成电位梯度。

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