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31. 发明授权

US09402962B2 Assembly for use in a drug delivery device 有权
标题翻译：用于药物输送装置的组装
公开(公告)号：US09402962B2
公开(公告)日：2016-08-02
申请号：US13497375
申请日：2010-09-29
申请人： Catherine Anne Macdonald , Robert Veasey , Garen Kouyoumjian , Christopher Jones , Andrew Mark Lindsay
发明人： Catherine Anne Macdonald , Robert Veasey , Garen Kouyoumjian , Christopher Jones , Andrew Mark Lindsay
IPC分类号： A61M5/00 , A61M5/315 , A61M5/31 , A61M5/24
CPC分类号： A61M5/31593 , A61M5/24 , A61M5/3146 , A61M5/31501 , A61M5/31511 , A61M5/31555 , A61M2005/2407 , A61M2205/581
摘要： The present invention relates to an assembly for a drug delivery device comprising a proximal end, a distal end and a moveable member, a dose member, a fixed member and coupling means, wherein in a first state, the moveable member is moveable in an axial direction with respect to the fixed member and the dose member and the coupling means retains the dose member to the fixed member, and wherein in a second state of the assembly, the moveable member is permanently connected with the dose member by means of the coupling means and the dose member is released from the fixed member and the assembly is configured to set and dispense a dose of a fluid medicinal product out of an assembled cartridge by movement of the dose member. Furthermore it relates to a method for setting-up a drug delivery device.
摘要翻译：本发明涉及一种用于药物输送装置的组件，其包括近端，远端和可移动构件，剂量构件，固定构件和联接装置，其中在第一状态下，可移动构件可在轴向相对于固定构件和剂量构件的方向，并且联接装置将剂量构件保持到固定构件，并且其中在组件的第二状态下，可移动构件通过联接装置永久地与剂量构件连接并且剂量构件从固定构件释放，并且组件构造成通过剂量构件的移动来将流体药物的剂量设置和分配出组装的筒。此外，它涉及一种用于设置药物递送装置的方法。

32. 发明授权

US09387294B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US09387294B2
公开(公告)日：2016-07-12
申请号：US13498620
申请日：2010-09-29
申请人： David Plumptre , Andrew Mark Lindsay , Catherine Anne MacDonald , Robert Veasey , Garen Kouyoumjian , Christopher Jones
发明人： David Plumptre , Andrew Mark Lindsay , Catherine Anne MacDonald , Robert Veasey , Garen Kouyoumjian , Christopher Jones
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24 , A61M5/31
CPC分类号： A61M5/31585 , A61M5/24 , A61M5/3146 , A61M5/31543 , A61M5/31555 , A61M5/3157 , A61M5/31575 , A61M2005/2407 , A61M2005/3126 , A61M2205/581 , A61M2205/582
摘要： A drug delivery device (4) for dispensing one or more doses of a drug is provided. The device (4) comprises a drive member (1) for driving a piston rod (5) and a dose member (46) for actuating the drive member (1). The piston rod (5) is coupled to the drive member (1) such that a relative translational movement of the drive member (1) and the piston rod (5) is allowed and a relative rotational movement is prevented. The drive member (1) is configured to be driven by the dose member (46) around the longitudinal axis in a first (110) and a second rotational direction (111) opposite to each other. Furthermore, a drug delivery device (4) is provided, wherein the drive member (1) has stable and unstable states and wherein in an unstable state the drive member (1) is biased by biasing means (3) towards a stable state.
摘要翻译：提供了用于分配一个或多个剂量的药物的药物输送装置（4）。装置（4）包括用于驱动活塞杆（5）的驱动构件（1）和用于致动驱动构件（1）的剂量构件（46）。活塞杆（5）联接到驱动构件（1），使得驱动构件（1）和活塞杆（5）的相对平移运动被允许并且防止相对的旋转运动。驱动构件（1）被配置为在彼此相对的第一（110）和第二旋转方向（111）中围绕纵向轴线由剂量构件（46）驱动。此外，提供了药物输送装置（4），其中驱动构件（1）具有稳定和不稳定的状态，并且其中在不稳定状态下，驱动构件（1）由偏置装置（3）朝向稳定状态偏置。

33. 发明授权

US09358340B2 Method and assembly for a drug delivery device 有权
标题翻译：药物输送装置的方法和装配
公开(公告)号：US09358340B2
公开(公告)日：2016-06-07
申请号：US13496337
申请日：2010-09-29
申请人： Christopher Jones , Robert Veasey , Garen Kouyoumjian , Catherine Anne MacDonald , Michael Jugl , Gunther Sendatzki
发明人： Christopher Jones , Robert Veasey , Garen Kouyoumjian , Catherine Anne MacDonald , Michael Jugl , Gunther Sendatzki
IPC分类号： A61M5/24 , A61M5/31 , A61M5/315 , A61M5/32 , A61M5/34
CPC分类号： A61M5/24 , A61M5/3146 , A61M5/31555 , A61M5/3202 , A61M5/3293 , A61M5/344 , A61M5/347 , A61M2005/2407 , A61M2005/2477 , A61M2005/2488 , A61M2205/6045 , A61M2207/00 , Y10T29/49826
摘要： A method for securing a cartridge (4) in a cartridge holder (3) is provided, the method comprising the steps of inserting the cartridge (4) into the cartridge holder (3), the cartridge holder (3) having a proximal end and a distal end, axially displacing the cartridge (4) in a proximal direction with respect to the cartridge holder (3) from a distal initial position to a proximal end position and securing the cartridge (4) in the end position against displacement in the distal direction with respect to the cartridge holder (3). An assembly for a drug delivery device (1) is provided comprising a cartridge (4), an adjusting member (12, 25, 28, 34) and a cartridge holder (3). The cartridge holder (3) has a distal end and a proximal end. The adjusting member (12, 25, 28, 34) is secured to the cartridge holder (3). The adjusting member (12, 25, 28, 34) holds a distal portion of the cartridge (4) at a distance with respect to a distal portion of the cartridge holder (3).
摘要翻译：提供了一种用于将盒（4）固定在盒保持器（3）中的方法，所述方法包括以下步骤：将盒（4）插入盒保持器（3），盒保持器（3）具有近端和一个远端，使药筒（4）相对于药筒保持器（3）的近端方向从远端初始位置轴向移位到近端位置，并将药筒（4）固定在终端位置，防止远端方向相对于盒保持器（3）。提供了一种用于药物输送装置（1）的组件，其包括盒（4），调节构件（12,25,28,34）和盒保持器（3）。药筒保持器（3）具有远端和近端。调节构件（12,25,28,34）固定在盒保持架（3）上。调节构件（12,25,28,34）将盒（4）的远端部分相对于盒保持器（3）的远端部分保持一段距离。

34. 发明授权

US08939945B2 Drive mechanism for a drug delivery device 有权
标题翻译：药物输送装置的驱动机构
公开(公告)号：US08939945B2
公开(公告)日：2015-01-27
申请号：US13497769
申请日：2010-09-29
申请人： Robert Veasey , David Plumptre , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , David Plumptre , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24
CPC分类号： A61M5/31511 , A61M5/24 , A61M5/31505 , A61M5/31555 , A61M5/3156 , A61M5/31585 , A61M2005/2407
摘要： A lead screw (5) with a screw thread (6) is arranged in a body (1) along an axis (4) and coupled to a lead screw nut (7) with a drive feature (8), so that the lead screw is helically rotatable in the lead screw nut. The lead screw and the lead screw nut are provided with stop features (9) interfering with a rotation of the lead screw in the lead screw nut when a force is applied to the lead screw in an axial direction. The lead screw nut has a surface area facing a guide feature (10) of the body. This surface area has a slope (12) varying around the axis. The assembly interacts such that the lead screw nut rotates in one rotational direction when a force is applied to the lead screw in the axial direction.
摘要翻译：具有螺纹（6）的导螺杆（5）沿着轴线（4）布置在主体（1）中并且与具有驱动特征（8）的丝杠螺母（7）连接，使得导螺杆可在导螺杆螺母中螺旋转动。导向螺钉和导螺杆螺母在沿轴向向导螺杆施加力时，设有阻止导螺杆螺母旋转的停止特征（9）。导螺杆螺母具有面向主体的引导特征（10）的表面区域。该表面区域具有围绕轴线变化的斜率（12）。组件相互作用，使得当螺杆沿轴向施加力时，导螺杆螺母在一个旋转方向上旋转。

35. 发明申请

US20120296287A1 Drive Mechanism for a Drug Delivery Device 有权
标题翻译：药物输送装置的驱动机制
公开(公告)号：US20120296287A1
公开(公告)日：2012-11-22
申请号：US13497769
申请日：2010-09-29
申请人： Robert Veasey , David Plumptre , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
发明人： Robert Veasey , David Plumptre , Christopher Jones , Garen Kouyoumjian , Catherine Anne MacDonald
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31511 , A61M5/24 , A61M5/31505 , A61M5/31555 , A61M5/3156 , A61M5/31585 , A61M2005/2407
摘要： A lead screw (5) with a screw thread (6) is arranged in a body (1) along an axis (4) and coupled to a lead screw nut (7) with a drive feature (8), so that the lead screw is helically rotatable in the lead screw nut. The lead screw and the lead screw nut are provided with stop features (9) interfering with a rotation of the lead screw in the lead screw nut when a force is applied to the lead screw in an axial direction. The lead screw nut has a surface area facing a guide feature (10) of the body. This surface area has a slope (12) varying around the axis. The assembly interacts such that the lead screw nut rotates in one rotational direction when a force is applied to the lead screw in the axial direction.
摘要翻译：具有螺纹（6）的导螺杆（5）沿着轴线（4）布置在主体（1）中并且与具有驱动特征（8）的丝杠螺母（7）连接，使得导螺杆可在导螺杆螺母中螺旋转动。导向螺钉和导螺杆螺母在沿轴向向导螺杆施加力时，设有阻止导螺杆螺母旋转的停止特征（9）。导螺杆螺母具有面向主体的引导特征（10）的表面区域。该表面区域具有围绕轴线变化的斜率（12）。组件相互作用，使得当螺杆沿轴向施加力时，导螺杆螺母在一个旋转方向上旋转。

36. 发明申请

US20120283657A1 MECHANISM FOR A DRUG DELIVERY DEVICE 有权
标题翻译：药物递送装置的机制
公开(公告)号：US20120283657A1
公开(公告)日：2012-11-08
申请号：US13496537
申请日：2010-09-29
申请人： Garen Kouyoumjian , Robert Veasey , David Plumptre , Christopher Jones , Catherine Anne Macdonald , Matthew Jones
发明人： Garen Kouyoumjian , Robert Veasey , David Plumptre , Christopher Jones , Catherine Anne Macdonald , Matthew Jones
IPC分类号： A61M5/315 , B23P17/04
CPC分类号： A61M5/31585 , A61M5/24 , A61M5/3146 , A61M5/31555 , A61M5/3158 , A61M2005/2407 , A61M2205/6081 , A61M2207/00 , Y10T29/49826
摘要： The present invention relates to an assembly forming a piston rod for advancing a cartridge bung in a drug delivery device, the assembly comprising a first member and a second member wherein in a first state, the first and the second member are moveable with respect to each other to adjust the length of the piston rod and wherein in a second state the first member is locked in position with respect to the second member in order to define a fixed length of the piston rod. Furthermore, it relates to a drug delivery device comprising the assembly and to a method for assembling such a drug delivery device.
摘要翻译：本发明涉及一种形成活塞杆的组件，该活塞杆用于推进药物输送装置中的筒塞，该组件包括第一构件和第二构件，其中在第一状态下，第一和第二构件可相对于每个构件移动另一个调节活塞杆的长度，并且其中在第二状态下，第一构件相对于第二构件被锁定就位，以便限定活塞杆的固定长度。此外，本发明涉及一种药物递送装置，其包括该组件以及用于组装这种药物递送装置的方法。

37. 发明申请

US20120283646A1 DRUG DELIVERY SYSTEM, DRUG DELIVERY DEVICE, NEEDLE ASSEMBLY AND METHOD FOR PRIMING 审中-公开
标题翻译：药物递送系统，药物递送装置，针头组件和用于预定的方法
公开(公告)号：US20120283646A1
公开(公告)日：2012-11-08
申请号：US13498372
申请日：2010-09-29
申请人： Garen Kouyoumjian , Robert Veasey , Christopher Jones , Catherine Anne Macdonald , Stephen Gilmore , George Cave
发明人： Garen Kouyoumjian , Robert Veasey , Christopher Jones , Catherine Anne Macdonald , Stephen Gilmore , George Cave
IPC分类号： A61M5/315 , A61M5/32
CPC分类号： A61M5/34 , A61M5/002 , A61M5/1456 , A61M5/2466 , A61M5/3146 , A61M5/31525 , A61M5/31533 , A61M5/31571 , A61M5/3202 , A61M5/3293 , A61M5/345
摘要： A drug delivery system comprises a drug delivery device which comprises a housing and a cartridge. The drug delivery device has a proximal end and a distal end. The drug delivery system further comprises a needle assembly which is attachable to the drug delivery device. The needle assembly and the drug delivery device are configured such that the cartridge is moved in the proximal direction with respect to the housing when the needle assembly is attached to the drug delivery device.
摘要翻译：药物递送系统包括药物递送装置，其包括壳体和药筒。药物递送装置具有近端和远端。药物递送系统还包括可组装到药物递送装置上的针组件。针组件和药物递送装置构造成使得当针组件附接到药物递送装置时，药筒相对于壳体在近侧方向上移动。

38. 发明授权

US09750890B2 Mechanism for a drug delivery device 有权
公开(公告)号：US09750890B2
公开(公告)日：2017-09-05
申请号：US13496537
申请日：2010-09-29
申请人： Garen Kouyoumjian , Robert Veasey , David Plumptre , Christopher Jones , Catherine Anne Macdonald , Matthew Jones
发明人： Garen Kouyoumjian , Robert Veasey , David Plumptre , Christopher Jones , Catherine Anne Macdonald , Matthew Jones
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24 , A61M5/31
CPC分类号： A61M5/31585 , A61M5/24 , A61M5/3146 , A61M5/31555 , A61M5/3158 , A61M2005/2407 , A61M2205/6081 , A61M2207/00 , Y10T29/49826
摘要： The present invention relates to an assembly forming a piston rod for advancing a cartridge bung in a drug delivery device, the assembly comprising a first member and a second member wherein in a first state, the first and the second member are moveable with respect to each other to adjust the length of the piston rod and wherein in a second state the first member is locked in position with respect to the second member in order to define a fixed length of the piston rod. Furthermore, it relates to a drug delivery device comprising the assembly and to a method for assembling such a drug delivery device.

39. 发明授权

US09463278B2 Resettable drive mechanism for a drug delivery device with guide track and blocking means 有权
标题翻译：具有导轨和阻塞装置的药物输送装置的可复位驱动机构
公开(公告)号：US09463278B2
公开(公告)日：2016-10-11
申请号：US13395701
申请日：2010-09-29
申请人： Catherine Anne MacDonald , Robert Veasey , Christopher Jones , Garen Kouyoumjian
发明人： Catherine Anne MacDonald , Robert Veasey , Christopher Jones , Garen Kouyoumjian
IPC分类号： A61M5/24 , A61M5/31 , A61M5/315
CPC分类号： A61M5/24 , A61M5/3146 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M5/3156 , A61M5/3158 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492
摘要： A resettable drive mechanism for a drug delivery device (1) comprises a piston rod assembly (32) and an interaction member (23). The piston rod assembly (32) comprises a guide track (18) running along the piston rod assembly (32), the guide track (18) comprising at least one delivery section (18A) and at least one reset section (18B). The reset section (18B) is arranged to continue the delivery section (18A). The delivery section (18A) comprises at least one blocking means (19). The interaction member (23) is configured to cooperate with the guide track (18). For delivering a dose of a drug (24), the piston rod assembly (32) is axially displaceable in a dose delivery direction away from an axial starting position, the interaction member (23) cooperating with the delivery section (18A) and the blocking means (19) passing the interaction member (23) when the piston rod assembly (32) is displaced in the dose delivery direction. Axial displacement of the piston rod assembly (32) towards the axial starting position is prevented by mechanical interaction of the blocking means (19) and the interaction member (23) when the interaction member (23) cooperates with the delivery section (18A). For resetting the drug delivery device (1), the interaction member (23) is configured to cooperate with the reset section (18B), the piston rod assembly (32) being axially displaced towards the axial starting position, the blocking means (19) being offset from the interaction member (23) and passing the axial position of the interaction member (23) when the piston rod assembly (32) is axially displaced towards the axial starting position. Also, a piston rod assembly (32) is proposed.
摘要翻译：用于药物输送装置（1）的可重置驱动机构包括活塞杆组件（32）和相互作用构件（23）。活塞杆组件（32）包括沿着活塞杆组件（32）延伸的导轨（18），导轨（18）包括至少一个输送部分（18A）和至少一个复位部分（18B）。复位部分（18B）布置成继续传送部分（18A）。输送部分（18A）包括至少一个阻挡装置（19）。相互作用构件（23）构造成与导轨（18）配合。为了递送药物（24）的剂量，活塞杆组件（32）可以在远离轴向起始位置的剂量递送方向上轴向移位，相互作用构件（23）与输送段（18A）配合并阻塞当活塞杆组件（32）在剂量递送方向上移位时，装置（19）使相互作用构件（23）通过。当相互作用构件（23）与输送段（18A）配合时，通过阻挡装置（19）和相互作用构件（23）的机械相互作用来防止活塞杆组件（32）朝向轴向起始位置的轴向位移。为了复位药物输送装置（1），相互作用构件（23）构造成与复位部分（18B）配合，活塞杆组件（32）朝着轴向起始位置轴向移位，阻挡装置（19）当所述活塞杆组件（32）朝向所述轴向起始位置轴向移位时，所述相互作用构件（23）偏离所述相互作用构件（23）的轴向位置。此外，提出了一种活塞杆组件（32）。

40. 发明授权

US09358341B2 Resettable drug delivery device 有权
标题翻译：可重配药物输送装置
公开(公告)号：US09358341B2
公开(公告)日：2016-06-07
申请号：US13496538
申请日：2010-09-29
申请人： David Plumptre , Andrew Mark Lindsay , Catherine Anne Macdonald , Robert Veasey , Christopher Jones , Garen Kouyoumjian
发明人： David Plumptre , Andrew Mark Lindsay , Catherine Anne Macdonald , Robert Veasey , Christopher Jones , Garen Kouyoumjian
IPC分类号： A61M5/24 , A61M5/31 , A61M5/315
CPC分类号： A61M5/24 , A61M5/3146 , A61M5/31501 , A61M5/31543 , A61M5/3156 , A61M5/31575 , A61M5/31585 , A61M5/31593 , A61M2005/2407 , A61M2005/2488 , A61M2005/3103 , A61M2005/3125 , A61M2005/3126 , A61M2205/581 , A61M2205/582
摘要： A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.
摘要翻译：提供了用于驱动药物输送装置中的活塞杆的驱动构件。驱动构件构造成通过致动构件在旋转运动中被驱动。驱动构件包括用于将驱动载荷从致动构件传递到驱动构件的轨道。轨道包括在远端运行的部分和沿着驱动构件的近端方向运行的部分。此外，提供了包括这种驱动构件的药物输送装置。

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