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31. 发明授权

US07501436B2 5-HT3 receptor antagonists and methods of use 失效
标题翻译： 5-HT 3受体拮抗剂和使用方法
公开(公告)号：US07501436B2
公开(公告)日：2009-03-10
申请号：US11551562
申请日：2006-10-20
申请人： Xiaoming Zhang , Jurg R. Pfister , Cyrus Becker , Pascal Druzgala
发明人： Xiaoming Zhang , Jurg R. Pfister , Cyrus Becker , Pascal Druzgala
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D403/06 , C07D451/14 , C07D471/04
摘要： The subject invention provides useful and novel 5-HT3 antagonists. The subject invention also provides methods for synthesizing the compounds of invention. The invention also provides methods for the treatment of irritable bowel syndrome and other such conditions.
摘要翻译：本发明提供有用的和新颖的5-HT 3拮抗剂。本发明还提供了合成本发明化合物的方法。本发明还提供了治疗肠易激综合征和其他此类病症的方法。

32. 发明授权

US07486196B1 Using audio to detect changes to the performance of an application 失效
标题翻译：使用音频检测应用程序性能的变化
公开(公告)号：US07486196B1
公开(公告)日：2009-02-03
申请号：US12102533
申请日：2008-04-14
申请人： Richard M. Bicheno , Tim Dunn , Ian P. Hurworth , Xiaoming Zhang
发明人： Richard M. Bicheno , Tim Dunn , Ian P. Hurworth , Xiaoming Zhang
IPC分类号： G08B5/00
CPC分类号： G06F11/324 , G06F11/3409 , G06F2201/81
摘要： A method for monitoring the performance of an application comprises determining an output of an application that requires monitoring, assigning an audible sound to the output, running the application and allowing the application to reach a state of equilibrium, determining a baseline for the output when the application is in the state of equilibrium, monitoring the output to detect a change relative to the baseline, emitting the audible sound assigned to the output when the detected change varies from the baseline by a predetermined amount, and adjusting configurable parameters of the audible sound to indicate the existence of the detected change, the magnitude of the detected change relative to the baseline, and the degree of deviation from the baseline. The amplitude of the audible sound may be adjusted to indicate the magnitude of the detected change from the baseline, and the pitch of the audible sound may be adjusted to indicate a positive change or a negative change from the baseline.
摘要翻译：用于监视应用的性能的方法包括确定需要监视的应用的输出，向输出分配可听见的声音，运行应用并且允许应用达到平衡状态，当输入的时候确定输出的基线应用程序处于均衡状态，监视输出以检测相对于基线的变化，当检测到的变化从基线改变预定量时发出分配给输出的可听见的声音，并且将可听见的声音的可配置参数调整为表示检测到的变化的存在，检测到的相对于基线的变化的幅度以及与基线的偏离程度。可以调节可听见的声音的幅度以指示从基线检测到的变化的幅度，并且可调节可听见的声音的音高以指示与基线的正变化或负变化。

33. 发明授权

US07384973B2 Materials and methods for treating hypercholesterolemia 失效
标题翻译：治疗高胆固醇血症的材料和方法
公开(公告)号：US07384973B2
公开(公告)日：2008-06-10
申请号：US11220364
申请日：2005-09-06
申请人： Pascal Druzgala , Xiaoming Zhang , Jurg R. Pfister
发明人： Pascal Druzgala , Xiaoming Zhang , Jurg R. Pfister
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D239/42 , A61K31/405 , A61K31/47 , A61K31/505 , C07C69/675 , C07C69/708 , C07C69/732 , C07C2602/28 , C07D207/34 , C07D209/12 , C07D209/24 , C07D213/55 , C07D215/14 , C07D307/80 , C07D311/72
摘要： The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can be advantageously used to treat patients suffering hypercholesterolemia.
摘要翻译：本发明提供新的HMG-CoA还原酶抑制剂。在优选的实施方案中，本发明的HMG-CoA还原酶抑制剂可以通过水解酶而失活至初级无活性代谢物。本发明的化合物可有利地用于治疗患有高胆固醇血症的患者。

34. 发明授权

US07145020B2 Materials and methods for treating coagulation disorders 有权
公开(公告)号：US07145020B2
公开(公告)日：2006-12-05
申请号：US10822129
申请日：2004-04-08
申请人： Pascal Druzgala , Xiaoming Zhang , Jurg R. Pfiste
发明人： Pascal Druzgala , Xiaoming Zhang , Jurg R. Pfiste
IPC分类号： C07D311/02
CPC分类号： A61K31/366 , A61K31/37 , C07D311/56
摘要： This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

35. 发明授权

US06608097B2 Materials and methods for the treatment of hypertension and angina 失效
标题翻译：用于治疗高血压和心绞痛的材料和方法
公开(公告)号：US06608097B2
公开(公告)日：2003-08-19
申请号：US10269139
申请日：2002-10-10
申请人： Pascal Druzgala , Peter G. Milner , Jürg Pfister , Xiaoming Zhang
发明人： Pascal Druzgala , Peter G. Milner , Jürg Pfister , Xiaoming Zhang
IPC分类号： A61K314184
CPC分类号： C07D235/14
摘要： The subject invention provides useful and novel calcium channel blockers based upon mibefradil. The subject invention also provides methods for synthesizing the compounds of the invention. The invention also provides methods for the control or prevention of hypertension, angina pectoris, ischemia, arrhythmias, and cardiac insufficiency in a patient by administering a compound, or composition, of the invention to an individual in need of such treatment.
摘要翻译：本发明提供了基于米非司定的有用和新颖的钙通道阻滞剂。本发明还提供了合成本发明化合物的方法。本发明还提供了通过向需要这种治疗的个体施用本发明的化合物或组合物来控制或预防患者的高血压，心绞痛，缺血，心律失常和心脏功能不全的方法。

36. 发明授权

US08756189B2 Rule generation for event processing system 失效
标题翻译：事件处理系统的规则生成
公开(公告)号：US08756189B2
公开(公告)日：2014-06-17
申请号：US13285232
申请日：2011-10-31
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： G06N5/02
CPC分类号： G06N5/025 , G06Q10/00 , G06Q40/00
摘要： A computer receives a plurality of input events, each input event comprising one or more factors. The computer processes each input event based on event processing rules that cause the computer to evaluate the one or more factors and assign each input event a Boolean output value. The computer generates an output event containing the one or more factors and the Boolean output value. The computer generates additional event processing rules based on output events for which the event processing rules caused the output events to have a false-negative or false-positive Boolean output value. The additional rules are then included in the event processing rules.
摘要翻译：计算机接收多个输入事件，每个输入事件包括一个或多个因素。计算机根据事件处理规则处理每个输入事件，这些事件处理规则使计算机评估一个或多个因素，并为每个输入事件分配布尔输出值。计算机生成包含一个或多个因子和布尔输出值的输出事件。计算机基于事件处理规则导致输出事件具有假负值或假阳性布尔输出值的输出事件生成附加事件处理规则。然后，附加规则将被包括在事件处理规则中。

37. 发明授权

US08742131B2 7-azoniabicyclo [2.2.1] heptane derivatives, methods of production, and pharmaceutical uses thereof 有权
标题翻译： 7-氮杂双环[2.2.1]庚烷衍生物，生产方法及其药物用途
公开(公告)号：US08742131B2
公开(公告)日：2014-06-03
申请号：US13512873
申请日：2011-01-27
申请人： Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
发明人： Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号： C07D487/08 , C07D487/10 , A61K31/403
CPC分类号： A61K31/407 , A61K9/0078 , A61K31/4188 , A61K45/06 , C07D487/08 , C07D487/20 , Y02A50/475
摘要： Muscarinic acetylcholine receptor antagonists and methods of using them for the treatment of muscarinic acetyl-choline receptor-mediated diseases, such as pulmonary diseases, are provided.
摘要翻译：提供毒蕈碱性乙酰胆碱受体拮抗剂及其用于治疗毒蕈碱性乙酰胆碱受体介导的疾病如肺疾病的方法。

38. 发明申请

US20120215871A1 INSTANT MESSAGING ROBOT TO PROVIDE PRODUCT INFORMATION 有权
标题翻译：即时消息机器人提供产品信息
公开(公告)号：US20120215871A1
公开(公告)日：2012-08-23
申请号：US13505362
申请日：2010-07-23
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： G06F15/16 , G06N5/02
CPC分类号： G06Q30/0613 , G06F17/30569 , G06Q30/0269 , G06Q30/0611 , G06Q30/0625 , H04L51/02 , H04L51/04 , H04L67/10
摘要： Methods and systems to automatically respond to a request for product information are described. In one embodiment, a data collection module may collect product data over a network, identify that the product data is related to a particular product, and store the product data and an association between the product data and the particular product in a database. An instant messaging engine may receive a request for the product data after the product data is stored in the database and an interpreter module may identify, in response to the request, the request to correspond to the particular product and retrieve the product data based on the association between the particular product and the product data. The instant messaging engine may also transmit, using an instant messaging protocol, a response to the request, the response including the product data.
摘要翻译：描述自动响应产品信息请求的方法和系统。在一个实施例中，数据收集模块可以通过网络收集产品数据，识别产品数据与特定产品相关，并且存储产品数据以及数据库中的产品数据和特定产品之间的关联。在产品数据存储在数据库中之后，即时消息发送引擎可以接收对产品数据的请求，并且解释器模块可以响应于该请求识别与特定产品相对应的请求，并基于特定产品与产品数据之间的关联。即时消息引擎还可以使用即时消息传递协议来发送对请求的响应，该响应包括产品数据。

39. 发明申请

US20090228498A1 METHODS FOR UTILIZING HUMAN PERCEPTUAL SYSTEMS FOR PROCESSING EVENT LOG DATA 失效
标题翻译：用于处理事件日志数据的人类感知系统的方法
公开(公告)号：US20090228498A1
公开(公告)日：2009-09-10
申请号：US12041874
申请日：2008-03-04
申请人： Xiaoming Zhang
发明人： Xiaoming Zhang
IPC分类号： G06F17/30
CPC分类号： G06F11/32 , G06F11/0706 , G06F11/0769
摘要： A method is provided for utilizing the human perceptual system by providing a spectrum of event log data for viewing. Event log data is received. Events of the event log data are mapped to an x-axis of a spectrum based on time, where the events of the event log data correspond to a time slot on the x-axis. Categories for the events are mapped to a y-axis of the spectrum, where the y-axis is a frequency axis, and where each of the categories respectively corresponds to a frequency of the multiple frequencies. Strength of events are mapped to a z-axis of the spectrum, where the z-axis is a magnitude axis, and where a magnitude value reflects the significance of the events happened at a particular time slot in a particular category. The magnitude of events (z-axis) of the event log data may be further mapped to a line thickness of the spectrum for the multiple frequencies. The spectrogram of the event log data is presented in a two-dimensional graphical format in time, frequency, and magnitude for observation by a user.
摘要翻译：提供了一种通过提供用于观看的事件日志数据的频谱来利用人类感知系统的方法。收到事件日志数据。基于时间将事件日志数据的事件映射到频谱的x轴，其中事件日志数据的事件对应于x轴上的时隙。事件的类别被映射到频谱的y轴，其中y轴是频率轴，并且其中每个类别分别对应于多个频率的频率。事件的强度被映射到频谱的z轴，其中z轴是幅度轴，并且其中幅度值反映在特定类别中的特定时隙发生的事件的重要性。可以将事件对数数据的事件（z轴）的大小进一步映射到多个频率的频谱的线宽。事件日志数据的频谱以时间，频率和大小的二维图形格式呈现，以供用户观察。

40. 发明授权

US07407980B2 Imidazolinylmethyl aralkylsulfonamides 失效
标题翻译：咪唑啉基甲基芳烷基磺酰胺
公开(公告)号：US07407980B2
公开(公告)日：2008-08-05
申请号：US10823012
申请日：2004-04-13
申请人： Michael Patrick Dillon , Clara Jeou Jen Lin , Counde O'Yang , Xiaoming Zhang
发明人： Michael Patrick Dillon , Clara Jeou Jen Lin , Counde O'Yang , Xiaoming Zhang
IPC分类号： A61K31/4174 , C07D233/24
CPC分类号： C07D233/24 , C07D405/06
摘要： Compounds of the Formula: where R1-R6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and methods for their use as therapeutic agents.
摘要翻译：其中R 1〜R 6的化合物是本文定义的化合物及其制备方法。还提供了包含式I化合物的药物组合物及其用作治疗剂的方法。

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