专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07678790B2 Platelet ADP receptor inhibitors 失效
标题翻译：血小板ADP受体抑制剂
公开(公告)号：US07678790B2
公开(公告)日：2010-03-16
申请号：US11286259
申请日：2005-11-23
申请人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles Marlowe
发明人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles Marlowe
IPC分类号： C07D417/12 , C07D411/12 , C07D417/14 , C07D401/04 , A61K31/40 , A61K31/38 , A61K31/44 , A61K31/425 , A61K31/495 , A61K31/55
CPC分类号： C07D239/22 , C07D239/48 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）至（VI）的新型化合物，其更具体地包括作为有效的血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰基氰胍基衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I） - （VI）化合物或其药学上可接受的盐的步骤。

32. 发明授权

US07022731B2 Platelet ADP receptor inhibitors 失效
公开(公告)号：US07022731B2
公开(公告)日：2006-04-04
申请号：US10759396
申请日：2004-01-15
申请人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles Marlowe
发明人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles Marlowe
IPC分类号： C07D409/12 , A61K31/4025 , A61P7/02
CPC分类号： C07D239/22 , C07D239/48 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)–(VI), or a pharmaceutically acceptable salt thereof.

33. 发明授权

US06906063B2 Platelet ADP receptor inhibitors 失效
标题翻译：血小板ADP受体抑制剂
公开(公告)号：US06906063B2
公开(公告)日：2005-06-14
申请号：US09920325
申请日：2001-08-02
申请人： Robert M. Scarborough , Wolin Huang , Charles K. Marlowe , Kim A. Kane-MaGuire
发明人： Robert M. Scarborough , Wolin Huang , Charles K. Marlowe , Kim A. Kane-MaGuire
IPC分类号： C07D239/96 , A61K31/16 , A61K31/175 , A61K31/381 , A61K31/4196 , A61K31/4725 , A61K31/519 , A61K31/54 , A61K31/64 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P43/00 , C07D209/48 , C07D213/70 , C07D239/22 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D521/00 , A61K31/40 , C07D411/12 , C07D417/14
CPC分类号： C07D487/04 , C07D209/48 , C07D239/22 , C07D239/48 , C07D239/50 , C07D239/96 , C07D333/34 , C07D333/62 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D521/00
摘要： Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）至（VIII）的新型化合物，其更具体地包括作为有效的血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰氰基胍衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I）至（VIII）化合物或其药学上可接受的盐的步骤。

34. 发明申请

US20120149688A1 PLATELET ADP RECEPTOR INHIBITORS 有权
标题翻译： PLATELET ADP受体抑制剂
公开(公告)号：US20120149688A1
公开(公告)日：2012-06-14
申请号：US13270193
申请日：2011-10-10
申请人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles K. Marlowe , Kim A. Kane-Maguire
发明人： Robert M. Scarborough , Hans-Michael Jantzen , Wolin Huang , David M. Sedlock , Charles K. Marlowe , Kim A. Kane-Maguire
IPC分类号： A61K31/55 , C07D471/04 , C07D487/04 , A61K31/4725 , A61K31/517 , A61P9/10 , A61K31/519 , A61K31/4709 , A61K31/404 , A61K31/5513 , A61P7/02 , A61P9/00 , C07D409/12 , A61K31/4745
CPC分类号： C07D487/04 , C07D209/48 , C07D239/22 , C07D239/48 , C07D239/50 , C07D239/96 , C07D333/34 , C07D333/62 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D521/00
摘要： Novel compounds of formulae (I) and (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）和（VIII）的新型化合物，其更具体地包括作为有效血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰基氰胍基衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I）至（VIII）化合物或其药学上可接受的盐的步骤。

35. 发明授权

US06689786B2 Platelet ADP receptor inhibitors 有权
标题翻译：血小板ADP受体抑制剂
公开(公告)号：US06689786B2
公开(公告)日：2004-02-10
申请号：US10350883
申请日：2003-01-23
申请人： Robert M. Scarborough , Wolin Huang
发明人： Robert M. Scarborough , Wolin Huang
IPC分类号： C07D41712
CPC分类号： C07D239/22 , C07D239/48 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）至（VI）的新型化合物，其更具体地包括作为有效的血小板ADP受体抑制剂的磺酰脲衍生物，磺酰基硫脲衍生物，磺酰基胍衍生物，磺酰基氰胍基衍生物，硫代酰基磺酰胺衍生物和酰基磺酰胺衍生物。这些衍生物可用于各种药物组合物中，并且对于预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物血栓形成的方法，包括施用治疗有效量的式（I） - （VI）化合物或其药学上可接受的盐的步骤。

36. 发明申请

US20120088736A1 [4-(6-HALO-7-Substituted-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS and Forms and Methods Related Thereto 审中-公开
标题翻译： [4-（6-HALO-7-取代的-2,4-二氧代-1,4-二氢-2H-喹喔啉-3-基） - 苯基] -5-氯代 - 噻吩-2-基]噻吩并[ 相关方法
公开(公告)号：US20120088736A1
公开(公告)日：2012-04-12
申请号：US13271037
申请日：2011-10-11
申请人： Robert Scarborough , Carroll Anna Crew Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
发明人： Robert Scarborough , Carroll Anna Crew Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
IPC分类号： A61K31/517 , A61K31/727 , A61P7/02 , A61P7/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61K31/616 , A61P9/00
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

37. 发明授权

US08058284B2 [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto 有权
标题翻译： [4-（6-卤代-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] -5-氯 - 噻吩-2-基 - 磺酰脲，形成和与之相关的方法
公开(公告)号：US08058284B2
公开(公告)日：2011-11-15
申请号：US11556490
申请日：2006-11-03
申请人： Robert Scarborough , Carroll Anna Scarborough, legal representative , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
发明人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig M. Grant
IPC分类号： A61K31/517 , C07D409/12
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

38. 发明申请

US20070123547A1 [4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO 有权
标题翻译： [4-（6-羟基-7-取代-2,4-二氧代-1,4-二氢-2H-喹唑啉-3-基） - 苯基] -5-氯代 - 噻吩-2-基] - 磺酰基和形式方法相关
公开(公告)号：US20070123547A1
公开(公告)日：2007-05-31
申请号：US11556490
申请日：2006-11-03
申请人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig Grant , Carroll Scarborough
发明人： Robert Scarborough , Wolin Huang , Mukund Mehrotra , Xiaoming Zhang , Hilary Cannon , Craig Grant , Carroll Scarborough
IPC分类号： A61K31/517 , C07D409/02
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.
摘要翻译：本发明提供式（I）的新型磺酰脲化合物及其药学上可接受的衍生物及其多晶型物和无定形形式。各种形式的化合物是有效的血小板ADP受体抑制剂，可用于各种药物组合物中，并且特别有效预防和/或治疗心血管疾病，特别是与血栓形成有关的疾病。本发明还提供了一种制备此类化合物和形式并用于预防或治疗哺乳动物血栓形成和血栓形成相关病症的方法，包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或其形式的步骤。

39. 发明授权

US06277583B1 Affinity labeling libraries and applications thereof 失效
标题翻译：亲和标记库及其应用
公开(公告)号：US06277583B1
公开(公告)日：2001-08-21
申请号：US08598054
申请日：1996-02-07
申请人： Alexander Krantz , Arthur M. Hanel , Wolin Huang
发明人： Alexander Krantz , Arthur M. Hanel , Wolin Huang
IPC分类号： G01N3353
CPC分类号： G01N33/532 , B01J2219/00572 , B01J2219/00592 , C07K1/047 , C40B70/00 , G01N33/53
摘要： Novel methods and compositions are provided for preferentially bonding an oligomeric molecule to a macromolecular target where the target is a member of a complex mixture and/or there is preferential bonding at one of a plurality of available bonding sites of the macromolecular target. The methods represent a complete system for both producing and identifying affinity label molecules from a combinatorial library which preferentially bind to a marcomolecular target or target site and preferentially binding those affinity labels to a macromolecule of interest either ex vivo or in vivo. Macromolecular targets include a variety of cellular- and non-cellular-associated proteins.
摘要翻译：提供了新颖的方法和组合物，用于将寡聚分子优先键合到靶是复合物混合物成分的大分子靶和/或在大分子靶的多个可用结合位点之一处具有优先键合。该方法代表一个完整的系统，用于产生和鉴定来自组合文库的亲和标记分子，其优先结合于分子靶标或靶位点，并优先将这些亲和标记物结合到感兴趣的大分子体外或体内。大分子靶标包括多种细胞和非细胞相关蛋白。

40. 发明申请

US20050228029A1 Platelet ADP receptor inhibitors 有权
公开(公告)号：US20050228029A1
公开(公告)日：2005-10-13
申请号：US10941053
申请日：2004-09-13
申请人： Robert Scarborough , Wolin Huang , Charles Marlowe , Kim Kane-MaGuire
发明人： Robert Scarborough , Wolin Huang , Charles Marlowe , Kim Kane-MaGuire
IPC分类号： C07D239/96 , A61K31/16 , A61K31/175 , A61K31/381 , A61K31/4196 , A61K31/4725 , A61K31/519 , A61K31/54 , A61K31/64 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P43/00 , C07D209/48 , C07D213/70 , C07D239/22 , C07D239/50 , C07D333/34 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D521/00
CPC分类号： C07D487/04 , C07D209/48 , C07D239/22 , C07D239/48 , C07D239/50 , C07D239/96 , C07D333/34 , C07D333/62 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D521/00
摘要： Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式