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31. 发明申请

US20120039932A1 Lentiviral Vectors Pseudotyped with a Sindbis Virus Envelope Glycoprotein 有权
标题翻译：用辛德毕斯病毒包膜糖蛋白伪型的慢病毒载体
公开(公告)号：US20120039932A1
公开(公告)日：2012-02-16
申请号：US13277900
申请日：2011-10-20
申请人： James M. Allen , Thomas W. Dubensky, JR. , Jin Zhong Li , Derek D. Sloan , Neal S. Van Hoeven
发明人： James M. Allen , Thomas W. Dubensky, JR. , Jin Zhong Li , Derek D. Sloan , Neal S. Van Hoeven
IPC分类号： A61K39/00 , A61P37/04 , A61P35/00 , A61P31/16 , A61P31/20 , A61P31/22 , A61P31/14 , C12N15/867 , A61P31/18
CPC分类号： C12N15/86 , A61K39/0011 , A61K2039/5256 , C12N7/00 , C12N2740/15022 , C12N2740/15043 , C12N2770/36145 , Y02A50/466
摘要： Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain).
摘要翻译：提供包含辛德毕斯病毒E2糖蛋白变体和包含感兴趣序列的慢病毒载体基因组的慢病毒载体颗粒。一种慢病毒载体颗粒，包括：（a）包含辛德毕斯病毒E2糖蛋白变体的包膜; 和（b）包含感兴趣序列的慢病毒载体基因组; 其中E2糖蛋白变体便于慢病毒载体颗粒感染树突状细胞，并且其中E2糖蛋白变体与参考序列（HR应变）相比具有减少的与硫酸乙酰肝素的结合。

32. 发明申请

US20110210925A1 HOSPITAL BED HAVING MULTIPLE TOUCHSCREEN DISPLAYS 有权
标题翻译：具有多个触摸屏显示的医院床
公开(公告)号：US20110210925A1
公开(公告)日：2011-09-01
申请号：US12714013
申请日：2010-02-26
申请人： William G. Pittenger , James M. Allen , Keith A. Huster
发明人： William G. Pittenger , James M. Allen , Keith A. Huster
IPC分类号： G06F3/041 , G06F3/048
CPC分类号： G05B19/414
摘要： Embodiments of an apparatus for controlling a plurality of modules coupled to a communications network of a bed are disclosed. The apparatus may comprise an interface module, a plurality of user interfaces, and a plurality of dedicated data links. The interface module may include a transceiver coupled to the communications network, a processor configured to output graphics data, and a plurality of transmitters configured to receive the graphics data and generate a plurality of synchronous graphics signals. Each of the plurality of user interfaces may include a graphical display. Each of the plurality of dedicated data links may be coupled to one of the plurality of transmitters and to one of the plurality of user interfaces.
摘要翻译：公开了一种用于控制耦合到床的通信网络的多个模块的装置的实施例。该装置可以包括接口模块，多个用户接口和多个专用数据链路。接口模块可以包括耦合到通信网络的收发器，被配置为输出图形数据的处理器以及被配置为接收图形数据并生成多个同步图形信号的多个发射器。多个用户界面中的每一个可以包括图形显示。多个专用数据链路中的每一个可以耦合到多个发射机之一和多个用户接口中的一个。

33. 发明申请

US20110074571A1 WIRELESS BED CONNECTIVITY 有权
标题翻译：无线床连接
公开(公告)号：US20110074571A1
公开(公告)日：2011-03-31
申请号：US12959486
申请日：2010-12-03
申请人： Williams F. Collins, JR. , James M. Allen , Keith A. Huster , Carl W. Riley , Patricia A. Glidwell , Irvin J. Vanderpohl, III , Richard J. Schuman , Benjamin E. Howell , Timothy D. Wildman
发明人： Williams F. Collins, JR. , James M. Allen , Keith A. Huster , Carl W. Riley , Patricia A. Glidwell , Irvin J. Vanderpohl, III , Richard J. Schuman , Benjamin E. Howell , Timothy D. Wildman
IPC分类号： G08B5/22 , G08B1/08
CPC分类号： A61B5/002 , A61B5/024 , A61B5/1115 , A61B5/1117 , A61B5/447 , A61B5/746 , A61G7/018 , A61G12/00 , G06F8/65 , G06F19/00 , G06F19/3418 , G07C3/00 , G08B5/22 , G08B5/222 , G08B21/22 , G16H40/20 , G16H40/40 , H04L67/10
摘要： A hospital bed has wireless communication circuitry operable to transmit wirelessly bed status data. A surface supported by the bed has wireless communication circuitry operable to transmit wirelessly surface status data. The wireless communication circuitry of the hospital bed and the wireless communication circuitry of the surface communicate with a network independently. A hospital bed with an integrated surface has wireless communication circuitry operable to transmit wirelessly bed status data and surface status data. The wireless bed status data and the wireless surface status data are received by wireless access points of a network of a healthcare facility.
摘要翻译：医院病床具有可操作以无线床状态数据传输的无线通信电路。由床支撑的表面具有可操作的无线通信电路，用于发送无线表面状态数据。医院病床的无线通信电路和表面的无线通信电路独立地与网络通信。具有综合表面的医院病床具有可操作的无线通信电路，用于传输无线床状态数据和表面状态数据。无线床状态数据和无线表面状态数据由医疗机构的网络的无线接入点接收。

34. 发明授权

US07208315B2 Compositions and methods for efficient AAV vector production 有权
标题翻译：用于高效AAV载体生产的组合物和方法
公开(公告)号：US07208315B2
公开(公告)日：2007-04-24
申请号：US10169785
申请日：2001-01-05
申请人： Arthur Dusty Miller , James M. Allen , Christine L. Halbert
发明人： Arthur Dusty Miller , James M. Allen , Christine L. Halbert
IPC分类号： C12N15/00
CPC分类号： A61K48/0091 , A61K35/12 , C12N7/00 , C12N15/86 , C12N2750/14143 , C12N2750/14152
摘要： The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods for their production and methods for producing recombinant AAV vector particles useful for human gene therapy are provided.
摘要翻译：本发明提供用于有效生产腺相关病毒（AAV）载体的包装细胞系，其不需要用于AAV载体颗粒的复制和包囊的“辅助”病毒功能。提供包装细胞，其生产方法和用于生产用于人基因治疗的重组AAV载体颗粒的方法。

35. 发明授权

US06924128B2 Packaging cell lines for generation of high titers of recombinant AAV vectors 失效
标题翻译：包装细胞系用于产生高滴度的重组AAV载体
公开(公告)号：US06924128B2
公开(公告)日：2005-08-02
申请号：US09731941
申请日：2000-12-06
申请人： James M. Allen
发明人： James M. Allen
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N5/10 , C12N15/864 , C12N15/64
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , C07K14/4712 , C12N15/86 , C12N2750/14143 , C12N2750/14152
摘要： AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be clinically useful for human gene therapy application. Stable AAV packaging cell lines have been elusive, mainly due to the activities of Rep protein, which down-regulates its own expression and can negatively affect the host cell. This invention provides packaging systems and processes for packaging AAV vectors that effectively circumvent these problems and that allow for substantially increased packaging efficiency.
摘要翻译： AAV载体可用于基因治疗，但迄今为止，显着的障碍是无法产生足够数量的这样的重组载体，其量将在临床上对人基因治疗应用有用。稳定的AAV包装细胞系一直难以捉摸，主要是由于Rep蛋白的活性，其下调其自身的表达，并可能对宿主细胞产生负面影响。本发明提供了用于包装AAV载体的包装系统和方法，其有效地规避了这些问题并且允许显着增加的包装效率。

36. 发明授权

US06593124B1 Hybrid genes for expression of stimulatory factors in activated T cells 失效
标题翻译：用于在活化的T细胞中表达刺激因子的杂交基因
公开(公告)号：US06593124B1
公开(公告)日：2003-07-15
申请号：US09213993
申请日：1998-12-16
申请人： Stephen D. Lupton , James M. Allen , Andrew L. Feldhaus
发明人： Stephen D. Lupton , James M. Allen , Andrew L. Feldhaus
IPC分类号： C12N121
CPC分类号： C12N15/85 , A61K38/00 , C07K14/5255 , C07K14/5403 , C07K14/55 , C07K14/57 , C07K14/70521 , C12N2830/00 , C12N2830/85
摘要： Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocyte is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.
摘要翻译：提供重组载体，其使活化的淋巴细胞，特别是细胞毒性T淋巴细胞的增殖反应减少对T辅助细胞的依赖性。载体由编码可操作地连接到异源转录控制区的刺激因子多肽的区域组成。来自重组多核苷酸的刺激因子多肽在活化淋巴细胞中的表达使得对淋巴细胞T辅助细胞较少依赖的增殖反应。当淋巴细胞通过其同源抗原的结合而被激活时，转录控制区引起刺激因子编码区的转录。含有载体，特别是CTL的细胞可用于免疫治疗。

37. 发明授权

US06541258B2 AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors 失效
标题翻译： AAV分裂包装基因和包含用于生产重组AAV载体的这些基因的细胞系
公开(公告)号：US06541258B2
公开(公告)日：2003-04-01
申请号：US08981172
申请日：1997-12-12
申请人： James M. Allen , Anthony M. Stepan , Tineka J. Quinton , Stephen D. Lupton
发明人： James M. Allen , Anthony M. Stepan , Tineka J. Quinton , Stephen D. Lupton
IPC分类号： C12N1587
CPC分类号： C12N7/00 , C12N15/86 , C12N2510/02 , C12N2750/14143 , C12N2750/14152
摘要： The present invention provides AAV “split-packaging” genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.
摘要翻译：本发明提供了AAV“分裂包装”基因，以及包含这些基因的包装细胞，用于生产可用于将感兴趣的转基因递送至多种哺乳动物细胞的高滴度复制无能的重组AAV载体。

38. 发明授权

US5226731A Apparatus for measuring rotor exhaust gas bulk temperature in a combustion turbine and method therefor 失效
标题翻译：用于测量燃气轮机中的转子排气体积温度的装置及其方法
公开(公告)号：US5226731A
公开(公告)日：1993-07-13
申请号：US890537
申请日：1992-05-28
申请人： James M. Allen
发明人： James M. Allen
IPC分类号： F01D17/08 , G01J5/04
CPC分类号： G01J5/0022 , F01D17/085 , G01J5/0088 , G01J5/02 , G01J5/029 , G01J5/041 , G01J5/047 , G01J5/061 , G01J5/08 , G01J5/089 , G01J5/0893
摘要： The rotor exhaust gas bulk total temperature relative to the last blade row of a combustion turbine is determined by traversing an optical pyrometer radially across the last stage blades. The resulting radial temperature measurements are then flow weight averaged to provide an accurate bulk gas temperature relative to the last row of blades. Such temperature is useful in a feedback control system for the turbine. A technique of traversing is to cause the optical pyrometer to traverse by mounting its line of sight or optical axis at an angle to its axis of rotation.
摘要翻译：相对于燃气轮机的最后一个叶片排的转子废气体积总温度通过在最后的叶片上径向穿过光学高温计来确定。然后将所得的径向温度测量值平均，以提供相对于最后一排叶片的精确的体积气体温度。这种温度在涡轮机的反馈控制系统中是有用的。横穿技术是使光学高温计通过将其视线或光轴安装在与其旋转轴线成一定角度的位置。

39. 发明授权

US4606701A Tip structure for a cooled turbine rotor blade 失效
标题翻译：冷却涡轮转子叶片的尖端结构
公开(公告)号：US4606701A
公开(公告)日：1986-08-19
申请号：US616786
申请日：1984-06-01
申请人： Augustine C. McClay , James M. Allen , William E. North
发明人： Augustine C. McClay , James M. Allen , William E. North
IPC分类号： F01D5/18 , F01D5/20
CPC分类号： F01D5/187 , F01D5/20 , F05D2250/231 , F05D2250/232 , F05D2250/241
摘要： The invention comprises a cooled turbine rotor blade having an improved blade tip structure. A groove is provided in the trailing edge end of the blade tip on those turbine blades whose trailing edge is too thin to support an extension of the blade walls to form a blade tip cavity which extends to the tip of the trailing edge of the blade. The groove protects adjoining exhaust apertures from closure by a blade tip smear.
摘要翻译：本发明包括具有改进的叶片尖端结构的冷却涡轮转子叶片。在这些涡轮机叶片上的叶片尖端的后缘端部设有凹槽，其后缘太薄而不能支撑叶片壁的延伸，以形成延伸到叶片后缘尖端的叶片尖端空腔。凹槽保护邻接的排气孔免受叶片尖端污迹的封闭。

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