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31. 发明授权

US07096213B2 Persistent key-value repository with a pluggable architecture to abstract physical storage 有权
公开(公告)号：US07096213B2
公开(公告)日：2006-08-22
申请号：US10253088
申请日：2002-09-23
申请人： Surojit Chatterjee , Raj Kumar , Jonathan Creighton , Alok K. Srivastava , Sameer Joshi
发明人： Surojit Chatterjee , Raj Kumar , Jonathan Creighton , Alok K. Srivastava , Sameer Joshi
IPC分类号： G06F17/30
CPC分类号： G06F17/3056 , Y10S707/99931 , Y10S707/99932 , Y10S707/99943 , Y10S707/99953
摘要： A system and techniques are described for managing key-value pairs using an architecture that does not restrict its users to any specific platform or storage subsystem. According to one aspect of the invention, the repository is portable in that the architecture need not change based on the environment and platform in which the repository is used. Rather, the portion of the architecture that is platform-specific is limited to plug-ins at a storage abstraction layer of the repository. The plug-ins expose the same storage abstraction interface to the other layers of the repository, but are implemented to interact with different platforms and storage subsystems. Consequently, in response to being ported from one platform to another, the repository may simply change the plug-in to invoke for persistent storage operations.

32. 发明授权

US06652659B1 Low species buffered rinsing fluids and method 失效
标题翻译：低品质缓冲冲洗液和方法
公开(公告)号：US06652659B1
公开(公告)日：2003-11-25
申请号：US09452015
申请日：1999-11-30
申请人： Glen Roeters , Raj Kumar
发明人： Glen Roeters , Raj Kumar
IPC分类号： C23G100
CPC分类号： H01L21/02063 , C11D7/08 , C11D7/12 , C11D11/0047 , H01L21/6704 , H05K3/26 , H05K2203/0766 , H05K2203/0786 , Y10S134/902 , Y10S438/906
摘要： A method of rinsing an electronic substrate recognizes that adding a buffer to a rinsing fluid eliminates fluctuations in the amount of residues on an electronic substrate, and a buffered rinsing fluid is prepared by (a) providing water from a water source; (b) deionizing the water to produce deionized water; (c) adding a buffer to the deionized water at a concentration effective to eliminate fluctuations in the amount of residues on the electronic substrate. The electronic substrate is rinsed with the buffered rinsing fluid.
摘要翻译：冲洗电子基板的方法认识到，向冲洗流体添加缓冲液消除电子基板上的残留物的量的波动，并且缓冲的冲洗液通过（a）从水源提供水来制备; （b）去离子水以产生去离子水; （c）以有效地消除电子基板上的残留物量的波动的浓度向去离子水中加入缓冲剂。用缓冲的冲洗液漂洗电子基片。

33. 发明授权

US06448392B1 Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use 失效
标题翻译：抗病毒核苷的脂质衍生物：脂质体掺入和使用方法
公开(公告)号：US06448392B1
公开(公告)日：2002-09-10
申请号：US08415769
申请日：1995-04-03
申请人： Karl Y. Hostetler , Raj Kumar , Louise M. Stuhmiller
发明人： Karl Y. Hostetler , Raj Kumar , Louise M. Stuhmiller
IPC分类号： A61K3722
CPC分类号： B82Y5/00 , A61K47/542 , A61K47/544 , A61K47/548 , C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16
摘要： Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral activity which are linked, commonly through a phosphate group at the 5′ position of the pentose residue, to one of a selected group of lipids. The lipophilic nature of these compounds provide advantages over the use of the nucleoside analogue alone. It also makes it possible to incorporate them into the lamellar structure of liposomes, either alone or combined with similar molecules. In the form of liposomes, these antiviral agents are preferentially taken up by macrophages and monocytes, cells which have been found to harbor the target HIV virus. Additional site specificity may be incorporated into the liposomes with the addition of ligands, such as monoclonal antibodies or other peptides or proteins which bind to viral proteins. Effective nucleoside analogues are dideoxynucleosides, azidothymine (AZT), and acyclovir; lipid groups may be glycolipids, sphingolipids, phospholipids or fatty acids. The compounds persist, after intracellular hydrolysis, as phosphorylated or non-phosphorylated antiviral nucleosides. The compounds are effective in improving the efficacy of antiviral nucleoside analogues by prolonging the antiviral activity after the administration of the drug has ended, and in preventing retroviral replication in HIV infections which have become resistant to therapy with conventional forms of the antiretroviral agents.
摘要翻译：公开了通过抗病毒剂的脂质衍生物治疗AIDS，疱疹和其它病毒感染的化合物。所述化合物由具有抗病毒活性的核苷类似物组成，通常通过戊糖残基的5'位置的磷酸基团连接到所选择的一组脂质之一中。这些化合物的亲油性质优于单独使用核苷类似物的优点。它还使得可以将它们单独或与类似分子组合在一起，将它们并入脂质体的层状结构中。以脂质体的形式，这些抗病毒剂优先被巨噬细胞和单核细胞（已被发现携带目标HIV病毒的细胞）吸收。可以通过加入配体如单克隆抗体或其它与病毒蛋白结合的肽或蛋白质将其中的位点特异性引入脂质体。有效的核苷类似物是双脱氧核苷，叠氮胸腺嘧啶（AZT）和阿昔洛韦; 脂质组可以是糖脂，鞘脂，磷脂或脂肪酸。化合物在细胞内水解后持续存在，作为磷酸化或非磷酸化的抗病毒核苷。该化合物通过在给药药物结束后延长抗病毒活性，以及在用常规形式的抗逆转录病毒药物治疗已经变得耐药的HIV感染中预防逆转录病毒复制，有效地改善了抗病毒核苷类似物的功效。

34. 发明授权

US5744592A Lipid prodrugs for oral administration 失效
标题翻译：用于口服给药的脂质前体药物
公开(公告)号：US5744592A
公开(公告)日：1998-04-28
申请号：US482431
申请日：1995-06-07
申请人： Karl Y. Hostetler , Raj Kumar , Nagarajan C. Sridhar
发明人： Karl Y. Hostetler , Raj Kumar , Nagarajan C. Sridhar
IPC分类号： A61K47/48 , A61K9/127 , A61K31/337 , A61P35/00 , C07F9/38 , C07F9/40 , C07F9/655 , C07H15/04 , C07H19/06 , C07H19/16 , C07H19/00 , A61K31/70 , A01N13/04
CPC分类号： C07H15/04 , A61K47/48023 , A61K47/48038 , A61K47/48053 , A61K47/48084 , A61K9/127 , B82Y5/00 , C07F9/3891 , C07F9/4006 , C07F9/4065 , C07F9/65512 , C07H19/06 , C07H19/16 , Y10S514/885
摘要： The oral delivery of many classes of drugs is facilitated by converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate derivatives. The method confers the ability to be absorbed through the digestive tract to drugs that are not orally bioavailable in the non-derivatized state, and enhances the effectiveness of drugs that are poorly absorbed or rapidly eliminated. The method provides orally bioavailable lipid prodrugs of pharmaceutical compounds having diverse physiological activities, including anticancer and antiviral agents, anti-inflammatory agents, antihypertensives and antibiotics. Potency of the lipid prodrugs is comparable to that of the corresponding non-derivatized drugs.
摘要翻译：通过将具有合适的官能团的药物转化为1-O-烷基 - ，1-O-酰基 - ，1-S-酰基和1-S-烷基-sn-甘油基-3，可促进许多类药物的口服递送磷酸酯衍生物。该方法赋予了在非衍生化状态下不经口服生物利用的药物通过消化道吸收的能力，并提高吸收不良或快速消除的药物的有效性。该方法提供具有不同生理活性的药物化合物的口服生物可利用的脂前药，包括抗癌和抗病毒剂，抗炎药，抗高血压药和抗生素。脂质前药的效力与相应的非衍生化药物的效力相当。

35. 发明授权

US09599042B2 Start of injection timing 有权
公开(公告)号：US09599042B2
公开(公告)日：2017-03-21
申请号：US13882341
申请日：2010-10-28
申请人： Raj Kumar , William de Ojeda , James Rynold Popp
发明人： Raj Kumar , William de Ojeda , James Rynold Popp
IPC分类号： F02D41/00 , F02D41/40 , F02D41/14
CPC分类号： F02D41/00 , F02D41/144 , F02D41/1454 , F02D41/401 , F02D2200/0406 , Y02T10/44
摘要： A method for controlling fuel injection timing into a cylinder of an internal combustion engine having an internal control system based on ignition delay correlation wherein intake manifold pressure and oxygen concentration values are compared to steady state values of manifold pressure and oxygen concentration of a particular indicated torque set-point and engine speed. Comparing intake manifold pressure and oxygen concentration to steady state reference values further comprises experimentally determining exponential factors for intake manifold pressure factor and oxygen concentration factors. A multiplier for intake manifold pressure and oxygen concentration is determined taking into consideration the exponential factors for manifold pressure and oxygen concentration. An equation for correlation ignition delay is used to determine optional SOI timing.

36. 发明授权

US07870256B2 Remote desktop performance model for assigning resources 有权
标题翻译：用于分配资源的远程桌面性能模型
公开(公告)号：US07870256B2
公开(公告)日：2011-01-11
申请号：US11248932
申请日：2005-10-12
申请人： Vanish Talwar , Sujoy Basu , Raj Kumar
发明人： Vanish Talwar , Sujoy Basu , Raj Kumar
IPC分类号： G06F15/173
CPC分类号： G06F9/5072 , G06F2209/5016 , G06F2209/5019 , H04L67/08 , H04L67/32
摘要： A request for a remote desktop session is received. A remote desktop session performance model is generated based on the applications to be used in the remote desktop session, and resources are assigned to the remote desktop session using the remote desktop session performance model.
摘要翻译：接收到远程桌面会话的请求。基于远程桌面会话中使用的应用程序生成远程桌面会话性能模型，并使用远程桌面会话性能模型将资源分配给远程桌面会话。

37. 发明授权

US07203700B1 Online instance addition and deletion in a multi-instance computer system 有权
标题翻译：多实例计算机系统中的在线实例添加和删除
公开(公告)号：US07203700B1
公开(公告)日：2007-04-10
申请号：US09945118
申请日：2001-08-31
申请人： Raj Kumar , Jonathan Creighton , Alok K. Srivastava
发明人： Raj Kumar , Jonathan Creighton , Alok K. Srivastava
IPC分类号： G06F17/00 , G06F9/44 , G06F17/30 , G06F12/00 , G06F15/16
CPC分类号： G06F9/4868 , H04L69/32 , Y10S707/99931 , Y10S707/99944
摘要： A new instance of an application is added to a group of existing instances (of that application) that share a resource, such as a database. The new instance is added by creating a new object for the new instance by cloning an existing object of an existing instance in the group, setting up connectivity between the new instance and a network through which the multiple instances communicate with one another, and starting up the new instance. The just-described acts are performed in the reverse order when deleting an existing instance. Each of these acts may be performed manually, or automatically without user input, with the user issuing at least one instruction to add or delete an instance.
摘要翻译：应用程序的新实例被添加到共享资源的一组现有实例（例如数据库）中。通过克隆组中现有实例的现有对象，设置新实例与多个实例通过其彼此通信的网络之间的连接，并为其启动，为新实例创建新对象，添加新实例新实例。当删除现有实例时，恰好描述的动作以相反的顺序执行。这些动作中的每一个都可以手动执行，也可以自动进行，无需用户输入，用户发出至少一个指令来添加或删除实例。

38. 发明授权

US07069270B1 Automated method and mechanism for converting a single instance application to a multiple instance application 有权
标题翻译：将单个实例应用程序转换为多个实例应用程序的自动化方法和机制
公开(公告)号：US07069270B1
公开(公告)日：2006-06-27
申请号：US10360257
申请日：2003-02-05
申请人： Raj Kumar
发明人： Raj Kumar
IPC分类号： G06F7/00 , G06F17/30 , G06F17/00 , G06F9/44
CPC分类号： G06F9/44505 , Y10S707/99942 , Y10S707/99943
摘要： A method and apparatus for converting a single instance computer application to a multiple instance application includes disabling the single instance application and linking the executable files associated with the single instance application to routines in a library that includes routines for use by a multiple instance application. Multiple instance metadata that represents the structure of the multiple instance application is automatically created based on metadata that represents the structure of the single instance application. The data from the single instance application is imported to complete the conversion to a multiple instance application.
摘要翻译：用于将单个实例计算机应用程序转换为多实例应用程序的方法和装置包括禁用单个实例应用程序并将与单个实例应用程序相关联的可执行文件链接到库中的例程，该程序库包括由多个实例应用程序使用的例程。基于表示单实例应用程序的结构的元数据自动创建表示多实例应用程序结构的多实例元数据。导入单实例应用程序的数据以完成转换为多实例应用程序。

39. 发明授权

US06299745B1 Flexible substrate plating rack 失效
标题翻译：柔性基板电镀架
公开(公告)号：US06299745B1
公开(公告)日：2001-10-09
申请号：US09564081
申请日：2000-05-03
申请人： Raj Kumar , Cheryle Rattey
发明人： Raj Kumar , Cheryle Rattey
IPC分类号： C25B900
CPC分类号： C25D17/08
摘要： A rack suitable for holding a flexible substrate panel, the rack having a plurality of clamps for providing current to a panel clamped to the rack, the clamps being positioned to uniformly distribute current to the substrate. Seven clamps are used to hold a flexible substrate panel bearing a copper seed or other conductive layer in place on the rack wherein one tautens the substrate while attaching the clamps so as to clamp the substrate in a “wrinkle free” manner. The seven clamps are arranged with 3 clamps on each of the left and right sides and one clamp on the bottom, the clamps making electrical contact with conductive layers of both the front and back surfaces of the substrate panel. The arrangement of the clamps provides adequate support to the substrate, provides for a good and uniform current distribution on the substrate, and allows a relatively large amount of current to flow through the panel without burning off the conductive/seed layers. In one rack, a spring clamp biased open is used wherein a thumbscrew is tightened against a surface of the clamp to force it against its spring into a closed, clamping position. The use of the spring clamp prevents the rotating pressure point contact which a thumbscrew causes.
摘要翻译：适于保持柔性基板的机架，所述机架具有多个夹具，用于向被夹紧在所述机架上的面板提供电流，所述夹具被定位成均匀地将电流分布到所述基板。七个夹具用于将一个带有铜种子或其他导电层的柔性基板保持在支架上的适当位置，其中，在安装夹具的同时使衬底拧紧，以便以“无皱纹”的方式夹紧衬底。七个夹具在左右两侧分别设有3个夹具，底部设有一个夹具，夹具与衬底面板的前后表面的导电层电接触。夹具的布置为基板提供了足够的支撑，在基板上提供良好且均匀的电流分布，并且允许相对大量的电流流过面板而不会导致导电/籽晶层的烧毁。在一个机架中，使用偏压打开的弹簧夹，其中指旋螺钉被紧固在夹具的表面上，以迫使其抵抗其弹簧进入关闭的夹紧位置。使用弹簧夹可以防止指旋螺钉造成的旋转压力点接触。

40. 发明授权

US5780617A Synthesis of liponucleotides 失效
标题翻译：脂质体的合成
公开(公告)号：US5780617A
公开(公告)日：1998-07-14
申请号：US251018
申请日：1994-05-31
申请人： Henk van den Bosch , Gysbert M. T. van Wijk , Raj Kumar , Karl Y. Hostetler
发明人： Henk van den Bosch , Gysbert M. T. van Wijk , Raj Kumar , Karl Y. Hostetler
IPC分类号： C07H19/20 , C07H1/02 , C07F9/02 , C07F9/06 , C07F9/28
CPC分类号： C07H19/20
摘要： A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.
摘要翻译：一种制备甘油二磷酸酯或三磷酸酯衍生物的方法，包括将一个磷酸酯羟基被一个离去基团取代的甘油一磷酸酯衍生物的磷酸酯基与一或二磷酸酯化合物的末端磷酸基团或的盐，在碱性催化剂的存在下，在无水条件下。

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