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31. 发明专利

NZ193084A 2-HYDROXY-5-(1-HYDROXY-2-(4-(2-OXOBENZIMIDAZOLIN-1-YL)-PIPERID-1-YL)ETHYL)BENZOIC ACID DERIVATIVES 未知
公开(公告)号：NZ193084A
公开(公告)日：1982-06-29
申请号：NZ19308480
申请日：1980-03-10
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G
IPC分类号： C07D401/04 , A61K20060101 , A61K31/415 , A61K31/435 , A61K31/445 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07C63/06 , C07D20060101 , C07D211/04 , C07D211/36 , C07D211/58 , C07D211/72 , C07D235/26
摘要： Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl ]benzoic acid are prepared which are useful for their blocking action on alpha and beta -adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.

32. 发明专利

ZA801603B 5-(2-((2,3-DIHYDRO-1,4-BENZODIOXAN-2-YLMETHYL)-AMINO)-1-HYDROXYETHYL)-2-HYDROXYBENZOIC ACID DERIVATIVES 未知
公开(公告)号：ZA801603B
公开(公告)日：1981-03-25
申请号：ZA801603
申请日：1980-03-19
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J
IPC分类号： C07D319/16 , A61K31/335 , A61K31/357 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , A61P25/08 , C07D319/20 , A61K , C07C
摘要： Derivatives of 5-[2-[(2,3-dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2 -hydroxybenzoic acid are prepared which are useful for their blocking action on alpha and beta -adrenergic receptors. In addition, these compounds are useful as antihypertensive agents.

33. 发明专利

BE883856A NOUVELLES AROYL-4 AMIDAZOLONES-2 UTILES COMME MEDICAMENTS LEUR PROCEDE DE PREPARATION ET COMPOSITIONS THERAPEUTIQUES LES CONTENANT 未知
公开(公告)号：BE883856A
公开(公告)日：1980-10-16
申请号：BE201057
申请日：1980-06-17
申请人： RICHARDSON MERRELL INC
发明人： DAGE R , SCHNETTLER R , GRISAR J
IPC分类号： A61K31/415 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/12 , C07D233/70 , C07D405/06 , C07D409/06 , C07D , A61K

34. 发明专利

PH12693A N-(PHENYLETHER-SUBSTITUTED BENZYL)ALKANEDIAMINES PHARMACEUTICAL COMPOSITION AND METHOD OF USE 未知
公开(公告)号：PH12693A
公开(公告)日：1979-07-18
申请号：PH18669
申请日：1976-07-09
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G
IPC分类号： A61P7/02 , A61K31/135 , A61P31/12 , A61P37/06 , C07C45/71 , C07C67/00 , C07C213/00 , C07C217/58 , C07C313/00 , C07C317/14 , C07C317/32 , C07C317/36 , C07C323/12 , C07C323/32 , C07D209/48 , C07C87/00
摘要： 1480579 Diamines RICHARDSON-MERRELL Inc 3 June 1976 [25 Aug 1975) 22883/76 Heading C2C Compounds of the general formula (R 1-4 =H, C 1-4 alkyl; X=O, S, SO 2 ; Y =O, # bond; m = 2-4; n = 1-4, but not 1 when Y=O) and their acid addition salts are prepared by the following route when R 1 , 2 = H and by condensing the starting material with H 2 N(CH 2 ) m NR 1 R 2 followed by reduction of the resulting Schiff base when R 1 and/or R 2 = alkyl. The product may be isolated as a salt. The preparation of the starting materials is described. The above compounds are antiviral agents and anticoagulants, and suppress immune response reactions. They may be administered in the form of pharmaceutical and veterinary preparations containing them in association with a carrier.

35. 发明专利

ZA7603240B N-(PHENYLETHER-SUBSTITUTED BENZYL)ALKANEDIAMINES 未知
公开(公告)号：ZA7603240B
公开(公告)日：1977-05-25
申请号：ZA7603240
申请日：1976-06-02
申请人： RICHARDSON MERRELL INC
发明人： CLAXTON G , GRISAR J
IPC分类号： A61K31/135 , A61P7/02 , A61P31/12 , A61P37/06 , C07C45/71 , C07C67/00 , C07C213/00 , C07C217/58 , C07C313/00 , C07C317/14 , C07C317/32 , C07C317/36 , C07C323/12 , C07C323/32 , C07D209/48 , C07C
CPC分类号： C07C317/00 , C07C45/71 , C07C323/00 , C07C49/84 , C07C47/575

36. 发明专利

ZA742734B DERIVATIVES OF 1,3-BENZODIOXOLE-2-CARBOXYLIC ACID 未知
公开(公告)号：ZA742734B
公开(公告)日：1975-05-28
申请号：ZA742734
申请日：1974-04-30
申请人： RICHARDSON MERRELL INC
发明人： KARIYA T , GRISAR J , PARKER R
IPC分类号： C07C37/14 , C07D317/46 , C07D

37. 发明专利

ZA7402734B DERIVATIVES OF 1,3-BENZODIOXOLE-2-CARBOXYLIC ACID 未知
公开(公告)号：ZA7402734B
公开(公告)日：1975-05-28
申请号：ZA7402734
申请日：1974-04-30
申请人： RICHARDSON MERRELL INC
发明人： KARIYA T , GRISAR J , PARKER R
IPC分类号： C07C37/14 , C07D317/46 , C07D
CPC分类号： C07C37/14 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D317/46 , Y10S514/824 , Y10S514/96 , Y10S514/962 , C07C39/15 , C07C39/17

38. 发明专利

ZA741670B D-CYCLOALKYLBENZYL LACTAMIMIDES 未知
公开(公告)号：ZA741670B
公开(公告)日：1975-02-26
申请号：ZA741670
申请日：1974-03-13
申请人： RICHARDSON MERRELL INC
发明人： CLAXTON G , GRISAR J
IPC分类号： C07D207/22 , C07D211/72 , C07D223/12 , C07D227/10 , C07C , C07D
摘要： 1413455 α-Cycloalkylbenzyl lactamimides RICHARDSON-MERRELL Inc 22 April 1974 [25 April 1973] 17546/74 Heading C2C Novel compounds of Formula I wherein n is an integer of from 3 to 9; R is hydrogen or methyl; R 1 is hydrogen or lower alkyl having from 1 to 4 carbon atoms; Y is cycloalkyl having from 3 to 5 carbon atoms; X is hydrogen, lower alkoxy having from 1 to 4 carbon atoms or lower alkyl having from 1 to 4 carbon atoms; m is an integer of from 1 to 2; and the pharmaceutically acceptable acid addition salts thereof are prepared (a) when R is H by reaction of a compound of Formula V with an amine of Formula VI or where n is H or methyl, the amine is reacted with the appropriate lactam complexed with phosphorous oxychloride, phosgene, borontrifluoride etherate, dimethyl sulphate, hydrogen halide or a combination of the same. 2,3,4,5,6,6 - Hexahydro - 8 - methoxyazocine, is prepared by reacting octahydroazocin-2-one with dimethyl sulphate. α - Cyclopropylbenzylamine is prepared by reacting cyclopropyl cyanide and phenyl magnesium bromide then lithium aluminium hydride and isolated as the hydrochloride. Pharmaceutical compositions in conventional forms for oral, sublingual, intrabuccal and parenteral administration and having hypglycemic activity comprise an above novel compound and a carrier therefor.

39. 发明专利

ZA7401671B 2-AZACYCLOALKYLMETNYL SUBSTITUTED PHENYL CARBINOLS AND KETONES 未知
公开(公告)号：ZA7401671B
公开(公告)日：1975-02-26
申请号：ZA7401671
申请日：1974-03-13
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G
IPC分类号： C07D223/04 , C07D207/08 , C07D207/18 , C07D211/22 , C07D211/32 , C07D225/02 , C07D487/22 , C07C , C07D
CPC分类号： C07D207/08 , C07D207/18 , C07D211/22 , C07D211/32 , Y10S514/822

40. 发明专利

ZA74734B IMIDAZO(1,2-A)AZACYCLOALKANES 未知
公开(公告)号：ZA74734B
公开(公告)日：1974-12-24
申请号：ZA74734
申请日：1974-02-05
申请人： RICHARDSON MERRELL INC
发明人： GRISAR J , CLAXTON G
IPC分类号： A61K31/415 , A61P3/08 , C07D207/22 , C07D471/04 , C07D487/04 , C07D

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