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31. 发明授权

US5237096A Process for the preparation of an antiviral agent 失效
公开(公告)号：US5237096A
公开(公告)日：1993-08-17
申请号：US961806
申请日：1992-10-16
申请人： Jollie D. Godfrey, Jr. , Richard H. Mueller , Thomas P. Kissick , Janak Singh
发明人： Jollie D. Godfrey, Jr. , Richard H. Mueller , Thomas P. Kissick , Janak Singh
IPC分类号： C07B57/00 , C07C45/58 , C07C49/753 , C07C51/487 , C07C61/35 , C07C69/68 , C07C69/743 , C07C309/73 , C07D473/00
CPC分类号： C07D473/00 , C07B57/00 , C07C309/73 , C07C45/58 , C07C49/753 , C07C51/487 , C07C61/35 , C07C69/68 , C07C69/743 , C07C2101/04
摘要： Racemic Feist's acid is treated with (R)-(+)-.alpha.-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-.alpha.-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.

32. 发明授权

US07616987B2 Microprobe for 3D bio-imaging, method for fabricating the same and use thereof 失效
标题翻译：用于3D生物成像的微探针，其制造方法及其用途
公开(公告)号：US07616987B2
公开(公告)日：2009-11-10
申请号：US11244919
申请日：2005-10-05
申请人： Chirayarikathuveedu Sankarapillai Premachandran , Janak Singh , Joseph Suresh Paul , Pamidighantam Venkata Ramana , Colin James Richard Sheppard
发明人： Chirayarikathuveedu Sankarapillai Premachandran , Janak Singh , Joseph Suresh Paul , Pamidighantam Venkata Ramana , Colin James Richard Sheppard
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0088
摘要： A microprobe that is capable of using an incident and reflected radiation ray for three-dimensional (3-D) bio-imaging. The microprobe comprises a hollow body closed at one end and having an aperture at an opposite end, at least one 3-D free space micromirror, at least one focusing lens, and a beam director or a beam coupler or other kind of device for beam coupling or splitting. The beam director is arranged at the aperture end of the hollow body and is adapted to direct the incident ray into the hollow body via the aperture. Within said hollow body is the at least one focusing lens and the at least one micromirror arranged respectively from the aperture, such that the distance between the focusing lens and the micromirror allows for the incident light ray to be directed onto the micromirror.
摘要翻译：能够使用入射和反射辐射线进行三维（3-D）生物成像的微探针。微探针包括在一端封闭并且在相对端具有孔的空心体，至少一个3-D自由空间微镜，至少一个聚焦透镜，以及光束导向器或光束耦合器或其他类型的用于光束的装置耦合或分裂。光束导向器布置在中空体的孔径端处，并且适于将入射光线经由孔径引导到中空体中。在所述中空体内的是至少一个聚焦透镜和分别从该孔排列的至少一个微反射镜，使得聚焦透镜和微反射镜之间的距离允许入射光线被引导到微反射镜上。

33. 发明授权

US07091057B2 Method of making a single-crystal-silicon 3D micromirror 失效
标题翻译：制造单晶硅3D微镜的方法
公开(公告)号：US07091057B2
公开(公告)日：2006-08-15
申请号：US10742120
申请日：2003-12-19
申请人： Chih Kiong Terence Gan , Ajay Agarwal , Janak Singh , Xiaolin Zhang
发明人： Chih Kiong Terence Gan , Ajay Agarwal , Janak Singh , Xiaolin Zhang
IPC分类号： H01L21/00
CPC分类号： G02B26/0866
摘要： First and second n-doped regions are formed at a surface of a p-doped single crystal silicon substrate. An aluminum layer is patterned overlying some of the second n-doped regions to form thermal actuators. A dielectric layer is deposited overlying the patterned aluminum layer and an underlying thermal oxide layer. A metal layer is deposited thereover and patterned to form bond pads to the thermal actuators and to form reflecting mirror surfaces overlying others of the second n-doped regions to form micromirrors. The substrate is etched away from the backside stopping at the first and second n-doped regions. Then the wafer is diced into mirror array chips. Portions of the first n-doped regions are etched away from the frontside to form flexible springs wherein the second n-doped regions covered by the patterned aluminum layer form thermal actuators and wherein the flexible springs connect the micromirrors to the thermal actuators.
摘要翻译：在p掺杂单晶硅衬底的表面上形成第一和第二n掺杂区域。将铝层图案覆盖在一些第二n掺杂区域上以形成热致动器。沉积在图案化的铝层和下面的热氧化物层上的电介质层。金属层沉积在其上并被图案化以形成到热致动器的接合焊盘并且形成覆盖第二n掺杂区域中的其它区域的反射镜表面以形成微镜。在第一和第二n掺杂区域处的衬底被从背面蚀刻掉。然后将晶片切成镜阵列芯片。第一n掺杂区域的部分从前侧被蚀刻以形成柔性弹簧，其中由图案化铝层覆盖的第二n掺杂区域形成热致动器，并且其中柔性弹簧将微镜连接到热致动器。

34. 发明授权

US06808644B2 Capillary with glass internal surface 失效
标题翻译：毛细管带玻璃内表面
公开(公告)号：US06808644B2
公开(公告)日：2004-10-26
申请号：US10139049
申请日：2002-05-02
申请人： Yu Chen , Janak Singh
发明人： Yu Chen , Janak Singh
IPC分类号： B44C122
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00907 , B01L3/5027 , G01N27/44704
摘要： A process to form a capillary that is well insulated from its environment is described. Said process has two stages. The first stage, which is the same for both of the invention's two embodiments, comprises forming a micro-channel in the surface of a sheet of glassy material. For the first embodiment, this sheet is bonded to a layer of oxide, that lies on the surface of a sheet of silicon, thereby sealing in the capillary. After all silicon has been selectively removed, a thin membrane of oxide remains. Using a low temperature bonding process, a second sheet of glassy material is then bonded to this membrane. In the second embodiment, the silicon is not fully removed. Instead, the oxide layer of the first embodiment is replaced by an oxide/nitride/oxide trilayer which provides improved electrical insulation between the capillary and the remaining silicon at a lower level of inter-layer stress.
摘要翻译：描述了形成与其环境绝缘的毛细管的方法。所述过程有两个阶段。与本发明的两个实施例相同的第一阶段包括在玻璃状材料片的表面中形成微通道。对于第一实施例，该片材结合到位于硅片表面上的氧化物层，从而密封在毛细管中。在所有的硅已经被选择性地去除之后，留下一薄层的氧化物。使用低温粘合工艺，然后将第二片玻璃状材料粘合到该膜上。在第二实施例中，硅没有完全去除。相反，第一实施例的氧化物层被氧化物/氮化物/氧化物三层替代，其在低层次的层间应力下在毛细管和剩余的硅之间提供改善的电绝缘。

35. 发明授权

US5608064A Purinyl salts useful for preparing guanine containing antiviral agents 失效
标题翻译：用于制备含有抗病毒药物的鸟嘌呤的嘌呤盐
公开(公告)号：US5608064A
公开(公告)日：1997-03-04
申请号：US457183
申请日：1995-06-01
申请人： Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
发明人： Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
IPC分类号： A61K31/52 , A61P31/12 , C07C211/63 , C07D473/00 , C07D473/32 , C07D473/40 , C07D473/18
CPC分类号： C07D473/00 , C07D473/40
摘要： A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl.
摘要翻译：其中Y 1是氯，溴或碘，并且R 1，R 2，R 3和R 4独立地选自烷基和取代的烷基。

36. 发明授权

US5539126A Method for preparing homochiral maleimide intermediates, via silylation techniques 失效
标题翻译：通过甲硅烷基化技术制备顺式马来酰亚胺中间体的方法
公开(公告)号：US5539126A
公开(公告)日：1996-07-23
申请号：US230570
申请日：1994-04-20
申请人： Michael J. Humora , Richard H. Mueller , Janak Singh , Yadagiri Pendri
发明人： Michael J. Humora , Richard H. Mueller , Janak Singh , Yadagiri Pendri
IPC分类号： A61K31/42 , A61P7/02 , C07D207/44 , C07D207/448 , C07D207/452 , C07D491/18 , C07D493/08
CPC分类号： C07D207/448 , C07D207/452 , C07D493/08
摘要： A method is provided for preparing homochiral maleimide intermediates of the structure ##STR1## wherein R.sup.7, R.sup.8 and R.sup.9 are as defined herein by reacting a homochiral amine of the structure ##STR2## with maleic anhydride and a silylating agent. The maleimide intermediate is used in the enantio-selective preparation of thromboxane A.sub.2 receptor antagonists.
摘要翻译：提供了一种用于制备结构单克隆马来酰亚胺中间体的方法，其中R 7，R 8和R 9如本文所定义，通过使结构式的同基因药物马来酰亚胺中间体用于血栓素A2的对映选择性制剂受体拮抗剂。

37. 发明授权

US5512690A 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-basopastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：US5512690A
公开(公告)日：1996-04-30
申请号：US528371
申请日：1995-09-14
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D407/02
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法

38. 发明授权

US5508445A 7-oxabicycloheptane carboxylic acid protaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效
标题翻译：可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸普洛草灵类似物中间体及其制备方法
公开(公告)号：US5508445A
公开(公告)日：1996-04-16
申请号：US356743
申请日：1994-12-15
申请人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
发明人： Michael A. Poss , Paul D. Pansegrau , Shaopeng Wang , John K. Thottathil , Janak Singh , Richard H. Mueller
IPC分类号： C07D491/18 , C07D493/08 , C07D493/18 , C07D307/77
CPC分类号： C07D493/08
摘要： A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
摘要翻译：提供了一种制备结构“IMAGE”的羧酸中间体的方法

39. 发明授权

US5210262A Method for preparing a phosphonic acid ester 失效
标题翻译：膦酸酯的制备方法
公开(公告)号：US5210262A
公开(公告)日：1993-05-11
申请号：US944583
申请日：1992-09-14
申请人： Janak Singh , Richard H. Mueller
发明人： Janak Singh , Richard H. Mueller
IPC分类号： C07F9/40
CPC分类号： C07F9/4006
摘要： A method is provided for preparing a phosphonic acid ester having the structure ##STR1## wherein R.sup.1 is farnesyl or a derivative or analog thereof, and R.sup.2 is lower alkyl, by treating a farnesyl halide R.sup.1 Hal(Hal=Cl,Br,I) with an alkoxide of the structure ##STR2## wherein M is an alkali metal and R.sup.2c is lower alkyl. The resulting phosphonic acid ester is an intermediate in preparing a squalene synthetase inhibitor which is used for inhibiting cholesterol biosynthesis.
摘要翻译：提供了一种制备具有结构式（其中R 1为法呢基或其衍生物或类似物，并且R 2为低级烷基）的膦酸酯的方法，其中用法呢基卤化物R 1 Hal（Hal = Cl，Br，I）结构的醇盐，其中M是碱金属，R2c是低级烷基。所得膦酸酯是制备用于抑制胆固醇生物合成的角鲨烯合成酶抑制剂的中间体。

40. 发明授权

US5177239A Method for preparing a phosphonic acid ester 失效
标题翻译：制备磷酸酯的方法
公开(公告)号：US5177239A
公开(公告)日：1993-01-05
申请号：US381339
申请日：1989-07-17
申请人： Janak Singh , Richard H. Mueller
发明人： Janak Singh , Richard H. Mueller
IPC分类号： C07F9/40
CPC分类号： C07F9/4006
摘要： A method is provided for preparing a phosphonic acid ester having the structure ##STR1## wherein R.sup.1 is farnesyl or a derivative or analog thereof, and R.sup.2 is lower alkyl, by treating a farnesyl halide R.sup.1 Hal(Hal.dbd.Cl,Br,I) with an alkoxide of the structure ##STR2## wherein M is an alkali metal and R.sup.2c is lower alkyl. The resulting phosphonic acid ester is an intermediate in preparing a squalene synthetase inhibitor which is used for inhibiting cholesterol biosynthesis.
摘要翻译：提供了一种制备具有结构式（其中R 1为法呢基或其衍生物或类似物，并且R 2为低级烷基）的膦酸酯的方法，其中用法呢基卤化物R 1 Hal（Hal = Cl，Br，I）结构的醇盐，其中M是碱金属，R2c是低级烷基。所得膦酸酯是制备用于抑制胆固醇生物合成的角鲨烯合成酶抑制剂的中间体。

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