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31. 发明申请

US20070098788A1 NON-BENZODIAZEPINE HYPNOTIC COMPOSITIONS 审中-公开
标题翻译：非苯二氮卓高分子组合物
公开(公告)号：US20070098788A1
公开(公告)日：2007-05-03
申请号：US11553342
申请日：2006-10-26
申请人： Subhash Gore , Sudeep Agrawal , Abhijeet Upadhye , Srinivasulu Rangineni , Sivakumar Bommareddy , Srinivas Gade , Basappa Nagaraj , Gautam Bakshi , Surjit Das , Satish Jain , Surya Devarakonda , Bharath Deevireddy , Eswaraiah Sajja , Venkata Naga Kali Veturi , Sreenadhacharyulu Kandala , Gurvinder Singh , Indu Bhushan , Mailatur Mohan
发明人： Subhash Gore , Sudeep Agrawal , Abhijeet Upadhye , Srinivasulu Rangineni , Sivakumar Bommareddy , Srinivas Gade , Basappa Nagaraj , Gautam Bakshi , Surjit Das , Satish Jain , Surya Devarakonda , Bharath Deevireddy , Eswaraiah Sajja , Venkata Naga Kali Veturi , Sreenadhacharyulu Kandala , Gurvinder Singh , Indu Bhushan , Mailatur Mohan
IPC分类号： A61K31/519 , A61K9/20
CPC分类号： A61K9/1664 , A61K9/146 , A61K9/1635 , A61K9/2013 , A61K9/205 , A61K31/519
摘要： Pharmaceutical compositions comprising non-benzodiazepine hypnotic drugs or their pharmaceutically acceptable salts, solvates, enantiomers or mixtures and processes for preparing the same. The invention also includes immediate release and extended release pharmaceutical compositions comprising non-benzodiazepine hypnotic drugs, useful for sleep induction and sleep maintenance.
摘要翻译：包含非苯并二氮卓催眠药物或其药学上可接受的盐，溶剂合物，对映异构体或混合物的药物组合物及其制备方法。本发明还包括用于睡眠诱导和睡眠维持的包含非苯二氮卓催眠药物的立即释放和缓释药物组合物。

32. 发明申请

US20060233878A1 Extended release formulation of beta-lactam antibiotics 审中-公开
标题翻译： β-内酰胺抗生素的延长释放制剂
公开(公告)号：US20060233878A1
公开(公告)日：2006-10-19
申请号：US10568325
申请日：2003-09-30
申请人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
发明人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
IPC分类号： A61K31/545 , A61K9/22
CPC分类号： A61K9/2018 , A61K9/2027 , A61K31/545
摘要： A pharmaceutical composition for controlled drug delivery comprising a β-lactam antibiotic or its pharmaceutically acceptable hydrates, salts or esters, and one or more carbomers. The above β-lactam antibiotics formulation avoids the limitations of known β-lactam controlled release form which are found to be either complex and/or cost-extensive to obtain requiring multiphase and/or selective coatings or fail to achieve the desired controlled release for once daily dosage form. Importantly, in the β-lactam antibiotic form of the above the rate-controlling polymer wherein the Cmax of the formulation is substantially the same as that of a single dose of the immediate release formulation. Also advantageously the formulation achieves a rate controlling polymer wherein the T>MIC for the formulation is more than 17 hours when the MIC is 0.25 mcg/ml and more than 10 hours when the MIC is 2 mcg/ml. The above β-lactam antibiotic form is thus directed to serve as the much desired simple and cost-effective controlled release form suitable for once daily administration.
摘要翻译：用于受控药物递送的药物组合物，其包含β-内酰胺抗生素或其药学上可接受的水合物，盐或酯，以及一种或多种卡波姆。上述β-内酰胺抗生素制剂避免了已知的β-内酰胺控制释放形式的限制，其被认为是复杂的和/或成本广泛的以获得需要多相和/或选择性涂层或不能达到期望的一次控制释放日剂量。重要的是，在上述β-内酰胺抗生素形式中，速率控制聚合物，其中制剂的最大值与单剂量的立即释放制剂基本上相同。还有利地，制剂实现速率控制聚合物，其中当MIC为0.25mcg / ml时，制剂的T> MIC大于17小时，当MIC为2mcg / ml时超过10小时。因此，上述β-内酰胺抗生素形式被用作适合于每日一次给药的理想的简单和成本有效的控制释放形式。

33. 发明申请

US20060188568A1 Stable formulations of ace inhibitors and methods for preparation thereof 审中-公开
标题翻译： ace抑制剂的稳定配方及其制备方法
公开(公告)号：US20060188568A1
公开(公告)日：2006-08-24
申请号：US10550181
申请日：2003-10-30
申请人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
发明人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
IPC分类号： A61K31/401 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/4858 , A61K31/403
摘要： Stabilized pharmaceutical solid composition of ACE inhibitor comprising an ACE inhibitor and a selective dosage formulation thereof comprising of meglumine. The ACE inhibitor selectively combined with a dosage form including essentially the meglumine is surprisingly found to avoid the degradation of ACE inhibitor by such dosage forms especially the commonly used pharmaceutical excepients. In particular, the presence of the meglumine in the dosage form for the active along with the active ACE inhibitor surprisingly avoid the degradation of the ACE inhibitor due to a) cyclization via internal nucleophilic attack to form substituted diketopiperazines, b) hydrolysis of the side chain ester group, and c) oxidation to form products having often unwanted coloration.
摘要翻译：稳定的ACE抑制剂的药物固体组合物，其包含ACE抑制剂及其选择性剂量制剂，其包含葡甲胺。令人惊奇地发现，选择性地与包含基本上葡甲胺的剂型组合的ACE抑制剂避免了ACE抑制剂通过这样的剂型，特别是常用的药物的降解。特别地，活性剂剂型中的葡甲胺与活性ACE抑制剂的存在令人惊奇地避免了由于通过内部亲核攻击而环化形成取代的二酮哌嗪的ACE抑制剂的降解，b）侧链的水解酯基，和c）氧化形成通常不需要着色的产品。

34. 发明申请

US20110236475A1 GRANULAR PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：颗粒药物组合物
公开(公告)号：US20110236475A1
公开(公告)日：2011-09-29
申请号：US13157621
申请日：2011-06-10
申请人： Mohammad Bala Pasha , Raghupathi Kandarapu , Vasanth Kumar Shetty , Indu Bhushan , Mailatur Sivaraman Mohan
发明人： Mohammad Bala Pasha , Raghupathi Kandarapu , Vasanth Kumar Shetty , Indu Bhushan , Mailatur Sivaraman Mohan
IPC分类号： A61K9/48 , A61K9/50 , A61K31/445 , A61K9/20 , A61P37/08 , B05D5/00 , B05D7/00
CPC分类号： A61K9/5078 , A61K9/2077 , A61K9/284 , A61K9/2866
摘要： Pharmaceutical compositions comprising a plurality of formulated particles containing at least one active ingredient and at least one pharmaceutically acceptable excipient, granulated with a granulating composition containing at least one pharmaceutical excipient.
摘要翻译：药物组合物包含多个配制的含有至少一种活性成分和至少一种药学上可接受的赋形剂的颗粒，其与含有至少一种药物赋形剂的制粒组合物制粒。

35. 发明申请

US20100029743A1 ATORVASTATIN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： ATORVASTATIN药物组合物
公开(公告)号：US20100029743A1
公开(公告)日：2010-02-04
申请号：US12443242
申请日：2007-09-27
申请人： Sudeep Kumar Agrawal , Abhijeet Ashok Upadhye , Indu Bhushan , Mailatur Sivaraman Mohan , Riswan Zafar , Alagumurugan Alagarsamy
发明人： Sudeep Kumar Agrawal , Abhijeet Ashok Upadhye , Indu Bhushan , Mailatur Sivaraman Mohan , Riswan Zafar , Alagumurugan Alagarsamy
IPC分类号： A61K31/40 , A61P9/00
CPC分类号： A61K9/209
摘要： The present invention relates to pharmaceutical formulations of atorvastatin or its pharmaceutically acceptable salts, solvates, hydrates, enantiomers, polymorphs or their mixtures; and processes for preparing the same, and their methods of use, treatment and administration. Further, the present invention relates to pharmaceutical compositions comprising an acid-solubility-enhanced form of atorvastatin or its salts.
摘要翻译：本发明涉及阿托伐他汀或其药学上可接受的盐，溶剂合物，水合物，对映体，多晶型物或其混合物的药物制剂; 及其制备方法及其使用方法，治疗和给药方法。此外，本发明涉及包含阿曲伐他汀或其盐的酸溶性增强形式的药物组合物。

36. 发明申请

US20090324728A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AMORPHOUS BENZIMIDAZOLE COMPOUNDS 审中-公开
标题翻译：包含不定性苯并咪唑化合物的药物组合物
公开(公告)号：US20090324728A1
公开(公告)日：2009-12-31
申请号：US12553409
申请日：2009-09-03
申请人： Indu Bhushan , Kavita Vermani , Ravinder Kodipyaka , Pavak Mehta , Mailatur Sivaraman Mohan
发明人： Indu Bhushan , Kavita Vermani , Ravinder Kodipyaka , Pavak Mehta , Mailatur Sivaraman Mohan
IPC分类号： A61K9/14 , A61K31/435
CPC分类号： C07D401/12 , A61K9/5078 , A61K9/5089 , A61K31/4184 , A61K31/4439
摘要： Compositions comprising amorphous substituted benzimidazole compounds.
摘要翻译：包含非晶取代的苯并咪唑化合物的组合物。

37. 发明申请

US20090124657A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONTELUKAST 审中-公开
标题翻译：包含MONTELUKAST的药物组合物
公开(公告)号：US20090124657A1
公开(公告)日：2009-05-14
申请号：US12191611
申请日：2008-08-14
申请人： Ramesh Kappala , Basety Srikanth , Rahul Sudhakar Gawande , Subhash Pandurang Gore , Irukulla Srinivas , Indu Bhushan , Mailatur Sivaraman Mohan
发明人： Ramesh Kappala , Basety Srikanth , Rahul Sudhakar Gawande , Subhash Pandurang Gore , Irukulla Srinivas , Indu Bhushan , Mailatur Sivaraman Mohan
IPC分类号： A61K31/47 , A61P11/06
CPC分类号： A61K9/2018 , A61K9/0056
摘要： Pharmaceutical compositions comprising montelukast or pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or mixtures thereof.
摘要翻译：包含孟鲁司特或其药学上可接受的盐，溶剂合物，多晶型物，对映体或其混合物的药物组合物。

38. 发明申请

US20080193524A1 Extended Release Venlafaxine Compositions 审中-公开
标题翻译：延长释放文拉法辛组合物
公开(公告)号：US20080193524A1
公开(公告)日：2008-08-14
申请号：US11997044
申请日：2006-07-28
申请人： Ravinder Kodipyaka , Subhash Pandurang Gore , Indu Bhushan , Mailatur Sivaraman Mohan
发明人： Ravinder Kodipyaka , Subhash Pandurang Gore , Indu Bhushan , Mailatur Sivaraman Mohan
IPC分类号： A61K9/48 , A61K9/30 , A61K31/135
CPC分类号： A61K9/2866 , A61K9/2846 , A61K9/4808 , A61K9/5026 , A61K9/5047 , C09D101/02 , C09D101/28
摘要： The invention relates to extended release pharmaceutical compositions of venlafaxine or pharmaceutically acceptable salts. More particularly this invention relates to a pharmaceutical composition having a core comprising venlafaxine and a coating thereupon. The coating utilizes at least one water insoluble polymer and at least one polymer having pH dependent solubility to delay and modulate the release of the drug in an extended manner.
摘要翻译：本发明涉及文拉法辛或其药学上可接受的盐的延长释放药物组合物。更具体地说，本发明涉及具有核心的药物组合物，其中包括文拉法辛及其上的涂层。该涂层利用至少一种水不溶性聚合物和至少一种具有pH依赖性溶解度的聚合物以延长的方式延迟和调节药物的释放。

39. 发明申请

US20080182880A1 PIOGLITAZONE COMPOSITION 审中-公开
标题翻译： PIOGLITAZONE组合物
公开(公告)号：US20080182880A1
公开(公告)日：2008-07-31
申请号：US11862577
申请日：2007-09-27
申请人： Mailatur Sivaraman Mohan , Indu Bhushan , Sivareddy Venkata Pallempalli , Kamlakar Golli Reddy
发明人： Mailatur Sivaraman Mohan , Indu Bhushan , Sivareddy Venkata Pallempalli , Kamlakar Golli Reddy
IPC分类号： A61K31/4439 , C07D417/02
CPC分类号： C07D417/12
摘要： Pioglitazone or a salt thereof having a particle size distribution wherein D90 is about 25 μm to about 40 μm, and pharmaceutical compositions prepared therefrom.
摘要翻译：具有粒径分布的吡格列酮或其盐，其中D 90为约25μm至约40μm，以及由其制备的药物组合物。

40. 发明申请

US20080139514A1 DIPHOSPHONIC ACID PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：二氢磷酸药物组合物
公开(公告)号：US20080139514A1
公开(公告)日：2008-06-12
申请号：US11945507
申请日：2007-11-27
申请人： Subhash Pandurang Gore , Dokku Somasundara Rao , Indu Bhushan , Mailatur Sivaraman Mohan , Kolakaluri Uma Maheswara Prasad
发明人： Subhash Pandurang Gore , Dokku Somasundara Rao , Indu Bhushan , Mailatur Sivaraman Mohan , Kolakaluri Uma Maheswara Prasad
IPC分类号： A61K31/663
CPC分类号： A61K31/663 , A61K9/2013 , A61K9/2018 , A61K9/2022 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K47/02 , A61K47/10 , A61K47/32
摘要： Solid pharmaceutical compositions comprising a diphosphonic acid or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, enantiomer or racemic mixture thereof. The invention includes compositions with inner and outer phases, wherein the inner phase comprises no more than about 80% w/w and the outer phase comprises at least about 20% w/w.
摘要翻译：包含二膦酸或其药学上可接受的盐，溶剂合物，水合物，前药，对映体或外消旋混合物的固体药物组合物。本发明包括具有内相和外相的组合物，其中内相包含不超过约80％w / w，外相包含至少约20％w / w。

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