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31. 发明申请

US20050287081A1 Pharmaceutically elegant, topical anhydrous aerosol foam 有权
标题翻译：药用优雅，局部无水气溶胶泡沫
公开(公告)号：US20050287081A1
公开(公告)日：2005-12-29
申请号：US10875470
申请日：2004-06-24
申请人： Duncan Aust , David Jones , Bhavesh Shah
发明人： Duncan Aust , David Jones , Bhavesh Shah
IPC分类号： A61K8/31 , A61K8/37 , A61K8/49 , A61K8/58 , A61K9/00 , A61Q17/00
CPC分类号： A61Q19/00 , A61K8/31 , A61K8/375 , A61K8/4973 , A61K8/585 , A61K2800/31 , A61Q17/00 , Y10S514/945
摘要： A topical pharmaceutical aerosol foam containing liquid silicones to enhance cosmetic elegance. Although liquid silicones are inherent defoamers, a high quality, stable foam is produced.
摘要翻译：含有液体硅酮的局部药物气溶胶泡沫，以增强化妆品的优雅性。虽然液体硅酮是固有的消泡剂，但是产生了高品质，稳定的泡沫。

32. 发明申请

US20050282657A1 Golf putter head with a visual alignment aid and an increased moment of inertia 有权
标题翻译：高尔夫推杆头具有视觉对准辅助功能和增加的惯性力矩
公开(公告)号：US20050282657A1
公开(公告)日：2005-12-22
申请号：US11210934
申请日：2005-08-23
申请人： John Solheim , David Jones , Derek Haines , John Solheim
发明人： John Solheim , David Jones , Derek Haines , John Solheim
IPC分类号： A63B53/06 , A63B20060101 , A63B53/04 , A63B69/36
CPC分类号： A63B53/0487 , A63B2053/0441
摘要： A golf putter head includes a face member with a front surface arranged for impacting a golf ball. A first arm extends substantially rearwardly from a heel end of the face member, a second arm extends substantially rearwardly from a toe end of the face member, and a central member extends rearwardly from the face member intermediate the heel and toe ends thereof. The central member is connected to and extends rearwardly from a back surface of the face member. The central member is connected to the first and second arms rearwardly of the face member. The first and second arms have top surfaces that slope downwardly as the first and second arms extend away from the face member.
摘要翻译：高尔夫推杆头包括面部构件，前表面布置成用于冲击高尔夫球。第一臂从面部构件的后端基本上向后延伸，第二臂从面部构件的趾端基本上向后延伸，并且中心构件从脚跟和脚趾端部之间的面构件向后延伸。中心构件从面构件的后表面连接并向后延伸。中心构件连接到面部构件后面的第一和第二臂。当第一和第二臂从面部构件延伸时，第一和第二臂具有向下倾斜的顶面。

33. 发明申请

US20050226844A1 Valency platform molecules comprising carbamate linkages 审中-公开
标题翻译：价值平台分子包含氨基甲酸酯键
公开(公告)号：US20050226844A1
公开(公告)日：2005-10-13
申请号：US11149779
申请日：2005-06-10
申请人： David Jones
发明人： David Jones
IPC分类号： C07D295/16 , A61K31/765 , A61K31/785 , C07B61/00 , C07C233/69 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/48 , C07D295/205 , C07D521/00 , C40B40/04
CPC分类号： C07D295/205 , C07C233/69 , C07C271/16 , C07C271/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate. More particularly, the present invention pertains to valency platform molecules which comprise a carbamate linkage (i.e., —O—C(═O)—N
摘要翻译：本发明一般涉及化合价分子，例如作为支架的价态平台分子，其中一个或多个分子可以共价连接以形成缀合物。更具体地说，本发明涉及包含氨基甲酸酯键（即-O-C（ - ） - N））的化合物平台分子。一方面，本发明涉及包含氨基甲酸酯键的化合物平台，该分子具有图1所示的式I，II或III中任一项的结构。一方面，本发明涉及包含氨基甲酸酯键的化合物平台，该分子具有图4所示的式Ⅳ，Ⅴ或Ⅵ中任一个的结构。本发明还涉及制备这种价态平台分子的方法，包含这种价态平台分子的共轭物，以及制备这种缀合物的方法。

34. 发明申请

US20050220785A1 Methods and formulations for reducing circulating antibodies 审中-公开
标题翻译：减少循环抗体的方法和制剂
公开(公告)号：US20050220785A1
公开(公告)日：2005-10-06
申请号：US11144155
申请日：2005-06-02
申请人： Steven Engle , Richard Jack , David Jones , Lin Yu
发明人： Steven Engle , Richard Jack , David Jones , Lin Yu
IPC分类号： A61K39/395 , A61K47/48
CPC分类号： A61K47/61 , A61K47/54 , A61K47/59 , A61K47/595 , A61K47/60
摘要： The invention provides methods for reducing circulating levels of antibodies, particularly disease-associated antibodies. The methods entail administering effective amounts of epitope-presenting carriers to an individual. In other embodiments, ex vivo methods for reducing circulating levels of antibodies are provided which employ epitope-presenting carriers.
摘要翻译：本发明提供降低抗体循环水平，特别是疾病相关抗体的方法。该方法需要向个体施用有效量的表位呈递载体。在其它实施方案中，提供用于降低抗体循环水平的离体方法，其使用表位呈递载体。

35. 发明申请

US20050208480A1 aPL immunoreactive peptides, conjugates thereof and methods of treatment for aPL antibody-mediated pathologies 审中-公开
标题翻译： aPL免疫反应肽，其缀合物和治疗aPL抗体介导的病理学的方法
公开(公告)号：US20050208480A1
公开(公告)日：2005-09-22
申请号：US10846079
申请日：2004-05-13
申请人： Edward Victoria , David Marquis , David Jones , Lin Yu
发明人： Edward Victoria , David Marquis , David Jones , Lin Yu
IPC分类号： A61K38/00 , A61K39/00 , C07C323/12 , C07K14/00 , C07K14/47 , C07K16/18 , C07K16/42 , C12Q1/70 , G01N33/53 , G01N33/543 , G01N33/564 , G01N33/68 , G01N33/92
CPC分类号： G01N33/92 , A61K38/00 , A61K39/0008 , A61K2039/6093 , A61K2039/645 , C07C323/12 , C07K14/001 , C07K14/4713 , C07K16/18 , C07K2317/34 , G01N33/54353 , G01N33/564 , G01N33/6878
摘要： aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Conjugates comprising aPL analogs and nonimmunogenic valency platform molecules are provides as are novel nonimmunogenic valency platform molecules and linkers. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.
摘要翻译：（a）特异性结合aPL表位结合并公开的B细胞的aPL类似物。优化的类似物缺乏T细胞表位可用作治疗aPL抗体介导的疾病的缀合物。提供包含aPL类似物和非免疫原性价态平台分子的缀合物是新的非免疫原性价态平台分子和接头。公开了制备和鉴定所述类似物的方法，使用所述类似物的治疗方法，用于制备所述类似物的缀合物的方法和组合物以及用于aPL抗体的诊断免疫测定。

36. 发明申请

US20050176526A1 Kick Toy for developing hand-eye-foot coordination skills 审中-公开
标题翻译：开发手足协调技能的玩具
公开(公告)号：US20050176526A1
公开(公告)日：2005-08-11
申请号：US10708135
申请日：2004-02-09
申请人： David Jones
发明人： David Jones
IPC分类号： A63B67/20 , A63B69/00
CPC分类号： A63B69/0086 , A63B2208/12
摘要： A kick toy that is used to help the user develop hand-eye-foot coordination skills. This is accomplished by giving the user the opprtunity to control the inflatable ball with the elastic cord that is attached to the ball. The inflatable ball is connected to a plastic plug which is inserted into the ball sealing the ball after the ball is inflated. The plastic plug is then connected to an elastic cord which is also connected to a swivel or hook device. The Swivel or hook device is then connected to a metal grommet with is mounted to the hook and loop wristband. The hook and loop wristband it then wraped around the users wrist and closed using the hook and loop material. The user then kickes the ball away from him or herself. The elastic cord causes the ball to return to the user. This can be repeated to long periods of time. This invention eliminates the frustration of retrieving the ball time after time and allows the user to spend more time developing their hand-eye-foot coordination skills.
摘要翻译：用于帮助用户开发手足协调技能的踢玩具。这是通过给予使用者使用附接到球的弹性绳来控制充气球的对象来实现的。充气球连接到一个塑料塞子，该插头插入球体，球体膨胀后密封球。然后将塑料塞连接到也连接到旋转或钩装置的弹性绳索。然后将旋转或钩装置连接到金属索环，其安装到钩环和腕环上。钩环腕带，然后围绕使用者手腕包裹，并使用钩环材料封闭。然后，用户将球从他或她身上踢开。弹性线使球回到使用者身上。这可以重复很长一段时间。本发明消除了在时间之后检索球时间的挫败感，并允许用户花费更多的时间来发展他们的手眼协调技能。

37. 发明申请

US20050106722A1 Efficient production of IgA in recombinant mammalian cells 有权
标题翻译：在重组哺乳动物细胞中有效地产生IgA
公开(公告)号：US20050106722A1
公开(公告)日：2005-05-19
申请号：US10644256
申请日：2003-08-20
申请人： David Jones , Abraham Bout
发明人： David Jones , Abraham Bout
IPC分类号： C07K14/075 , C07K14/11 , C07K14/16 , C12N15/861 , C12N5/06 , C12N5/08 , C12N15/86
CPC分类号： C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , C12N2800/108 , C12N2830/00 , C12N2830/15 , C12N2830/60
摘要： The invention provides an immortalized human retina cell expressing E1A and E1B proteins of an adenovirus, wherein the cell has recombinant nucleic acid encoding an IgA molecule in expressible format. Also provided is a method for recombinant production of an IgA molecule, the method involving culturing a cell of the invention and expressing the recombinant nucleic acid encoding an IgA.
摘要翻译：本发明提供了表达腺病毒E1A和E1B蛋白的永生化人视网膜细胞，其中所述细胞具有编码可表达形式的IgA分子的重组核酸。还提供了重组生产IgA分子的方法，该方法涉及培养本发明的细胞并表达编码IgA的重组核酸。

38. 发明申请

US20050090327A1 Golf club head having an insert cavity rear aperture 有权
标题翻译：具有插入腔后孔的高尔夫球杆头
公开(公告)号：US20050090327A1
公开(公告)日：2005-04-28
申请号：US10693382
申请日：2003-10-23
申请人： John Solheim , David Jones , Derek Haines
发明人： John Solheim , David Jones , Derek Haines
IPC分类号： A63B53/02 , A63B53/04
CPC分类号： A63B53/0487 , A63B2053/021 , A63B2053/0416 , A63B2053/0425 , A63B2209/00
摘要： A golf club head includes a body having a front face with a cavity formed therein. The cavity has at least one aperture passing through the cavity bottom wall to the rear surface of the club head body. A face insert is installed in the cavity by applying an adhesive layer between the face insert and the bottom of the cavity. As the face insert is pressed into the cavity, air and any excess adhesive escapes through the aperture to the rear surface of the club where it can easily be removed by wiping with solvent.
摘要翻译：高尔夫球杆头包括具有形成在其中的腔的正面的主体。空腔具有穿过腔体底壁至球杆头本体后表面的至少一个孔。通过在面部插入件和腔的底部之间施加粘合剂层，将面插入件安装在空腔中。当面部插入物被压入空腔时，空气和任何多余的粘合剂通过孔径逸出到球杆的后表面，其中可以通过用溶剂擦拭而容易地除去。

39. 发明授权

US5838230A Method of detecting a deflated tire on a vehicle 失效
标题翻译：检测车辆上的放气轮胎的方法
公开(公告)号：US5838230A
公开(公告)日：1998-11-17
申请号：US84967
申请日：1993-07-02
申请人： David Jones
发明人： David Jones
IPC分类号： B60C23/06 , B60C23/00
CPC分类号： B60C23/061
摘要： A method of detecting a deflated tire on a vehicle by comparing the rolling radii of the tires by means of comparing angular velocity speed signals from wheel speed sensors one at each wheel characterized by calculating an error value (DEL') where DEL'=��(C1+C4)/2-(C2+C3)/2!.times.100!/�(C1+C2+C3+C4)/4! where C1, C2, C3 and C4 are angular velocity values for left-hand front, right-hand front, left-hand rear and right-hand rear wheels of the vehicle respectively, determining a correction factor LAT, calculating a corrected error value DEL wherein in the case that the sign of the product LAT.times.A of the correction factor LAT and the vehicle related constant A is opposite to the sign of the error value DEL' then the corrected error value DEL is given by DEL=DEL', and in the case that the product LAT.times.A and the error value DEL' have the same sign but the product LAT.times.A is greater in absolute magnitude then the error value DEL' the corrected error value DEL is given by DEL=0, otherwise the corrected error value DEL is given by DEL=DEL'-(LAT.times.A) and a tire warning indicator is operated in the vehicle to indicate that at least one tire is deflected when it is sensed that the magnitude of the corrected error value DEL is in the range 0.05 to 0.5.
摘要翻译：通过比较轮胎的滚动半径，通过比较来自车轮速度传感器的角速度传感器信号，在每个车轮上对其进行比较来检测车辆上的放气轮胎的方法，其特征在于计算误差值（DEL'），其中DEL'= [[ （C1 + C4）/ 2-（C2 + C3）/ 2]×100] / [（C1 + C2 + C3 + C4）/ 4]其中C1，C2，C3和C4是左前锋的角速度值，分别确定校正系数LAT，计算校正误差值DEL，其中在校正系数LAT的乘积LATxA的符号和车辆相关常数A与错误值DEL'的符号相反，则校正误差值DEL由DEL = DEL'给出，并且在产品LATxA和误差值DEL'具有相同的符号但产品 LATxA的绝对值大，误差值DEL'校正误差值DEL由DEL = 0给出，否则校正后的e 雷达值DEL由DEL = DEL' - （LATxA）给出，并且在车辆中操作轮胎警告指示器以指示当检测到校正误差值DEL的大小在范围内时，至少一个轮胎被偏转 0.05〜0.5。

40. 发明授权

US5725272A Drain assembly for acoustic baffle system 失效
标题翻译：隔声系统排水组件
公开(公告)号：US5725272A
公开(公告)日：1998-03-10
申请号：US670151
申请日：1996-06-27
申请人： David Jones
发明人： David Jones
IPC分类号： B62D25/04 , B60R13/07 , B60R13/08 , B62D25/07 , B60R27/00
CPC分类号： B62D25/07 , B60R13/07 , B60R13/08 , Y10S277/933
摘要： An acoustic baffle apparatus is provided for sealing a cavity of a vehicle body at a predetermined cross section of the cavity. The apparatus includes a piece of heat expandable sealing material that is formed in a shape corresponding to but smaller than the shape of the cross section of the cavity. The sealing material has an activation temperature at which the material expands, and a support element can be provided beneath the piece of sealing material for supporting it. A drain assembly is secured to the support element and extends upward past the piece of sealing material. The drain assembly includes an outer side wall defining a drain passage having an upper end above the support element and a lower end beneath the support element, and a plurality of baffles are secured within the drain passage for defining a serpentine path between the upper and lower ends. A flange is spaced above the support element and the piece of sealing material, and accommodates expansion of the sealing material when the apparatus is subjected to the activation temperature and directs the sealing material outward away from the upper end of the passage.
摘要翻译：提供一种隔音装置，用于在空腔的预定横截面处密封车体的空腔。该装置包括一块热膨胀密封材料，其形成为与空腔的横截面相对应但小于形状的形状。密封材料具有材料膨胀的活化温度，并且支撑元件可以设置在用于支撑它的密封材料下方。排水组件固定到支撑元件并向上延伸穿过该密封材料片。排水组件包括外侧壁，其限定排水通道，该排水通道具有在支撑元件上方的上端和在支撑元件下方的下端，并且多个挡板固定在排水通道内，用于限定上下两者之间的蛇形路径结束。凸缘在支撑元件和密封材料上方间隔开，并且当设备经受活化温度并且将密封材料向外远离通道的上端时，容纳密封材料的膨胀。

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