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31. 发明申请

US20150228176A1 ECG-ENABLED PERSONAL EMERGENCY RESPONSE SYSTEMS 有权
标题翻译： ECG启动的个人应急响应系统
公开(公告)号：US20150228176A1
公开(公告)日：2015-08-13
申请号：US14691717
申请日：2015-04-21
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： G08B21/02 , A61B5/044 , A61B5/0432 , A61B5/11 , A61B5/0408 , A61B5/00
CPC分类号： G08B21/0211 , A61B5/0006 , A61B5/0022 , A61B5/0404 , A61B5/04085 , A61B5/0432 , A61B5/044 , A61B5/1112 , A61B5/1117 , A61B5/6843 , A61B5/6898 , A61B5/7415 , A61B5/746 , A61B5/747 , A61B5/7475 , A61B2560/0468 , A61B2562/0219 , G06F19/00 , G08B21/02 , G08B21/0269 , G08B21/0283 , G08B21/043 , G08B21/0446 , G08B25/001 , G08B25/016 , G16H40/67
摘要： The invention provides personal emergency response systems (PERS) with expanded life-saving capabilities. One embodiment of the invention provides a wearable PERS pendant that incorporates a cell phone transmitter or transceiver, a GPS location system, an accelerometer-based fall detector that automatically triggers an alert, and an electrocardiogram (ECG) recorder permitting a remote service center or medical personnel to receive and respond to transmitted alerts and electrocardiographic data.
摘要翻译：本发明提供具有延长救生能力的个人应急系统（PERS）。本发明的一个实施例提供了一种可佩戴的PERS吊坠，其包括手机发射器或收发器，GPS定位系统，自动触发警报的基于加速度计的跌倒检测器和允许远程服务中心或医疗的心电图（ECG）记录器人员接收和响应传输的警报和心电图数据。

32. 发明授权

US5653738A DDI pacing with protection against induction of a pacemaker medicated retrograde rhythm 失效
标题翻译： DDI起搏保护起搏器诱导逆行节律
公开(公告)号：US5653738A
公开(公告)日：1997-08-05
申请号：US646183
申请日：1996-05-07
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3622
摘要： A DDI pacemaker detects when a pacemaker mediated retrograde rhythm (PMRR) occurs, and automatically alters the DDI operation to terminate the PMRR. The PMRR is detected by measuring the P-to-V time interval in a DDI pacing cycle that terminates in the generation of a ventricular stimulation pulse (V-pulse). A PMRR is presumed to be present whenever the measured P-to-V interval exceeds a prescribed time interval, or whenever a programmed number of consecutive P-to-V time intervals, e.g., ten, are greater than the prescribed time interval. Once a PMRR is detected, the pacemaker automatically extends the post-ventricular atrial refractory period (PVARP) of the pacemaker to block any retrograde P-waves that may be occurring as part of the PMRR. As soon as the extended PVARP terminates, an alert time interval, T.sub.ALERT, begins that is selected to be of sufficient length to allow atrial tissue to repolarize and/or to detect a normal P-wave. If a P-wave is not sensed during the T.sub.ALERT interval, which will normally be the case in the presence of a PMRR, an atrial stimulation pulse (A-pulse) is generated that effectively prevents the next ventricular event from triggering a retrograde P-wave, thereby terminating the PMRR.
摘要翻译： DDI起搏器检测何时发生起搏器介导的逆行节律（PMRR），并自动改变DDI操作以终止PMRR。通过测量终止于产生心室刺激脉冲（V脉冲）的DDI起搏循环中的P-V时间间隔来检测PMRR。只要测量的P-V间隔超过规定的时间间隔，或每当连续的P-to-V时间间隔（例如十）的编程数量大于规定的时间间隔时，PMRR被假定存在。一旦检测到PMRR，起搏器自动延长起搏器的心室心房不应期（PVARP），以阻止可能作为PMRR一部分发生的任何逆行P波。一旦延长的PVARP终止，则警报时间间隔TALERT开始被选择为具有足够的长度以允许心房组织复极化和/或检测正常P波。如果在TALERT间隔期间没有检测到P波，则在存在PMRR的情况下通常将是这种情况，产生心房刺激脉冲（A脉冲），其有效地防止下一个心室事件触发逆行P- 波，从而终止PMRR。

33. 发明授权

US5222493A Verification of capture using an indifferent electrode mounted on the pacemaker connector top 失效
标题翻译：使用安装在PACEMAKER连接器顶部的不同电极进行捕获的验证
公开(公告)号：US5222493A
公开(公告)日：1993-06-29
申请号：US590989
申请日：1990-10-01
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61B5/0402 , A61N1/365 , A61N1/37
CPC分类号： A61N1/371 , A61N1/3714
摘要： A cardiac pacing system includes circuitry for verification of capture having an indifferent electrode mounted on the pacemaker connector top. The cardiac pacing system may use one or two bipolar or unipolar leads. Capture is sensed between the indifferent electrode and one of the electrodes on the lead or leads. Either electrode on the lead or leads can be used as the other electrode forming a sensing pair with the indifferent electrode. The electrode is located in the plastic connector top portion of the implanted pacemaker, and may be disposed at a side of the pacemaker, when implanted, facing the interior of the patient, or facing the exterior of the patient.

34. 发明授权

US4771780A Rate-responsive pacemaker having digital motion sensor 失效
标题翻译：具有数字运动传感器的速率响应式起搏器
公开(公告)号：US4771780A
公开(公告)日：1988-09-20
申请号：US3433
申请日：1987-01-15
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36542
摘要： A rate-responsive pacemaker includes a motion sensor mounted therein. The output signal from the motion sensor is a digital signal that can be connected directly to the digital processing and control circuits of the pacemaker in order to adjust its basic pacing rate as a function of the physical motion or activity that is sensed. The motion sensor includes an enclosed housing having a conductive element therein that partially fills the space of a cavity within the enclosed housing. The conductive element is free to roll, flow, or otherwise move around the inside of the housing in response to external forces. The external forces that cause the conductive element to move include the physical motion of the patient as well as the force of gravity. As the conductive element moves within the enclosed housing, it makes electrical contact with at least two of three electrodes that are selectively spaced around the inside periphery of the housing. By monitoring whether and for how long an electrical contact is made or broken between electrodes, a determination is thus made relative to the movement of the conductive element within the housing, and the rapidity with which such movement occurs. This sensed motion is directly related to the physical activity or movement of the patient. This signal is processed over time to determine whether and how the pacing rate of the pacemaker should be altered.
摘要翻译：速率响应起搏器包括安装在其中的运动传感器。来自运动传感器的输出信号是可以直接连接到起搏器的数字处理和控制电路的数字信号，以便根据感测到的物理运动或活动来调整其基本起搏速率。运动传感器包括其中具有导电元件的封闭壳体，其部分地填充封闭壳体内的空腔的空间。导电元件响应于外力而自由地滚动，流动或以其它方式围绕壳体的内部移动。引起导电元件移动的外力包括患者的物理运动以及重力。当导电元件在封闭壳体内移动时，它与三个电极中的至少两个电气接触，三个电极围绕壳体的内周边选择性间隔开。通过监测电极之间是否产生电触点或断开多长时间，因此相对于壳体内的导电元件的运动以及发生这种运动的速度，进行了确定。这种感觉到的运动与患者的身体活动或运动直接相关。随着时间的推移处理此信号，以确定起搏器起搏速率是否以及如何改变。

35. 发明授权

US5741308A Dual-chamber implantable pacemaker and method of operating same for automatically setting the pacemaker's AV interval as a function of a natural measured conduction time 失效
标题翻译：双腔植入式起搏器及其操作方法可自动将起搏器的AV间隔设定为自然测量的传导时间的函数
公开(公告)号：US5741308A
公开(公告)日：1998-04-21
申请号：US440599
申请日：1995-05-15
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3682
摘要： A dual-chamber implantable pacemaker automatically sets its AV or PV interval to a value that is a function of the measured natural conduction time, or AR interval, of a user of the pacemaker. The AR interval is determined on a regular basis, thereby permitting the AV or PV interval set by the pacemaker to adaptively change with any changes in the AR interval. The AV or PV interval is set to a value that is a prescribed amount .DELTA. less than or greater than the measured AR interval. The measured AR interval is typically averaged, or otherwise determined or estimated, based on measurements of several cardiac cycles.
摘要翻译：双腔植入式起搏器自动将其AV或PV间隔设置为起搏器用户的测量自然传导时间（AR间隔）的函数值。定期确定AR间隔，从而允许起搏器设置的AV或PV间隔随着AR间隔的任何变化自适应地改变。 AV或PV间隔被设置为小于或大于测量的AR间隔的规定量DELTA的值。测量的AR间隔通常基于几个心动周期的测量来平均或以其他方式确定或估计。

36. 发明授权

US5074308A System and method for recognizing pacemaker-mediated tachycardia 失效
标题翻译：用于识别心脏起搏器介导的心动过速的系统和方法
公开(公告)号：US5074308A
公开(公告)日：1991-12-24
申请号：US588226
申请日：1990-09-26
申请人： Jason A. Sholder , Stuart W. Buchanan , Brian M. Mann
发明人： Jason A. Sholder , Stuart W. Buchanan , Brian M. Mann
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3622
摘要： A pacemaker mediated tachycardia (PMT) is detected by circuitry within an implantable pacemaker. The PMT is detected by first detecting a tachycardia condition that includes a prescribed number of consecutive cardiac cycles having a rate faster than a prescribed rate. Each cardiac cycle of the tachycardia condition includes a natural atrial event, i.e., a P-wave, and a paced ventricular event, i.e., a V-pulse generated by a pacemaker. After the prescribed number of such cardiac cycles, e.g., two to ten, a P-V delay in a single cardiac cycle is modified by a first prescribed amount, e.g., 50 milliseconds. The time interval of a V-P interval associated with at least one cardiac cycle preceding the modified P-V delay is then compared to a V-P interval immediately following the modified P-V delay. Only if the difference between the V-P intervals thus measured is less than a second prescribed amount, e.g., 25 milliseconds, is a PMT indicated. If a PMT is indicated, a PMT termination regimen, e.g., extending PVARP, is automatically invoked by the pacemaker for a prescribed number of cardiac cycles, such as one or two cardiac cycles.

37. 发明授权

US4974589A Automatically adjustable blanking period for implantable pacemaker 失效
标题翻译：可植入起搏器的自动调整消隐期
公开(公告)号：US4974589A
公开(公告)日：1990-12-04
申请号：US422714
申请日：1989-10-17
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/368
摘要： An automatically adjustable blanking circuit and method of generating an adjustable blanking interval for use with a dual channel implantable pacemaker includes means for generating a basic blanking interval for a first channel of the pacemaker each time a stimulation pulse is generated on a second channel. The basic blanking interval includes a first absolute refractory portion and a second relative refractory portion. During the absolute refractory portion, the sensing circuits of the first channel are disabled. During the relative refractory portion, the sensing circuits of the first channel are enabled and any activity sensed in the first channel is considered to be crosstalk or noise and the basic blanking interval is retriggered. Retriggering of the basic blanking interval continues for so long as activity is sensed in the first channel during the relative refractory portion of each retriggered basic blanking interval, up to a maximum blanking interval. If no activity is sensed during the relative refractory portion of the basic blanking interval, the blanking interval ends, and the sensing circuits of the first channel thereafter monitor the first channel for spontaneous cardiac activity.

38. 发明授权

US4712555A Physiologically responsive pacemaker and method of adjusting the pacing interval thereof 失效
标题翻译：生理反应起搏器和调整其起搏间隔的方法
公开(公告)号：US4712555A
公开(公告)日：1987-12-15
申请号：US716831
申请日：1985-03-27
申请人： Hans T. Thornander , John W. Poore , Jason A. Sholder , James R. Thacker , David C. Amundson
发明人： Hans T. Thornander , John W. Poore , Jason A. Sholder , James R. Thacker , David C. Amundson
IPC分类号： A61N1/08 , A61N1/365 , A61N1/368 , A61N1/37 , A61N1/36
CPC分类号： A61N1/365 , A61N1/368 , A61N1/3712 , A61N1/3714 , A61N1/3716
摘要： A pacemaker and physiological sensor for use therewith that allows the rate at which the pacemaker delivers electrical stimulation pulses to the heart, or the escape interval during which a natural heart event must occur before an electrical stimulation pulse is delivered, to be adjusted as needed in order to satisfy the body's physiological needs. The sensor measures the depolarization time interval between an atrial stimulation pulse, A, and the responsive atrial or ventricle depolarization, P or R respectively, as an indication of the physiological demands placed on the heart. The time interval between a ventricular stimulation pulse, V, and the responsive ventricular depolarization, R, may also be measured and used as an indication of physiological need, and hence as an alternative criteria for rate control. Atrial depolarization is sensed by detecting a P-wave, and ventricular depolarization is preferably sensed by detecting an R-wave. A method of measuring A-P, A-R, or V-R intervals is used to ascertain if these intervals are increasing or decreasing. If, over several heart cycles or beats, an increase or decrease in these measurements is detected, the pacing interval set by the pacemaker is adjusted in an appropriate direction in order to adjust the heart stimulation rate accordingly.
摘要翻译：用于其的起搏器和生理传感器允许起搏器向心脏传递电刺激脉冲的速率，或者在传送电刺激脉冲之前必须发生自然心脏事件的逃逸间隔，以根据需要进行调整为了满足身体的生理需要。传感器测量心房刺激脉冲A与反应性心房或心室去极化P或R之间的去极化时间间隔，作为对心脏的生理需求的指示。也可以测量心室刺激脉冲V与响应性心室去极化R之间的时间间隔，并将其用作生理需要的指示，并因此用作速率控制的替代标准。通过检测P波来感测心房去极化，并且优选通过检测R波来感测心室去极化。使用测量A-P，A-R或V-R间隔的方法来确定这些间隔是否增加或减少。如果在几个心脏周期或节拍中检测到这些测量值的增加或减少，起搏器设定的起搏间隔将在适当的方向进行调节，以便相应地调整心脏刺激速率。

39. 发明授权

US4686988A Pacemaker system and method for measuring and monitoring cardiac activity and for determining and maintaining capture 失效
标题翻译：起搏器系统和测量和监测心脏活动以及确定和维持捕获的方法
公开(公告)号：US4686988A
公开(公告)日：1987-08-18
申请号：US662723
申请日：1984-10-19
申请人： Jason A. Sholder
发明人： Jason A. Sholder
IPC分类号： A61N1/08 , A61N1/365 , A61N1/368 , A61N1/37 , A61N1/36
CPC分类号： A61N1/365 , A61N1/368 , A61N1/3712 , A61N1/3714 , A61N1/3716
摘要： A system for determining P-wave and R-wave capture in response to pacemaker supplied electrical stimuli. One embodiment includes a conventional bipolar atrial lead having a tip electrode, connected to a P-wave pace/sense amplifier and pulse output circuits within an implantable pacemaker, and a ring electrode, spaced apart from the tip electrode, connected to a P-wave sensing EGM amplifier within the pacemaker. The bandpass characteristics of the P-wave pace/sense amplifier allow detection of P-wave frequencies in the absence of atrial stimulation pulses. The bandpass characteristics of the P-wave sensing EGM amplifier allow detection of all electrical frequencies in the atrium within the bandpass chosen. Output signals from these two amplifiers are selectively telemetered to an external receiver, where the occurrence of atrial stimulation pulses and P-waves can be monitored. In operation, if constant time intervals between the monitored atrial stimulation pulses and P-wave occurrences are present, P-wave capture has occurred. In the event of variable time intervals, capture has not occurred and the magnitude of the atrial stimulation pulses can be increased until P-wave capture does occur. An alternative embodiment measures this time differential and makes the stimulation pulse adjustment automatically. Other embodiments use the same manual or automatic systems to determine R-wave capture.
摘要翻译：用于响应于起搏器提供的电刺激来确定P波和R波捕获的系统。一个实施例包括具有尖端电极的常规双极性心房线，其连接到P波步速/感测放大器和可植入起搏器内的脉冲输出电路，以及与尖端电极间隔开的环形电极，连接到P波感应起搏器内的EGM放大器。 P波速度/读出放大器的带通特性允许在没有心房刺激脉冲的情况下检测P波频率。 P波感测EGM放大器的带通特性允许检测所选带通内心房中的所有电频率。来自这两个放大器的输出信号被选择性地遥测到外部接收器，其中可以监测心房刺激脉冲和P波的发生。在操作中，如果存在监测的心房刺激脉冲和P波发生之间的恒定时间间隔，则发生P波捕获。在可变时间间隔的情况下，没有发生捕获，并且可以增加心房刺激脉冲的幅度直到P波捕获确实发生。替代实施例测量该时间差并使得刺激脉冲自动调整。其他实施例使用相同的手动或自动系统来确定R波捕获。

40. 发明授权

US4596255A Apparatus for interpreting and displaying cardiac events of a heart connected to a cardiac pacing means 失效
标题翻译：用于解释和显示与心脏起搏装置连接的心脏心脏事件的装置
公开(公告)号：US4596255A
公开(公告)日：1986-06-24
申请号：US701795
申请日：1985-02-15
申请人： Jeffery D. Snell , Brian M. Mann , Jason A. Sholder
发明人： Jeffery D. Snell , Brian M. Mann , Jason A. Sholder
IPC分类号： A61B5/00 , A61N1/08 , A61N1/372 , A61B5/04
CPC分类号： A61N1/37247 , A61B5/0006 , A61N1/08 , A61N1/37252
摘要： The present invention is an apparatus (1) for interpreting and displaying cardiac events of a heart connected to a cardiac pacing means (2) comprising a telemetry head (4), a first interpreting mean 6 with means connected to said telemetry head (4), a second interpreting means (12) with means connected to a plurality of ECG electrodes having paddles 8a at their digital end via electrical conduit (10), a control means (14) with means connected to said first and second interpreting means, (6) and (12) respectively, a multi-section memory means (16) with means connected to said control means (14), a D/A convertor (20) with means connected to said memory (16) a printing means (22) with means connected to said D/A convertor (20), logic means (24) with means connected to said memory means (16) and a display means (26) with means connected to said logic means (24).
摘要翻译：本发明是一种用于解释和显示与包括遥测头（4）的心脏起搏装置（2）连接的心脏的心脏事件的装置（1），具有连接到所述遥测头（4）的装置的第一解释装置6，，具有连接到多个ECG电极的装置的第二解释装置（12），其具有经由电导管（10）的数字端的桨叶8a，具有连接到所述第一和第二解释装置的装置的控制装置（14））和（12）分别具有连接到所述控制装置（14）的装置的多段存储装置（16），具有连接到所述存储器（16）的装置的打印装置（22）的D / A转换器（20）具有连接到所述D / A转换器（20）的装置，具有连接到所述存储装置（16）的装置的逻辑装置（24）和连接到所述逻辑装置（24）的装置的显示装置（26）。

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