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31. 发明授权

EP2579879B1 TRIAZINE DERIVATIVES FOR DELAYING THE ONSET OF TYPE 1 DIABETES 失效
标题翻译：三嗪衍生物以延迟1型糖尿病的发展
公开(公告)号：EP2579879B1
公开(公告)日：2016-03-23
申请号：EP11724228.9
申请日：2011-06-09
申请人： Poxel
发明人： FOUQUERAY, Pascale , CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , BOLZE, Sébastien
IPC分类号： A61K31/53 , A61K9/20 , A61P3/00
CPC分类号： A61K31/53 , A61K9/2027 , A61K9/2054

32. 发明授权

EP2579880B1 PREVENTION OF TYPE 2 DIABETES 有权
公开(公告)号：EP2579880B1
公开(公告)日：2019-09-11
申请号：EP11726105.7
申请日：2011-06-09
申请人： Poxel
发明人： FOUQUERAY, Pascale , CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , BOLZE, Sébastien
IPC分类号： A61K31/53 , A61K9/20 , A61P3/10

33. 发明公开

EP3043865A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION 有权转让
标题翻译：方法和药物组合物，乙型肝炎病毒治疗INFECTION-
公开(公告)号：EP3043865A1
公开(公告)日：2016-07-20
申请号：EP14771231.9
申请日：2014-09-10
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Claude Bernard Lyon 1 , ENS - Ecole Normale Supérieure de Lyon , Centre National de la Recherche Scientifique (C.N.R.S.) , EDELRIS , Poxel
发明人： ANDRE, Patrice , LOTTEAU, Vincent , RADREAU, Pauline , GILARDONE, Marine , PATIN, Amaury , ROCHE, Didier , CRAVO, Daniel , HALLAKOU-BOZEC, Sophie
IPC分类号： A61P1/16 , A61P31/20 , A61K31/42 , A61K31/453 , A61K31/575
摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of hepatitis B virus infection. In particular, the present invention relates to farnesoid X receptor (FXR) agonists for use in a method for the treatment of hepatitis B virus infection in a subject in need thereof.

34. 发明授权

EP2367802B1 TETRAHYDROTRIAZINE COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH AMPK ACTIVITY 有权
标题翻译：用于治疗与AMPK活性相关的疾病的四氢三嗪化合物
公开(公告)号：EP2367802B1
公开(公告)日：2016-04-20
申请号：EP09799313.3
申请日：2009-12-11
申请人： Poxel
发明人： CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , MESANGEAU, Didier , ELBAWAB, Samer
IPC分类号： C07D251/10 , A61K31/53 , A61P3/10
CPC分类号： C07D251/10 , A61K31/53

35. 发明公开

EP2579880A1 TREATMENT OF TYPE 2 DIABETES 有权
标题翻译：治疗2型糖尿病的
公开(公告)号：EP2579880A1
公开(公告)日：2013-04-17
申请号：EP11726105.7
申请日：2011-06-09
申请人： Poxel
发明人： FOUQUERAY, Pascale , CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , BOLZE, Sébastien
IPC分类号： A61K31/53 , A61K9/20
CPC分类号： A61K31/53 , A61K9/2027 , A61K9/2054
摘要： The present invention relates to triazine derivatives of Formula I for their use in the treatment of Type 2 diabetes, and to compositions comprising said triazine derivatives.

36. 发明公开

EP4125887A1 USE OF A THIENOPYRIDONE DERIVATIVE IN THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) 有权
公开(公告)号：EP4125887A1
公开(公告)日：2023-02-08
申请号：EP21715913.6
申请日：2021-04-02
申请人： Poxel
发明人： BOLZE, Sébastien , FOUQUERAY, Pascale , HALLAKOU-BOZEC, Sophie
IPC分类号： A61K31/4365 , A61P13/12

37. 发明公开

EP3691650A1 METHODS OF TREATING HEART FAILURE WITH PRESERVED EJECTION FRACTION 审中-公开
公开(公告)号：EP3691650A1
公开(公告)日：2020-08-12
申请号：EP18792513.6
申请日：2018-10-02
申请人： Poxel
发明人： HALLAKOU-BOZEC, Sophie
IPC分类号： A61K31/53 , A61P9/00

38. 发明公开

EP2867240A1 THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK 有权转让
标题翻译：用作AMPK活化剂的噻吩并吡啶酮衍生物
公开(公告)号：EP2867240A1
公开(公告)日：2015-05-06
申请号：EP13732533.8
申请日：2013-06-28
申请人： Poxel
发明人： CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , BOLZE, Sébastien , LEPIFRE, Franck , FAVERIEL, Laurent , DURAND, Jean-Denis , CHARON, Christine
IPC分类号： C07D495/04 , A61K31/4365 , A61P3/10
CPC分类号： C07D495/04
摘要： Activators of AMPK and therapeutic uses thereof The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, liver disease, hepatic steatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steato- hepatitis (NASH), liver fibrosis, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, inflammation, cancer, cardiovascular diseases, atherosclerosis, high blood pressure, retinopathies or neuropathies.
摘要翻译： AMPK的激活剂及其治疗用途本发明涉及作为AMPK（AMP-活化的蛋白激酶）的直接激活剂的化合物及其在治疗由AMPK活化调节的病症中的用途。例如，根据本发明的化合物可用于治疗糖尿病，代谢综合征，肥胖症，肝脏疾病，肝脂肪变性，非酒精性脂肪肝病（NAFLD），非酒精性脂肪肝炎（NASH），肝纤维化，血脂异常，高甘油三酯血症，高胆固醇血症，炎症，癌症，心血管疾病，动脉粥样硬化，高血压，视网膜病或神经病。

39. 发明授权

EP2519527B1 THIENO[2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF 有权
标题翻译：噻吩并[2,3-B]吡啶二酮AMPK活化剂和治疗用途THEREFOR
公开(公告)号：EP2519527B1
公开(公告)日：2013-12-18
申请号：EP10800766.7
申请日：2010-12-28
申请人： Poxel
发明人： CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , BOLZE, Sébastien , LEPIFRE, Franck , FAVERIEL, Laurent , DURAND, Jean-Denis , CHARON, Christine
IPC分类号： C07D495/04 , A61K31/33 , A61P3/10
CPC分类号： C07D495/04
摘要： The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.

40. 发明公开

EP2367802A2 TETRAHYDROTRIAZINE COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH AMPK ACTIVITY 有权
标题翻译：用于治疗与AMPK活性相关的疾病的四氢三嗪化合物
公开(公告)号：EP2367802A2
公开(公告)日：2011-09-28
申请号：EP09799313.3
申请日：2009-12-11
申请人： Poxel
发明人： CRAVO, Daniel , HALLAKOU-BOZEC, Sophie , MESANGEAU, Didier , ELBAWAB, Samer
IPC分类号： C07D251/10 , A61K31/53 , A61P3/10
CPC分类号： C07D251/10 , A61K31/53
摘要： The invention relates to compounds of formula (I) wherein the radicals R
1 to R
6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.
摘要翻译：本发明涉及其中基团R 1至R 6具有根据权利要求1的含义的式（I）化合物和/或其生理学上可接受的盐，用于预防性或治疗性治疗和/或监测生理和/或病理学与AMP活化蛋白激酶（AMPK）活性有关的条件。本发明的另一目的涉及所述化合物用于增强葡萄糖体内平衡，改善足细胞病和/或减少活性氧（ROS）产生的用途。本发明还涉及一种用于体外诊断糖尿病肾病的方法和一种用于筛选降低podocytopathy的化合物的方法，在每种情况下通过应用synaptopodin作为生物标志物。

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