专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

PL375979A1 PYRAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS 未知
公开(公告)号：PL375979A1
公开(公告)日：2005-12-12
申请号：PL37597903
申请日：2003-09-08
申请人： PFIZER PROD INC
发明人： MUNCHHOF MICHAEL JOHN , BLUMBERG LAURA COOK
IPC分类号： A61K31/4439 , A61P35/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-² signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

32. 发明专利

HRP20050250A2 NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TFG) INHIBITOR 未知
公开(公告)号：HRP20050250A2
公开(公告)日：2005-10-31
申请号：HRP20050250
申请日：2005-03-17
申请人： PFIZER PROD INC
发明人： BLUMBERG LAURA COOK , MUNCHHOF MICHAEL JOHN
IPC分类号： A61P35/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14 , C07D471/04 , C07D487/04
摘要： Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-beta signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

33. 发明专利

CO5550458A2 NUEVOS COMPUESTOS DE ISOTIAZOL E ISOXAZOL COMO INHIBIDORES DEL FACTOR DE CRECIMIENTO TRANSFORMADOR (TGF) 未知
公开(公告)号：CO5550458A2
公开(公告)日：2005-08-31
申请号：CO05025189
申请日：2005-03-18
申请人： PFIZER PROD INC
发明人： MUNCHHOF MICHAEL JOHN
IPC分类号： A61K31/4353 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4709 , A61K31/4985 , A61P35/00 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： 1.- Un compuesto de fórmula (A) o una sal, profármaco, hidrato, tautómero o solvato farmacéuticamente aceptable del mismo en el que:X es O o S;R1 es un anillo saturado, insaturado o aromático C3-C20, mono-, bi- o policíclico que contiene, opcionalmente, al menos un heteroátomo seleccionado del grupo constituido por N, O y S; R1 puede estar opcionalmente sustituido independientemente además con al menos un resto seleccionado independientemente del grupo constituido por: carbonilo, halo, haloalquilo(C1-C6), perhaloalquilo(C1-C6), perhaloalcoxi(C1-C6), alquilo(C1-C6), alquenilo(C2-C6), alquinilo (C2-C6), hidroxi, oxo, mercapto, alquil(C1-C6)tio, alcoxi(C1-C6), arilo(C5-C10) o heteroarilo(C5-C10), aril(C5-C10)oxi o heteroaril(C5-C10)oxi, aril(C5-C10)alquilo(C1-C6) o heteroaril(C5-C10)alquilo(C1-C6), aril(C5-C10)alcoxi(C1-C6) o heteroaril(C5-C10)alcoxi(C1-C6), HO-(C=O)-, éster, amido, éter, amino, aminoalquilo(C1-C6), alquil(C1-C6)aminoalquilo(C1-C6), dialquil(C1-C6)aminoalquilo(C1-C6), heterociclil(C5-C10)alquilo(C1-C6), alquil(C1-C6)- y dialquil(C1-C6)amino, ciano, nitro, carbamoílo, alquil(C1-C6)carbonilo, alcoxi(C1-C6)carbonilo, alquil(C1-C6)aminocarbonilo, dialquil(C1-C6)aminocarbonilo, aril(C5-C10)carbonilo, aril(C5-C10)oxicarbonilo, alquil(C1-C6)sulfonilo y aril( C5-C10)sulfonilo;cada R3 se selecciona independientemente del grupo constituido por hidrógeno, halo, haloalquilo(C1-C6), alquilo(C1-C6), alquenilo(C2-C6), alquinilo(C2-C6), perhaloalquilo(C1-C6), fenilo, heteroarilo(C5-C10), heterociclilo(C5-C10), cicloalquil(C3-C10), hidroxi, alcoxi(C1-C6), perhaloalcoxi(C1-C6), fenoxi, heteroaril(C5-C10)-O-, heterociclil(C5-C10)-O-, cicloalquil(C3-C10)-O-, alquil(C1-C6)-S-, alquil(C1-C6)-SO2-, alquil(C1-C6)-NH-SO2-, O2N-, NC-, amino, Ph(CH2)1-6HN-, alquil(C1-C6)-HN-, alquil(C1-C6)amino, [alquil(C1-C6)]2-amino, alquil(C1-C6)-SO2-NH-, amino(C=O)-, aminoO2S-, alquil(C1-C6)-(C=O)-NH-, alquil(C1-C6)-(C=O)-[(alquil(C1-C6))-N]-, fenil-(C=O)-NH-, fenil-(C=O)-[alquil(C1-C6)-N]-, alquil(C1-C6)-(C=O)-, fenil-(C=O)-, heteroaril(C5-C10)-(C=O)-, heterociclil(C5-C10)-(C=O)-, cicloalquil(C3 -C10)-(C=O)-, HO-(C=O)-, alquil(C1-C6)-O-(C=O)-, H2N(C=O)-, alquil(C1-C6)-NH-(C=O)-, ...

34. 发明专利

BR0314286A 未知
公开(公告)号：BR0314286A
公开(公告)日：2005-08-02
申请号：BR0314286
申请日：2003-09-12
申请人： PFIZER PROD INC
发明人： BLUMBERG LAURA COOK , MUNCHHOF MICHAEL JOHN
IPC分类号： A61K31/4353 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4709 , A61K31/4985 , A61P35/00 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-beta signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

35. 发明专利

MA27442A1 DERIVES DE TRIAZOLE SERVANT D'INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT (TGF) 未知
公开(公告)号：MA27442A1
公开(公告)日：2005-07-01
申请号：MA28156
申请日：2005-03-18
申请人： PFIZER PROD INC
发明人： BLUMBERG LAURA COOK , MUNCHHOF MICHAEL JOHN
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/517 , A61K31/519 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 18 Septembre 2002 60/412,079 US 2 Juillet 2003 60/484,535 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés de triazole servant d'inhibiteurs du facteur de croissance transformant Des dérivés de triazole nouveaux de formule (Ia-c), des intermédiaires pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")-(bêta). Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF comprenant, par exemple, le cancer et des maladies fibrotiques.

36. 发明专利

HRP20020509B1 PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS 未知
公开(公告)号：HRP20020509B1
公开(公告)日：2005-06-30
申请号：HRP20020509
申请日：2002-06-10
申请人： PFIZER PROD INC
发明人： BLUMENKOPF TODD ANDREW , FLANAGAN MARK EDWARD , MUNCHHOF MICHAEL JOHN
IPC分类号： A61K31/365 , A61K31/445 , A61K31/519 , A61K38/13 , A61K45/06 , A61P1/00 , A61P1/04 , A61P3/10 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P43/00 , C07D487/02 , C07D487/04
摘要： The invention relates to combinations of one or more antiinflammatory agents and a compound of the formula wherein R , R and R are as defined above, which are are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

37. 发明专利

NO20051010A 未知
公开(公告)号：NO20051010A
公开(公告)日：2005-05-31
申请号：NO20051010
申请日：2005-02-24
申请人： PFIZER PROD INC
发明人： MUNCHHOF MICHAEL JOHN , BLUMBERG LAURA COOK
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/517 , A61K31/519 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D401/14

38. 发明专利

PE20050306A1 COMPUESTOS IMIDAZOL CONDENSADO, 2-PIRIDILO SUSTITUIDO COMO INHIBIDORES DEL FACTOR DE CRECIMIENTO TRANSFORMANTE (TGF) 未知
公开(公告)号：PE20050306A1
公开(公告)日：2005-05-16
申请号：PE2004000223
申请日：2004-03-01
申请人： PFIZER PROD INC
发明人： BLUMBERG LAURA COOK , MUNCHHOF MICHAEL JOHN , SHAVNYA ANDRE
IPC分类号： A61K31/4188 , A61P35/00 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： SE REFIERE A COMPUESTOS DERIVADOS DE LAS FORMULAS (Ia) O (Ib), EN DONDE R1 ES UN ANILLO MONO, BI O POLICICLICO(C3-C20) SATURADO, INSATURADO O AROMATICO, OPCIONALMENTE SUSTITUIDO, QUE CONTIENE AL MENOS UN HETEROATOMO DE N, O Y S; CADA R3 ES H, HALO, HALOALQUILO(C1-C6), ALQUILO(C1-C6), ALQUENILO O ALQUILO(C2-C6), HETEROCICLILO(C5-C10), PERHALOALQUILO(C1-C6), ENTRE OTROS; S ES DE 1 A 5; R4 Y R6 TOMADOS JUNTO CON LOS ATOMOS A LOS QUE ESTAN UNIDOS FORMAN UN NUCLEO HETEROAROMATICO CONDENSADO. SON COMPUESTOS PREFERIDOS: 6-[2-(6-METILPIRIDIN-2-IL)IMIDAZOL[1,2-a]PIRIDIN-3-IL]QUINOLINA, 2-BENZO[1,3]DIOXOL-5-IL-3-(6-METILPIRIDINIL-2-IL)-1H-IMIDAZOL[1,2-a]IMIDAZOL, 1-METIL-6-[6-(6-METILPIRIDIN-2-IL)IMIDAZOL[2,1-b]TIAZOL-5-IL]-1H-BENZOTRIAZOL, 3-BENZOTIAZOL-6-IL-2-(6-METILPIRIDIN-2-IL)IMIDAZOL[1,2-a]PIRIMIDIN-7-ILAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA RUTA SENALIZADORA DEL FACTOR DE CRECIMIENTO TRANSFORMANTE (TGF)-BETA Y SON UTILES EN EL TRATAMIENTO DEL CANCER Y ENFERMEDADES FIBROTICAS

39. 发明专利

AU2002301080B2 Thienopyrimidine and Thienopyridine Derivatives Useful as Anticancer Agents 未知
公开(公告)号：AU2002301080B2
公开(公告)日：2005-04-28
申请号：AU2002301080
申请日：2002-09-16
申请人： PFIZER PROD INC
发明人： SOBOLOV-JAYNES SUSAN BETH , MUNCHHOF MICHAEL JOHN
IPC分类号： C07D495/04 , A61K031/44 , A61K031/505

40. 发明专利

NO20051838L 未知
公开(公告)号：NO20051838L
公开(公告)日：2005-04-15
申请号：NO20051838
申请日：2005-04-15
申请人： PFIZER PROD INC
发明人： MUNCHHOF MICHAEL JOHN , BLOMBERG LAURA COOK
IPC分类号： A61P35/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14 , C07D471/04 , C07D487/04
摘要： Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-beta signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式