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31. 发明授权

US06364865B1 Drug delivery systems and methods 失效
标题翻译：药物输送系统和方法
公开(公告)号：US06364865B1
公开(公告)日：2002-04-02
申请号：US09439614
申请日：1999-11-12
申请人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
发明人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
IPC分类号： A61M100
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2013 , A61J1/2017 , A61J1/2051 , A61J1/2058 , A61J1/2082 , A61M5/148 , A61M5/162 , A61M5/1782 , A61M5/19 , A61M5/2046 , A61M5/2053 , A61M5/2425 , A61M5/2448 , A61M5/3234 , A61M2005/14252 , A61M2005/1581 , A61M2005/3128 , A61M2005/3223 , A61M2205/215 , A61M2205/583
摘要： The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle s used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.
摘要翻译：本发明涉及通过注射混合和输送药物的药物递送装置。该装置包括具有其中的第一端口或开口的壳体，其容纳包含流体或粉末状药物的第一容器，例如冻干药物。壳体还可以包括接收第二容器的第二端口或开口，第二容器包含待与药物混合以形成可注射流体的流体。该装置包括具有流体连接第一和第二容器的通道的歧管。用于将药物注射到与第一容器流体连通的患者中的诸如针的穿透膜。针可以从壳体中的存储位置移动到延伸穿过壳体的注射位置。

32. 发明申请

US20140194854A1 SUBCUTANEOUS AND INTRADERMAL PATCH INFUSERS 审中-公开
标题翻译：婴幼儿和肛门输卵管
公开(公告)号：US20140194854A1
公开(公告)日：2014-07-10
申请号：US14240902
申请日：2012-08-23
申请人： Izrail Tsals
发明人： Izrail Tsals
IPC分类号： A61M5/158
CPC分类号： A61M5/158 , A61M5/14248 , A61M5/1454 , A61M5/1456 , A61M2005/14256 , A61M2005/14513 , A61M2005/1581 , A61M2005/1585
摘要： The device infuses a compound subcutaneously or intradermally over an extended period of time. The delivery is from a conventional prefilled syringe with a staked cannula with the device adhered to the injection site and the syringe positioned substantially parallel to the injection site. The cannula is formed by a mechanism integral to the device to provide the cannula distal section substantially perpendicular to the syringe axis. The compound delivery is based on springs or other mechanisms. The approach offers a low cost mechanical system for the infusion of high volume, viscous compounds. The activation of the patch infuser required a few simple steps by the user. A single lever is used to trigger all device functions.
摘要翻译：该装置在长时间内皮下或皮内注入化合物。该传送来自具有插入式插管的常规预充式注射器，该装置将该装置粘附到注射部位并且注射器基本上平行于注射部位定位。套管由与装置成一体的机构形成，以提供基本上垂直于注射器轴线的套管远端部分。复合输送是基于弹簧或其他机构。该方法提供了低成本的机械系统，用于输注大体积，粘稠的化合物。补丁infuser的激活需要用户简单的几个步骤。单个杆用于触发所有设备功能。

33. 发明授权

US06719719B2 Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same 失效
标题翻译：用于液体转移装置的尖钉，包括尖头的液体转移装置以及使用其的液体转移方法
公开(公告)号：US06719719B2
公开(公告)日：2004-04-13
申请号：US09863539
申请日：2001-05-23
申请人： Ehoud Carmel , Gilad Lavi , Gil Yigal , Izrail Tsals
发明人： Ehoud Carmel , Gilad Lavi , Gil Yigal , Izrail Tsals
IPC分类号： A61M3700
CPC分类号： A61M5/24 , A61J1/201 , A61J1/2013 , A61J1/2017 , A61J1/2051 , A61J1/2058 , A61J1/2065 , A61J1/2082 , A61J1/2089 , A61M5/1782 , A61M5/19 , A61M5/2046 , A61M5/2053 , A61M5/2425 , A61M5/2448 , A61M5/3234 , A61M5/38 , A61M2005/14252 , A61M2005/1581 , A61M2005/3128 , A61M2005/3223 , A61M2205/215 , A61M2205/583
摘要： A spike for facilitating the introduction of liquid under pressure into a container containing a substance is provided which includes an elongate spike shaft having a spike side wall, a longitudinal axis, a distal end and a proximally located end portion, where the distal end has a sharp, pointed tip. An introduction channel is located within the spike shaft for receiving liquid into the container where a portion of the introduction channel is angled to cause liquid to travel out of the introduction channel in a direction non-parallel to the longitudinal axis of the spike shaft. An extraction channel may be included within the spike shaft for removing liquid from the container, where the extraction channel extends through the elongate spike shaft towards the proximally located end portion.
摘要翻译：提供了一种用于促进在压力下将液体引入容纳物质的容器中的尖头，其包括具有尖峰侧壁，纵向轴线，远端和近端定位的端部的细长尖钉轴，其中远端具有锋利尖尖。引入通道位于尖钉轴内，用于将液体接收到容器中，其中导入通道的一部分成角度以使液体在不平行于尖头轴的纵向轴线的方向上从引入通道移出。提取通道可以包括在钉轴内，用于从容器中去除液体，其中提取通道延伸穿过细长尖钉轴朝向近端定位的端部。

34. 发明授权

US5791466A Medicament conversion system 失效
标题翻译：药物转化系统
公开(公告)号：US5791466A
公开(公告)日：1998-08-11
申请号：US709486
申请日：1996-09-06
申请人： Izrail Tsals
发明人： Izrail Tsals
IPC分类号： A61J1/05 , A61J1/00 , A61J1/06 , A61J1/20 , A61J3/00 , B65D25/08
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201
摘要： A system for converting a medicament from a storage form to an administrable form comprises an evacuted medicament container, a container for a liquid, and means in the form of a hollow needle for establishing communication between said containers and thereby causing liquid to be drawn by suction from the liquid container to the medicament container. By establishing communication between an evacuated container and an unevacuated container, there is an instant, reliable and controlled addition of liquid to the medicament from the liquid container. The system has particular application to lyophilised medicaments.
摘要翻译：用于将药物从储存形式转化为可施用形式的系统包括抽空的药物容器，用于液体的容器和中空针形式的装置，用于建立所述容器之间的连通，从而使液体通过抽吸被拉伸从液体容器到药物容器。通过建立抽真空的容器和未消毒的容器之间的连通，从液体容器向药物中立即，可靠和可控地添加液体。该系统特别适用于冻干药物。

35. 发明授权

US4904995A Integrated remote electricity meter transponder and combination 失效
标题翻译：集成远程电表应答器和组合
公开(公告)号：US4904995A
公开(公告)日：1990-02-27
申请号：US820071
申请日：1986-01-21
申请人： Mark N. Bonner , Ralph H. Carmen , Geoffrey F. Ringle , Douglas W. Smith , Izrail Tsals , Thomas G. Moore, Jr. , Ronald K. Hamlin
发明人： Mark N. Bonner , Ralph H. Carmen , Geoffrey F. Ringle , Douglas W. Smith , Izrail Tsals , Thomas G. Moore, Jr. , Ronald K. Hamlin
IPC分类号： G01R21/00 , H01Q1/22
CPC分类号： H01Q1/2233 , G01R21/00 , H01Q1/22
摘要： A remote transponder unit is secured to the front of an electricity meter which, in turn, is electrically connected to an electric distribution system. The remote transponder unit is adjacent the power measuring disk of the electricity meter without obscuring the analog display of the meter. The transponder transmits data over the electric distribution system, including data representing the energy used by a user. The transponder unit includes a housing which is secured to the base of the meter and is electrically connected through the electricity meter through the electric distribution system.
摘要翻译：远程转发器单元被固定到电表的前部，电表又与配电系统电连接。远程转发器单元与电表的功率测量盘相邻，而不会模糊仪表的模拟显示。应答器通过配电系统发送数据，包括表示用户使用的能量的数据。应答器单元包括固定到仪表的底座并通过配电系统通过电表电连接的壳体。

36. 发明授权

US4796463A Variable permeability steering torque sensor 失效
标题翻译：可变磁导率转向扭矩传感器
公开(公告)号：US4796463A
公开(公告)日：1989-01-10
申请号：US34535
申请日：1987-04-06
申请人： Izrail Tsals , Ilya Feygin , William Marder
发明人： Izrail Tsals , Ilya Feygin , William Marder
IPC分类号： G01L3/10 , G01L5/22
CPC分类号： G01L5/221 , G01L3/105
摘要： An electromagnetic torque sensor arrangement comprising a pair of magnetic circuits differentially responsive to the twist of a rotary shaft under load. Each magnetic circuit comprises a stator assembly, and at least one deflectable element disposed therein on a pair of pins which experience relative rotation in relation to the twist of the shaft. The relative rotation causes deflection of the deflectable elements in relation to the twist, and the resulting variation in the permeability of the magnetic circuits is detected as a measure of the applied torque.

37. 发明授权

US4559661A Paint scraper 失效
标题翻译：油漆刮板
公开(公告)号：US4559661A
公开(公告)日：1985-12-24
申请号：US747378
申请日：1985-06-21
申请人： Izrail Tsals , Gerald E. Peterson , Rudy R. Karliner , Scott R. Carpenter , Peter L. Frank
发明人： Izrail Tsals , Gerald E. Peterson , Rudy R. Karliner , Scott R. Carpenter , Peter L. Frank
IPC分类号： B44D3/16
CPC分类号： B44D3/164
摘要： A manually operable power unit for paint scraping and the like comprising a casing with a longitudinal axis having a handle to enable portable use by the operator, an electro-magnetic motor mounted within the casing including a stator and an armature mounted relative to the stator for movement parallel to the longitudinal axis, a bladeholder connected to the armature reciprocally movable in unison together, the bladeholder extending generally parallel to the longitudinal axis of the casing and the direction of movement of the reciprocating armature to provide contemporaneous colinear movement of the bladeholder and the armature to substantially eliminate bending forces on the bladeholder imposed by the electromagnetic drive forces of the motor, the motor being operable on energization to move the armature and the bladeholder from a starting position to an extended position, and a spring connected to the bladeholder which is compressed when the bladeholder is moved to its extended position and the spring operating to move the bladeholder to its starting position upon release of the electromagnetic forces generated by the motor.
摘要翻译：一种用于油漆刮擦等的手动可操作的动力单元，包括具有手柄的纵向轴线的壳体，以使得操作者能够轻松使用;安装在壳体内的电磁马达，其包括定子和相对于定子安装的电枢，平行于纵向轴线的运动，连接到衔铁的刀片架可以一起往复运动，刀片架大致平行于壳体的纵向轴线延伸，并且往复运动的电枢的运动方向提供刀片架的同时运动，所述衔铁基本上消除由马达的电磁驱动力施加的刀架上的弯曲力，所述马达可在通电作用下操作以将所述衔铁和所述刀架从起始位置移动到延伸位置，以及连接到所述刀架的弹簧当刀片夹持器移动到其延伸孔时被压缩并且弹簧操作以在释放由电动机产生的电磁力的同时将刀架移动到其起始位置。

38. 发明申请

US20130006189A1 ASSEMBLY FOR USE WITH A SYRINGE 有权
标题翻译：装配与SYRINGE一起使用
公开(公告)号：US20130006189A1
公开(公告)日：2013-01-03
申请号：US13583096
申请日：2011-03-11
申请人： Izrail Tsals , Christopher Evans , Brian Costello
发明人： Izrail Tsals , Christopher Evans , Brian Costello
IPC分类号： A61M5/32
CPC分类号： A61M5/425 , A61M5/158 , A61M5/24 , A61M5/3287 , A61M5/46 , A61M2005/1585
摘要： An assembly for use with a syringe having a barrel and a needle includes a sealing element surrounding and positioned over at least a portion of the distal end of the syringe. An adapter at least partially surrounds the sealing element and is positioned over the distal end of the syringe. The adapter has a first skin contacting surface positioned at a distal end thereof. At least a portion of the first skin contacting surface extends generally parallel to at least a terminal end of the needle. The adapter also has a second skin contacting surface positioned proximally relative to the terminal end of the needle and at an angle to the first skin contacting surface. A needle shield at least partially surrounds and is removably positioned over at least one of the adapter, the sealing element and the syringe barrel.
摘要翻译：用于具有镜筒和针头的注射器的组件包括围绕并定位在注射器的远端的至少一部分上方的密封元件。适配器至少部分地围绕密封元件并且被定位在注射器的远端上方。适配器具有位于其远端处的第一皮肤接触表面。第一皮肤接触表面的至少一部分大致平行于针的至少末端延伸。适配器还具有相对于针的终端向近侧定位并与第一皮肤接触表面成一定角度的第二皮肤接触表面。针护罩至少部分地围绕并且可移除地定位在适配器，密封元件和注射器筒中的至少一个上。

39. 发明授权

US07717877B2 Injecting apparatus 有权
标题翻译：注射装置
公开(公告)号：US07717877B2
公开(公告)日：2010-05-18
申请号：US10566333
申请日：2004-07-28
申请人： Gilad Lavi , Izrail Tsals
发明人： Gilad Lavi , Izrail Tsals
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/2033 , A61M5/3157 , A61M5/3202 , A61M5/326 , A61M5/3271 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/2418 , A61M2005/3247 , A61M2205/581 , A61M2205/582
摘要： An injector is automatic in that the needle is inserted into the injection site (e.g., a patient's skin) with user or caregiver assistance, the delivery is automatically initiated upon needle insertion, and the needle is retracted automatically after the end of delivery. Preferably the needle is not seen by the user prior to, during or after injection. Prior to and after injection, the needle is hidden in the device so as to avoid any potential injury or health risk to the user or health care provider. The injector includes a housing and a shield arranged to slide relative to the housing and a driver moving during drug delivery. The housing and shield form a cartridge enclosure. The cartridge is shielded and locked after delivery is completed. A needle-locking mechanism can be used in any number of pen-like injectors or safety needles.
摘要翻译：注射器是自动的，因为用户或照顾者帮助将针插入注射部位（例如，患者的皮肤），在针插入时自动启动输送，并且在递送结束后针自动缩回。优选地，在注射之前，期间或之后使用者看不到针。在注射之前和之后，针头隐藏在设备中，以避免对使用者或医疗保健提供者造成任何潜在的伤害或健康风险。注射器包括壳体和屏蔽件，其布置成相对于壳体滑动并且驱动器在药物递送期间移动。外壳和屏蔽形成盒式磁带。送货完成后，盒式屏蔽和锁定。针状锁定机构可用于任何数量的笔式注射器或安全针。

40. 发明授权

US6012453A Apparatus for withdrawal of liquid from a container and method 失效
标题翻译：用于从容器中取出液体的方法和方法
公开(公告)号：US6012453A
公开(公告)日：2000-01-11
申请号：US951138
申请日：1997-10-15
申请人： Izrail Tsals , Dominick J. Frustaci , Scott J. Hynek
发明人： Izrail Tsals , Dominick J. Frustaci , Scott J. Hynek
IPC分类号： A62B7/02 , A62B7/06 , F17C7/04 , F17C9/02 , F17C7/02
CPC分类号： A62B7/06 , A62B7/02 , F17C7/04 , F17C9/02 , B63C2011/2263 , F17C2201/0109 , F17C2201/056 , F17C2203/0391 , F17C2205/013 , F17C2205/0332 , F17C2205/0338 , F17C2205/0385 , F17C2205/0391 , F17C2205/0397 , F17C2221/011 , F17C2221/014 , F17C2223/0161 , F17C2223/033 , F17C2223/047 , F17C2227/0302 , F17C2250/0413 , F17C2270/025 , F17C2270/0509 , Y10S128/913
摘要： An apparatus that provides for withdrawal of the liquid contents from a closed container 14 independent of the spatial orientation thereof, is described. The liquid withdrawal apparatus includes flexible withdrawal conduits 58 disposed inside the container and in fluid flow communication with external heat exchangers 144, 146. The heat exchangers serve to transfer heat to the withdrawn liquid to thereby provide a breathable gas mixture. The upstream end of the withdrawal conduits 58 are provided with a weighted pick-up means comprising a wicking material that draws liquid into the interior thereof to ensure contact of the liquid with the conduits, even when the supply of liquid is nearly depleted. A pressure differential between the inside of the container and the external heat exchangers, normally brought about by an inhalation event of the user, provides the motive force for withdrawing the liquid contents from the container through the conduits.
摘要翻译：描述了一种提供液体内容物从封闭容器14排出而与其空间取向无关的装置。液体提取装置包括设置在容器内部并与外部热交换器144,146流体连通的柔性抽出管道58.热交换器用于将热量传送到排出的液体，从而提供可透气的气体混合物。提取导管58的上游端设置有加重的拾取装置，该拾取装置包括将液体吸入其内部的芯吸材料，以确保液体与导管的接触，即使当液体供应几乎耗尽时。通常由使用者的吸入事件引起的容器内部和外部热交换器之间的压差提供了通过导管从容器中取出液体内容物的动力。

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