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31. 发明申请

WO2004062494A1 SAMPLE ELEMENT FOR REAGENTLESS WHOLE BLOOD GLUCOSE METER 审中-公开
标题翻译：无菌全血葡萄糖测定仪的样品元件
公开(公告)号：WO2004062494A1
公开(公告)日：2004-07-29
申请号：PCT/US2004/000145
申请日：2004-01-06
申请人： OPTISCAN BIOMEDICAL CORPORATION , RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
发明人： RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B5/14546 , G01N21/03 , G01N2021/0346
摘要： A reagentless whole-blood analyte detection system includes an infrared radiation source, a detector, and a sample element (700, 800). The sample element (700, 800) includes an elongate member (705, 802), a first sample cell wall (716), a second sample cell wall (715), a cover (720), and a sample supply passage (750, 815). The first sample cell wall in part defines a first sample cell (740). The first and second sample cell walls comprise materials that transmits a substantial portion of radiation in a range of wavelengths between about 6 µm and about 12 µm. The cover (720) at least partially defines at least one of the first sample cell (740) and the second sample cell (745). The sample supply passage comprises a first branch (755) and a second branch (760). The first branch of the sample supply passage extends from the opening (735) to the first sample cell. The second branch of the sample supply passage extends from the first sample cell to the second sample cell.
摘要翻译：无试剂全血分析物检测系统包括红外辐射源，检测器和样品元件（700,800）。样品元件（700,800）包括细长构件（705,802），第一样品池壁（716），第二样品池壁（715），盖（720）和样品供应通道（750） 815）。第一样品池壁部分地限定第一样品池（740）。第一和第二样品池壁包括在约6μm至约12μm之间的波长范围内透射大部分辐射的材料。盖（720）至少部分地限定第一样品池（740）和第二样品池（745）中的至少一个。样品供给通道包括第一分支（755）和第二分支（760）。样品供应通道的第一分支从开口（735）延伸到第一样品池。样品供应通道的第二分支从第一样品池延伸到第二样品池。

32. 发明申请

WO2003045233A1 METHOD AND APPARATUS FOR IMPROVING THE ACCURACY OF ALTERNATIVE SITE ANALYTE CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：提高替代位点分析浓度测量精度的方法和装置
公开(公告)号：WO2003045233A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/037511
申请日：2002-11-21
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , WHITE, Kenneth, G. , SMITH, Heidi, M. , KLONOFF, David, C. , STERLING, Bernhard, B. , HARTSTEIN, Philip, C. , GABLE, Jennifer, H.
发明人： BRAIG, James, R. , RULE, Peter , WHITE, Kenneth, G. , SMITH, Heidi, M. , KLONOFF, David, C. , STERLING, Bernhard, B. , HARTSTEIN, Philip, C. , GABLE, Jennifer, H.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1491 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61B2562/146 , G06F19/00
摘要： Methods and apparatuses for improving the accuracy of analyte concentration measurements at alternative sites and information provided to the user. The present invention advantageously utilizes information relating to the rate of change of analyte concentrations to adjust analyte concentrations measurements and/or information provided to the user. Therefore, the present invention provides new and improved methods and apparatuses for obtaining analyte concentration information at physiological sites other than the fingertips while ensuring that the analyte concentration information accurately reflects systemic analyte concentration values.
摘要翻译：用于提高替代地点的分析物浓度测量精度的方法和设备以及提供给用户的信息。本发明有利地利用与分析物浓度的变化率相关的信息来调节分析物浓度测量和/或提供给用户的信息。因此，本发明提供了用于在确保分析物浓度信息准确地反映全身分析物浓度值的同时在指尖以外的生理位置获得分析物浓度信息的新的和改进的方法和装置。

33. 发明申请

WO2003039362A1 REAGENT-LESS WHOLE-BLOOD GLUCOSE METER 审中-公开
标题翻译：试剂不足全血糖测定仪
公开(公告)号：WO2003039362A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/035707
申请日：2002-11-06
申请人： OPTISCAN BIOMEDICAL CORPORATION , STERLING, Bernhard, B. , HARTSTEIN, Philip, C. , LI, Kenneth, I. , AGOSTINO, Mark, D. , KLONOFF, David, C. , GAFFNEY, Robert, D. , ZHENG, Peng , GABLE, Jennifer, H. , WITTE, Kenneth, G. , SMITH, Heidi, M. , SHEILL, Jane, J. , MUNROW, Mike, A. , HALL, W., Dale , GOLDBERGER, Daniel, S. , FENNELL, Martin, J. , CORTELLA, Julian, M. , BRAIG, James, R. , RULE, Peter
发明人： STERLING, Bernhard, B. , HARTSTEIN, Philip, C. , LI, Kenneth, I. , AGOSTINO, Mark, D. , KLONOFF, David, C. , GAFFNEY, Robert, D. , ZHENG, Peng , GABLE, Jennifer, H. , WITTE, Kenneth, G. , SMITH, Heidi, M. , SHEILL, Jane, J. , MUNROW, Mike, A. , HALL, W., Dale , GOLDBERGER, Daniel, S. , FENNELL, Martin, J. , CORTELLA, Julian, M. , BRAIG, James, R. , RULE, Peter
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system (200, 400, 450, 1000, 1100) that is capable of being deployed near a patient has a source (220) capable of emitting a beam of radiation that includes a spectral band. The whole-blood system (200, 400, 450, 1000, 1100) also has at least one detector (250, 1152, 1154) in an optical path of the beam. The whole-blood system (200, 400, 450, 1000, 1100) also has a housing (402, 452) that is configured to house the source (220) and the detector(s) (250, 1152, 1154). The whole-blood system (200, 400, 450, 1000, 1100) also has a sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) that is situated in the optical path of the beam. The sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) has a sample cell (242, 310, 610, 810) and a sample cell wall (244, 330, 335) that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统（200,400,450,1000,1100）具有能够发射包括光谱带的辐射束的源（220）。全血系统（200,400,450,1000,1100）还具有在光束的光路中的至少一个检测器（250,1152,1154）。全血系统（200,400,450,1000,1100）还具有构造成容纳源（220）和检测器（250,1152,1154）的壳体（402,452）。全血系统（200,400,450,1000,1100）还具有位于光学系统中的样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405）梁的路径。样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405）具有样品池（242,310,610,810）和样品池壁（244,330,335）），其不消除光谱带中的辐射束的透射率。

34. 发明申请

WO2003030731A2 METHOD AND APPARATUS FOR IMPROVING CLINICAL ACCURACY OF ANALYTE MEASUREMENTS 审中-公开
标题翻译：提高分析物测量临床准确度的方法和设备
公开(公告)号：WO2003030731A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032281
申请日：2002-10-09
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
发明人： BRAIG, James, R. , RULE, Peter , HARTSTEIN, Philip, C. , SMITH, Heidi, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14514 , A61B5/14532 , A61B5/1491 , A61B5/150022 , A61B5/150061 , A61B5/150083 , A61B5/150213 , A61B5/150343 , A61B5/150412 , A61B5/150503 , A61B5/15134 , A61B5/15136 , A61B5/15186 , A61B5/157
摘要： Herein is described a system that includes a processing circuit for identifying possible zone D errors among estimated blood glucose concentration values. The system converts estimated blood glucose concentration values which are identified as possible zone D errors into adjusted blood glucose concentration values which are lower in blood glucose concentration magnitude than their corresponding estimated blood glucose concentration values, thereby decreasing the occurrence of zone D errors. Herein is also disclosed a method for improving the clinical accuracy of an analyte concentration measurement. One method includes a first act of computing an estimated analyte concentration having an associated first error that is clinically significant and a second act of processing the estimated analyte concentration to generate an adjusted analyte concentration having a second error that is clinically insignificant.
摘要翻译：这里描述了一种系统，该系统包括用于识别估计的血糖浓度值中的可能的区域D错误的处理电路。该系统将被识别为可能的区域D错误的估计血糖浓度值转换为血糖浓度量值低于其对应的估计血糖浓度值的调整血糖浓度值，由此减少区域D错误的发生。本文还公开了用于改善分析物浓度测量的临床准确度的方法。一种方法包括计算具有临床显着相关第一误差的估计分析物浓度的第一行为和处理估计分析物浓度以产生具有临床无关紧要第二误差的调整分析物浓度的第二行为。

35. 发明申请

WO2003016865A3 CALIBRATOR 审中-公开
公开(公告)号：WO2003016865A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/026190
申请日：2002-08-15
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , STERLING, Bernhard, B. , SMITH, Heidi, M. , CORTELLA, Julian, M. , GABLE, Jennifer, H.
发明人： BRAIG, James, R. , RULE, Peter , STERLING, Bernhard, B. , SMITH, Heidi, M. , CORTELLA, Julian, M. , GABLE, Jennifer, H.
IPC分类号： A61B5/00
摘要： A method calibrates a monitor (100) that comprises a non-invasive blood constituent monitor (102) and a traditional measurement system (116). The non-invasive blood constituent monitor includes a thermal gradient inducing element (110) an analyzer window (108). A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system (116). A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor (102). The traditional monitor output and the non-invasive monitor output is corrected by the amount of error.

36. 发明申请

WO2011159956A1 SYSTEMS AND METHODS TO REDUCE FLUID CONTAMINATION 审中-公开
标题翻译：减少流体污染的系统和方法
公开(公告)号：WO2011159956A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040783
申请日：2011-06-16
申请人： OPTISCAN BIOMEDICAL CORPORATION
发明人： KEENAN, Richard , RULE, Peter , BRAIG, James, R. , CALLICOAT, David, N.
IPC分类号： A61M25/01
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/6866 , A61M5/1415 , A61M5/1452 , A61M5/1723 , A61M2005/14208 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2230/201
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient' s vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.
摘要翻译：描述了用于测定来自样品如血液或血浆的一种或多种分析物的浓度的方法和系统。本文描述的系统可以被配置为从体液源抽出一定体积的样品，将抽出的样品的第一部分引导到分析物监测系统，并将样品的第二部分返回给患者。分析物监测系统可以包括自动化血液提取系统，其被配置为以低压和/或撤出速率从患者的脉管系统中提取血液，以便减少或防止从输注液体中排出的流体的污染。

37. 发明申请

WO2015095239A1 SYSTEMS AND METHODS FOR DETECTING LEAKS 审中-公开
标题翻译：用于检测泄漏的系统和方法
公开(公告)号：WO2015095239A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070681
申请日：2014-12-16
申请人： OPTISCAN BIOMEDICAL CORPORATION
发明人： RULE, Peter , CAUSEY III, James, D.
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61B5/14532 , A61B5/15 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150786 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/157 , A61M5/1413 , A61M5/16831 , A61M5/16854 , A61M2205/15
摘要： Various embodiments disclosed herein relate to detecting leaks in a patient monitoring system. The system can include a fluid handling network configured to receive a fluid sample drawn from a patient and to deliver at least a portion of the fluid sample to an analyte measurement system. The system can isolate at least a portion of the fluid handling network, can apply pressure to the at least a portion of the fluid handling network, can measure the pressure in the at least a portion of the fluid handling network, and can determine whether a leak is present in the at least a portion of the fluid handling network based at least in part on the measured pressure.
摘要翻译：本文公开的各种实施例涉及检测患者监测系统中的泄漏。该系统可以包括流体处理网络，该流体处理网络被配置为接收从患者抽取的流体样品并将至少一部分流体样品输送到分析物测量系统。该系统可以隔离流体处理网络的至少一部分，可以向流体处理网络的至少一部分施加压力，可以测量流体处理网络的至少一部分中的压力，并且可以确定是否至少部分地基于所测量的压力，在流体处理网络的至少一部分中存在泄漏。

38. 发明公开

EP1973472A1 ANALYTE DETECTION SYSTEM AND METHOD WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
标题翻译： ANALYTENNACHWEISSYSTEM带有周期采样，津液分析仪程序
公开(公告)号：EP1973472A1
公开(公告)日：2008-10-01
申请号：EP06734992.8
申请日：2006-02-13
申请人： Optiscan Biomedical Corporation
发明人： BRAIG, James R. , RULE, Peter
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： Described is a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system (203) is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element (9520) is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system (334) is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.

39. 发明公开

EP1618389A1 SAMPLE ELEMENT QUALIFICATION 审中-公开
标题翻译：样本单元资质
公开(公告)号：EP1618389A1
公开(公告)日：2006-01-25
申请号：EP04759507.9
申请日：2004-04-14
申请人： Optiscan Biomedical Corporation
发明人： BRAIG, James, R. , LI, Ken, I. , WITTE, Kenneth, G. , RULE, Peter , HARTSTEIN, Philip, C.
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element (1305) includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber (1310) configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.

40. 发明公开

EP1617762A1 SAMPLE ELEMENT WITH BARRIER MATERIAL 审中-公开
标题翻译：与阻隔材料样品元
公开(公告)号：EP1617762A1
公开(公告)日：2006-01-25
申请号：EP04759512.9
申请日：2004-04-14
申请人： Optiscan Biomedical Corporation
发明人： BRAIG, James, R. , HARTSTEIN, Philip, C. , RULE, Peter
IPC分类号： A61B5/15 , B01L3/00
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150412 , A61B5/150755 , A61B5/15117 , A61B5/15144 , A61B5/1519 , A61B2562/0295 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0672 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0683 , G01N21/0303
摘要： Disclosed is a sample element (1000) for holding a volume of bodily fluid drawn from the skin of a patient (ps) at a withdrawal site (LS). The sample element comprises a housing defining a sample chamber (1002) therein, and a barrier (1004). The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance (1013), to permit the bodily fluid to pass from the first side to the second side. Also disclosed is a method of drawing a bodily fluid from the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first opening and the second opening are in fluid communication. The method further comprises placing a sample chamber in fluid communication with a second side of the barrier.

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