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31. 发明授权

US4785349A Digital video decompression system 失效
标题翻译：数字视频解压系统
公开(公告)号：US4785349A
公开(公告)日：1988-11-15
申请号：US104131
申请日：1987-10-05
申请人： John M. Keith , Stuart J. Golin , Allen H. Simon , Brian Astle
发明人： John M. Keith , Stuart J. Golin , Allen H. Simon , Brian Astle
IPC分类号： G06T9/00 , H03M7/42 , H04N1/41 , H04N5/85 , H04N5/926 , H04N7/26 , H04N7/32 , H04N7/36 , H04N9/804 , H04N9/806 , H04N9/808 , H04N11/04 , H04N7/13
CPC分类号： H04N11/042 , H03M7/425 , H04N19/124 , H04N19/50 , H04N19/503 , H04N5/9262 , H04N9/8045 , H04N9/8066 , H04N5/85
摘要： A full motion color digital video signal is compressed, formatted for transmission, recorded on compact disc media and decoded at conventional video frame rates. During compression, regions of a frame are individually analyzed to select optimum fill coding methods specific to each region. Region decoding time estimates are made to optimize compression thresholds. Region descriptive codes conveying the size and locations of the regions are grouped together in a first segment of a data stream. Region fill codes conveying pixel amplitude indications for the regions are grouped together according to fill code type and placed in other segments of the data stream. The data stream segments are individually variable length coded according to their respective statistical distributions and formatted to form data frames. The number of bytes per frame is dithered by the addition of auxiliary data determined by a reverse frame sequence analysis to provide an average number selected to minimize pauses of the compact disc during playback thereby avoiding unpredictable seek mode latency periods characteristic of compact discs. A decoder includes a variable length decoder responsive to statistical information in the code stream for separately variable length decoding individual segments of the data stream. Region location data is derived from region descriptive data and applied with region fill codes to a plurality of region specific decoders selected by detection of the fill code type (e.g., relative, absolute, dyad and DPCM) and decoded region pixels are stored in a bit map for subsequent display.
摘要翻译：全运动彩色数字视频信号被压缩，格式化用于传输，记录在光盘介质上并以常规视频帧速率进行解码。在压缩期间，单独地分析帧的区域以选择对于每个区域特定的最佳填充编码方法。进行区域解码时间估计以优化压缩阈值。将区域的尺寸和位置的区域描述代码分组在数据流的第一段中。传送区域的像素幅度指示的区域填充代码根据填充代码类型分组在一起并放置在数据流的其他段中。数据流段根据各自的统计分布进行单独变长编码，并进行格式化以形成数据帧。通过添加由反向帧序列分析确定的辅助数据来提供每帧的字节数，以提供所选择的平均数，以在重放期间最小化光盘的暂停，从而避免光盘特征的不可预测的寻道模式等待时间周期。解码器包括响应于代码流中的统计信息的可变长度解码器，用于单独变长数据流解码数据流的各个段。区域位置数据从区域描述数据导出，并且通过区域填充码应用于通过检测填充码类型（例如，相对，绝对，二进制和DPCM）选择的多个区域特定解码器，并将解码的区域像素存储在位中地图以供后续显示。

32. 发明授权

US08637520B2 Substituted pyridyl amide compounds as modulators of the histamine H3 receptor 有权
标题翻译：取代的吡啶酰胺化合物作为组胺H3受体的调节剂
公开(公告)号：US08637520B2
公开(公告)日：2014-01-28
申请号：US12828883
申请日：2010-07-01
申请人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要： Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译：某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。

33. 发明授权

US07846930B2 Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators 有权
标题翻译：二芳基取代的四氢异喹啉作为组胺H3受体和血清素转运体调节剂
公开(公告)号：US07846930B2
公开(公告)日：2010-12-07
申请号：US12119811
申请日：2008-05-13
申请人： John M. Keith
发明人： John M. Keith
IPC分类号： A61K31/5377 , A61K31/4725 , C07D217/14 , C07D413/14 , C07D413/12
CPC分类号： C07D217/14 , C07D401/12 , C07D401/14 , C07D417/12
摘要： Certain diaryl-substituted tetrahydroisoquinoline compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译：某些二芳基取代的四氢异喹啉化合物是可用于治疗组胺H3受体和/或血清素介导的疾病的组胺H3受体和/或血清素转运蛋白调节剂。

34. 发明申请

US20100240648A1 HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS 有权
标题翻译： HEXAHYDRO-PYRROLO-ISOQUINOLINE化合物
公开(公告)号：US20100240648A1
公开(公告)日：2010-09-23
申请号：US12792675
申请日：2010-06-02
申请人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
发明人： Richard Apodaca , Ann J. Barbier , Nicholas I. Carruthers , Leslie A. Gomez , John M. Keith , Timothy W. Lovenberg , Ronald L. Wolin
IPC分类号： A61K31/5377 , C07D221/06 , A61K31/437 , C07D413/14 , A61P25/24
CPC分类号： C07D471/04
摘要： Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
摘要翻译：某些六氢 - 吡咯并 - 异喹啉化合物是可用于治疗组胺H3受体和5-羟色胺介导的疾病的组胺H3受体和5-羟色胺转运体调节剂。

35. 发明申请

US20080318952A1 DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS 有权
标题翻译：二胺取代的四氢喹啉作为组胺H3受体和丝氨酸运输调节剂
公开(公告)号：US20080318952A1
公开(公告)日：2008-12-25
申请号：US12119811
申请日：2008-05-13
申请人： John M. Keith
发明人： John M. Keith
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4725 , A61P25/28 , A61P25/00 , C07D413/14
CPC分类号： C07D217/14 , C07D401/12 , C07D401/14 , C07D417/12
摘要： Certain diaryl-substituted tetrahydroisoquinoline compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译：某些二芳基取代的四氢异喹啉化合物是可用于治疗组胺H3受体和/或血清素介导的疾病的组胺H3受体和/或血清素转运蛋白调节剂。

36. 发明授权

US4816913A Pixel interpolation circuitry as for a video signal processor 失效
标题翻译：像素插值电路，用于视频信号处理器
公开(公告)号：US4816913A
公开(公告)日：1989-03-28
申请号：US121021
申请日：1987-11-16
申请人： Kevin Harney , John M. Keith , David L. Sprague , Brian Astle
发明人： Kevin Harney , John M. Keith , David L. Sprague , Brian Astle
IPC分类号： H04N7/26 , G06F17/17 , H04N7/46 , H04N7/13
CPC分类号： H04N19/59 , G06F17/17
摘要： A processor for expanding a compressed video signal includes a pixel interpolator which interpolates between input pixel values in two dimensions. This interpolator calculates and stores intermediate pixel values which are interpolated in the vertical direction. A pair of these intermediate pixel values are then fed back into the interpolator which performs a horizontal interpolation to produce pixel values that are interpolated in both the horizontal and vertical dimensions. In steady state operation, the horizontal and vertical interpolation operations are alternated to produce a stream of two-dimensionally interpolated values.
摘要翻译：用于扩展压缩视频信号的处理器包括在二维输入像素值之间插值的像素内插器。该内插器计算并存储在垂直方向上插值的中间像素值。然后将一对这些中间像素值反馈到内插器中，该内插器执行水平内插以产生在水平和垂直维度上内插的像素值。在稳态操作中，水平和垂直内插操作被交替以产生二维内插值流。

37. 发明申请

US20130053398A1 MODULATORS OF FATTY ACID AMIDE HYDROLASE 有权
公开(公告)号：US20130053398A1
公开(公告)日：2013-02-28
申请号：US13695855
申请日：2011-05-02
申请人： John M. Keith , Jing Liu
发明人： John M. Keith , Jing Liu
IPC分类号： C07D405/14 , A61K31/496 , A61P25/22 , A61P25/24 , A61P29/00 , A61P3/00 , A61P25/08 , A61P25/16 , A61P35/00 , A61P3/10 , A61P25/00 , A61P19/08 , C12N9/99 , A61P25/28
CPC分类号： C07D405/12
摘要： 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.

38. 发明申请

US20100267701A1 SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 有权
标题翻译：作为组胺H3受体的调节剂的取代的吡啶酰胺化合物
公开(公告)号：US20100267701A1
公开(公告)日：2010-10-21
申请号：US12828883
申请日：2010-07-01
申请人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
发明人： John M. Keith , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , John E. Mills , Chennagiri R. Pandit , Frank J. Villani , Hua Zhong
IPC分类号： A61K31/551 , A61K31/496 , C07D403/14 , C07D403/12 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/24 , A61P25/06 , A61P25/08 , A61P27/02 , A61P25/30 , A61P25/20 , A61P25/00
CPC分类号： C07D213/82 , C07D213/81 , C07D213/84 , C07D401/06
摘要： Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译：某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。

39. 发明申请

US20100256122A1 BUTYL AND BUTYNYL BENZYL AMINE COMPOUNDS 审中-公开
标题翻译：丁基和丁基苄基化合物
公开(公告)号：US20100256122A1
公开(公告)日：2010-10-07
申请号：US12820365
申请日：2010-06-22
申请人： John M. Keith , Michael A. Letavic , Emily M. Stocking
发明人： John M. Keith , Michael A. Letavic , Emily M. Stocking
IPC分类号： A61K31/551 , A61K31/5375 , A61K31/4453 , A61K31/54 , A61K31/495 , A61K31/137 , A61K31/5377 , A61P25/28 , A61P25/30 , A61P25/00 , A61P25/18 , A61P25/24 , A61P29/00 , A61P15/00
CPC分类号： C07C323/21 , C07C217/58 , C07C323/20 , C07C2601/02 , C07D211/38 , C07D213/64 , C07D213/65 , C07D213/70 , C07D241/08 , C07D243/08 , C07D295/08 , C07D295/096 , C07D295/135
摘要： Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译：某些取代的丁基和丁炔基苄胺化合物是可用于治疗组胺H3受体和/或5-羟色胺介导的疾病的组胺H3受体和/或5-羟色胺转运体调节剂。

40. 发明授权

US07479493B2 Substituted benzyl amine compounds 有权
标题翻译：取代的苄胺化合物
公开(公告)号：US07479493B2
公开(公告)日：2009-01-20
申请号：US11766172
申请日：2007-06-21
申请人： Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M. B. Miller , Emily M. Stocking
发明人： Brett Allison , Michael P. Curtis , Cheryl A. Grice , John M. Keith , Michael A. Letavic , Jennifer M. B. Miller , Emily M. Stocking
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07C237/34 , C07D209/08 , C07D209/40 , C07D213/65 , C07D213/70 , C07D213/74 , C07D241/08 , C07D243/24 , C07D295/13 , C07D295/135 , C07D295/192 , C07D401/10 , C07D401/12 , C07D413/04
摘要： Certain substituted benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
摘要翻译：某些取代的苄胺化合物是可用于治疗组胺H3受体和/或血清素介导的疾病的组胺H3受体和/或血清素转运体调节剂。

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