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31. 发明专利

HK1080087A1 心磷脂分子和其合成方法未知
公开(公告)号：HK1080087A1
公开(公告)日：2006-04-21
申请号：HK05112200
申请日：2005-12-30
申请人： NEOPHARM INC
发明人： AHMAD MOGHIS U , UKKALAM MURALI K , AHMAD IMRAN
IPC分类号： C07F20060101 , A61K9/127 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K47/18 , A61K47/24 , C07C217/04 , C07C219/04 , C07F9/09 , C07F9/10

32. 发明专利

BRPI0708187A2 未知
公开(公告)号：BRPI0708187A2
公开(公告)日：2011-05-24
申请号：BRPI0708187
申请日：2007-02-22
申请人： NEOPHARM INC
发明人： ALI SHOUKATH M , AHMAD MOGHIS U , AHMAD IMRAN
IPC分类号： A61K48/00 , C07F5/06
摘要： The invention provides novel methods for preparing cardiolipin and cardiolipin analogs having varying fatty acid chain lengths, particularly 1,1′,2,2′-tetramyristoyl cardiolipin. The methods comprise reacting a starting compound, such as a 1,2-O-sn-diacylglycerol and a 2-protected glycerol, with a phosphoramidite reagent to produce a protected cardiolipin, which is deprotected to prepare cardiolipin. The cardiolipin and cardiolipin analogs may be prepared in the presence of an activator, such as pyridinium trifluororacetate. The methods of the present invention are used to prepare cardiolipin and cardiolipin analogs in large quantities. The cardiolipin prepared by the present methods can be incorporated into liposomes which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays.

33. 发明专利

AU2003239614A1 CARDIOLIPIN COMPOSITIONS THEIR METHODS OF PREPARATION AND USE 未知
公开(公告)号：AU2003239614A1
公开(公告)日：2003-12-12
申请号：AU2003239614
申请日：2003-05-23
申请人： NEOPHARM INC
发明人： LIN ZHEN , ALI SHOUKATH M , AHMAD IMRAN , AHMAD MOGHIS U
IPC分类号： A61K9/127 , A61K9/19 , A61K31/522 , A61K31/675 , A61K31/7068 , A61K31/7072 , A61K38/16 , A61K47/24 , A61K48/00 , C07F5/06 , C07F9/02 , C07F9/10 , C07H21/04 , C07K14/47 , C12N15/88

34. 发明专利

CA2486967A1 CARDIOLIPIN COMPOSITIONS, METHODS OF PREPARATION AND USE 未知
公开(公告)号：CA2486967A1
公开(公告)日：2003-12-04
申请号：CA2486967
申请日：2003-05-23
申请人： NEOPHARM INC
发明人： AHMAD MOGHIS U , LIN ZHEN , ALI SHOUKATH M , AHMAD IMRAN
IPC分类号： A61K9/127 , A61K9/19 , A61K31/522 , A61K31/675 , A61K31/7068 , A61K31/7072 , A61K38/16 , A61K47/24 , A61K48/00 , C07F5/06 , C07F9/02 , C07F9/10 , C07H21/04 , C07K14/47 , C12N15/88
摘要： The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and othe r lipid formulations that can also include active agents such as hydrophobic o r hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g ., for targeting them to a cell type or specific tissue.

35. 发明专利

CA2559352A1 LIPID COMPOSITIONS AND USE THEREOF 未知
公开(公告)号：CA2559352A1
公开(公告)日：2005-07-28
申请号：CA2559352
申请日：2005-01-07
申请人： NEOPHARM INC
发明人： AHMAD IMRAN , ZHANG ZHI-YI , ZHANG JIA-AI , UGWU SYDNEY , CHIEN PEI-YU , SHEIKH SAIFUDDIN , ALI SHOUKATH , JAMIL HARIS , AHMAD ZAFEER , AHMAD MOGHIS U , WANG JINKANG , BHAMIDIPATI SHASTRI
IPC分类号： A61K31/7088 , A61K9/127 , A61K31/14 , A61K31/355 , A61K31/575 , A61K31/685 , A61K31/7105 , A61K31/711 , A61K45/06 , A61K48/00 , C12N15/11 , C12N15/113
摘要： The invention provides a composition suitable for use as a transfection agen t, comprising a cationic cardiolipin analogue and, another lipid species. The composition of the present invention can facilitate transfection of a wide variety of polynucleotide species (e.g., oligodeoxyribonucleotides, plasmids , RNAi species, etc.). Moreover, the transfection agent of the present inventi on is effective in promoting transfection of primary cell cultures as well as transformed cells. Also, the inventive transfection agent is suitable for us e both in vitro and in vivo. The inventive composition has additional uses as well, such as delivery of a variety of active agents, dermatological and cosmetic uses, and uses in agriculture. The invention further provides a method of introducing an active agent into a cell by contacting the cell wit h the inventive composition. The invention further provides a method of inhibiting the growth of neoplastic cells and a method of treating a patient suffering from a neoplastic disease by employing the inventive composition, wherein an active agent is an antineoplastic agent. The invention further provides a method for validating a genetic target, comprising (a) administering to a cell a composition comprising a cationic liposome and a siRNA, whereby the siRNA enters the cell inhibits the expression of a gene within the cell and (b) assaying for the inhibition of the gene. The method also provides a fluorescent/ luminescent cationic cardiolipin analogue and compositions including such analogues. Using a cationic cardiolipin analogue , the invention provides a method of tracking the migration of a lipid substan ce within an animal.

36. 发明专利

AU2005204689A2 Lipid compositions and use thereof 未知
公开(公告)号：AU2005204689A2
公开(公告)日：2005-07-28
申请号：AU2005204689
申请日：2005-01-07
申请人： NEOPHARM INC
发明人： ZHANG JIA-AI , SHEIKH SAIFUDDIN , JAMIL HARIS , WANG JINKANG , CHIEN PEI-YU , BHAMIDIPATI SHASTRI , ZHANG ZHI-YI , AHMAD MOGHIS U , AHMAD ZAFEER , UGWU SYDNEY , AHMAD IMRAN , ALI SHOUKATH
IPC分类号： C12N15/00 , A61K9/127 , A61K31/14 , A61K31/355 , A61K31/575 , A61K31/685 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K45/06 , A61K48/00 , C12N15/11 , C12N15/113
摘要： The invention provides a composition suitable for use as a transfection agent, comprising a cationic cardiolipin analogue and, another lipid species. The composition of the present invention can facilitate transfection of a wide variety of polynucleotide species (e.g., oligodeoxyribonucleotides, plasmids, RNAi species, etc.). Moreover, the transfection agent of the present invention is effective in promoting transfection of primary cell cultures as well as transformed cells. Also, the inventive transfection agent is suitable for use both in vitro and in vivo. The inventive composition has additional uses as well, such as delivery of a variety of active agents, dermatological and cosmetic uses, and uses in agriculture. The invention further provides a method of introducing an active agent into a cell by contacting the cell with the inventive composition. The invention further provides a method of inhibiting the growth of neoplastic cells and a method of treating a patient suffering from a neoplastic disease by employing the inventive composition, wherein an active agent is an antineoplastic agent. The invention further provides a method for validating a genetic target, comprising (a) administering to a cell a composition comprising a cationic liposome and a siRNA, whereby the siRNA enters the cell inhibits the expression of a gene within the cell and (b) assaying for the inhibition of the gene. The method also provides a fluorescent/ luminescent cationic cardiolipin analogue and compositions including such analogues. Using a cationic cardiolipin analogue, the invention provides a method of tracking the migration of a lipid substance within an animal.

37. 发明专利

AU2003277445A1 CATIONIC CARDIOLIPIN ANALOGS AND USE THEREOF 未知
公开(公告)号：AU2003277445A1
公开(公告)日：2004-05-04
申请号：AU2003277445
申请日：2003-10-16
申请人： NEOPHARM INC
发明人： AHMAD MOGHIS U , KASIREDDY KRISHNUDU , AHMAD IMRAN
IPC分类号： A61K9/127 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K47/18 , A61K47/24 , C07C217/04 , C07C219/04 , C07F9/09 , C07F9/10
摘要： The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

38. 发明专利

CA2501990A1 CATIONIC CARDIOLIPIN ANALOGS AND USE THEREOF 未知
公开(公告)号：CA2501990A1
公开(公告)日：2004-04-29
申请号：CA2501990
申请日：2003-10-16
申请人： NEOPHARM INC
发明人： AHMAD MOGHIS U , AHMAD IMRAN , KASIREDDY KRISHNUDU
IPC分类号： A61K9/127 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K47/18 , A61K47/24 , C07C217/04 , C07C219/04 , C07F9/09 , C07F9/10
摘要： The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc . In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, i n delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

39. 发明专利

AU2003239614A8 Cardiolipin compositions, methods of preparation and use 未知
公开(公告)号：AU2003239614A8
公开(公告)日：2003-12-12
申请号：AU2003239614
申请日：2003-05-23
申请人： NEOPHARM INC
发明人： ALI SHOUKATH M , AHMAD IMRAN , AHMAD MOGHIS U , LIN ZHEN
IPC分类号： A61K9/127 , A61K9/19 , A61K31/522 , A61K31/675 , A61K31/7068 , A61K31/7072 , A61K38/16 , A61K47/24 , A61K48/00 , C07F5/06 , C07F9/02 , C07F9/10 , C07H21/04 , C07K14/47 , C12N15/88
摘要： The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

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