专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20100093848A1 PROPARGYLATED AMINOINDANS, PROCESSES FOR PREPARATION, AND USES THEREOF 有权
标题翻译：衍生的氨基甲酸酯，制备方法及其用途
公开(公告)号：US20100093848A1
公开(公告)日：2010-04-15
申请号：US12582491
申请日：2009-10-20
申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb , Marta Weinstock-Rosin
发明人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb , Marta Weinstock-Rosin
IPC分类号： A61K31/27 , A61P25/28
CPC分类号： C07C271/48 , A61K31/27 , A61K31/325 , C07B2200/07 , C07C271/44 , C07C2602/08
摘要： A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.
摘要翻译：治疗已被鉴定为患有阿尔茨海默病的个体的方法，其通过向个体口服施用治疗有效量的前消炎症或其药物活性盐，其中治疗有效量为每天70mg，每天140mg，或每天200毫克。而且，剂量为50mg，70mg，80mg或100mg的地斯达格或其药物活性盐的单位剂型。

32. 发明授权

US07630757B2 System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 有权
标题翻译：用于预测，快速检测，警告，预防或控制受试者大脑活动状态变化的系统
公开(公告)号：US07630757B2
公开(公告)日：2009-12-08
申请号：US10210497
申请日：2002-08-01
申请人： Josef Dorfmeister , Mark Frei , David Lerner , Ivan Osorio , John Ralston
发明人： Josef Dorfmeister , Mark Frei , David Lerner , Ivan Osorio , John Ralston
IPC分类号： A61B5/04
CPC分类号： A61B5/048 , A61B5/4094 , A61B5/7257 , A61B5/726 , A61N1/08 , A61N1/36064 , A61N1/36082 , G06F19/00
摘要： A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
摘要翻译：系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成至少在临床癫痫发作前需要进行分析。优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

33. 发明授权

US07625946B2 Propargylated aminoindans, processes for preparation, and uses thereof 有权
标题翻译：炔丙基化氨基茚满，制备方法及其应用
公开(公告)号：US07625946B2
公开(公告)日：2009-12-01
申请号：US11710118
申请日：2007-02-23
申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
发明人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
IPC分类号： C07C271/10 , C07C271/16
CPC分类号： C07C271/48 , A61K31/27 , A61K31/325 , C07B2200/07 , C07C271/44 , C07C2602/08
摘要： This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
摘要翻译：本发明提供具有以下结构的化合物：其中R1是甲基，R2是H，或R1是乙基，R2是羟甲基; R3是H或炔丙基; 且R 4为H或叔丁氧基羰基; 或其对映异构体或其药学上可接受的盐。本发明进一步提供了治疗有效量的这些化合物用于治疗患有精神障碍，帕金森病，阿尔茨海默病，痴呆或神经障碍的受试者的用途。

34. 发明授权

US5995868A System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 失效
公开(公告)号：US5995868A
公开(公告)日：1999-11-30
申请号：US778771
申请日：1997-01-06
申请人： Josef Dorfmeister , Mark Frei , David Lerner , Ivan Osorio , John Ralston
发明人： Josef Dorfmeister , Mark Frei , David Lerner , Ivan Osorio , John Ralston
IPC分类号： A61B5/0476 , A61B5/048 , A61N1/08 , A61N1/36 , A61B5/04
CPC分类号： A61B5/415 , A61B5/048 , A61B5/4094 , A61N1/08 , A61N1/36135 , A61B5/7257 , A61B5/726 , A61N1/36025 , A61N1/36064
摘要： A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

35. 发明授权

US4339980A Loop tape recorder 失效
标题翻译：环形录音机
公开(公告)号：US4339980A
公开(公告)日：1982-07-20
申请号：US182773
申请日：1980-08-29
申请人： Helen Hooke , David Lerner
发明人： Helen Hooke , David Lerner
IPC分类号： G10H1/00 , G10H1/40 , G10H3/03
CPC分类号： G10H1/40 , G10H1/0033 , Y10S84/12
摘要： A series of beat signals (e.g. sixteen) corresponding to a desired rhythm or tempo are recorded on one track of a multi-track magnetic tape, which is then cut and spliced into a loop just long enough to contain the entire series of recorded beats. During a performance the loop is used in a recorder designed to cause the recorded beat signals repeatedly to be played back by a first head at a first terminal, which can be connected through an amplifier to an ear-piece and/or lamp so that the reproduced beat signals can be heard and/or seen only by the performer. A second, combination record-playback-erase head in the recorder is mounted adjacent a second track on the tape and is connected by, for example, a foot-operated switch to a circuit which enables the second head instantaneously to be switched from a record to a playback mode, and vice versa. The performer can then use the foot-operated switch momentarily to switch the second head into its recording mode to record on the second track, during one complete revolution of the tape, background music or rhythm compatible to the beat signals. The last-recorded material can then be amplified and instantly played back through a second terminal to a live audience repeatedly as the performer continues the performance. The beat signals appearing at the first-named terminal can also be utilized to energize a synthesizer or a light show.
摘要翻译：对应于期望的节奏或速度的一系列节拍信号（例如，十六）被记录在多磁道磁带的一个磁道上，然后将其剪切并拼接成刚刚足够长的循环，以容纳整个记录的节拍序列。在执行期间，该循环用于记录器中，该记录器被设计成使得记录的节拍信号在第一终端处被重复地由第一头重放，该第一终端可以通过放大器连接到耳机和/或灯，再现的节拍信号可以被演奏者听到和/或看到。记录器中的第二个组合记录重放擦除磁头安装在磁带上的第二磁道附近，并且通过例如脚踏操作的开关连接到电路，该电路使第二磁头能够从记录切换到播放模式，反之亦然。然后，表演者可以立即使用脚踏开关将第二个磁头切换到记录模式，以便在磁带的一个完整的旋转期间，与拍子信号兼容的背景音乐或节奏进行记录。然后，随着演员继续演出，最后录制的材料可以被放大，并通过第二个终端立即回放到现场观众。出现在第一名终端的节拍信号也可以用于激励合成器或灯光显示。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式