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31. 发明申请

US20060177427A1 DNA coding for endo-beta-galactosidase 失效
标题翻译：编码内切β-半乳糖苷酶的DNA
公开(公告)号：US20060177427A1
公开(公告)日：2006-08-10
申请号：US11407596
申请日：2006-04-20
申请人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
发明人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
IPC分类号： A61K35/12 , C07H21/04 , C12P21/06 , C12N9/38
CPC分类号： A61K39/001 , A61K35/12 , A61K38/00 , C12N9/2471 , C12Y302/01023
摘要： A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of Clostridium perfringens as a template to thereby obtain a fragment of cDNA encoding endo-β-galactosidase, effecting cassette PCR by using the cDNA fragment thus obtained to thereby obtain the 5′-terminal and 3′-terminal domains, and further effecting PCR with the use of primers constructed on the basis of the data acquired above.
摘要翻译：通过分析纯化的内切β-半乳糖苷酶C的部分氨基酸序列，构建其上的引物，利用产气荚膜梭菌的基因组DNA作为模板进行PCR，从而获得cDNA片段，从而获得全长cDNA 编码内切β-半乳糖苷酶，通过使用由此获得的cDNA片段进行盒式PCR，从而获得5'-末端和3'末端结构域，并且使用基于上述获得的数据构建的引物进一步进行PCR 。

32. 发明授权

US06383480B1 Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells 有权
标题翻译：包含中期因子或多余肌营养蛋白的组合物和增加造血细胞的方法
公开(公告)号：US06383480B1
公开(公告)日：2002-05-07
申请号：US09214569
申请日：1999-01-07
申请人： Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
发明人： Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
IPC分类号： A61K3800
CPC分类号： C12N5/0647 , A61K35/28 , A61K38/18 , A61K38/193 , C12N2500/25 , C12N2501/10 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , Y10S514/885 , A61K2300/00
摘要： The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
摘要翻译：本发明提供了单独使用作为增殖造血干细胞和造血前体细胞的药剂的MK家族的新用途。本发明还提供了用于显着增强上述促进造血干细胞和造血前体细胞增殖的作用的药剂，其包含MK家族与已知造血因子如IL-3，IL-6，G-CSF的组合，GM-CSF，M-CSF，SCF和EPO。

33. 发明申请

US20130100215A1 INK-JET RECORDING APPARATUS, INK SUPPLY METHOD, POWER SHUTDOWN METHOD, AND METHOD FOR SHUTTING DOWN TEMPERATURE ADJUSTMENT UNIT OF INK-JET RECORDING DEVICE 审中-公开
标题翻译：墨水记录装置，墨水供应方法，电源关闭方法和用于切换喷墨记录装置的温度调节单元的方法
公开(公告)号：US20130100215A1
公开(公告)日：2013-04-25
申请号：US13805374
申请日：2011-06-16
申请人： Takakazu Kuki , Takashi Muramatsu
发明人： Takakazu Kuki , Takashi Muramatsu
IPC分类号： B41J2/175
CPC分类号： B41J2/0454 , B41J2/04586 , B41J2/16547 , B41J2/17593
摘要： An ink jet recording apparatus includes: a head that ejects droplets of ink; a flow passage portion; and a temperature adjustment unit. The flow passage portion supplies the ink to the head. The flow passage portion includes, in a part thereof, a reservoir unit that reserves the ink. The temperature adjustment unit is capable of adjusting temperatures of the flow passage portion and the head independently of each other. The temperature adjustment unit controls the temperatures of the flow passage portion and the head so that the ink in the head becomes liquid from solid after ink in the flow passage portion is turned to liquid from solid.
摘要翻译：一种喷墨记录装置，包括：喷墨墨滴的头; 流路部分; 和温度调节单元。流动通道部分将墨水供应到头部。流通部分在其一部分中包括储存墨水的储存单元。温度调节单元能够彼此独立地调节流路部分和头部的温度。温度调节单元控制流路部分和头部的温度，使得在流动通道部分中的墨水从固体转变成液体之后，头部中的墨水从固体变成液体。

34. 发明申请

US20100311187A1 ANTIBODY RECOGNIZING C-DOMAIN OF MIDKINE 有权
标题翻译：抗体识别中间体的C域
公开(公告)号：US20100311187A1
公开(公告)日：2010-12-09
申请号：US12312522
申请日：2007-11-13
申请人： Takashi Matsui , Takashi Muramatsu , Masatoshi Hayashibara , Takanori Ito , Tsukasa Uno , Sadatoshi Sakuma
发明人： Takashi Matsui , Takashi Muramatsu , Masatoshi Hayashibara , Takanori Ito , Tsukasa Uno , Sadatoshi Sakuma
IPC分类号： G01N33/53 , C07K16/24 , C12N5/18
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/565 , C07K2317/76 , G01N33/6854 , G01N33/6857
摘要： It is intended to provide an antibody which inhibits the function of midkine. An antibody which recognizes an epitope consisting of amino acid residues 62 to 104 of midkine or a fragment thereof; DNA encoding the antibody or a fragment thereof; a recombinant vector which contains the DNA; a transformant which has the vector or a hybridoma which produces the antibody; a method for producing the antibody by allowing the transformant or hybridoma to produce the antibody or a fragment thereof and collecting the resulting antibody or fragment thereof; a pharmaceutical composition containing the antibody or a fragment thereof as an active ingredient; and a diagnostic agent containing the antibody or a fragment thereof as an active ingredient.
摘要翻译：旨在提供抑制中期因子功能的抗体。识别由中期因子的氨基酸残基62至104或其片段组成的表位的抗体; 编码抗体或其片段的DNA; 含有DNA的重组载体; 具有产生抗体的载体或杂交瘤的转化体; 通过使转化体或杂交瘤产生抗体或其片段并收集得到的抗体或其片段，制备抗体的方法; 含有抗体或其片段作为活性成分的药物组合物; 和含有该抗体或其片段作为活性成分的诊断剂。

35. 发明申请

US20100015632A1 METHOD FOR EXAMINING COLORECTAL CANCER AND COLORECTAL ADENOMA 审中-公开
标题翻译：检查阴道癌和色素性腺瘤的方法
公开(公告)号：US20100015632A1
公开(公告)日：2010-01-21
申请号：US12567944
申请日：2009-09-28
申请人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
发明人： Reiji Kannagi , Mineko Izawa , Takashi Muramatsu , Kenji Uchimura , Hideaki Hosokawa
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57419 , G01N2333/91097 , G01N2400/02
摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. There are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore, colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.
摘要翻译：本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂其中。 GlcNAc-6-磺基转移酶同工酶，糖残基硫酸化酶，非癌症结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织分布差异均有统计学意义。此外，通过测定来自患者或粪便样品的组织中的一定范围的GlcNAc-6-硫酸化糖残基来检测结肠直肠癌和腺瘤。与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查结肠直肠癌和结直肠腺瘤。

36. 发明授权

US07060483B1 DNA encoding endo-β-galactosidase 有权
标题翻译：编码内切β-半乳糖苷酶的DNA
公开(公告)号：US07060483B1
公开(公告)日：2006-06-13
申请号：US10111349
申请日：2000-10-10
申请人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
发明人： Takashi Muramatsu , Haruko Ogawa , Hisako Muramatsu , Takaaki Kobayashi , Itsuo Yokoyama
IPC分类号： C12N9/38 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A61K39/001 , A61K35/12 , A61K38/00 , C12N9/2471 , C12Y302/01023
摘要： A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of Clostridium perfringens as a template to thereby obtain a fragment of cDNA encoding endo-β-galactosidase, effecting cassette PCR by using the cDNA fragment thus obtained to thereby obtain the 5′-terminal and 3′-terminal domains, and further effecting PCR with the use of primers constructed on the basis of the data acquired above.
摘要翻译：通过分析纯化的内切β-半乳糖苷酶C的部分氨基酸序列，构建其上的引物，利用产气荚膜梭菌的基因组DNA作为模板进行PCR，从而获得cDNA片段，从而获得全长cDNA 编码内切β-半乳糖苷酶，通过使用由此获得的cDNA片段进行盒式PCR，从而获得5'-末端和3'末端结构域，并且使用基于上述获得的数据构建的引物进一步进行PCR 。

37. 发明授权

US06939669B2 Expansion of hematopoietic cells using midkine or pleiotrophin 失效
标题翻译：使用中期因子或多余营养素扩大造血细胞
公开(公告)号：US06939669B2
公开(公告)日：2005-09-06
申请号：US10071039
申请日：2002-02-08
申请人： Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
发明人： Makoto Kikuchi , Shinya Ikematsu , Munehiro Oda , Sadatoshi Sakuma , Takashi Muramatsu
IPC分类号： A61K35/28 , A61K38/18 , A61K38/19 , A61K38/20 , C12N5/0789 , C12N5/00 , C07K14/475 , C07K14/52
CPC分类号： C12N5/0647 , A61K35/28 , A61K38/18 , A61K38/193 , C12N2500/25 , C12N2501/10 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , Y10S514/885 , A61K2300/00
摘要： The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO.
摘要翻译：本发明提供了单独使用作为增殖造血干细胞和造血前体细胞的药剂的MK家族的新用途。本发明还提供了用于显着增强上述促进造血干细胞和造血前体细胞增殖的作用的药剂，其包含MK家族与已知造血因子如IL-3，IL-6，G-CSF的组合，GM-CSF，M-CSF，SCF和EPO。

38. 发明授权

US6083907A Treatment of peptic ulcers using midkine (MK) proteins 失效
标题翻译：使用midkine（MK）蛋白治疗消化性溃疡
公开(公告)号：US6083907A
公开(公告)日：2000-07-04
申请号：US12084
申请日：1998-01-22
申请人： Masayuki Uchida , Shinya Ikematsu , Minehiko Yokoyama , Akio Yamashita , Hideshi Kumai , Munehiro Oda , Naoki Kato , Sadatoshi Sakuma , Takashi Muramatsu
发明人： Masayuki Uchida , Shinya Ikematsu , Minehiko Yokoyama , Akio Yamashita , Hideshi Kumai , Munehiro Oda , Naoki Kato , Sadatoshi Sakuma , Takashi Muramatsu
IPC分类号： A61K38/00 , A61K38/18 , A61P1/04 , C07K14/47 , C07K14/52
CPC分类号： A61K38/18 , A61K31/4164 , A61K31/727 , A61K45/06
摘要： An anti-ulcer composition is provided, which comprises as an active ingredient at least one of MK protein, its derivative having biological activity of MK protein, and their fragment having biological activity of MK protein, and a pharmaceutically acceptable carrier. The composition exhibits an effect for treating ulcer by promoting autotherapy without recurrence of ulcer.
摘要翻译：提供了一种抗溃疡组合物，其包含作为活性成分的至少一种MK蛋白，其具有MK蛋白生物活性的衍生物及其具有MK蛋白生物活性的片段和药学上可接受的载体。该组合物通过促进自体治疗而不复发溃疡具有治疗溃疡的作用。

39. 发明授权

US4725557A Production of fucosyl antigens and antibodies for recognizing same determination of cancer associated carbohydrate linkage using same and kit for the determination 失效
标题翻译：生产岩藻糖基抗原和抗体，用于识别使用相同的癌症相关碳水化合物连锁的确定和用于测定的试剂盒
公开(公告)号：US4725557A
公开(公告)日：1988-02-16
申请号：US573920
申请日：1984-01-19
申请人： Teruo Miyauchi , Suguru Yonezawa , Masayuki Ozawa , Eiichi Sato , Takashi Muramatsu , Setsuzo Tejima , Taku Chiba
发明人： Teruo Miyauchi , Suguru Yonezawa , Masayuki Ozawa , Eiichi Sato , Takashi Muramatsu , Setsuzo Tejima , Taku Chiba
IPC分类号： C07H21/00 , G01N33/531 , G01N33/574
CPC分类号： C07H21/00 , G01N33/531 , G01N33/57469 , Y10S530/813
摘要： The invention relates to a process for producing a fucosyl antigen charcterized in that an oligosaccharide contaning an .alpha.-fucoyransoyl-(1.fwdarw.3)-, -(1.fwdarw.4)- or -(1.fwdarw.6)-galactoyransoyl group and serving as a hapten is reacted wtih a carrier protein to obtain a carbohydrate antigen and to a process for producing from the antigen an antibody having specific reactivity with cells of cancers of the digestive system, especially human colon carcinoma cells, and murine teratocarcinoma cells.The invention also relates to a method of determining a cancer associated crabohydrate linkage with use of such antibody capable of specifically recognizing specific carbohydrate linkage and to a cancer diagnosing kit containing the antibody.
摘要翻译： PCT No.PCT / JP83 / 00169 Sec。 371日期1984年1月19日 102（e）日期1984年1月19日PCT提交1983年5月28日PCT公布。公开号WO83 / 04311 日期：1983年12月8日。本发明涉及一种制备岩藻糖基抗原的方法，其特征在于，含有α-羧基酰基 - （1-> 3） - ， - （1-> 4） - 或 - （1- > 6） - 半乳糖基，并且作为半抗原与载体蛋白质反应以获得碳水化合物抗原，以及从抗原产生与消化系统癌症特别是人结肠癌细胞的细胞具有特异性反应性的抗体，和鼠类畸胎癌细胞。本发明还涉及使用能够特异性识别特定碳水化合物连接的这种抗体以及含有该抗体的癌症诊断试剂盒来测定与癌症相关的水合物结合的方法。

40. 发明授权

US07192110B2 Inkjet cartridge detection and switching apparatus 有权
标题翻译：喷墨墨盒检测和开关装置
公开(公告)号：US07192110B2
公开(公告)日：2007-03-20
申请号：US10916957
申请日：2004-08-11
申请人： Akihiro Taguchi , Nobuya Yamamoto , Tetsushi Aoki , Takashi Muramatsu , Minoru Maekawara , Shingo Tsubotani
发明人： Akihiro Taguchi , Nobuya Yamamoto , Tetsushi Aoki , Takashi Muramatsu , Minoru Maekawara , Shingo Tsubotani
IPC分类号： B41J2/195 , B41J29/393 , B41J2/175
CPC分类号： B41J2/17566 , B41J2/17523 , B41J2/195
摘要： An inkjet recording apparatus includes: exchangeable first and second ink cartridges; a recording head which jets ink to a recording medium; an intermediate tank which receives the ink from the ink cartridge and supplies the ink to the recording head; a detecting sensor which detects whether ink residual quantity of an ink cartridge is not more than predetermined quantity based on ink quantity in the intermediate tank; a switching section which, if the ink residual quantity is not more than the predetermined quantity, switches the ink cartridge for supplying the ink to the intermediate tank; a first detector which detects the reset of the first ink cartridge; a second detector which detects the reset of the second ink cartridge; and a controller which, if the first ink cartridge is reset, controls the switching section to switch the second ink cartridge to the first ink cartridge, for supplying the ink.
摘要翻译：喷墨记录装置包括：可更换的第一和第二墨盒; 将墨水喷射到记录介质上的记录头; 中间罐，其从墨盒接收墨水并将墨水供应到记录头; 检测传感器，其基于中间容器中的墨水量来检测墨盒的墨水剩余量是否不大于预定量; 切换部，如果墨剩余量不大于预定量，则将用于供应墨的墨盒切换到中间罐; 第一检测器，其检测第一墨盒的复位; 检测第二墨盒的复位的第二检测器; 以及控制器，如果第一墨盒被复位，则控制切换部分将第二墨盒切换到第一墨盒以供应墨水。

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