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31. 发明申请

US20070118104A1 AUTO-ALIGNING ABLATING DEVICE AND METHOD OF USE 有权
标题翻译：自动对准装置及其使用方法
公开(公告)号：US20070118104A1
公开(公告)日：2007-05-24
申请号：US11275244
申请日：2005-12-20
申请人： Michael Wallace , Robert Garabedian , Brent Gerberding , Winnie Chung , David Utley
发明人： Michael Wallace , Robert Garabedian , Brent Gerberding , Winnie Chung , David Utley
IPC分类号： A61B18/14
CPC分类号： A61B18/18 , A61B18/02 , A61B18/1492 , A61B18/1815 , A61B34/71 , A61B90/50 , A61B2017/00296 , A61B2018/0022 , A61B2018/00285 , A61B2018/00482 , A61B2018/00488 , A61B2018/00577 , A61B2018/046 , A61B2018/1495
摘要： An ablation device and methods for use thereof including a support structure adapted to support an ablation structure within an alimentary tract of a patient are provided. The support structure includes a longitudinal support with a longitudinal axis and a rotational support. The rotational support is adapted to permit at least part of the ablation structure to rotate with respect to the longitudinal support's longitudinal axis.
摘要翻译：提供消融装置及其使用方法，其包括适于支撑患者消化道内的消融结构的支撑结构。支撑结构包括具有纵向轴线和旋转支撑件的纵向支撑件。旋转支撑件适于允许至少部分消融结构相对于纵向支撑件的纵向轴线旋转。

32. 发明申请

US20060194786A1 Process and intermediates for preparing benzazepines 失效
标题翻译：制备苯并氮杂的方法和中间体
公开(公告)号：US20060194786A1
公开(公告)日：2006-08-31
申请号：US10551710
申请日：2004-03-29
申请人： Jose Conde , Lewilynn Goldfinger , Michael McGuire , Susan Shilcrat , Michael Wallace , Marvin Yu
发明人： Jose Conde , Lewilynn Goldfinger , Michael McGuire , Susan Shilcrat , Michael Wallace , Marvin Yu
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D401/12 , C07D223/16
摘要： Disclosed is a new process and intermediates for preparing benzazepines of Formula (I): wherein R1 and R2 are as defined herein.
摘要翻译：公开了用于制备式（I）的苯并氮杂的新方法和中间体：其中R 1和R 2如本文所定义。

33. 发明申请

US20060111322A1 Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 审中-公开
标题翻译：吲唑化合物，药物组合物和介导或抑制细胞增殖的方法
公开(公告)号：US20060111322A1
公开(公告)日：2006-05-25
申请号：US11329303
申请日：2006-01-10
申请人： Siegfried Reich , Ted Bleckman , Susan Kephart , William Romines , Michael Wallace
发明人： Siegfried Reich , Ted Bleckman , Susan Kephart , William Romines , Michael Wallace
IPC分类号： A61K31/695 , A61K31/69 , C07F5/02
CPC分类号： C07D249/08 , B22D41/56 , C07D231/12 , C07D231/56 , C07D233/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07F7/1804
摘要： The invention is directed to intermediates useful for making indazole compounds that modulate and/or inhibit cell proliferation.
摘要翻译：本发明涉及可用于制备调节和/或抑制细胞增殖的吲唑化合物的中间体。

34. 发明申请

US20060084650A1 Kinase inhibitors 有权
标题翻译：激酶抑制剂
公开(公告)号：US20060084650A1
公开(公告)日：2006-04-20
申请号：US11251616
申请日：2005-10-14
申请人： Qing Dong , David Hosfield , Bheema Paraselli , Nicholas Scorah , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人： Qing Dong , David Hosfield , Bheema Paraselli , Nicholas Scorah , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译：化合物，药物组合物和试剂盒提供用于包含选自以下的化合物的激酶：其中变量如本文所定义。

35. 发明申请

US20060041225A1 Targeted drug delivery device and method 失效
标题翻译：靶向药物输送装置及方法
公开(公告)号：US20060041225A1
公开(公告)日：2006-02-23
申请号：US10920735
申请日：2004-08-17
申请人： Michael Wallace , Robert Garabedian
发明人： Michael Wallace , Robert Garabedian
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting an region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译：提供了靶向药物递送装置。该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。还提供了一种治疗组织的方法。该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅对该区域进行治疗。

36. 发明申请

US20050154515A1 Vehicle occupant classification system and method 审中-公开
标题翻译：车辆乘员分类系统及方法
公开(公告)号：US20050154515A1
公开(公告)日：2005-07-14
申请号：US10622362
申请日：2003-07-17
申请人： Michael Wallace
发明人： Michael Wallace
IPC分类号： B60R21/01 , B60R21/015 , G06K9/00 , G06F7/00
CPC分类号： B60R21/01516 , B60R21/0154 , G06K9/00362
摘要： A vehicle occupant classification system classifies a vehicle occupant based on data from an array of sensors using a combination of weight estimation, pattern recognition, and evaluation of statistical characteristics. This occupant classification can then be used to make an airbag deployment state decision. The major modules of this system can include a calibration unit, a weight estimation module, a pattern module, and a decision-making module. The calibration unit can perform a calibration process to normalize sensor deflections using a known deflection force in order to compensate for variations in sensors and the effects of the seat trim and foam. The weight estimation module can perform a weight estimation process that uses calibration data from the calibration process and sensor data from the sensors to translate sensor deflection due to a vehicle occupant into a displacement value. The pattern module can look for traits in the pattern of sensor deflections that are common for objects other than people. Finally, the decision-making module can make a deployment state decision for the airbag by looking at displacement trends to evaluate occupant weight and movement, and by evaluating pattern information.
摘要翻译：车辆乘员分类系统使用重量估计，模式识别和统计特征的评估的组合，基于来自传感器阵列的数据对车辆乘客进行分类。然后可以使用该乘员分类来做出安全气囊展开状态的决定。该系统的主要模块可以包括校准单元，重量估计模块，模式模块和决策模块。校准单元可以执行校准过程以使用已知的偏转力归一化传感器偏转，以补偿传感器的变化以及座椅装饰和泡沫的影响。重量估计模块可以执行使用来自校准过程的校准数据和来自传感器的传感器数据的权重估计处理，以将由车辆乘员引起的传感器偏转转换为位移值。模式模块可以在除人之外的对象常见的传感器偏转模式中寻找特征。最后，决策模块可以通过查看位移趋势来评估乘客的重量和运动，并通过评估模式信息，对安全气囊进行部署状态决策。

37. 发明申请

US20050143585A1 Processes for preparing pyrroles 失效
标题翻译：制备吡咯的方法
公开(公告)号：US20050143585A1
公开(公告)日：2005-06-30
申请号：US10978301
申请日：2004-10-28
申请人： Michael Wallace
发明人： Michael Wallace
IPC分类号： C07D207/34 , C07D207/416 , C07D27/34
CPC分类号： C07D207/416 , C07D207/34
摘要： The present invention relates to an improved synthesis of pyrrole capping group precursors.
摘要翻译：本发明涉及吡咯封端基前体的改进合成。

38. 发明申请

US20050094491A1 Clock movement with moon dial 审中-公开
标题翻译：时钟运动与月亮表盘
公开(公告)号：US20050094491A1
公开(公告)日：2005-05-05
申请号：US10699171
申请日：2003-10-31
申请人： Michael Wallace
发明人： Michael Wallace
IPC分类号： G04B19/26 , G04B49/00
CPC分类号： G04B19/268
摘要： A clock movement having a moon dial that includes symmetric teeth about its periphery. The movement also includes a driving gear with a pin that engages the teeth so that each rotation of the drive gear advances the moon disk. Because the moon dial teeth are symmetric, the moon dial can be rotated either forward or backward by moving the driving gear either forward or backward. The rotational support of the moon dial includes a wave washer to apply a small frictional force to prevent freewheeling.
摘要翻译：具有月球表盘的钟表机构围绕其周边包括对称的齿。该运动还包括具有与齿接合的销的驱动齿轮，使得驱动齿轮的每个旋转使月球盘前进。因为月亮表盘齿是对称的，所以通过向前或向后移动驱动齿轮，月球表盘可以向前或向后旋转。月球表盘的旋转支撑件包括一个波形垫圈，以施加小的摩擦力来防止续航。

39. 发明申请

US20050075330A1 Dipeptidyl peptidase inhibitors 有权
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US20050075330A1
公开(公告)日：2005-04-07
申请号：US10918327
申请日：2004-08-12
申请人： Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen Gwaltney , Stephen Kaldor , Jeffrey Stafford , Michael Wallace , Zhiyuan Zhang
IPC分类号： A61K9/08 , A61K9/20 , A61K31/506 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D239/02 , C07D239/36 , C07D239/46 , C07D239/52 , C07D285/16 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04 , A61K31/513 , A61K31/549 , C07D43/04
CPC分类号： C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
摘要翻译：提供化合物，药物，试剂盒和方法用于包含式I的DPP-IV抑制剂：其中取代基如本文所述。

40. 发明申请

US20050065501A1 Energy activated vaso-occlusive devices 审中-公开
标题翻译：能量激活血管闭塞装置
公开(公告)号：US20050065501A1
公开(公告)日：2005-03-24
申请号：US10669203
申请日：2003-09-23
申请人： Michael Wallace
发明人： Michael Wallace
IPC分类号： A61B17/00 , A61B17/12 , A61F7/00 , A61F7/12 , A61F11/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/005
摘要： A vaso-occlusive device for treating a site within a patient's vasculature, the device comprising a material which may be heated by application of a source of energy external to the body after the device is implanted at a treatment site in a patient's body. The device is introduced in a cavity of a patient's vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or activate a diagnostic or therapeutic agent carried by the vaso-occlusive device, and/or to fuse together portions of the vaso-occlusive device to help stabilize the device in a three-dimensional shape.
摘要翻译：一种用于治疗患者脉管系统内的部位的血管闭塞装置，所述装置包括可在将装置植入患者体内的治疗部位之后通过施加身体外部的能量来加热的材料。将该装置引入病人脉管系统（例如动脉瘤）的空腔中，之后激活诸如MRI机器的外部能量源以加热血管闭塞装置以协助在治疗部位内形成血栓或栓塞以释放和/或激活由血管闭塞装置携带的诊断或治疗剂，和/或将血管闭塞装置的部分熔合在一起，以有助于将装置稳定在三维形状中。

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