专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US5977329A Methods of synthesizing GM3 失效
标题翻译： GM3合成方法
公开(公告)号：US5977329A
公开(公告)日：1999-11-02
申请号：US24528
申请日：1998-02-17
申请人： Richard Schmidt , Julio C. Castro-Palomino , Gerd Ritter , Lloyd J. Old
发明人： Richard Schmidt , Julio C. Castro-Palomino , Gerd Ritter , Lloyd J. Old
IPC分类号： C07H15/10 , A61P35/00 , A61P37/02 , C07B61/00 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18 , C07H15/00
CPC分类号： C07H13/04 , C07H1/00 , C07H3/06
摘要： The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the .alpha. and .beta. isomers of GM3 are formed. The .alpha. isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the .beta. isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.
摘要翻译：本发明描述了制备单唾液酸神经节苷脂GM3及其中间体的改进方法。在酸催化剂存在下，神经氨酸供体和乳糖受体反应后，形成GM3的α和β异构体。通过形成碱性催化剂的作用，将α异构体转化成内酯，然后将其与β异构体分离。然后在醇的存在下用碱性催化剂处理内酯，形成GM3或GM3中间体。

32. 发明申请

US20170362336A1 Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for Cancer Therapy 审中-公开
公开(公告)号：US20170362336A1
公开(公告)日：2017-12-21
申请号：US15609839
申请日：2017-05-31
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： C07K16/30 , A61K39/00 , A61K39/395 , G01N33/574 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K7/08
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present invention relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.

33. 发明授权

US09032001B2 Field transformations for user interface data elements 有权
标题翻译：用户界面数据元素的字段转换
公开(公告)号：US09032001B2
公开(公告)日：2015-05-12
申请号：US13331039
申请日：2011-12-20
申请人： Dirk Stumpf , Tim Kornmann , Gerd Ritter , Rene Gross
发明人： Dirk Stumpf , Tim Kornmann , Gerd Ritter , Rene Gross
IPC分类号： G06F17/30
CPC分类号： G06F17/30398
摘要： A method and system, the method may include determining a user interface to be displayed, the user interface including a user interface data element associated with a service input parameter. Information about the service input parameter may be provided to a field transformation as a transformation input, and a transformation output may be received from the field transformation.
摘要翻译：一种方法和系统，所述方法可以包括确定要显示的用户界面，所述用户界面包括与服务输入参数相关联的用户界面数据元素。可以将关于服务输入参数的信息提供给作为变换输入的场变换，并且可以从场变换接收变换输出。

34. 发明申请

US20140193417A1 Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for Cancer Therapy 有权
标题翻译：膜转运体NaPi2b（SCL34A2）抗体治疗表位，针对其的抗体和癌症治疗靶向
公开(公告)号：US20140193417A1
公开(公告)日：2014-07-10
申请号：US14037504
申请日：2013-09-26
申请人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
发明人： Gerd Ritter , Beatrice Yin , Anne Murray , George Mark , Lloyd J. Old , Kenneth Lloyd , Serhiy Souchelnytskiy , Ivan Gout , Valeriy Filonenko , Ramziya Kiyamova
IPC分类号： C07K16/18 , A61K39/00 , C07K7/08 , A61K39/395 , C07K14/47
CPC分类号： C07K16/3069 , A61K39/00 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/53 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57449 , G01N2333/705 , G01N2500/04
摘要： The present disclosure relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.
摘要翻译：本公开总体上涉及作为治疗靶标的膜转运体NaPi2b（SLC34A2），包括免疫治疗，特别是癌症治疗。包含SLC34A2的氨基酸312-340的SLC34A2表位肽已经使用单克隆抗体MX35鉴定为卵巢癌表位。本发明还涉及SLC34A2和特别是SLC34A2肽在产生具有抗肿瘤或抗癌活性或刺激免疫应答的抗体中的用途。本发明进一步涉及特异性针对NaPi2b（SLC34A2）和SLC34A2肽的抗体，包括贴面，嵌合，单链和人源化抗体。还提供了产生免疫应答和治疗肿瘤和癌症的方法。提供筛选和鉴定针对SLC34A2的化合物，包括SLC34A2表位肽和其他抗体的测定。

35. 发明授权

US08541202B2 Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权
标题翻译：用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法
公开(公告)号：US08541202B2
公开(公告)日：2013-09-24
申请号：US13404633
申请日：2012-02-24
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C12P21/02 , C12N15/09 , C12N15/12 , C12N15/63 , C12N1/21 , C07H21/04
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译：本发明涉及结合MHC I类和MHC II类分子的肽。这些肽可用于不同的治疗和诊断情境。

36. 发明授权

US08440807B2 A34 and A33-like 3 DNA protein, antibodies thereto and methods of treatment using same 有权
标题翻译： A34和A33样3 DNA蛋白，其抗体及使用其的治疗方法
公开(公告)号：US08440807B2
公开(公告)日：2013-05-14
申请号：US13233086
申请日：2011-09-15
申请人： Gerd Ritter , Lloyd Old , Achim Jungbluth , Cynthia H. Scanlan
发明人： Matthew Scanlan , Gerd Ritter , Lloyd Old , Achim Jungbluth
IPC分类号： C07H21/04
CPC分类号： G01N33/574 , C07K16/2803 , G01N2500/00
摘要： Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33-like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.
摘要翻译：描述了多核苷酸分子和多肽分子A34和A33样3，以及对多肽分子A34和A33样3的抗体。还描述了检测表达这些多肽的癌症的方法，以及用于诊断所述癌症的方法和试剂盒，以及方法抑制癌症在患者中的作用。

37. 发明申请

US20130111381A1 Modeling Properties of Data and Events as Transformations of Document Data and System Values 有权
标题翻译：将数据和事件的属性建模为文档数据和系统值的转换
公开(公告)号：US20130111381A1
公开(公告)日：2013-05-02
申请号：US13284020
申请日：2011-10-28
申请人： Gerd Ritter , Rene Gross , Tim Kornmann , Steffen Tatzel , Dirk Stumpf , Dirk Giebel
发明人： Gerd Ritter , Rene Gross , Tim Kornmann , Steffen Tatzel , Dirk Stumpf , Dirk Giebel
IPC分类号： G06F3/048
CPC分类号： G06Q10/06 , G06Q10/10
摘要： A system and method for modeling properties of data and events of a business application is presented. The system include a user interface frontend system that displays a user interface, and a user interface backend system that hosts a business application that generates the user interface for display in the user interface frontend system. The system further includes an enterprise service framework comprising one or more data processors that define one or more properties of data and/or events related to the business application, and model each of the one or more properties as a data field of the business application. A dynamic properties calculator includes one or more data processors that access a set of transformation logic representing data transformation rules for each of the data fields of the business application, and apply the transformation rules to the data fields that represent the one or more properties.
摘要翻译：介绍了一种用于建模业务应用程序的数据和事件属性建模的系统和方法。该系统包括显示用户界面的用户界面前端系统，以及主机业务应用程序的用户界面后端系统，用于生成用户界面以在用户界面前端系统中显示。所述系统还包括企业服务框架，其包括一个或多个数据处理器，所述数据处理器定义与所述业务应用相关的数据和/或事件的一个或多个属性，以及将所述一个或多个属性中的每个属性建模为所述业务应用的数据字段。动态属性计算器包括访问代表业务应用的每个数据字段的数据变换规则的一组变换逻辑的一个或多个数据处理器，并将转换规则应用于表示一个或多个属性的数据字段。

38. 发明授权

US08357373B2 Methods for stimulating an immune response using bacterial antigen delivery system 失效
标题翻译：使用细菌抗原递送系统刺激免疫应答的方法
公开(公告)号：US08357373B2
公开(公告)日：2013-01-22
申请号：US12083188
申请日：2006-10-03
申请人： Lloyd J. Old , Gerd Ritter , Hiroyoshi Nishikawa , Sacha Gnjatic , Jorge E. Galan
发明人： Lloyd J. Old , Gerd Ritter , Hiroyoshi Nishikawa , Sacha Gnjatic , Jorge E. Galan
IPC分类号： A61K39/00 , A01N63/00
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/542 , C07K14/255 , C07K2319/036
摘要： The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided for stimulating and/or increasing an immune response against tumor antigens. The invention also relates to the preparation of antigen presenting cells from peripheral blood mononuclear cells using bacteria having a type III secretion system.
摘要翻译：本发明涉及细菌的III型分泌系统在刺激抗肿瘤抗原的免疫应答中用于治疗抗原缺失型变体肿瘤的用途。提供了刺激和/或增加针对肿瘤抗原的免疫应答的方法。本发明还涉及使用具有III型分泌系统的细菌从外周血单核细胞制备抗原呈递细胞。

39. 发明授权

US08188313B2 Analogs of alpha galactosylceramide and uses thereof 有权
标题翻译： α半乳糖神经酰胺的类似物及其用途
公开(公告)号：US08188313B2
公开(公告)日：2012-05-29
申请号：US13231403
申请日：2011-09-13
申请人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
发明人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
IPC分类号： C07C233/18 , C07C233/20 , C07C305/20 , C07F9/09 , A61K31/66 , A61K31/661 , A61K31/16
CPC分类号： C07H15/00
摘要： Compounds of formula wherein the variable are defined in the specification, are used in compositions which stimulate T cell responses.
摘要翻译：在本说明书中定义变体的式的化合物用于刺激T细胞应答的组合物中。

40. 发明申请

US20120034269A1 ANALOGS OF ALPHA GALACTOSYLCERAMIDE AND USES THEREOF 有权
标题翻译：阿尔法胶乳酰胺的模拟物及其用途
公开(公告)号：US20120034269A1
公开(公告)日：2012-02-09
申请号：US13231403
申请日：2011-09-13
申请人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
发明人： Vincenzo Cerundolo , Richard Schmidt , Gopal Reddy , Rengarajan Balamurugan , Gerd Ritter , Gurdyal Besra , Mariolina Salio , Jonathan Silk
IPC分类号： A61K39/39 , A61P35/00 , A61P37/04
CPC分类号： C07H15/00
摘要： Compounds of formula wherein the variable are defined in the specification, are used in compositions which stimulate T cell responses.
摘要翻译：在本说明书中定义变体的式的化合物用于刺激T细胞应答的组合物中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式