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31. 发明授权

US06867051B1 Point of care diagnostic systems 有权
标题翻译：护理点诊断系统
公开(公告)号：US06867051B1
公开(公告)日：2005-03-15
申请号：US09717478
申请日：2000-11-20
申请人： Emory V. Anderson , Jerome Lapointe , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Edward Nemec , Andrew E. Senyei , Duane DeSieno
发明人： Emory V. Anderson , Jerome Lapointe , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Edward Nemec , Andrew E. Senyei , Duane DeSieno
IPC分类号： G01N33/53 , G01N21/27 , G01N21/47 , G01N33/558 , G01N33/68 , G06F19/00 , G06Q50/00 , G01N33/543
CPC分类号： G01N21/474 , G01N21/8483 , G01N33/558 , G01N33/6887 , G01N33/689 , G01N2333/78 , G01N2800/368 , G06F19/00 , G06F19/321 , G16H10/40 , G16H10/60 , G16H15/00 , G16H50/20 , Y02A90/26 , Y10S436/811 , Y10S436/814
摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.
摘要翻译：提供了用于医疗诊断或患者风险评估的系统和方法。这些系统和方法被设计为在护理点使用，例如在急诊室和手术室中，或在需要快速和准确的结果的任何情况下使用。系统和方法处理患者数据，特别是来自护理诊断测试或测定的数据，包括免疫测定，心电图，X射线和其他此类测试，并提供医疗状况或其风险或不存在的指示。系统包括用于读取或评估测试数据的工具，以及用于将数据转换为诊断或风险评估信息的软件。

32. 发明授权

US5185270A Fetal fibronectin pregnancy test 失效
标题翻译：胎儿纤连蛋白妊娠试验
公开(公告)号：US5185270A
公开(公告)日：1993-02-09
申请号：US282426
申请日：1988-12-12
申请人： Andrew E. Senyei , Nelson N. H. Teng
发明人： Andrew E. Senyei , Nelson N. H. Teng
IPC分类号： G01N33/68 , G01N33/76
CPC分类号： G01N33/689 , G01N33/76 , G01N2800/368 , Y10S436/814
摘要： A method for determining normal intrauterine pregnancy during the first 20 weeks of pregnancy comprises obtaining a test sample; and determining the presence of a fetal restricted antigen in the sample. The test sample is removed the vaginal cavity in the vicinity of the cervical canal and/or the cervical os. One fetal restricted antigen is fetal fibronectin.In one embodiment of this invention, the test sample is contacted with an insoluble support to which anti-(fetal restricted antigen) antibody is adhered, and the fetal restricted antigen binding to the support is determined. Alternatively, the test sample is contacted with an insoluble support to which is adhered an antibody which binds a class of substances including the fetal restricted antigen; and the fetal restricted antigen binding to the support is determined. Reagents and reagent kits are also included.
摘要翻译：妊娠前20周确定正常子宫内孕的方法包括获得试验样品; 并确定样品中胎儿限制性抗原的存在。将测试样品移除在子宫颈管和/或子宫颈附近的阴道腔。一种胎儿限制性抗原是胎儿纤连蛋白。在本发明的一个实施方案中，将测试样品与抗（胎儿限制性抗原）抗体所粘附的不溶性支持物接触，并确定与载体结合的胎儿限制性抗原。或者，将测试样品与不溶性载体接触，所述不溶性载体附着有结合一类物质（包括胎儿限制性抗原）的抗体; 确定与载体结合的胎儿限制性抗原。还包括试剂和试剂盒。

33. 发明申请

US20120259652A1 SYSTEMS AND METHODS FOR REMOTE MONITORING, MANAGEMENT AND OPTIMIZATION OF PHYSICAL THERAPY TREATMENT 审中-公开
标题翻译：远程监控，管理和物理治疗优化的系统与方法
公开(公告)号：US20120259652A1
公开(公告)日：2012-10-11
申请号：US13082330
申请日：2011-04-07
申请人： Patrick J. Mallon , Andrew E. Senyei
发明人： Patrick J. Mallon , Andrew E. Senyei
IPC分类号： G06Q50/00
CPC分类号： G06Q10/06 , G06F19/3418 , G06F19/3481 , G06Q10/10 , G06Q50/22
摘要： A movement monitoring and management system, comprises a communication interface; a database configured to store treatment information, sensor data, subject information, reporting, and billing information for a plurality of subjects; a server coupled with the database and the communication interface, the server configured to: receive sensor data via the communication interface, the sensor data including data related to certain activities, exercises or movements performed by the subject according to a treatment plan, analyze the sensor data to assess performance with the treatment plan, automatically determine whether the treatment plan is being complied with or not, whether the treatment plan needs to be altered, and whether the subject is progressing, regressing, or a successful outcome is being or has been achieved based on the analysis, and automatically generate and send at least one message to the subject via the communication interface, the message including instructions for the subject related to whether the treatment plan is being performed and complied with or not, whether the treatment plan needs to be altered, and whether the subject is progressing, regressing, or success is being or has been achieved based on the analysis.
摘要翻译：运动监测和管理系统，包括通信接口; 数据库，被配置为存储多个对象的处理信息，传感器数据，主题信息，报告和计费信息; 与数据库和通信接口耦合的服务器，所述服务器被配置为：经由所述通信接口接收传感器数据，所述传感器数据包括与所述对象根据处理计划执行的某些活动，锻炼或运动有关的数据，分析所述传感器使用治疗计划评估绩效的数据，自动确定治疗计划是否得到遵守，治疗计划是否需要改变，以及受试者是否正在进行，回归或成功的结果正在或已经实现基于所述分析，通过所述通信接口自动生成并发送至少一个消息给所述对象，所述消息包括与所述主题有关的指示是否正在执行和遵守所述治疗计划，所述治疗计划是否需要被改变，主体是否正在进步，回归或成功正在或已经实现对此进行分析。

34. 发明申请

US20120259651A1 SYSTEMS AND METHODS FOR REMOTE MONITORING, MANAGEMENT AND OPTIMIZATION OF PHYSICAL THERAPY TREATMENT 审中-公开
公开(公告)号：US20120259651A1
公开(公告)日：2012-10-11
申请号：US13082328
申请日：2011-04-07
申请人： Patrick J. Mallon , Andrew E. Senyei
发明人： Patrick J. Mallon , Andrew E. Senyei
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G06F19/3418 , G06F19/3481 , G06Q10/06 , G06Q50/24
摘要： A movement monitoring and management system, comprises a communication interface; a database configured to store treatment information, sensor data, subject information, reporting, and billing information for a plurality of subjects; a server coupled with the database and the communication interface, the server configured to: receive sensor data via the communication interface, the sensor data including data related to certain activities, exercises or movements performed by the subject according to a treatment plan, analyze the sensor data to assess performance with the treatment plan, automatically determine whether the treatment plan is being complied with or not, whether the treatment plan needs to be altered, and whether the subject is progressing, regressing, or a successful outcome is being or has been achieved based on the analysis, and automatically generate and send at least one message to the subject via the communication interface, the message including instructions for the subject related to whether the treatment plan is being performed and complied with or not, whether the treatment plan needs to be altered, and whether the subject is progressing, regressing, or success is being or has been achieved based on the analysis.

35. 发明授权

US06936476B1 Point of care diagnostic systems 有权
公开(公告)号：US06936476B1
公开(公告)日：2005-08-30
申请号：US09717355
申请日：2000-11-20
申请人： Emory V. Anderson , Jerome Lapointe , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Edward Nemec , Andrew E. Senyei , Duane DeSieno
发明人： Emory V. Anderson , Jerome Lapointe , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Edward Nemec , Andrew E. Senyei , Duane DeSieno
IPC分类号： G01N33/53 , G01N21/27 , G01N21/47 , G01N33/558 , G01N33/68 , G06F19/00 , G06Q50/00 , B01N33/543
CPC分类号： G01N21/474 , G01N21/8483 , G01N33/558 , G01N33/6887 , G01N33/689 , G01N2333/78 , G01N2800/368 , G06F19/00 , G06F19/321 , G16H10/40 , G16H10/60 , G16H15/00 , G16H50/20 , Y02A90/26 , Y10S436/811 , Y10S436/814
摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.

36. 发明授权

US06267722B1 Point of care diagnostic systems 失效
标题翻译：护理点诊断系统
公开(公告)号：US06267722B1
公开(公告)日：2001-07-31
申请号：US09017901
申请日：1998-02-03
申请人： Emory V. Anderson , Edward Nemec , Jerome Lapointe , Duane DeSieno , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Andrew E. Senyei
发明人： Emory V. Anderson , Edward Nemec , Jerome Lapointe , Duane DeSieno , Ricardo Martinez , Gail Marzolf , Ronald Pong , Lynn Jones , Robert O. Hussa , Andrew E. Senyei
IPC分类号： A61B500
CPC分类号： G01N21/474 , G01N21/8483 , G06F19/00 , G16H10/60 , G16H15/00 , Y02A90/26 , Y10S436/811 , Y10S436/814
摘要： Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate result is desired. The systems and methods process patient data, particularly data from point of care diagnostic tests or assays, including immunoassays, electrocardiograms, X-rays and other such tests, and provide an indication of a medical condition or risk or absence thereof. The systems include an instrument for reading or evaluating the test data and software for converting the data into diagnostic or risk assessment information.
摘要翻译：提供了用于医疗诊断或患者风险评估的系统和方法。这些系统和方法被设计为在护理点使用，例如在急诊室和手术室中，或在需要快速和准确的结果的任何情况下使用。系统和方法处理患者数据，特别是来自护理诊断测试或测定的数据，包括免疫测定，心电图，X射线和其他此类测试，并提供医疗状况或其风险或不存在的指示。系统包括用于读取或评估测试数据的工具，以及用于将数据转换为诊断或风险评估信息的软件。

37. 发明授权

US5516702A Screening method for identifying women at increased risk for imminent delivery 失效
标题翻译：筛选方法，用于识别即将发生的风险增加的妇女
公开(公告)号：US5516702A
公开(公告)日：1996-05-14
申请号：US268210
申请日：1994-06-29
申请人： Andrew E. Senyei , David C. Casal
发明人： Andrew E. Senyei , David C. Casal
IPC分类号： G01N33/68 , G01N33/53 , G01N33/543
CPC分类号： G01N33/689 , G01N2800/368 , Y10S436/814
摘要： The present invention provides an early, biochemical indication of increased risk of impending preterm delivery. The method comprises obtaining a cervicovaginal secretion sample from a pregnant patient after week 12 of gestation and determining the level of a local inflammatory product protein in the sample. The presence of an elevated level of the selected protein in the sample indicates an increased risk of delivery. The test is a screening assay that can detect women at risk of imminent delivery, as early as two to three weeks prior to delivery.
摘要翻译：本发明提供了即将到来的早产的风险增加的早期生化指示。该方法包括在妊娠第12周后从怀孕患者获得宫颈阴道分泌物样品，并确定样品中局部炎性产物蛋白的水平。在样品中存在升高的所选蛋白质水平表明递送的风险增加。该测试是一种筛选测定法，可以在交付前两至三周检测有即将分娩危险的妇女。

38. 发明授权

US5468619A Screening method for identifying women at increased risk for imminent delivery 失效
标题翻译：筛选方法，用于识别即将发生的风险增加的妇女
公开(公告)号：US5468619A
公开(公告)日：1995-11-21
申请号：US61755
申请日：1993-05-12
申请人： Andrew E. Senyei , David C. Casal
发明人： Andrew E. Senyei , David C. Casal
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/689 , G01N2800/368 , Y10S436/814
摘要： The present invention provides an early, biochemical indication of increased risk of impending delivery. The method is particularly useful to identify those pregnant women who are at increased risk for preterm delivery and can also be used to identify those women at risk for a post-date delivery. The method comprises obtaining a cervicovaginal secretion sample from a pregnant patient after week 12 of gestation and determining the level of total fibronectin in the sample. The presence of an elevated fibronectin level in the sample indicates an increased risk of delivery. The test detects greater than 80% of women who deliver prematurely, as early as two to three weeks prior to delivery.
摘要翻译：本发明提供了即将发生的风险增加的早期生化指示。该方法特别有助于确定那些处于早产风险增加的孕妇，也可用于鉴定那些处于后期分娩风险的妇女。该方法包括在妊娠第12周后从怀孕患者获得宫颈阴道分泌物样品，并确定样品中总纤连蛋白的水平。样品中纤连蛋白水平升高的存在表明递送的风险增加。该测试检测到超过80％的妇女提前过早，早在交付前两到三个星期。

39. 发明授权

US5236846A Ectopic pregnancy test 失效
标题翻译：异位妊娠试验
公开(公告)号：US5236846A
公开(公告)日：1993-08-17
申请号：US732364
申请日：1991-07-18
申请人： Andrew E. Senyei , Nelson N. H. Teng
发明人： Andrew E. Senyei , Nelson N. H. Teng
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2800/368
摘要： A method for determining ectopic pregnancy in pregnant persons comprises obtaining a test sample; and determining the absence of a fetal restricted antigen in the sample. The sample is obtained from the vaginal cavity in the vicinity of the cervical canal or the cervical os. One fetal restricted antigen is fetal fibronectin. In one embodiment of this invention, the sample is contacted with an insoluble support to which anti-(fetal restricted antigen) antibody is adhered, and the fetal restricted antigen binding to the support is determined. Alternatively, a class of substances of which the fetal restricted antigen is a member is captured with a general binding antibody such as an anti-(fibronectin) antibody; an anti-(fetal restricted antigen) antibody such as anti-(fetal fibronectin) antibody is bound to the support; and the absence of binding with fetal restricted antigen is determined. Competition or sandwich assay procedures can be used. Reagents and reagent kits are also included.
摘要翻译：用于确定孕妇异位妊娠的方法包括获得测试样品; 并确定样品中不存在胎儿限制性抗原。样品从宫颈管或宫颈口附近的阴道腔获得。一种胎儿限制性抗原是胎儿纤连蛋白。在本发明的一个实施方案中，将样品与抗（胎儿限制性抗原）抗体所粘附的不溶性载体接触，并确定与载体结合的胎儿限制性抗原。或者，用一般结合抗体如抗（纤连蛋白）抗体捕获一类胎儿限制性抗原成员的物质; 抗（胎儿限制性抗原）抗体如抗（胎儿纤连蛋白）抗体与载体结合; 并确定与胎儿限制性抗原不结合。可以使用竞争或三明治测定程序。还包括试剂和试剂盒。

40. 发明授权

US4357259A Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres 失效
标题翻译：在白蛋白微球中掺入水溶性热敏治疗剂的方法
公开(公告)号：US4357259A
公开(公告)日：1982-11-02
申请号：US859842
申请日：1977-12-12
申请人： Andrew E. Senyei , Kenneth J. Widder
发明人： Andrew E. Senyei , Kenneth J. Widder
IPC分类号： A61K47/42 , A61K9/107 , A61K9/16 , A61K9/50 , A61K9/64 , A61K41/00 , A61K47/02 , A61K49/18 , B01J13/02 , A01N25/28
CPC分类号： B82Y5/00 , A61K41/0052 , A61K49/1821 , A61K49/1869 , A61K49/1887 , A61K9/1641 , A61K9/1658 , A61K9/5094 , G01N2333/765 , G01N2446/20 , G01N2446/30
摘要： A method is provided for incorporating water-soluble therapeutic agents in albumin microspheres. This method is particularly advantageous where the therapeutic agent is heat-sensitive. All steps of the method can be carried out at relatively low temperatures, such as ambient room temperature. The method may be applied to the preparation of intravascularly-administrable, magnetically-responsive microspheres.
摘要翻译：提供了一种在白蛋白微球中掺入水溶性治疗剂的方法。当治疗剂是热敏感时，该方法是特别有利的。该方法的所有步骤可以在相对较低的温度下进行，例如环境室温。该方法可应用于血管内施用的磁反应性微球的制备。

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