专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20050227967A1 Treatment of T-helper cell type 2-mediated immune diseases by retinoid antagonists 审中-公开
标题翻译：类维生素A拮抗剂治疗T-辅助细胞2型介导的免疫疾病
公开(公告)号：US20050227967A1
公开(公告)日：2005-10-13
申请号：US11131062
申请日：2005-05-17
申请人： Werner Bollag , Michael Klaus , Paola Panina-Bordignon , Francesco Sinigaglia
发明人： Werner Bollag , Michael Klaus , Paola Panina-Bordignon , Francesco Sinigaglia
IPC分类号： A61K9/06 , A61K9/08 , A61K9/107 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/72 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/216 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/382 , A61K31/385 , A61K31/407 , A61K31/415 , A61K31/4162 , A61K31/4184 , A61K31/44 , A61K31/4439 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K45/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07C57/42 , C07C57/48 , C07D235/02 , C07D243/38 , C07D311/58 , C07D335/06 , C07D339/02 , C07D401/06 , C07D495/04
CPC分类号： C07C57/42 , A61K31/192 , A61K31/195 , A61K31/352 , A61K31/353 , A61K31/382 , A61K31/385 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/551 , C07C57/48
摘要： Retinoids with retinoid receptor antagonistic activity, pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, have been found efficacious in treating T-helper cell type 2 (Th2)-mediated immune diseases, such as immunoglobulin E (IgE)-mediated allergic diseases.
摘要翻译：已经发现已知有维甲酸受体拮抗活性的类维生素A，其药学上可接受的盐和药学上可接受的可水解的酯在治疗T-辅助细胞2型（Th2）介导的免疫疾病如免疫球蛋白E（IgE）介导的过敏性疾病中是有效的。

32. 发明申请

US20050113447A1 Selective retinoid agonists 审中-公开
标题翻译：选择性维甲酸激动剂
公开(公告)号：US20050113447A1
公开(公告)日：2005-05-26
申请号：US10979355
申请日：2004-11-02
申请人： Paula Belloni , Michael Klaus , Jean-Marc Lapierre
发明人： Paula Belloni , Michael Klaus , Jean-Marc Lapierre
IPC分类号： A61K31/167 , A61K31/19 , A61K31/192 , A61K31/202 , A61K31/215 , A61K31/235 , A61K31/4418 , A61K31/455 , A61P11/00 , A61P17/00 , A61P43/00 , C07C57/26 , C07C61/24 , C07C61/29 , C07C63/64 , C07C63/66 , C07C69/753 , C07C69/757 , C07C69/86 , C07C69/90 , C07C233/63 , C07D213/80 , A61K31/343 , A61K31/195
CPC分类号： C07D213/80 , C07C61/29 , C07C63/66 , C07C69/753 , C07C233/63 , C07C2602/08
摘要： This invention relates to new RAR selective retinoid agonists of formula I wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers or to a racemic or non-racemic mixture; to pharmaceutical compositions containing them, and to methods for their use as therapeutic agents.
摘要翻译：本发明涉及式I的新的RAR选择性类视黄醇激动剂，其中符号如本说明书中对其药学上可接受的盐，单个异构体或外消旋或非外消旋混合物所定义; 含有它们的药物组合物及其用作治疗剂的方法。

33. 发明申请

US20050049238A1 Heterocyclic retinoid compounds 失效
标题翻译：杂环类视黄醇化合物
公开(公告)号：US20050049238A1
公开(公告)日：2005-03-03
申请号：US10960372
申请日：2004-10-07
申请人： Michael Klaus , Jean-Marc Lapierre
发明人： Michael Klaus , Jean-Marc Lapierre
IPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , A61P11/00 , A61P11/06 , A61P11/14 , A61P17/00 , A61P35/00 , C07D215/12 , C07D215/14 , C07D311/58 , C07D335/06 , C07D409/04 , C07D409/12 , A61K31/55
CPC分类号： C07D335/06 , C07D215/12 , C07D311/58 , C07D409/04 , C07D409/12
摘要： The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of these disorders and methods for delivering formulations of these retinoids to a mammal having these disorders.
摘要翻译：本发明提供了新颖的杂环类视黄醇化合物，治疗或预防慢性阻塞性肺疾病，癌症和皮肤疾病的方法，适于治疗或预防这些病症的药物组合物以及将这些类视色素的制剂输送到具有这些疾病的哺乳动物的方法。

34. 发明授权

US06844466B2 Alkyl urea retinoid agonists 失效
标题翻译：烷基脲维甲酸激动剂
公开(公告)号：US06844466B2
公开(公告)日：2005-01-18
申请号：US10245133
申请日：2002-09-17
申请人： Paula Nanette Belloni , Denis John Kertesz , Michael Klaus , Jean-Marc Lapierre
发明人： Paula Nanette Belloni , Denis John Kertesz , Michael Klaus , Jean-Marc Lapierre
IPC分类号： A61K31/192 , A61K31/196 , A61P11/00 , A61P17/00 , A61P35/00 , A61P43/00 , C07C275/12 , C07C275/42 , C07C279/18 , C07C335/22 , C07C241/00
CPC分类号： C07C275/42 , C07C2602/10
摘要： The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.
摘要翻译：本发明提供新的化合物，治疗或预防肺气肿，癌症和皮肤病学的方法，适用于治疗或预防肺气肿，癌症和皮肤病学的药物组合物以及将制剂输送到患有肺气肿，哺乳动物的哺乳动物的肺中的方法和皮肤病。

35. 发明授权

US06326397B1 Retinoid antagonists and use thereof 有权
标题翻译：类视黄醇拮抗剂及其用途
公开(公告)号：US06326397B1
公开(公告)日：2001-12-04
申请号：US09307009
申请日：1999-05-07
申请人： Werner Bollag , Michael Klaus , Peter Mohr , Paola Panina-Bordignon , Michael Rosenberger , Francesco Sinigaglia
发明人： Werner Bollag , Michael Klaus , Peter Mohr , Paola Panina-Bordignon , Michael Rosenberger , Francesco Sinigaglia
IPC分类号： A01N5300
CPC分类号： C07C57/48 , C07C57/42
摘要： The present invention relates to novel retinoid antagonists of the formula I wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a double bond, R1 is lower alkyl and R2 is hydrogen; and, when the dotted bond is hydrogenated, R1 and R2 taken together are methylene to form a cis-substituted cyclopropyl ring; R3 is hydroxy or lower alkoxy; R4 is alkyl or alkoxy; and R5 and R6 are, independently, a C4-12 alkyl or a 5-12 cycloalkyl substituent containing from 1-3 rings which are either unsubstituted or substituted with from 1-3 lower alkyl groups, with the carbon atom of R5 and R6 being linked to the remainder of the molecule to form a quaternary carbon atom pharmaceutically acceptable salts of carbocylic acids of the formula I; as well as method for the treatment of osteoporosis and preneoplastic and neoplastic diseases, and a method for reducing or abolishing adverse events in subjects receiving retinoid agonist treatment by administering a retinoid antagonist.
摘要翻译：本发明涉及式I的新型类视黄醇拮抗剂，其中虚线键可以被氢化或形成双键; 并且当虚线键形成双键时，R 1为低级烷基且R 2为氢; 并且当点键被氢化时，R 1和R 2一起为亚甲基以形成顺式取代的环丙基环; R3是羟基或低级烷氧基; R4是烷基或烷氧基; 并且R 5和R 6独立地是C 1-4烷基或含有1-3个环的5-12个环烷基取代基，它们是未取代的或被1-3个低级烷基取代，R5和R6的碳原子是与分子的其余部分连接以形成式I的碳酸的药学上可接受的盐的季碳原子; 以及用于治疗骨质疏松症和肿瘤前和肿瘤性疾病的方法，以及通过施用类视黄醇拮抗剂减少或消除接受类视黄醇激动剂治疗的受试者的不良事件的方法。

36. 发明授权

US5986131A RXR selective ligands 失效
标题翻译： RXR选择配体
公开(公告)号：US5986131A
公开(公告)日：1999-11-16
申请号：US953361
申请日：1997-10-17
申请人： Michael Klaus , Allen John Lovey , Peter Mohr , Michael Rosenberger
发明人： Michael Klaus , Allen John Lovey , Peter Mohr , Michael Rosenberger
IPC分类号： A61K31/07 , A61K31/16 , A61K31/20 , A61K31/23 , A61K31/38 , A61K31/381 , A61P3/02 , A61P17/10 , A61P35/00 , A61P35/02 , C07C47/45 , C07C47/548 , C07C59/64 , C07C61/16 , C07C63/00 , C07C403/20 , C07D211/70 , C07D333/24
CPC分类号： C07D333/24 , C07C403/14 , C07C403/20 , C07C47/45 , C07C47/548 , C07B2200/09 , C07C2101/16
摘要： Novel nonatetraenoic acid derivatives which selectively bind to retinoic acid X-receptors (RXR) and which have anti-acne acitvity and which potentiate the activity of retinoids having RAR.alpha. activity are disclosed.
摘要翻译：公开了选择性结合视黄酸X受体（RXR）并具有抗痤疮活性并且增强具有RARα活性的类视黄醇活性的新型非四烯酸衍生物。

37. 发明授权

US5512683A Alkyl or alkoxy substituted S-heterocyclic retinoids 失效
标题翻译：烷基或烷氧基取代的S-杂环类视黄醇
公开(公告)号：US5512683A
公开(公告)日：1996-04-30
申请号：US324836
申请日：1994-10-18
申请人： Michael Klaus , Peter Mohr
发明人： Michael Klaus , Peter Mohr
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61P17/00 , A61P37/06 , C07D333/54 , C07D335/06 , C07D337/08 , C07D337/04
CPC分类号： C07D333/54 , C07D335/06 , C07D337/08
摘要： Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.
摘要翻译：其中X是-S-，-SO-或-SO 2 - 的式I的化合物; R1是C7-10-烷基或C7-10-烷氧基; R 2是下式的残基：R 3是羧基或低级烷氧基羰基; n为1,2或3的整数; 式I的羧酸盐可用于治疗具有强免疫组分的自身免疫性疾病和疾病，例如牛皮癣。

38. 发明授权

US06828337B2 Selective retinoid agonists 失效
标题翻译：选择性维甲酸激动剂
公开(公告)号：US06828337B2
公开(公告)日：2004-12-07
申请号：US10323306
申请日：2002-12-19
申请人： Paula Nanette Belloni , Michael Klaus , Jean-Marc Lapierre
发明人： Paula Nanette Belloni , Michael Klaus , Jean-Marc Lapierre
IPC分类号： A61K3144
CPC分类号： C07D213/80 , C07C61/29 , C07C63/66 , C07C69/753 , C07C233/63 , C07C2602/08
摘要： This invention relates to new RAR selective retinoid agonists of formula I wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers or to a racemic or non-racemic mixture; to pharmaceutical compositions containing them, and to methods for their use as therapeutic agents.
摘要翻译：本发明涉及式I的新的RAR选择性类视黄醇激动剂，其符号如本说明书中对其药学上可接受的盐，单个异构体或外消旋或非外消旋混合物所定义; 含有它们的药物组合物及其用作治疗剂的方法。

39. 发明授权

US6133309A Treatment of T-helper cell type 2-mediated immune disease by retinoid antagonists 有权
标题翻译：类维生素A拮抗剂治疗T-辅助细胞2型介导的免疫疾病
公开(公告)号：US6133309A
公开(公告)日：2000-10-17
申请号：US189189
申请日：1998-11-10
申请人： Werner Bollag , Michael Klaus , Paola Panina-Bordignon , Francesco Sinigaglia
发明人： Werner Bollag , Michael Klaus , Paola Panina-Bordignon , Francesco Sinigaglia
IPC分类号： A61K9/06 , A61K9/08 , A61K9/107 , A61K9/12 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/72 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/20 , A61K31/201 , A61K31/202 , A61K31/216 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/382 , A61K31/385 , A61K31/407 , A61K31/415 , A61K31/4162 , A61K31/4184 , A61K31/44 , A61K31/4439 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K45/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07C57/42 , C07C57/48 , C07D235/02 , C07D243/38 , C07D311/58 , C07D335/06 , C07D339/02 , C07D401/06 , C07D495/04
CPC分类号： C07C57/42 , A61K31/192 , A61K31/195 , A61K31/352 , A61K31/353 , A61K31/382 , A61K31/385 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/551 , C07C57/48
摘要： Retinoids with retinoid receptor antagonistic activity, pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, have been found efficacious in treating T-helper cell type 2 (Th2)-mediated immune diseases, such as immunoglobulin E (IgE)-mediated allergic diseases.
摘要翻译：已经发现已知有维甲酸受体拮抗活性的类维生素A，其药学上可接受的盐和药学上可接受的可水解的酯在治疗T-辅助细胞2型（Th2）介导的免疫疾病如免疫球蛋白E（IgE）介导的过敏性疾病中是有效的。

40. 发明授权

US5990329A Retinoids 失效
标题翻译：维甲酸
公开(公告)号：US5990329A
公开(公告)日：1999-11-23
申请号：US832493
申请日：1997-04-03
申请人： Michael Klaus , Peter Mohr
发明人： Michael Klaus , Peter Mohr
IPC分类号： A61K31/07 , A61K20060101 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/23 , A61K31/35 , A61P3/02 , A61P17/00 , A61P29/00 , A61P35/00 , C07C20060101 , C07C57/30 , C07C57/34 , C07C59/147 , C07C59/40 , C07C59/46 , C07C59/62 , C07C59/76 , C07C59/82 , C07C69/013 , C07C69/587 , C07C69/602 , C07C69/73 , C07C69/732 , C07C403/20 , C07D309/00
CPC分类号： C07C403/20 , C07B2200/09 , C07C2101/16
摘要： Compounds of the formula: ##STR1## wherein R.sup.2 and X are as described, are disclosed. The compounds are useful for treating dermatological disorders which are accompanied by epithelial lesions, e.g., acne and psoriasis, as well as malignant and premalignant epithelial lesions, tumours and precancerous changes of the mucous membrane in the mouth, tongue, larynx, oesophagus, bladder, cervix and colon.
摘要翻译：公开了下式的化合物：其中R2和X如上所述。这些化合物可用于治疗伴有上皮病变（例如痤疮和牛皮癣）的皮肤病，以及恶性和恶化前上皮病变，口腔，舌头，喉，食道，膀胱中的粘膜的肿瘤和癌前变化，子宫颈和结肠。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式