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31. 发明授权

US06472220B1 Method of using cassette of lancet cartridges for sampling blood 有权
标题翻译：使用刺血针盒式磁带取样血液的方法
公开(公告)号：US06472220B1
公开(公告)日：2002-10-29
申请号：US09417276
申请日：1999-10-13
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： G01N3349
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/15113 , A61B5/15153 , A61B5/15159 , A61B5/15165 , A61B5/15174 , A61B2562/0295 , Y10S436/808
摘要： A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.
摘要翻译：包含用于从患者取血的药筒的药盒。盒式磁带包括用于存储多个盒的容器和容器中的至少一个盒。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动柳叶刀将尖端延伸到药筒壳体外部，以便撕裂患者的皮肤以产生血液。容器具有包含至少一个盒的隔间。来自隔室的药筒可以被装载到驱动药筒中的刺血针的血糖仪上以刺激患者的皮肤。

32. 发明授权

US06276196B1 Thermometric vapor sensor with evaporation surface having micropores 有权
公开(公告)号：US06276196B1
公开(公告)日：2001-08-21
申请号：US09733511
申请日：2000-12-07
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N700
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.

33. 发明授权

US06231531B1 Apparatus and method for minimizing pain perception 有权
标题翻译：用于最小化疼痛感知的装置和方法
公开(公告)号：US06231531B1
公开(公告)日：2001-05-15
申请号：US09289884
申请日：1999-04-09
申请人： Paul Lum , Michael Greenstein , Edward Dennis Verdonk , Tad Decatur Simons , Dominique Freeman , Ganapati Ramnath Mauze , David King , Jerry Zawadzki
发明人： Paul Lum , Michael Greenstein , Edward Dennis Verdonk , Tad Decatur Simons , Dominique Freeman , Ganapati Ramnath Mauze , David King , Jerry Zawadzki
IPC分类号： A61H100
CPC分类号： A61H23/0263 , A61B5/150022 , A61B5/150076 , A61B5/150137 , A61B5/150435 , A61B5/15087 , A61B5/150893 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61H23/0218 , A61H2201/105 , A61M5/422
摘要： An apparatus and method for minimizing a subject's pain perception during an invasive medical procedure, such as blood sampling and the like. The apparatus can include a receiving surface constructed to contact a portion of the subject's skin and a vibratory mechanism associated with the receiving surface such that the vibratory mechanism transmits vibrations through the receiving surface and to the subject's skin. An invasive sharp can be substantially permanently supported and moveably disposed with respect to the receiving surface such that the invasive sharp reciprocates between a first position in which the sharp is spaced from the receiving surface, away from the subject's skin, and a second position in which at least a portion of the sharp protrudes through an opening in the receiving surface.
摘要翻译：一种用于在侵入性医疗过程（例如血液取样等）期间使受试者的疼痛感觉最小化的装置和方法。该装置可以包括构造成接触受试者皮肤的一部分的接收表面和与接收表面相关联的振动机构，使得振动机构通过接收表面和对象的皮肤传递振动。侵入性锋利物可以基本上永久地支撑并相对于接收表面可移动地设置，使得侵入性尖锐物在第一位置与第二位置之间往复运动，在第一位置中，尖锐部与受体表面间隔开远离被检者的皮肤，第二位置锋利的至少一部分突出穿过接收表面中的开口。

34. 发明授权

US06202480B1 Thermometric vapor sensor with evaporation surface having micropores 失效
标题翻译：具有蒸发表面的微孔蒸气传感器具有微孔
公开(公告)号：US06202480B1
公开(公告)日：2001-03-20
申请号：US09054852
申请日：1998-04-02
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N2562
CPC分类号： G01N25/64
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.
摘要翻译：一种传感器，用于在气流中检测液体的蒸汽。该传感器包括微孔和湿温度传感器。微孔具有蒸发端，并且具有内腔以在蒸发端从用于蒸发的液体供应源输送液体。湿式温度传感器具有与微孔中的液体接触的热敏部分。热敏部分围绕微孔并形成管腔的一部分。将潮湿的温度传感器用液体湿润时液体的蒸发导致的热损失被放置在气流中将导致由湿式温度传感器感测到的温度低于气流的非蒸发温度。可以测量这种温度降低以确定气流中的蒸气的浓度。这种传感器的示例具有热电偶结，其具有穿过热电偶结的微孔。

35. 发明授权

US6071294A Lancet cartridge for sampling blood 失效
标题翻译：柳叶刀筒用于取样血液
公开(公告)号：US6071294A
公开(公告)日：2000-06-06
申请号：US985384
申请日：1997-12-04
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/150022 , A61B5/15019 , A61B5/150297 , A61B5/150358 , A61B5/150412 , A61B5/15109 , A61B5/15117 , A61B5/15194 , A61B5/157 , A61B2562/0295 , A61B5/0002
摘要： A cartridge for sampling and analyzing blood from the skin of a patient. The cartridge has a cartridge case, a lancet, and associated with the cartridge case an analytical region for analyzing the property of blood. The lancet has a tip for lancing the skin and is housed in the cartridge case. The lancet is operatively connected to the cartridge case such that the lancet can be pushed to extend its tip outside the cartridge case for lancing the skin to yield blood. The blood from the lancing wound is transferred to the analytical region and be analyzed.
摘要翻译：用于从患者皮肤取样和分析血液的药筒。药筒具有药筒壳体，刺血针，并且与药筒壳体相关联，用于分析血液的性质的分析区域。刺血针具有用于穿刺皮肤的尖端，并且被容纳在盒壳中。柳叶刀可操作地连接到药筒壳体，使得刺血针可以被推动以将其尖端延伸到药筒壳体外部，以刺穿皮肤以产生血液。将穿刺伤口的血液转移到分析区域并进行分析。

36. 发明授权

US5971941A Integrated system and method for sampling blood and analysis 失效
标题翻译：用于血液采样和分析的综合系统和方法
公开(公告)号：US5971941A
公开(公告)日：1999-10-26
申请号：US985307
申请日：1997-12-04
申请人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/15019 , A61B5/150412 , A61B5/150748 , A61B5/15109 , A61B5/15117 , A61B5/15153 , A61B5/15174 , A61B5/15194 , A61B5/157 , A61B2562/0295
摘要： A blood sampling apparatus for sampling blood from the skin of a patient for analysis. The apparatus includes a cartridge and a housing with a driver. The cartridge has a cartridge case, lancet, and a compartment associated with the cartridge case for receiving blood. The lancet is housed in the cartridge case and operatively connected thereto such that it is drivable to extend outside the cartridge case through a lancing opening for lancing the skin to yield blood. The housing has a driver for urging the lancet to extend outside the cartridge case. During lancing, the cartridge is preferably detachably held in the housing such that the cartridge can be disassociated from the driver after sampling blood.
摘要翻译：一种用于从患者皮肤取血的血液取样装置，用于分析。该装置包括一个盒和一个带有驱动器的壳体。药筒具有药筒外壳，刺血针和与药筒外壳相关联的用于接收血液的隔室。刺血针容纳在药筒壳体中并且可操作地连接到其上，使得其可驱动以通过穿刺开口延伸到药筒外部，用于刺穿皮肤以产生血液。壳体具有用于推动刺血针延伸到盒壳体外部的驱动器。在穿刺期间，药筒优选地可拆卸地保持在壳体中，使得在取样血液之后，药筒可以与驾驶员分离。

37. 发明授权

US5510251A Agents and method of production thereof 失效
公开(公告)号：US5510251A
公开(公告)日：1996-04-23
申请号：US318001
申请日：1994-10-04
申请人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
发明人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
IPC分类号： A01N63/02 , C07H19/01 , C12P1/06 , C12P17/18 , C12N1/20
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/88 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LLF28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.

38. 发明授权

US5509418A Ultrasound diagnostic probe having acoustically driven turbin 失效
标题翻译：超音波诊断探头具有声驱动的涡卷
公开(公告)号：US5509418A
公开(公告)日：1996-04-23
申请号：US373682
申请日：1995-01-17
申请人： Paul Lum , Michael Greenstein , Edward Verdonk
发明人： Paul Lum , Michael Greenstein , Edward Verdonk
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： A catheter apparatus for obtaining an image of internal surface characteristics of a vascular vessel is provided. The catheter apparatus comprises an tubular element adapted for insertion into the vascular vessel, a non-rotating acoustic waveguide disposed within the tubular element and coupled to a source of an ultrasonic signal located external to the vascular vessel, and an acoustically driven turbine. The turbine is responsive to the ultrasonic signal for directing the ultrasonic signal in a rotating pattern from a distal end of the acoustic waveguide through the tubular element at an angle relative to an axis of the vascular vessel. The ultrasonic signal includes a low frequency ultrasonic signal and a high frequency ultrasonic signal. The low frequency ultrasonic signal drives the acoustically driven turbine to direct the high frequency ultrasonic signal in the rotating pattern. The acoustically driven turbine comprises a plurality of turbine blades, and either an acoustic reflecting surface or an acoustic refracting lens. At least one transducer disposed external to the vascular vessel provides the source of the high and the low frequency ultrasonic signals. The tubular element may further be provided with a lumen for carrying a guidewire.
摘要翻译：提供一种用于获得血管容器的内表面特征的图像的导管装置。导管装置包括适于插入血管容器的管状元件，设置在管状元件内并连接到位于血管容器外部的超声信号源的非旋转声波导，以及声驱动涡轮。涡轮机响应于超声波信号，以相对于血管容器轴线成一定角度的方式将超声波信号从声波导管的远端引导通过管状元件。超声波信号包括低频超声信号和高频超声波信号。低频超声波信号驱动声驱动涡轮以引导旋转图案中的高频超声波信号。声驱动涡轮机包括多个涡轮叶片，以及声反射表面或声折射透镜。设置在血管容器外部的至少一个换能器提供高频和低频超声波信号的源。管状元件还可以设置有用于承载导丝的内腔。

39. 发明授权

US5375600A Ultrasonic frequency-domain system and method for sensing fluid flow 失效
标题翻译：超声频域系统和感应流体流的方法
公开(公告)号：US5375600A
公开(公告)日：1994-12-27
申请号：US104309
申请日：1993-08-09
申请人： Hewlett E. Melton, Jr. , King-Wah W. Yeung , Michael Greenstein
发明人： Hewlett E. Melton, Jr. , King-Wah W. Yeung , Michael Greenstein
IPC分类号： A61B8/06 , G01P5/00 , G01P13/00 , G01S15/58
CPC分类号： G01S15/8984 , A61B8/06 , A61B8/488 , G01S15/582
摘要： Pulses of ultrasound are focused in the patient's body to create an interrogation volume where a characteristic of blood flow is to be measured. The bandwidth of the back-scattered Doppler return signal is measured. In order to measure flow velocity independent of direction, the interrogation volume is generated substantially as a sphere in which the range dimension is set equal to the lateral dimensions (azimuth and elevation) of the interrogation signal. The Doppler bandwidth is then scaled to provide a direction-independent measurement of flow velocity. In order to determine the direction of flow, the interrogation volume is generated substantially as an ellipsoid. The long axis of the ellipsoidal interrogation volume is then rotated until the measured Doppler bandwidth is at a minimum, which is reached when the long axis is aligned with the flow direction. The interrogation volume is preferably rotated and translated using differential phasing of the ultrasonic signals from different transducer elements in a two-dimensional array.
摘要翻译：超声波的脉冲聚焦在患者的身体中以产生要测量血流特征的询问体积。测量背散射多普勒返回信号的带宽。为了独立于方向测量流速，询问体积基本上产生为范围尺寸设置为等于询问信号的横向尺寸（方位角和仰角）的球体。然后缩放多普勒带宽以提供流速独立的方向测量。为了确定流动的方向，询问体积基本上产生为椭圆体。然后旋转椭圆询问体积的长轴直到测量的多普勒带宽处于最小值，当长轴与流动方向对准时达到最小。询问体积优选地以二维阵列使用来自不同换能器元件的超声波信号的微分相位来旋转和平移。

40. 发明授权

US5329498A Signal conditioning and interconnection for an acoustic transducer 失效
标题翻译：声换能器的信号调理和互连
公开(公告)号：US5329498A
公开(公告)日：1994-07-12
申请号：US62665
申请日：1993-05-17
申请人： Michael Greenstein
发明人： Michael Greenstein
IPC分类号： A61B8/00 , B06B1/06 , H01L41/08 , H04R3/00 , H04R17/00
CPC分类号： B06B1/0629
摘要： An ultrasonic device having an acoustic transducer with a lamination of parallel integrated circuit chips having active circuitry. A backing member made of a material for attenuating acoustic waves provides Z-axis conduction of signals from the parallel integrated circuit chips to individual piezoelectric elements. Preferably, each piezoelectric element is operatively associated with a particular circuit that is within the acoustic shadow of the element, so that the lamination of chips does not add to the cross sectional area of the transducer. The integrated circuit chips are coterminus at first edges to provide a planar contact surface having a pad grid array of contact pads for connection with conductors extending through the backing member. In one embodiment, the piezoelectric elements provide a two-dimensional array of elements that corresponds to the pad grid array. Circuitry on the integrated circuit chips can include protective diodes, preamplifiers and one or more multiplexers.
摘要翻译：一种具有声学换能器的超声波装置，其具有具有有源电路的并联集成电路芯片的叠层。由用于衰减声波的材料制成的背衬构件将来自并联集成电路芯片的信号的Z轴导通到各个压电元件。优选地，每个压电元件与位于元件的声阴内的特定电路可操作地相关联，使得芯片的层叠不会增加换能器的横截面积。集成电路芯片在第一边缘处是邻接的，以提供具有用于与延伸穿过背衬构件的导体连接的接触垫的焊盘格栅阵列的平面接触表面。在一个实施例中，压电元件提供对应于焊盘格栅阵列的元件的二维阵列。集成电路芯片上的电路可以包括保护二极管，前置放大器和一个或多个多路复用器。

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