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31. 发明授权

US06723743B1 High affinity small molecule C5a receptor modulators 失效
标题翻译：高亲和力小分子C5a受体调节剂
公开(公告)号：US06723743B1
公开(公告)日：2004-04-20
申请号：US09672071
申请日：2000-09-28
申请人： Andrew Thurkauf , Xiao-shu He , He Zhao , John Peterson , Xiaoyan Zhang , Robbin Brodbeck , James Krause , George Maynard , Alan Hutchison
发明人： Andrew Thurkauf , Xiao-shu He , He Zhao , John Peterson , Xiaoyan Zhang , Robbin Brodbeck , James Krause , George Maynard , Alan Hutchison
IPC分类号： A61K31415
CPC分类号： C07D207/327 , C07C233/11 , C07C233/22 , C07C233/65 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/46 , C07C235/48 , C07C235/54 , C07C235/60 , C07C235/62 , C07C235/66 , C07C237/20 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D213/38 , C07D213/82 , C07D215/12 , C07D217/04 , C07D217/06 , C07D217/14 , C07D217/16 , C07D231/12 , C07D233/64 , C07D233/68 , C07D235/02 , C07D235/14 , C07D235/18 , C07D317/58 , C07D333/24 , C07D333/28 , C07D333/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04
摘要： This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as antagonists or inverse agonists of complement C5a receptors, preferably human C5a receptors, Preferred compounds of the invention possess one or more, and preferably two or more, three or more, four or more, or all of the following properties in that they are; 1) multi-aryl in structure (having a plurality of un-fused or fused aryl groups), 2) heteroaryl in structure, 3) orally available in vivo (such that a sub-lethal or preferably a pharmaceutically acceptable oral dose can provide a detectable in vitro effect such as a reduction of C5a-induced neutropenia), 4) comprised of fewer than four, preferably fewer than three, or fewer than two, or no amide bonds, and 5) capable of inhibiting leukocyte chemotaxis at nanomolar concentrations and preferably at sub-nanomolar concentrations. Specifically exemplified representative compounds include, but are not limited to optionally substituted arylimidazoles, optionally substituted arylpyridyls, optionally substituted aryl-substituted cycloalkylimidazoles, optionally substituted arylpyrazoles, optionally substituted benzimidazoles, optionally substituted aryl-substituted tetrahydroisoquinolines, and optionally substituted biaryl carboxamides. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders. Additionally, this invention relates to the use such compounds as probes for the localization of C5a receptors.
摘要翻译：本发明涉及作为哺乳动物补体C5a受体调节剂的低分子量，非肽，非拟肽，有机分子，优选用作高亲和力C5a受体配体的调节剂，还涉及作为拮抗剂或反向激动剂的这些配体的补体C5a受体，优选人C5a受体。本发明的优选化合物具有一个或多个，优选两个或更多个，三个或更多个，四个或更多个或全部以下性质： 1）结构上的多芳基（具有多个未稠合或稠合芳基），2）结构上的杂芳基，3）在体内可口服（使得亚致死或优选药学上可接受的口服剂量可提供可检测的体外效应，例如C5a诱导的中性粒细胞减少的减少），4）由少于4个，优选少于3个，或少于2个或不存在的酰胺键组成，以及5）能够以纳摩尔浓度抑制白细胞趋化性，优选亚纳摩尔浓度。具体示例的代表性化合物包括但不限于任选取代的芳基咪唑，任选取代的芳基吡啶基，任选取代的芳基取代的环烷基咪唑，任选取代的芳基吡唑，任选取代的苯并咪唑，任选取代的芳基取代的四氢异喹啉和任选取代的双芳基甲酰胺。本发明还涉及包含这些化合物的药物组合物。它还涉及这些化合物在治疗各种炎性和免疫系统疾病中的应用。此外，本发明涉及使用这些化合物作为C5a受体定位的探针。

32. 发明授权

US06482844B1 1-benzylimidazole derivatives 失效
标题翻译： 1-苄基咪唑衍生物
公开(公告)号：US06482844B1
公开(公告)日：2002-11-19
申请号：US09827565
申请日：2001-04-06
申请人： Xiao-Shu He , Xiaoyan Zhang , He Zhao , Robert DeSimone , Andrew Thurkauf
发明人： Xiao-Shu He , Xiaoyan Zhang , He Zhao , Robert DeSimone , Andrew Thurkauf
IPC分类号： A61K31415
CPC分类号： C07D233/64
摘要： Provided are compounds (and pharmaceutically acceptable non-toxic salt of such compounds) of the formula: in which A and B are C1-C3 alkylene; R1 is C1-C6 alkyl; R2 and R3 are hydrogen or C1-C6 alkyl; U and V are C1-C6 alkyl or halogen; X, Y and Z are hydrogen, C1-C6 alkyl, trifluoromethyl, C1-C6 alkoxy, trifluoromethoxy, halogen, or cyano; and W represents up to three substituents which are C1-C6 alkyl, trifluoromethyl, C1-C6 alkoxy, trifluoromethoxy, halogen, hydroxy, amino, or cyano. These compounds act as modulators of blood glucose levels and are useful for the treatment of diabetes, eating disorders, and obesity. Pharmaceutical compositions and methods of use of the compounds as pharmaceutical agents are also provided.
摘要翻译：本发明提供下式的化合物（和这些化合物的药学上可接受的无毒盐）：其中A和B是C1-C3亚烷基; R1是C1-C6烷基; R2和R3是氢或C1-C6烷基; U和V是C 1 -C 6烷基或卤素; X，Y和Z是氢，C 1 -C 6烷基，三氟甲基，C 1 -C 6烷氧基，三氟甲氧基，卤素或氰基; W代表最多三个取代基，它们是C1-C6烷基，三氟甲基，C1-C6烷氧基，三氟甲氧基，卤素，羟基，氨基或氰基。这些化合物作为血糖水平的调节剂，可用于治疗糖尿病，进食障碍和肥胖症。还提供了药物组合物和化合物作为药剂的使用方法。

33. 发明授权

US06294530B1 1-azatricyclic-4-benzylpiperazines 失效
标题翻译： 1-氮杂环己基-4-苄基哌嗪
公开(公告)号：US06294530B1
公开(公告)日：2001-09-25
申请号：US09596020
申请日：2000-06-14
申请人： Xiaoyan Zhang , Kevin Hodgetts , Stanislaw Rachwal , Daniel Rosewater , Andrew Thurkauf
发明人： Xiaoyan Zhang , Kevin Hodgetts , Stanislaw Rachwal , Daniel Rosewater , Andrew Thurkauf
IPC分类号： C07D48704
CPC分类号： C07D471/06 , C07D487/06 , G01N33/6896 , G01N33/9413 , G01N2333/70571 , G01N2800/2835
摘要： Disclosed are 1-Azatricyclic-4-benzylpiperazine compounds which are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.
摘要翻译：公开了可用于治疗和/或预防神经心理障碍的1-叠氮基-4-苄基哌嗪化合物，包括但不限于精神分裂症，躁狂症，痴呆，抑郁症，焦虑症，强迫行为，药物滥用，帕金森氏样运动与使用神经安定药相关的疾病和运动障碍。还提供药物组合物，包括包装的药物组合物。本发明的化合物也可用作组织样品中GABA A受体定位的探针。

34. 外观设计

USD991555S1 False eyelash 有权
公开(公告)号：USD991555S1
公开(公告)日：2023-07-04
申请号：US29843515
申请日：2022-06-22
申请人： Xiaoyan Zhang
设计人： Xiaoyan Zhang
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
FIG. 1 is a front elevation view of a false eyelash showing my new design;
FIG. 2 is a rear elevation view thereof;
FIG. 3 is a left side elevation view thereof;
FIG. 4 is a right side elevation view thereof;
FIG. 5 is a top plan view thereof; and,
FIG. 6 is a bottom plan view thereof.

35. 发明申请

US20150080362A1 ANTIBACTERIAL COMPOUNDS AND METHODS FOR USE 有权
公开(公告)号：US20150080362A1
公开(公告)日：2015-03-19
申请号：US14241372
申请日：2012-08-29
申请人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
发明人： Arthur Branstrom , Vara Prasad Venkata Nagendra Josyula , Michael Andrew Arnold , Aleksey I. Gerasyuto , Gary Karp , Jiashi Wang , Tamil Arasu , John David Baird , Wu Du , Olya Ginzburg , Yi Jin Kim Gorske , Jana Narasimhan , Srinivasa Peddi , Hongyan Qi , Sean Wesley Smith , Anthony Allan Turpoff , Richard Gerald Wilde , Tianle Yang , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D515/04 , A61K31/4412 , C07D401/10 , A61K45/06 , A61K31/5377 , A61K31/4439 , C07D487/08 , A61K31/5383 , C07D213/80 , A61K31/4427
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

36. 发明授权

US08340283B2 Method and system for a PKI-based delegation process 失效
标题翻译：基于PKI的委托过程的方法和系统
公开(公告)号：US08340283B2
公开(公告)日：2012-12-25
申请号：US10881978
申请日：2004-06-30
申请人： Anthony Joseph Nadalin , Bruce Arland Rich , Xiaoyan Zhang
发明人： Anthony Joseph Nadalin , Bruce Arland Rich , Xiaoyan Zhang
IPC分类号： H04L29/06
CPC分类号： H04L63/02 , H04L9/006 , H04L9/0825 , H04L9/3213 , H04L9/3247 , H04L9/3268 , H04L63/0807 , H04L63/0823 , H04L2209/76 , H04L2463/062
摘要： A client generates a session key and a delegation ticket containing information for a requested delegation operation. The client generates a first copy of the session key and encrypts it using a public key of a proxy. The client generates a second copy of the session key and encrypts it using a public key of a server. The client then puts the encrypted session keys and delegation ticket into a first message that is sent to the proxy. The proxy extracts and decrypts its copy of the session key from the first message. The proxy then encrypts a proof-of-delegation data item with the session key and places it and the delegation ticket along with the encrypted copy of the session key for the server into a second message, which is sent to the server. The server extracts and decrypts its copy of the session key from the second message and uses the session key to obtain the proof-of-delegation data. Authority is successfully delegated to the proxy only if the server can verify the proof-of-delegation data.
摘要翻译：客户端生成会话密钥和包含所请求的委派操作的信息的委托票证。客户端生成会话密钥的第一个副本，并使用代理的公钥对其进行加密。客户端生成会话密钥的第二个副本，并使用服务器的公钥对其进行加密。然后，客户端将加密的会话密钥和委派票证放入发送到代理的第一条消息中。代理从第一条消息中提取并解密会话密钥的副本。然后，代理使用会话密钥对代理证件数据项进行加密，并将其和委托凭证以及服务器的会话密钥的加密副本一起放入发送到服务器的第二个消息中。服务器从第二个消息中提取和解密其会话密钥的副本，并使用会话密钥获取授权证明数据。只有当服务器可以验证授权证明数据时，才将成功委托给代理。

37. 发明授权

US07772271B2 Methods for treating hepatitis C 有权
公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

38. 发明申请

US20080244094A1 Method and Apparatus for Time Synchronization in a Network Data Processing System 有权
标题翻译：网络数据处理系统中时间同步的方法与装置
公开(公告)号：US20080244094A1
公开(公告)日：2008-10-02
申请号：US12129490
申请日：2008-05-29
申请人： Bruce Arland Rich , Xiaoyan Zhang
发明人： Bruce Arland Rich , Xiaoyan Zhang
IPC分类号： G06F15/177
CPC分类号： H04L9/3297 , H04J3/0667 , H04L9/083 , H04L9/12
摘要： A method, apparatus, and computer implemented instructions for synchronizing time in a network data processing system. A request for time synchronization is received at a target data processing system. A current target time at the target data processing system is placed in a reply. The reply is sent to the source data processing system. A current source time from when the reply is received at the source data processing system is compared to the current target time to generate a comparison. A synchronization factor is generated using the comparison.
摘要翻译：一种用于在网络数据处理系统中同步时间的方法，装置和计算机实现的指令。在目标数据处理系统处接收到时间同步请求。在目标数据处理系统中的当前目标时间被放置在回复中。答复发送到源数据处理系统。从源数据处理系统接收到应答的当前源时间与当前目标时间进行比较以生成比较。使用比较生成同步因子。

39. 发明申请

US20050210306A1 Method and apparatus for time synchronization in a network data processing system 审中-公开
公开(公告)号：US20050210306A1
公开(公告)日：2005-09-22
申请号：US11134639
申请日：2005-05-20
申请人： Bruce Rich , Xiaoyan Zhang
发明人： Bruce Rich , Xiaoyan Zhang
IPC分类号： H04J3/06 , H04L9/32 , G06F1/12 , G06F13/42 , H04L5/00 , H04L7/00
CPC分类号： H04L9/3297 , H04J3/0667 , H04L9/083 , H04L9/12
摘要： A method, apparatus, and computer implemented instructions for synchronizing time in a network data processing system. A request for time synchronization is received at a target data processing system. A current target time at the target data processing system is placed in a reply. The reply is sent to the source data processing system. A current source time from when the reply is received at the source data processing system is compared to the current target time to generate a comparison. A synchronization factor is generated using the comparison.

40. 发明申请

US20050210153A1 Method and apparatus for time synchronization in a network data processing system 审中-公开
标题翻译：网络数据处理系统中时间同步的方法和装置
公开(公告)号：US20050210153A1
公开(公告)日：2005-09-22
申请号：US11134707
申请日：2005-05-20
申请人： Bruce Rich , Xiaoyan Zhang
发明人： Bruce Rich , Xiaoyan Zhang
IPC分类号： H04J3/06 , H04L9/32 , H04L9/00
CPC分类号： H04L9/3297 , H04J3/0667 , H04L9/083 , H04L9/12
摘要： A method, apparatus, and computer implemented instructions for synchronizing time in a network data processing system. A request for time synchronization is received at a target data processing system. A current target time at the target data processing system is placed in a reply. The reply is sent to the source data processing system. A current source time from when the reply is received at the source data processing system is compared to the current target time to generate a comparison. A synchronization factor is generated using the comparison.
摘要翻译：一种用于在网络数据处理系统中同步时间的方法，装置和计算机实现的指令。在目标数据处理系统处接收到时间同步请求。在目标数据处理系统中的当前目标时间被放置在回复中。答复发送到源数据处理系统。从源数据处理系统接收到应答的当前源时间与当前目标时间进行比较以生成比较。使用比较生成同步因子。

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