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31. 发明授权

US09668668B2 Electrogram summary 有权
公开(公告)号：US09668668B2
公开(公告)日：2017-06-06
申请号：US13250515
申请日：2011-09-30
申请人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
发明人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
IPC分类号： A61B5/04 , A61B5/044 , A61B5/046 , A61B5/0464 , A61B5/00
CPC分类号： A61B5/044 , A61B5/046 , A61B5/0464 , A61B5/7217
摘要： The present disclosure is directed to an electrogram summary. In various examples, a subset of cardiac episodes are selected and displayed based on a set of summary rules. The subset of cardiac episodes includes at least one episode from each of a plurality of episode categories with at least one cardiac episode. In some examples, the order in which the cardiac episodes selected are displayed is based on the set of summary rules. The electrogram summary may include images or information regarding each of the selected cardiac episodes.

32. 发明授权

US09101772B2 Secure and efficacious therapy delivery for a pacing engine 有权
标题翻译：针对起搏引擎安全有效的治疗方法
公开(公告)号：US09101772B2
公开(公告)日：2015-08-11
申请号：US12633893
申请日：2009-12-09
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
IPC分类号： A61N1/365 , A61N1/368 , A61N1/362 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： A method of stimulation therapy and an apparatus for providing the therapy which addresses cardiac dysfunction including heart failure. The therapy employs atrial pacing pulses delivered to a heart after the atrial refractory period and timed so that they will not cause a ventricular contraction. These atrial pacing are timed to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：刺激疗法的方法和用于提供包括心力衰竭在内的心脏功能障碍的治疗的装置。该疗法使用心房起搏脉搏在心房不应期后输送到心脏并且定时，使得它们不会引起心室收缩。这些心房起搏的时间是为了获得对心肌力学（功效）的有益影响，同时保持心律失常诱导的极低水平的风险。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

33. 发明授权

US08725259B2 Vagal stimulation 有权
公开(公告)号：US08725259B2
公开(公告)日：2014-05-13
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

34. 发明授权

US08478407B2 Methods for promoting intrinsic activation in single chamber implantable cardiac pacing systems 有权
公开(公告)号：US08478407B2
公开(公告)日：2013-07-02
申请号：US13192706
申请日：2011-07-28
申请人： Wade M. Demmer , Karen J. Kleckner , Paul A. Belk
发明人： Wade M. Demmer , Karen J. Kleckner , Paul A. Belk
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/36507 , A61N1/36592
摘要： Cardiac pacing methods for an implantable single chamber pacing system, establish an offset rate for pacing at a predetermined decrement from either a baseline rate (i.e. dictated by a rate response sensor), or an intrinsic rate. Pacing maintains the offset rate until x of y successive events are paced events, at which time the offset rate is switched to the baseline rate for pacing over a predetermined period of time. Following the period, if an intrinsic event is not immediately detected, within the interval of the offset rate, the rate is switched back to baseline for pacing over an increased period of time. Some methods establish a preference rate, between the offset and baseline rates, wherein an additional criterion, for switching from the offset rate to the baseline rate, is established with respect to the preference rate.

35. 发明申请

US20130085406A1 ELECTROGRAM SUMMARY 有权
标题翻译：电机概要
公开(公告)号：US20130085406A1
公开(公告)日：2013-04-04
申请号：US13250676
申请日：2011-09-30
申请人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
发明人： Bruce D. Gunderson , Karen J. Kleckner , Kevin T. Ousdigian , Amisha S. Patel , Julian Sanchez
IPC分类号： A61B5/0464 , A61B5/046
CPC分类号： A61N1/37247 , A61B5/0031 , A61B5/044 , A61B5/0452 , A61B5/0464 , A61B5/0468 , A61B5/076 , A61B5/7217 , A61B5/7264
摘要： The present disclosure is directed to generating and displaying an electrogram (EGM) summary for use by physicians or other clinicians. An implantable medical device (IMD) transmits EGM signal data for a number of cardiac episodes to an external computing device. The external computing device selects a subset of the cardiac episodes for which information or images are displayed to the user. In various examples, cardiac episodes may be selected for display based at least in part on a retrospective analysis classification of the cardiac episode.
摘要翻译：本公开涉及生成和显示用于医生或其他临床医师使用的电描记图（EGM）摘要。可植入医疗装置（IMD）向多个心脏发作的EGM信号数据发送到外部计算装置。外部计算设备选择向用户显示信息或图像的心脏发作的子集。在各种示例中，可以至少部分地基于心脏发作的回顾性分析分类来选择心脏发作来进行显示。

36. 发明申请

US20120303084A1 SECURE AND EFFICACIOUS THERAPY DELIVERY FOR A PACING ENGINE 审中-公开
标题翻译：安全和有效的治疗发动机
公开(公告)号：US20120303084A1
公开(公告)日：2012-11-29
申请号：US13569523
申请日：2012-08-08
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译：据信上述方法和装置对于患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益被指示。应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。

37. 发明申请

US20120185009A1 VAGAL STIMULATION 有权
公开(公告)号：US20120185009A1
公开(公告)日：2012-07-19
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

38. 发明申请

US20120053477A1 METHOD AND APPARATUS FOR ENHANCING TREATABLE ARRHYTHMIA DETECTION SPECIFICITY BY USING ACCUMULATED PATIENT ACTIVITY 有权
标题翻译：通过使用累积患者活动来增强可治疗性脑膜炎检测特异性的方法和装置
公开(公告)号：US20120053477A1
公开(公告)日：2012-03-01
申请号：US12869180
申请日：2010-08-26
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
IPC分类号： A61B5/04
CPC分类号： A61B5/1118 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61N1/36542 , A61N1/3962
摘要： A method and apparatus for detecting a cardiac event in a medical device determine an activity level count from an activity sensor signal for each of a number of time segments, store an activity level count for each of the time segments in a histogram, and accumulate the stored activity level counts to determine a percentage of time segments having an activity level count above a given activity level count.
摘要翻译：用于检测医疗装置中的心脏事件的方法和装置根据多个时间段中的每一个的活动传感器信号确定活动水平计数，将每个时间段的活动水平计数存储在直方图中，并且累积存储的活动级别计数以确定具有高于给定活动级别计数的活动级别计数的时间段的百分比。

39. 发明授权

US08095206B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08095206B2
公开(公告)日：2012-01-10
申请号：US11742618
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for adjusting a sensing parameter in a medical device that includes a sensing electrode sensing cardiac signals, a processor to determine an adjusting characteristic associated with the cardiac signals sensed over a predetermined sensing window, and a control unit to update the sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于调整包括感测心脏信号的感测电极的医疗装置中的感测参数的方法和装置，用于确定与在预定感测窗口上感测到的心脏信号相关联的调整特性的处理器以及用于更新感测参数的控制单元响应于确定的调整特性。

40. 发明授权

US08046065B2 Fusion pacing enhancements 有权
标题翻译：融合起搏增强功能
公开(公告)号：US08046065B2
公开(公告)日：2011-10-25
申请号：US11671304
申请日：2007-02-05
申请人： John E. Burnes , Karen J. Kleckner , Thomas J. Mullen
发明人： John E. Burnes , Karen J. Kleckner , Thomas J. Mullen
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The disclosure provides methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes—upon expiration or reset of a programmable AV Evaluation Interval (AVEI)—performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles). In the event that the AV conduction test reveals an AV conduction block condition or if unacceptably long PR intervals are revealed then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.
摘要翻译：本公开提供了左心室起搏的方法和装置，包括自动调节心房（AV）起搏延迟间隔和内部AV节点传导测试。它包括 - 可编程AV评估间隔（AVEI）的到期或复位 - 执行以下操作：临时增加节奏的AV间隔和感测到的AV间隔，并测试足够的AV传导并测量内在的心房（PR）间隔右心室（RV）室。因此，在AV传导测试揭示生理上可接受的固有PR间隔的情况下，然后将生理上可接受的PR间期存储在存储器结构中（例如，来自一个或多个心动周期的中值P-R）。在AV传导测试显示AV传导阻滞状态或者如果不能接受的长PR间隔被揭示的情况下，则起搏模式切换到双心室（Bi-V）起搏模式并且增加AVEI的幅度。

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