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31. 发明申请

WO2007148115A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007148115A3
公开(公告)日：2008-10-02
申请号：PCT/GB2007002346
申请日：2007-06-25
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/00
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (6) arranged upstream of a collision or fragmentation cell (8). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (6). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (6) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (8). During the time that the potential of the ion mobility spectrometer or separator (6) is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator (6) such as an ion source (1), ion guide (2), quadrupole mass filter (3), optional second collision or fragmentation cell (4) and an ion trapping device (5) are kept constant.
摘要翻译：公开了一种质谱仪，其包括设置在碰撞或破碎电池（8）上游的离子迁移谱仪或分离器（6）。根据离子迁移谱仪或分离器（6）内的离子迁移率分离离子。离子离子迁移谱仪或分离器（6）离子的动能随着时间的推移基本线性地增加，以优化离子进入碰撞或破碎电池（8）时的碎裂能。在离子迁移谱仪或分离器（6）的电位变化的时间内，离子迁移谱仪或分离器（6）上游离子光学部件的离子源（1），离子导向器 2），四极质量过滤器（3），任选的第二碰撞或碎裂单元（4）和离子捕获装置（5）保持恒定。

32. 发明申请

WO2007054712A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007054712A3
公开(公告)日：2008-06-05
申请号：PCT/GB2006004202
申请日：2006-11-10
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2) , a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译：公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器）。在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。

33. 发明申请

WO2007125354A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007125354A2
公开(公告)日：2007-11-08
申请号：PCT/GB2007001589
申请日：2007-04-30
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK , KENNY DANIEL JAMES
CPC分类号： H01J49/4235 , H01J49/065
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.
摘要翻译：公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。在离子导向器或质量分析器（2）的出口处产生伪势垒。伪势垒的幅度或深度与离子的质荷比成反比。一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，使得离子以其质荷比相反的顺序从离子导向器或质量分析器（2）发射。

34. 发明申请

WO2007066114A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007066114A2
公开(公告)日：2007-06-14
申请号：PCT/GB2006004574
申请日：2006-12-07
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： G01N27/622 , H01J49/062
摘要： A closed-loop ion guide (1) is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. Ions are injected into the closed- loop ion guide (1) and may make several circuits of the closed- loop ion guide (1) before being ejected from the ion guide (1). In a mode of operation the ion guide (1) may be arranged to separate ions temporally according to their ion mobility.
摘要翻译：公开了一种闭环离子导向器（1），其包括具有孔的多个电极，在使用中通过该孔具有离子。离子被注入到闭环离子导向器（1）中，并且可以在从离子导向器（1）喷出之前制造闭环离子导向器（1）的几个电路。在操作模式中，离子导向器（1）可以被布置成根据离子迁移率暂时分离离子。

35. 发明申请

WO2007052025A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007052025A2
公开(公告)日：2007-05-10
申请号：PCT/GB2006004078
申请日：2006-11-01
申请人： MICROMASS LTD , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
发明人： PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/062 , H01J49/004 , H01J49/4235 , H01J49/427
摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyser (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of mass to charge ratio .
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中离子通过该孔传输。沿着质量分析器（2）的轴线产生多个潜在的波纹。伪电位波纹的幅度或深度与离子的质荷比成反比。一个或多个瞬态直流电压被施加到质量分析器（2）的电极，以促使离子沿着质量分析器（2）的长度。施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以质荷比的相反顺序发射离子。

36. 发明申请

WO2006090138A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006090138A2
公开(公告)日：2006-08-31
申请号：PCT/GB2006000613
申请日：2006-02-22
申请人： MICROMASS LTD , GREEN MARTIN , WILDGOOSE JASON LEE , GORENSTEIN MARC V
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , GORENSTEIN MARC V
IPC分类号： H01J49/40
CPC分类号： H01J49/025 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Q i which arrived in an i th time bin, wherein: Formula (I) and wherein q i is the actual total number of ion arrival events recorded in the i th time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.
摘要翻译：公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Q i校正质谱中的失真，其中：式（I），其中q i i i是在第i个时间仓中记录的离子到达事件的实际总数，x是与时间数相对应的整数与预计的死时间相对应的箱子。

37. 发明申请

WO2006075182A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006075182A2
公开(公告)日：2006-07-20
申请号：PCT/GB2006000138
申请日：2006-01-17
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/04 , H01J49/40
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱（1），其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子在径向上被限制在离子导向器或离子阱（1）内。沿离子导向器或离子阱（1）的轴向长度的至少一部分保持静电势阱。沿离子导向器或离子阱（1）的轴向长度的至少一部分施加时变均匀电场。静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱（1）喷出。

38. 发明申请

WO2015189552A8 CONTROLLING GAS-PHASE ION INTERACTIONS 审中-公开
标题翻译：控制气相离子相互作用
公开(公告)号：WO2015189552A8
公开(公告)日：2017-03-02
申请号：PCT/GB2015000184
申请日：2015-06-15
申请人： MICROMASS LTD
发明人： GREEN MARTIN RAYMOND , WILDGOOSE JASON LEE
IPC分类号： G01N27/62
CPC分类号： G01N27/624 , H01J49/0031 , H01J49/0422 , H01J49/421
摘要： A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property (3); an ion mobility separation device (4) for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply (6-10) connected to said ion mobility separation device (4) for supplying gas into said ion mobility separation device (4); and a control system (11) configured to adjust said gas supply (6-10) so as to change the composition of gas within the ion mobility separation device (4) as a function of time.
摘要翻译：公开了质谱仪或离子迁移谱仪，其包括：用于根据物理化学性质（3）分离离子或分子的第一装置; 离子迁移率分离装置（4），用于根据其离子迁移率接收和分离衍生自所述分子的至少一些所述离子或离子; 连接到所述离子迁移率分离装置（4）的用于将气体供应到所述离子迁移率分离装置（4）中的气体供应装置（6-10）; 以及控制系统（11），其被配置为调节所述气体供应（6-10），以便随着时间的推移改变离子迁移率分离装置（4）内的气体的组成。

39. 发明申请

WO2013171501A3 ORTHOGONAL ACCELERATION COAXIAL CYLINDER TIME OF FLIGHT MASS ANALYSER 审中-公开
标题翻译：飞行质量分析仪的正交加速同轴气缸时间
公开(公告)号：WO2013171501A3
公开(公告)日：2014-07-17
申请号：PCT/GB2013051271
申请日：2013-05-16
申请人： MICROMASS LTD
发明人： HOYES JOHN BRIAN , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/405 , H01J49/406 , H01J49/408
摘要： A Time of Flight mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. The ions are then orthogonally accelerated ions from the first annular ion guide section into the second annular ion guide section. An ion detector is disposed within the annular ion guide and has an ion detecting surface arranged in a plane which is substantially perpendicular to the longitudinal axis.
摘要翻译：公开了一种飞行时间质量分析器，其包括具有纵向轴线的环形离子引导件，并且包括第一环形离子引导部分和第二环形离子引导部分。离子被引入到第一环形离子引导部分中，使得离子在第一环形离子引导部分内围绕纵向轴线形成基本上稳定的圆周轨道。然后离子是从第一环形离子引导部分到第二环形离子引导部分的正交加速离子。离子检测器设置在环形离子引导件内，并且具有布置在基本上垂直于纵向轴线的平面中的离子检测表面。

40. 发明申请

WO2013171459A3 METHOD OF IDENTIFYING PRECURSOR IONS 审中-公开
标题翻译：识别前体离子的方法
公开(公告)号：WO2013171459A3
公开(公告)日：2014-06-26
申请号：PCT/GB2013051199
申请日：2013-05-09
申请人： MICROMASS LTD
发明人： WILDGOOSE JASON LEE
IPC分类号： H01J49/00
CPC分类号： H01J49/0045 , H01J49/0031 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions.
摘要翻译：公开了一种质谱方法，其包括质量选择性地将前体离子从质量分析器传输到碎裂或反应装置中，其中传输的离子的质荷比随时间变化; 将片段或反应装置中的前体离子破碎，以产生片段或产物离子; 大量分析片段或产物离子; 确定检测到第一片段或产物离子的开始和结束时间; 使用所述开始和结束时间来确定由所述质量分析器传输所述第一碎片或产物离子的前体离子的开始和结束时间; 并且使用由所述质量分析器传输所述前体离子的开始和结束时间以确定所述前体离子的质荷比。本发明即使当使用低分辨率质量分析器来分析前体离子时，也能够从片段数据中分离前体离子峰。

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