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31. 发明授权

EP2004036B1 APPARATUS FOR THE TREATMENT OF MOVEMENT DISORDERS 有权
标题翻译： DEVICE FOR运动障碍的治疗
公开(公告)号：EP2004036B1
公开(公告)日：2011-07-20
申请号：EP06840113.2
申请日：2006-12-05
申请人： Medtronic, Inc.
发明人： MOLNAR, Gregory, F. , MIYAZAWA, Gabriela, C. , MIESEL, Keith, A. , WERDER, Jonathan, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E.
IPC分类号： A61B5/0482
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A apparatus and system for treating patients suffering from movement disorders, including the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.

32. 发明公开

EP1558131A2 TIMED DELAY FOR REDELIVERY OF TREATMENT THERAPY FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：延迟开始治疗一个发出的医用设备系统
公开(公告)号：EP1558131A2
公开(公告)日：2005-08-03
申请号：EP03809098.1
申请日：2003-10-15
申请人： Medtronic Inc.
发明人： FREI, Mark, G. , OSORIO, Ivan , BHAVARAJU, Naresh, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus (100) and method support a repetitive administration of a therapeutic treatment through a delivery unit (953) during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.

33. 发明授权

EP2429644B1 PATIENT STATE DETECTION BASED ON SUPPORT VECTOR MACHINE BASED ALGORITHM 有权转让
标题翻译： ERKENNUNG EINES PATITENTENZUSTANUSTAS NEC EINEM ALGORITHMUS AUF DER BASIS EINER SUPPTOR-VECTOR-MASCHINE
公开(公告)号：EP2429644B1
公开(公告)日：2017-05-31
申请号：EP10702192.5
申请日：2010-01-26
申请人： Medtronic, Inc.
发明人： CARLSON, David, L. , DENISON, Timothy, J. , SHOEB, Ali, H.
IPC分类号： A61N1/36 , G06N99/00 , G06K9/62 , G06F19/00
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N99/005 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. The patient state can be, for example, a patient posture state. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译：用监督机器学习技术（例如支持向量机）产生的至少一个分类边界来检测患者状态。患者状态可以是例如患者姿势状态。在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，启动数据记录或评估患者状况中的至少一个。此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

34. 发明授权

EP1827213B1 APPARATUS FOR DATA RETENTION IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：设备，用于一个植入式医疗设备数据保存
公开(公告)号：EP1827213B1
公开(公告)日：2010-12-08
申请号：EP05825557.1
申请日：2005-11-02
申请人： Medtronic, Inc.
发明人： DREW, Touby, A. , WERDER, Jonathan, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

35. 发明授权

EP1827212B1 METHODS FOR DATA RETENTION IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：的程序对一个植入式医疗设备数据保存
公开(公告)号：EP1827212B1
公开(公告)日：2010-09-22
申请号：EP05825372.5
申请日：2005-11-02
申请人： Medtronic, Inc.
发明人： DREW, Touby, A. , GRAVES, Nina, M. , WERDER, Jonathan, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E.
IPC分类号： A61B5/00
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

36. 发明公开

EP2019621A2 FLEXIBLE MEMORY MANAGEMENT SCHEME FOR LOOP RECORDING IN AN IMPLANTABLE DEVICE 审中-公开
标题翻译：灵活的内存管理模型循环录制在可植入产品
公开(公告)号：EP2019621A2
公开(公告)日：2009-02-04
申请号：EP07753166.3
申请日：2007-03-15
申请人： MEDTRONIC, INC.
发明人： DREW, Touby, A. , CARLSON, David, L.
IPC分类号： A61B5/07 , A61B5/0432
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/7232
摘要： A method and apparatus is provided for handling multiple recordings that result from events in a limited memory device. The events may include various automatic and manual triggers. The method provides a mechanism for storing different configurations of data, associated with different events.

37. 发明公开

EP2012659A2 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 有权
标题翻译：用于检测神经系统病症的方法和装置
公开(公告)号：EP2012659A2
公开(公告)日：2009-01-14
申请号：EP07811786.8
申请日：2007-01-26
申请人： MEDTRONIC, INC.
发明人： CARLSON, David, L. , PANKEN, Eric, J. , GIFTAKIS, Jonathon, E.
IPC分类号： A61B5/00
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/4094 , A61B5/7275 , A61N1/36082 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施例总体上涉及适用于检测和治疗IMD患者的神经系统病症的可植入医疗装置（IMD）。本发明的某些实施例包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施例包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测癫痫发作活动。

38. 发明公开

EP2004036A1 METHOD AND APPARATUS FOR THE TREATMENT OF MOVEMENT DISORDERS 有权
标题翻译： DEVICE FOR运动障碍的治疗
公开(公告)号：EP2004036A1
公开(公告)日：2008-12-24
申请号：EP06840113.2
申请日：2006-12-05
申请人： MEDTRONIC, INC.
发明人： MOLNAR, Gregory, F. , MIYAZAWA, Gabriela, C. , MIESEL, Keith, A. , WERDER, Jonathan, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E.
IPC分类号： A61B5/00
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A apparatus and system for treating patients suffering from movement disorders, including the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.

39. 发明公开

EP1827213A1 APPARATUS FOR DATA RETENTION IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：设备，用于一个植入式医疗设备数据保存
公开(公告)号：EP1827213A1
公开(公告)日：2007-09-05
申请号：EP05825557.1
申请日：2005-11-02
申请人： Medtronic Inc.
发明人： DREW, Touby, A. , WERDER, Jonathan, C. , CARLSON, David, L. , GIFTAKIS, Jonathon, E. , GRAVES, Nina, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

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