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31. 发明申请

US20100247490A1 SIMIAN E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 有权
标题翻译： SIMIAN E ADENOVIRUSES SAdV-39，-25.2，-26，-30，-37和-38
公开(公告)号：US20100247490A1
公开(公告)日：2010-09-30
申请号：US12744441
申请日：2008-11-24
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K35/76 , C12N7/00 , C12N7/01 , C07H21/04 , C12N15/861 , C07K14/075 , A61K38/16 , A61P31/12 , C12N5/02
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361 , C12N2760/16122
摘要： A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-38序列，以及在调控序列控制下的异源基因。还公开了表达猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-383基因的细胞系。提供了使用载体和细胞系的方法。

32. 发明授权

US07358787B2 Dual operational mode CML latch 失效
标题翻译：双操作模式CML锁存器
公开(公告)号：US07358787B2
公开(公告)日：2008-04-15
申请号：US11307923
申请日：2006-02-28
申请人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
发明人： Joseph O. Marsh , Joseph Natonio , James M. Wilson
IPC分类号： H03K3/289
CPC分类号： H03K3/356043
摘要： A dual purpose current mode logic (“CML”) latch circuit is provided which includes a CML latch operable to receive at least a pair of differential input data signals and at least one clock signal. The CML latch is operable to generate at least one output signal in accordance with the states of the pair of input differential data signals. A mode control device is operable to receive a mode control signal to operate the CML latch as a buffer or as a latch. In such way, when the mode control signal is inactive, the CML latch generates and latches the output signal at a timing determined by the at least one clock signal, and when the mode control signal is active the CML latch generates the output signal such that the output signal changes whenever the states of the pair of differential input data signals change.
摘要翻译：提供了一种双用途电流模式逻辑（“CML”）锁存电路，其包括可操作以接收至少一对差分输入数据信号和至少一个时钟信号的CML锁存器。 CML锁存器可操作以根据输入差分数据信号对的状态产生至少一个输出信号。模式控制装置可操作以接收模式控制信号以将CML锁存器作为缓冲器或锁存器操作。以这种方式，当模式控制信号无效时，CML锁存器产生并以由至少一个时钟信号确定的定时锁存输出信号，并且当模式控制信号有效时，CML锁存器产生输出信号，使得每当差分输入数据信号对的状态改变时，输出信号就会改变。

33. 发明授权

US06372208B1 Method of reducing an immune response to a recombinant virus 失效
标题翻译：降低对重组病毒的免疫应答的方法
公开(公告)号：US06372208B1
公开(公告)日：2002-04-16
申请号：US09407490
申请日：1999-09-28
申请人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K39/39541 , A61K48/00 , A61K2039/505 , C07K16/2812 , C07K16/2875 , C12N2710/10343 , A61K2300/00
摘要： A method of reducing immune response to a viral vector containing a selected transgene is provided. The method involves co-administration of the viral vector and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.
摘要翻译：提供了减少对含有所选转基因的病毒载体的免疫应答的方法。该方法包括在重复给药时共同给予病毒载体和能够抑制中和抗体形成和/或CTL消除的选择的免疫调节剂。

34. 发明授权

US06281010B1 Adenovirus gene therapy vehicle and cell line 失效
标题翻译：腺病毒基因治疗载体和细胞系
公开(公告)号：US06281010B1
公开(公告)日：2001-08-28
申请号：US08549489
申请日：1995-10-27
申请人： Guang-Ping Gao , James M. Wilson
发明人： Guang-Ping Gao , James M. Wilson
IPC分类号： C12N1500
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2750/14143 , Y10S977/802 , Y10S977/907
摘要： A novel adenovirus E1/E4 expressing packaging cell line is provided, which permits the generation of recombinant adenoviruses deleted in both gene regions. The E1/E4 deleted recombinant adenovirus is capable of expressing a selected transgene product in cells in vivo or in vitro. This recombinant virus is useful in the treatment of genetic disorders.
摘要翻译：提供了表达新型腺病毒E1 / E4的包装细胞系，其能够在两个基因区域中产生缺失的重组腺病毒。 E1 / E4缺失的重组腺病毒能够在体内或体外在细胞中表达所选择的转基因产物。这种重组病毒可用于治疗遗传疾病。

35. 发明授权

US06252695B1 Multiple wobble correction optical elements to reduce height of raster output scanning (ROS) system 有权
标题翻译：多个摆动校正光学元件，以减少光栅输出扫描（ROS）系统的高度
公开(公告)号：US06252695B1
公开(公告)日：2001-06-26
申请号：US09467756
申请日：1999-12-20
申请人： James M. Wilson
发明人： James M. Wilson
IPC分类号： G02B2608
CPC分类号： G02B26/126
摘要： Two shorter focal length wobble correction optical elements reduce the height of a raster output scanning (ROS) system. The wobble correction optical elements can be two lenses or two mirrors.
摘要翻译：两个较短的焦距摆动校正光学元件降低了光栅输出扫描（ROS）系统的高度。摆动校正光学元件可以是两个镜头或两个镜子。

36. 发明授权

US06224858B1 Hepatocytes transduced with a retroviral vector comprising splice sites and methods of expression 失效
标题翻译：用包含剪接位点和表达方法的逆转录病毒载体转导的肝细胞
公开(公告)号：US06224858B1
公开(公告)日：2001-05-01
申请号：US08488424
申请日：1995-06-07
申请人： Richard C. Mulligan , James M. Wilson
发明人： Richard C. Mulligan , James M. Wilson
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/635 , C07K14/705 , C12N2710/10243 , C12N2740/13043 , Y10S435/948
摘要： Genetically engineered or transduced hepatocytes which express genetic material of interest introduced or incorporated into them, as well as methods of producing, transplanting and using the genetically engineered hepatocytes. The genetic material of interest can be incorporated through use of a vector, such as a recombinant retrovirus, which contains the genetic material of interest, or by other means.
摘要翻译：表达遗传材料的转基因或转导肝细胞引入或并入其中，以及生产，移植和使用遗传工程化肝细胞的方法。感兴趣的遗传物质可以通过使用载体，如包含感兴趣的遗传物质的重组逆转录病毒载体，或通过其他方式加入。

37. 发明授权

US06211160B1 Method for tolerizing a mammalian patient to administration of gene therapy virus vectors 失效
标题翻译：用于耐受哺乳动物患者施用基因治疗病毒载体的方法
公开(公告)号：US06211160B1
公开(公告)日：2001-04-03
申请号：US08889930
申请日：1997-07-10
申请人： James M. Wilson , Youhai Chen
发明人： James M. Wilson , Youhai Chen
IPC分类号： A61K4800
CPC分类号： A61K48/00
摘要： A method for tolerizing a mammalian subject to administration of a live virus carrying a gene for delivery to a cell of the subject is disclosed. The method entails administering to the subject a suitable amount of an inactivated virus prior to administration of the live virus. The prior administration of the inactivated virus suppresses anti-virus cytotoxic T cells, permitting longer transgene persistence once the live virus is administered, and permitting effective readministration of live virus.
摘要翻译：公开了一种用于耐受哺乳动物受试者施用携带用于递送至受试者细胞的基因的活病毒的方法。该方法需要在施用活病毒之前向受试者施用适量的灭活病毒。先前施用灭活病毒抑制抗病毒细胞毒性T细胞，一旦施用活病毒就允许更长的转基因持久性，并且允许有效重新施用活病毒。

38. 发明授权

US5994835A Thin film organic light emitting diode with edge emitter waveguide and electron injection layer 失效
标题翻译：薄膜有机发光二极管与边缘发射波导和电子注入层
公开(公告)号：US5994835A
公开(公告)日：1999-11-30
申请号：US782134
申请日：1997-01-13
申请人： James M. Wilson , David K. Fork
发明人： James M. Wilson , David K. Fork
IPC分类号： G02B6/42 , H01L51/50 , H01L51/52 , H01J1/02
CPC分类号： G02B6/42 , H01L51/5262 , H01L51/5092 , Y10S428/917
摘要： A thin film organic light emitting diode with edge emitter waveguide comprises, in sequence, a substrate, a waveguide, an anode, a hole transport layer, an electroluminescent layer, an electron injection layer and a cathode. Voltage applied between the anode and cathode causes the electroluminescent layer to emit light through the hole transport layer and the anode into the waveguide where the light is internally reflected within the waveguide and propagates through the length of the waveguide to be emitted through the edge of the waveguide. The electron injection layer also functions as a cladding layer to increase the efficiency of the waveguide. The non-emission edge of the waveguide may be sloped with a conductor layer to the anode and a conductor layer to the cathode forming a reflective surface to the non-emission edge.
摘要翻译：具有边缘发射波导的薄膜有机发光二极管依次包括衬底，波导，阳极，空穴传输层，电致发光层，电子注入层和阴极。施加在阳极和阴极之间的电压使得电致发光层通过空穴传输层和阳极发射到波导中，其中光在波导内部被反射并且在波导的长度内传播以通过波导的边缘发射波导。电子注入层也用作包覆层以提高波导的效率。波导的非发射边缘可以与导体层倾斜到阳极，并且导体层向阴极形成到非发射边缘的反射表面。

39. 发明授权

US5872154A Method of reducing an immune response to a recombinant adenovirus 失效
标题翻译：降低对重组腺病毒的免疫应答的方法
公开(公告)号：US5872154A
公开(公告)日：1999-02-16
申请号：US394032
申请日：1995-02-24
申请人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A61K35/76 , A61K35/761 , A61K38/20 , A61K38/21 , A61K39/395 , A61K48/00 , C12N15/861 , A61K38/00 , A61K39/235
CPC分类号： C12N15/86 , A61K35/761 , A61K38/208 , A61K38/217 , A61K39/395 , A61K48/00 , C12N7/00 , C12N2710/10332 , C12N2710/10343
摘要： A method of reducing an immune response to a recombinant adenovirus which involves co-administration of the recombinant adenovirus and a selected immune modulator. The immune modulator functions by inhibiting the formation of neutralizing antibodies and/or reducing CTL killing of the virally infected cells. The method additionally encompasses the step of re-administering the recombinant adenovirus.
摘要翻译：一种降低对重组腺病毒的免疫应答的方法，其涉及共同给予重组腺病毒和选定的免疫调节剂。免疫调节剂通过抑制中和抗体的形成和/或减少病毒感染细胞的CTL杀伤而起作用。该方法还包括重新施用重组腺病毒的步骤。

40. 发明授权

US5756283A Method for improved production of recombinant adeno-associated viruses for gene therapy 失效
标题翻译：通过重组腺相关病毒改善转导的方法
公开(公告)号：US5756283A
公开(公告)日：1998-05-26
申请号：US462014
申请日：1995-06-05
申请人： James M. Wilson , Krishna J. Fisher , Guang-Ping Gao
发明人： James M. Wilson , Krishna J. Fisher , Guang-Ping Gao
IPC分类号： A61K48/00 , C12N15/864 , C12Q1/70 , C12N7/04 , C12N13/00 , C12N15/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143
摘要： A method for enhancing the efficiency of transduction of a recombinant AAV into a target cell is provided. The target cell is infected with a recombinant adeno-associated virus comprising a selected transgene under the control of regulatory sequences. The infected cell is contacted with an agent which facilitates the conversion of single stranded recombinant virus to its double stranded form. When this conversion occurs in the target cell, enhanced transduction of the recombinant virus into said target cell results. The agent can be a helper virus providing a gene which facilitates the conversion, or an agent to which the infected cell is exposed, which facilitates the conversion. In a similar manner, a novel recombinant AAV is provided which contains the facilitating gene and the transgene. The methods may be performed ex vivo or in vivo.
摘要翻译：提供了一种用于提高重组AAV转导入靶细胞的效率的方法。靶细胞用包含选择的转基因的重组腺相关病毒感染，在调控序列的控制下。将感染的细胞与促进单链重组病毒转化为其双链形式的试剂接触。当转化发生在靶细胞中时，将重组病毒增强转导到所述靶细胞中。该试剂可以是提供有助于转化的基因的辅助病毒，或感染细胞暴露于其中的试剂，其有助于转化。以类似的方式，提供了含有促进基因和转基因的新型重组AAV。该方法可以离体或体内进行。

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