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31. 发明授权

US08821473B2 Methods and compositions to treat myocardial conditions 有权
标题翻译：治疗心肌病症的方法和组合物
公开(公告)号：US08821473B2
公开(公告)日：2014-09-02
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00 , A61K31/7088 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译：用于治疗心肌梗塞的方法，装置，试剂盒和组合物。在一个实施例中，该方法包括防止脑室梗死区的重塑。在其它实施方案中，该方法包括引入结构上增强剂。在其它实施方案中，将药剂引入心室以增加心室的依从性。在替代实施例中，预防重塑包括防止心室梗塞区变薄。在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。在其它实施方案中，结构上增强剂可以伴随其它治疗剂。这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

32. 发明授权

US08637069B2 Device and method for combining a treatment agent and a gel 有权
标题翻译：用于组合处理剂和凝胶的装置和方法
公开(公告)号：US08637069B2
公开(公告)日：2014-01-28
申请号：US13559423
申请日：2012-07-26
申请人： Charles D. Claude , Paul J. Kawula , Syed Faiyaz Ahmed Hossainy , Kimchi Tran
发明人： Charles D. Claude , Paul J. Kawula , Syed Faiyaz Ahmed Hossainy , Kimchi Tran
IPC分类号： A61F13/00
CPC分类号： A61K9/0024 , A61K9/06
摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
摘要翻译：一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在治疗部位。

33. 发明申请

US20140025161A1 SHAPE MEMORY BIORESORBABLE POLYMER PERIPHERAL SCAFFOLDS 有权
标题翻译：形状记忆可生物降解聚合物外周血
公开(公告)号：US20140025161A1
公开(公告)日：2014-01-23
申请号：US13555903
申请日：2012-07-23
申请人： John S. Stankus , Hugh Zhao , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Yunbing Wang , Benny Serna
发明人： John S. Stankus , Hugh Zhao , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Yunbing Wang , Benny Serna
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/915 , A61F2002/91508 , A61F2002/91541 , A61F2002/91558 , A61F2210/0019 , A61F2230/0054 , A61F2230/0056 , A61F2230/006 , A61F2250/001 , A61L31/041 , A61L31/06 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2400/16 , C08L67/04
摘要： Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone.
摘要翻译：公开了具有高压碎可恢复性，高抗断裂性和由于在生理条件下的自膨胀性能而减少或无反冲的生物可吸收支架。支架由PLLA和橡胶状聚合物如聚己内酯的无规共聚物制成。

34. 发明授权

US08389044B2 Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权
标题翻译：具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统
公开(公告)号：US08389044B2
公开(公告)日：2013-03-05
申请号：US13037173
申请日：2011-02-28
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K33/00
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described. A method of treating a disorder in a patient using the medical device is described.
摘要翻译：描述了在具有受控形态的医疗装置上形成涂层的方法。描述了使用医疗装置治疗患者的病症的方法。

35. 发明授权

US08267990B2 Controlled degradation of stents 有权
标题翻译：受控控制的支架退化
公开(公告)号：US08267990B2
公开(公告)日：2012-09-18
申请号：US12872166
申请日：2010-08-31
申请人： David C. Gale , Bin Huang , Vincent Gueriguian , Syed Faiyaz Ahmed Hossainy
发明人： David C. Gale , Bin Huang , Vincent Gueriguian , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61L31/06 , C08L67/04
摘要： Stents fabricated from hydrolytically degradable polymers with accelerated degradation rates and methods of fabricating stents with accelerated degradation rates are disclosed.
摘要翻译：公开了由具有加速降解速率的水解可降解聚合物制备的支架和具有加速降解速率的制造支架的方法。

36. 发明授权

US08241653B1 Piezoelectricity modulated release rate of drug from a coating 有权
标题翻译：来自涂层的药物的压电调节释放速率
公开(公告)号：US08241653B1
公开(公告)日：2012-08-14
申请号：US11890905
申请日：2007-08-07
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , William E. Webler , Benjamyn Serna
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , William E. Webler , Benjamyn Serna
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L2300/602
摘要： Provided herein is a method of controlling release rate of a bioactive agent from an implantable medical device comprising a coating, a coating on the implantable device and a method of making the coating.
摘要翻译：本文提供了一种控制来自可植入医疗装置的生物活性剂的释放速率的方法，其包括涂层，可植入装置上的涂层和制备涂层的方法。

37. 发明申请

US20110281022A1 Methods For Controlling The Release Rate And Improving The Mechanical Properties Of A Stent Coating 审中-公开
标题翻译：控制释放速率和提高支架涂层力学性能的方法
公开(公告)号：US20110281022A1
公开(公告)日：2011-11-17
申请号：US13191336
申请日：2011-07-26
申请人： Syed Faiyaz Ahmed Hossainy
发明人： Syed Faiyaz Ahmed Hossainy
IPC分类号： B05D3/06
CPC分类号： A61L31/16 , A61L31/08 , A61L31/14 , A61L2300/416 , A61L2300/602 , C08L27/20
摘要： Methods for controlling the release rate and improving the mechanical properties of a stent coating are disclosed.
摘要翻译：公开了用于控制释放速率和改善支架涂层的机械性能的方法。

38. 发明授权

US08017140B2 Drug-delivery stent formulations for restenosis and vulnerable plaque 有权
标题翻译：用于再狭窄和易损斑块的药物输送支架制剂
公开(公告)号：US08017140B2
公开(公告)日：2011-09-13
申请号：US11804997
申请日：2007-05-21
申请人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Faiyaz Ahmed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译：提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。支架可用于治疗诸如再狭窄和易损斑块的疾病。

39. 发明授权

US07794776B1 Modification of polymer stents with radiation 有权
标题翻译：用辐射改性聚合物支架
公开(公告)号：US07794776B1
公开(公告)日：2010-09-14
申请号：US11478974
申请日：2006-06-29
申请人： Timothy A. Limon , David C. Gale , Syed Faiyaz Ahmed Hossainy , Fuh-Wei Tang
发明人： Timothy A. Limon , David C. Gale , Syed Faiyaz Ahmed Hossainy , Fuh-Wei Tang
IPC分类号： B05D3/06 , C08F2/46 , C08F2/54 , C08J7/18 , B29C71/04 , A61F2/06
CPC分类号： B05D3/068 , A61F2/91 , A61F2250/003 , B05D3/061 , B05D5/00 , B29C71/04 , C08J7/123
摘要： Methods of modifying properties such as degradation rate and drug release rate of polymer stents with radiation are disclosed.
摘要翻译：公开了使用辐射改性聚合物支架的降解速率和药物释放速率等性能的方法。

40. 发明授权

US07699889B2 Poly(ester amide) block copolymers 有权
标题翻译：聚（酯酰胺）嵌段共聚物
公开(公告)号：US07699889B2
公开(公告)日：2010-04-20
申请号：US12114645
申请日：2008-05-02
申请人： Syed Faiyaz Ahmed Hossainy
发明人： Syed Faiyaz Ahmed Hossainy
IPC分类号： A61L9/16 , C08G69/44 , A61L31/16 , A61L31/10 , A61K47/48
CPC分类号： C08G69/44 , A61K47/593 , A61K47/595 , A61K47/64 , A61L27/34 , A61L31/10 , C08L77/12
摘要： Provided herein is a copolymer that includes a soft block (A) and a hard block (B) comprising a tyrosine di-peptide. The copolymer can be any of AB, ABA or BAB type block copolymers. The soft block can include a PEA polymer. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.
摘要翻译：本文提供了包含软嵌段（A）和包含酪氨酸二肽的硬嵌段（B）的共聚物。共聚物可以是AB，ABA或BAB型嵌段共聚物中的任一种。软块可以包括PEA聚合物。由共聚物形成的涂层也可以包括生物活性剂。可植入装置可以植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖等障碍人工移植物，胆管阻塞，输尿管梗阻和/或肿瘤阻塞。

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