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31. 发明申请

US20120015944A1 TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS 有权
标题翻译：作为P2X3和P2X2 / 3拮抗剂的四唑取代的芳基
公开(公告)号：US20120015944A1
公开(公告)日：2012-01-19
申请号：US13240249
申请日：2011-09-22
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A61K31/41 , C07D405/12 , C07D257/04 , C07D403/12 , A61K31/5355 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P29/00 , A61P25/06 , A61P11/00 , C07D413/12 , A61K31/497
CPC分类号： C07D257/04 , C07D401/10 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D471/04
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的四唑基，R 2为任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，R 3，R 4，R 5，R 6 R 7和R 8如本文所定义。还提供了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

32. 发明授权

US08048905B2 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists 有权
标题翻译：四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
公开(公告)号：US08048905B2
公开(公告)日：2011-11-01
申请号：US12317026
申请日：2008-12-17
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A01N43/64 , A01N33/02 , A61K31/41 , A61K31/13 , C07D257/04
CPC分类号： C07D257/04 , C07D401/10 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D471/04
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的四唑基，R 2为任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，R 3，R 4，R 5，R 6 R 7和R 8如本文所定义。还提供了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

33. 发明申请

US20100152203A1 THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS 有权
标题翻译：作为P2X3和P2X2 / 3拮抗剂的噻唑烷取代的芳基
公开(公告)号：US20100152203A1
公开(公告)日：2010-06-17
申请号：US12636723
申请日：2009-12-12
申请人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
发明人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
IPC分类号： A61K31/444 , C07D417/14 , C07D285/06 , A61K31/497 , A61K31/433 , A61P13/00 , A61P13/10 , A61P25/00
CPC分类号： C07D417/14 , A61K31/166 , A61K31/433 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , C07D285/06 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的噻二唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

34. 发明申请

US20090170873A1 Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists 有权
标题翻译：吡唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
公开(公告)号：US20090170873A1
公开(公告)日：2009-07-02
申请号：US12317008
申请日：2008-12-17
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A61K31/4965 , C07D231/00 , A61K31/415 , C07D401/14
CPC分类号： C07D405/14 , C07D213/12 , C07D213/14 , C07D231/12 , C07D231/56 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的吡唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

35. 发明授权

US08809402B2 Oxazolone and pyrrolidinone-substituted biphenyls as P2X3 and P2X2/3 antagonists 有权
标题翻译：恶唑酮和吡咯烷酮取代的联苯作为P2X3和P2X2 / 3拮抗剂
公开(公告)号：US08809402B2
公开(公告)日：2014-08-19
申请号：US13314529
申请日：2011-12-08
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
IPC分类号： A61K31/015 , C07D473/00 , C07D207/27 , C07D413/10 , C07D263/20 , C07D413/14 , C07D401/14 , C07D413/12 , C07D233/32
CPC分类号： A61K31/497 , C07D207/27 , C07D233/32 , C07D263/20 , C07D401/14 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中X，Y，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

36. 发明授权

US08440673B2 Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists 有权
公开(公告)号：US08440673B2
公开(公告)日：2013-05-14
申请号：US12317008
申请日：2008-12-17
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A61K31/4965 , A61K31/415 , C07D231/00 , C07D401/14 , C07D221/00
CPC分类号： C07D405/14 , C07D213/12 , C07D213/14 , C07D231/12 , C07D231/56 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

37. 发明申请

US20120122886A1 THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS 审中-公开
标题翻译：作为P2X3和P2X2 / 3拮抗剂的噻唑烷取代的芳基
公开(公告)号：US20120122886A1
公开(公告)日：2012-05-17
申请号：US13359330
申请日：2012-01-26
申请人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
发明人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
IPC分类号： A61K31/495 , C07C233/69 , A61P1/00 , C07D285/06 , A61K31/4192 , A61P29/00 , A61K31/166 , C07D417/12
CPC分类号： C07D417/14 , A61K31/166 , A61K31/433 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , C07D285/06 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的噻二唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

38. 发明申请

US20110245271A1 TRIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS 有权
标题翻译：三唑取代的ARYLAMIDES作为P2X3和P2X2 / 3拮抗剂
公开(公告)号：US20110245271A1
公开(公告)日：2011-10-06
申请号：US13162378
申请日：2011-06-16
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A61K31/497 , C07D403/12 , C07D401/14 , C07D249/06 , A61K31/4192 , A61P25/04 , A61P11/00 , A61P11/06
CPC分类号： C07D403/12 , C07D249/06 , C07D401/14
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的三唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

39. 发明授权

US09464891B2 Method for measuring thickness by pulsed infrared thermal wave technology 有权
标题翻译：脉冲红外热波技术测量厚度的方法
公开(公告)号：US09464891B2
公开(公告)日：2016-10-11
申请号：US14002022
申请日：2011-06-14
申请人： Zhi Zeng , Xun Wang , Ning Tao , Lichun Feng , Cunlin Zhang
发明人： Zhi Zeng , Xun Wang , Ning Tao , Lichun Feng , Cunlin Zhang
IPC分类号： G01B21/08 , G01N25/72
CPC分类号： G01B21/085 , G01N25/72
摘要： A method for measuring thickness or defect depth by pulsed infrared thermal wave technology is described. The method includes heating a measured object by pulsed heating devices, and at the same time, obtaining a thermal image sequence on the surface of the measured object by an infrared thermography device, and storing the thermal image sequence in a general-purpose memory. The method also includes multiplying a temperature-time curve at every point of the thermal image sequence by a corresponding time, thereby obtaining a new curve. The method also includes calculating a first-order differential and obtaining a peak time thereof. The method also includes use of one or more formulas to thereby determine the thickness or the defect depth of the measured object.
摘要翻译：描述了通过脉冲红外热波技术测量厚度或缺陷深度的方法。该方法包括通过脉冲加热装置加热测量对象，同时通过红外热成像装置获得被测物体表面上的热图像序列，并将热图像序列存储在通用存储器中。该方法还包括将热图像序列的每个点处的温度 - 时间曲线乘以相应的时间，从而获得新的曲线。该方法还包括计算一阶差分并获得其峰值时间。该方法还包括使用一个或多个公式从而确定被测物体的厚度或缺陷深度。

40. 发明申请

US20150191487A1 TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS 审中-公开
标题翻译：作为P2X3和P2X2 / 3拮抗剂的四唑取代的芳基
公开(公告)号：US20150191487A1
公开(公告)日：2015-07-09
申请号：US14151680
申请日：2014-01-09
申请人： Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
发明人： Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Lichun Feng , Minmin Yang
IPC分类号： C07D498/08 , C07D241/12 , C07D405/12 , C07D403/12 , C07D401/14 , C07D401/12 , C07D417/12 , C07D491/107 , C07D471/04 , C07D257/04 , C07D409/12
CPC分类号： A61K31/41 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D241/12 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/08
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的四唑基，R 2为任选取代的苯基，任选取代的吡啶基或任选取代的噻吩基，R 3，R 4，R 5和R 6如本文所定义。还提供了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

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