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31. 发明申请

WO2012013676A1 POLYURETHANE WITH IMPROVED ABRASION RESISTANCE, THE METHOD FOR PREPARING THE SAME AND USE THEREOF 审中-公开
标题翻译：具有改善耐磨性的聚氨酯，其制备方法及其用途
公开(公告)号：WO2012013676A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062831
申请日：2011-07-26
申请人： BAYER MATERIALSCIENCE AG , TORRES, Sam , CAO, Zhong , LIU, Xiang
发明人： TORRES, Sam , CAO, Zhong , LIU, Xiang
IPC分类号： C08G18/10 , C08G18/40 , C08G18/63 , C08L75/04
CPC分类号： C08G18/08 , C08G18/10 , C08G18/4072 , C08G18/632 , C08G2101/0008 , C08G2101/0066 , C08G2101/0083 , C08G2380/00 , C08G2410/00 , C08L9/00 , C08L75/04 , C08G18/6674 , C08L7/00 , C08G18/40 , C08G18/6564
摘要： The present invention relates to a polyurethane with improved abrasion resistance. The reaction components comprise a certain content of polyisoprene. The polyurethane presented in this invention possesses improved abrasion resistance and good surface quality.
摘要翻译：本发明涉及具有改善耐磨性的聚氨酯。反应组分包含一定量的聚异戊二烯。本发明中提供的聚氨酯具有改进的耐磨性和良好的表面质量。

32. 发明申请

WO2011110485A2 POLYURETHANE WITH IMPROVED ABRASION RESISTANCE, THE METHOD FOR PREPARING THE SAME AND USE THEREOF 审中-公开
标题翻译：具有改善耐磨性的聚氨酯，其制备方法及其用途
公开(公告)号：WO2011110485A2
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053279
申请日：2011-03-04
申请人： BAYER MATERIALSCIENCE AG , TORRES, Sam , CAO, Zhong , LIU, Xiang , ZHANG, Yue Dong
发明人： TORRES, Sam , CAO, Zhong , LIU, Xiang , ZHANG, Yue Dong
CPC分类号： C08G18/698 , C08G18/10 , C08G18/4072 , C08G18/42 , C08L9/00 , C08L21/00 , C08L75/04 , C08G18/6564 , C08G18/40
摘要： The present invention pertains to a polyurethane with improved abrasion resistance. The reactive component for preparing the polyurethane includes a polybutadiene, wherein the polybutadiene comprises 1,2-butene structure unit, 2,3-(cis) butene structure unit and 2,3-(trans) butene structure unit, wherein the amount of the 2,3-(trans) butene structure unit is more than the amount of the 2,3- (cis) butene structure unit. The polyurethane presented in this invention possesses improved abrasion resistance and good surface quality.
摘要翻译：本发明涉及具有改善耐磨性的聚氨酯。用于制备聚氨酯的反应性组分包括聚丁二烯，其中聚丁二烯包括1,2-丁烯结构单元，2,3-（顺式）丁烯结构单元和2,3-（反式）丁烯结构单元，其中 2,3-（反式）丁烯结构单元多于2,3-（顺式）丁烯结构单元的量。本发明提供的聚氨酯具有改进的耐磨性和良好的表面质量。

33. 发明申请

WO2011037806A1 DIGITAL COHERENT DETECTION OF MULTI-CARRIER OPTICAL SIGNAL 审中-公开
标题翻译：多载波光信号的数字相关检测
公开(公告)号：WO2011037806A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049019
申请日：2010-09-16
申请人： ALCATEL-LUCENT USA INC. , LIU, Xiang , SETHUMADHAVAN, Chandrasekhar , TKACH, Robert, William
发明人： LIU, Xiang , SETHUMADHAVAN, Chandrasekhar , TKACH, Robert, William
IPC分类号： H04B10/148 , H04B10/158 , H04J14/02
CPC分类号： H04B10/675 , H04B10/61 , H04B10/614 , H04B10/6161 , H04B10/6165
摘要： Embodiments for optical communication are provided in which subbands of a multi- carrier optical signal are digital coherent detected and then processed to recover data carried by the modulated carriers corresponding to at least one of the subbands. An exemplary optical communication system includes a multi-carrier coherent optical receiver for receiving a multi-carrier optical signal having M modulated carriers that are frequency locked, wherein M is greater than 2. The multi-carrier coherent optical receiver includes a subband digital coherent detector configured to provide output signals in a digital form for N different subbands of the multi-carrier optical signal, where N is an integer greater than 1 and less than M; and a digital signal processor configured to process the digital form of the detected output signals in order to recover the data carried by the modulated carriers corresponding to at least one of the subbands of the multicarrier optical signal.
摘要翻译：提供了用于光通信的实施例，其中多载波光信号的子带被数字相干检测，然后被处理以恢复由至少一个子带对应的调制载波承载的数据。示例性光通信系统包括多载波相干光接收机，用于接收具有频率锁定的M个调制载波的多载波光信号，其中M大于2.多载波相干光接收机包括子带数字相干检测器被配置为为多载波光信号的N个不同子带提供数字形式的输出信号，其中N是大于1且小于M的整数; 以及数字信号处理器，被配置为处理检测到的输出信号的数字形式，以便恢复与多载波光信号的至少一个子带对应的调制载波承载的数据。

34. 发明申请

WO2010144870A3 OPTICAL ABSORBANCE MEASUREMENTS WITH SELF-CALIBRATION AND EXTENDED DYNAMIC RANGE 审中-公开
公开(公告)号：WO2010144870A3
公开(公告)日：2010-12-16
申请号：PCT/US2010/038417
申请日：2010-06-11
申请人： SPECTRASENSORS, INC. , LIU, Xiang , FEITISCH, Alfred , ZHOU, Xin
发明人： LIU, Xiang , FEITISCH, Alfred , ZHOU, Xin
IPC分类号： G01J3/42 , G01N21/25
摘要： Detector data representative of an intensity of light that impinges on a detector after being emitted from a light source and passing through a gas over a path length can be analyzed using a first analysis method to obtain a first calculation of an analyte concentration in the volume of gas and a second analysis method to obtain a second calculation of the analyte concentration. The second calculation can be promoted as the analyte concentration upon determining that the analyte concentration is out of a first target range for the first analysis method.

35. 发明申请

WO2010002425A1 APPARATUS AND METHOD FOR IMPROVING THE TOLERANCE OF TONE-BASED OPTICAL CHANNEL MONITORING TO STIMULATED RAMAN SCATTERING 审中-公开
标题翻译：改进基于色调的光通道监测对刺激拉曼散射的装置和方法
公开(公告)号：WO2010002425A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/002964
申请日：2009-05-13
申请人： ALCATEL-LUCENT USA INC. , JIANG, Song , KELLY, Colin, G. , LIU, Xiang , REMEDIOS, Derrick, A.
发明人： JIANG, Song , KELLY, Colin, G. , LIU, Xiang , REMEDIOS, Derrick, A.
IPC分类号： H04J14/02 , H04B10/08
CPC分类号： H04J14/0221 , H04B10/0775 , H04B2210/075 , H04J14/0227 , H04J14/0258 , H04J14/0276 , H04J14/0298
摘要： For wavelength division multiplexing (WDM) communications, apparatus and methods are provided for performing tone-based optical channel monitoring that is less sensitive to stimulated Raman scattering (SRS). In tone-based optical channel monitoring, in which WDM channels are modulated with one or more tones, detecting and measuring the tone power is commonly used as a measure of signal power in each channel. In WDM systems with long fiber spans and high signal powers, however, SRS tends to transfer energy from shorter wavelengths to longer wavelengths, whereby the tones are no longer accurately indicative of the signal power of the individual wavelength channels. Apparatus and methods are provided which reduce the effect of SRS by filtering the monitored WDM signals into sub-bands and detecting each sub-band independently.
摘要翻译：对于波分复用（WDM）通信，提供了用于执行对受激拉曼散射（SRS）较不敏感的基于色调的光信道监视的装置和方法。在基于色调的光信道监视中，其中WDM信道用一个或多个音调进行调制，检测和测量音调功率通常用作每个信道中信号功率的度量。然而，在具有长光纤跨距和高信号功率的WDM系统中，SRS倾向于将能量从较短波长传输到较长波长，由此音调不再准确地指示各个波长信道的信号功率。提供了通过将监视的WDM信号滤波成子带并独立地检测每个子带来降低SRS的影响的装置和方法。

36. 发明申请

WO2009078980A2 ELECTRODE TUNING METHOD AND APPARATUS FOR A LAYERED HEATER STRUCTURE 审中-公开
标题翻译：用于分层加热器结构的电极调节方法和设备
公开(公告)号：WO2009078980A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/013737
申请日：2008-12-16
申请人： MOMENTIVE PERFORMANCE MATERIALS INC. , FAN, Wei , OLECHNOWICZ, Benjamin, J. , SCHAEPKENS, Marc , RUSINKO, David, M. , LIU, Xiang , MARINER, John, T.
发明人： FAN, Wei , OLECHNOWICZ, Benjamin, J. , SCHAEPKENS, Marc , RUSINKO, David, M. , LIU, Xiang , MARINER, John, T.
IPC分类号： H01L21/687 , C23C16/458
CPC分类号： H01L21/68735 , H01L21/67103 , H05B3/143
摘要： A layered heater structure including an electrode layer and a localized tuning method for tuning the electrode layer of a layered heater structure with high precision is provided. The localized tuning method tunes the electrode layer to its proper local resistance to minimize temperature offsets on the heater surface and thus provide a desired thermal profile that is in marked contrast to conventional, non-localized resistance tuning approaches based on thickness trimming practices, such as grinding or blasting, or resistivity adjustment, such as local heat treatment.
摘要翻译：提供了包括电极层和用于以高精度调谐层状加热器结构的电极层的局部调谐方法的分层加热器结构。局部调谐方法将电极层调整到其适当的局部电阻，以最小化加热器表面上的温度偏移，并因此提供与基于厚度调整实践的常规非局部电阻调整方法形成鲜明对比的期望热曲线，例如研磨或爆破，或电阻率调整，如局部热处理。

37. 发明申请

WO2008003244A1 METHODS FOR IDENTIFICATION OF ALLELES 审中-公开
标题翻译：方法识别对象
公开(公告)号：WO2008003244A1
公开(公告)日：2008-01-10
申请号：PCT/CN2007/002039
申请日：2007-06-29
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , LI, Caixia , GAO, Huafang , LIU, Xiang , CAI, Bin , ZHANG, Di , CHENG, Jing
发明人： LI, Caixia , GAO, Huafang , LIU, Xiang , CAI, Bin , ZHANG, Di , CHENG, Jing
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16 , C12Q2565/501 , C12Q2535/125 , C12Q2525/161
摘要： The invention provides a method for identification of alleles. In this method, genomic DNA is used as target. Multiple allele-specific PCR amplification are carried out with a group of primers comprising one or more allele-specific primers for a target gene, a universal primer, and a common primer; and a DNA polymerase without 5' to 3' exonuclease activity. The PCR products are hybridized with tag probes immobilized on a DNA chip. Results are determined based on the signal intensity and the position of the probe immobilized on the array. Each allele-specific primer comprises a unique tag sequence at the 5' end. Each tag probe immobilized on the DNA chip comprises a sequence identical to its corresponding tag sequence; and each tag probe hybridizes only with the complementary sequence in the PCR amplification product.
摘要翻译：本发明提供了一种鉴定等位基因的方法。在该方法中，使用基因组DNA作为靶。使用包含靶基因，通用引物和通用引物的一个或多个等位基因特异性引物的引物组进行多重等位基因特异性PCR扩增; 和没有5'至3'外切核酸酶活性的DNA聚合酶。 PCR产物与固定在DNA芯片上的标签探针杂交。结果基于信号强度和固定在阵列上的探针的位置来确定。每个等位基因特异性引物包含在5'末端的唯一标签序列。固定在DNA芯片上的每个标签探针包含与其对应的标签序列相同的序列; 并且每个标签探针仅与PCR扩增产物中的互补序列杂交。

38. 发明申请

WO2021211455A1 HLA CLASS I-RESTRICTED T CELL RECEPTORS AGAINST LMP2 审中-公开
公开(公告)号：WO2021211455A1
公开(公告)日：2021-10-21
申请号：PCT/US2021/026883
申请日：2021-04-12
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , HINRICHS, Christian S. , LIU, Xiang
发明人： HINRICHS, Christian S. , LIU, Xiang
IPC分类号： C07K14/725 , A61K39/00 , A61K39/12 , C07K14/005 , C12N5/0783
摘要： Disclosed are isolated or purified T cell receptors (TCRs), wherein the TCRs have antigenic specificity for a LMP2 amino acid sequence presented by a human leukocyte antigen (HLA) Class I molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

39. 发明申请

WO2019199667A3 PLADIENOLIDE COMPOUNDS AND THEIR USE 审中-公开
公开(公告)号：WO2019199667A3
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
申请人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC分类号： C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

40. 发明申请

WO2019199667A2 CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019199667A2
公开(公告)日：2019-10-17
申请号：PCT/US2019/026313
申请日：2019-04-08
申请人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , MARCAURELLE, Lisa A. , NEVALAINEN, Marta , HAO, Ming-Hong , O'SHEA, Morgan Welzel , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , LUO, Touping , GEARHART, Nicholas C. , LOWE, Jason T. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONOBE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , COOK, Andrew , ELLERY, Shelby , ENDO, Atsushi , PALACINO, James , REYNOLDS, Dominic
IPC分类号： C07D313/00 , C07D407/12 , C07D407/14 , A61K31/497 , A61K31/4427 , A61K31/365 , A61P35/00
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

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