专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US08466290B2 STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient 有权
标题翻译：含有喹啉甲酰胺衍生物的STAT3抑制剂作为活性成分
公开(公告)号：US08466290B2
公开(公告)日：2013-06-18
申请号：US13003441
申请日：2009-07-10
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , A61K31/4709 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供含有作为活性成分的式（I）所示的喹啉甲酰胺衍生物的STATS抑制剂（式中，W表示键或亚烷基链; X表示O，S或NR34; R1〜R8 和R 34各自表示H，卤素，烷基，苯基，呋喃基，噻吩基等）或其药理学上可接受的盐。

32. 发明申请

US20120302524A1 1,3,4-OXADIAZOLE-2-CARBOXAMIDE COMPOUND 有权
标题翻译： 1,3,4-氧杂氮杂-2-羧酰胺化合物
公开(公告)号：US20120302524A1
公开(公告)日：2012-11-29
申请号：US13519707
申请日：2010-12-28
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： A61K31/4245 , C07D413/14 , A61K31/4439 , C07F7/10 , A61K31/695 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K31/498 , C07D513/04 , A61K31/4545 , A61K31/541 , A61K31/437 , C07D487/04 , A61K31/55 , A61P35/00 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
摘要翻译：提供具有STAT3抑制活性并可用作抗癌剂的1,3,4-恶二唑-2-甲酰胺化合物。提供由式（I）表示的1,3,4-恶二唑-2-甲酰胺化合物或其药学上可接受的盐（在该式中，Ar表示呋喃基等; R 1表示氢原子等; -X-Y表示二苯基等二芳基）。

33. 发明授权

US5981558A DC107 derivatives 失效
标题翻译： DC107衍生品
公开(公告)号：US5981558A
公开(公告)日：1999-11-09
申请号：US133614
申请日：1998-08-13
申请人： Hitoshi Arai , Yutaka Kanda , Hiroyuki Yamaguchi , Tadashi Ashizawa , Chikara Murakata , Shun-ichi Ikeda , Tatsuya Tamaoki
发明人： Hitoshi Arai , Yutaka Kanda , Hiroyuki Yamaguchi , Tadashi Ashizawa , Chikara Murakata , Shun-ichi Ikeda , Tatsuya Tamaoki
IPC分类号： C07D513/18 , C07H15/26 , C07D513/08 , A61K31/425
CPC分类号： C07D513/18 , C07H15/26
摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).
摘要翻译：提供了具有抗微生物活性和抗肿瘤活性的由式（I）表示的DC107衍生物或其药学上可接受的盐，其中R1表示氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4等; R2表示氢或COR6; R3表示-CH2OCOR7，苯二甲酰亚氨基甲基等; W表示氧或NR8（其中R8表示羟基，低级烷氧基，低级烯氧基，芳烷氧基，取代或未取代的芳基磺酰基氨基或低级烷氧基羰基氨基）。

34. 发明申请

US20110172429A1 STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT 有权
标题翻译：含有喹啉甲酰胺衍生物的STAT3抑制剂作为活性成分
公开(公告)号：US20110172429A1
公开(公告)日：2011-07-14
申请号：US13003441
申请日：2009-07-10
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Takane Yokotagawa , Osamu Takahashi , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： C07D215/14
CPC分类号： C07D401/12 , A61K31/4709 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供含有作为活性成分的式（I）所示的喹啉甲酰胺衍生物的STATS抑制剂（式中，W表示键或亚烷基链; X表示O，S或NR34; R1〜R8 和R 34各自表示H，卤素，烷基，苯基，呋喃基，噻吩基等）或其药理学上可接受的盐。

35. 发明授权

US5733924A DC 107 derivatives and treatment methods 失效
标题翻译： DC 107衍生物和处理方法
公开(公告)号：US5733924A
公开(公告)日：1998-03-31
申请号：US776938
申请日：1997-04-17
申请人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
发明人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
IPC分类号： C07D513/08 , A61K37/00
CPC分类号： C07D513/08
摘要： DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, �wherein R.sup.1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4 or the like; R.sup.2 represents hydrogen or COR.sup.5 ; R.sup.3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R.sup.3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR.sup.6, with the proviso that the compound wherein R.sup.1, R.sup.2 and Z each represents hydrogen, R.sup.3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.!
摘要翻译： PCT No.PCT / JP96 / 01646 Sec。 371日期1997年04月17日 102（e）1997年4月17日PCT PCT 1996年6月14日PCT公布。出版物WO97 / 00260 PCT 日本1997年3月1日由式（I）代表的DC107衍生物：其中R1为氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4或类似; R2表示氢或COR5; R3代表低级烷基，低级烯基，可被取代或未取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，取代或未取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基烷基，脂环族烷酰氧基烷基等，或与Y键合以表示单键 ; Y键合到R3表示单键，或键合到Z表示单键; Z表示氢或与Y键合以表示单键; W表示氧或NR 6，条件是其中R1，R2和Z各自表示氢，R3与Y键合以表示单键，W表示氧（DC107）的化合物。

36. 发明授权

US4847387A Antibiotic compounds DC-92B and DC-92D 失效
标题翻译：抗生素化合物DC-92B和DC-92D
公开(公告)号：US4847387A
公开(公告)日：1989-07-11
申请号：US199043
申请日：1988-03-17
申请人： Hirofumi Nakano , Isami Takahashi , Fusao Tomita , Kozo Asano , Toru Yasuzawa , Tadashi Ashizawa , Keiichi Takahashi
发明人： Hirofumi Nakano , Isami Takahashi , Fusao Tomita , Kozo Asano , Toru Yasuzawa , Tadashi Ashizawa , Keiichi Takahashi
IPC分类号： C07H7/06 , C07H15/12 , C07H17/04 , C12P19/26 , C12P19/44
CPC分类号： C07H15/12 , C07H17/04 , C12P19/26 , C12P19/44
摘要： The present invention relates to novel compounds DC-92B and DC-92D having anthraquinone moiety and represented by the following planar structural formula (I) and to a process for producing the same. These compounds can be produced by culture of a microorganism belonging to the genus Actinomadura, and are useful as medicaments because of their antibacterial and anti-tumor activities. ##STR1## wherein R is a group represented by formula (II) or formula (III): ##STR2##

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式