专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20090250658A1 Dehydroxyfluorination Agent 有权
标题翻译：脱羟基氟化剂
公开(公告)号：US20090250658A1
公开(公告)日：2009-10-08
申请号：US12306826
申请日：2007-06-25
申请人： Akihiro Ishii , Takashi Ootsuka , Manabu Yasumoto , Hideyuki Tsuruta , Kenjin Inomiya , Koji Ueda , Kaori Mogi
发明人： Akihiro Ishii , Takashi Ootsuka , Manabu Yasumoto , Hideyuki Tsuruta , Kenjin Inomiya , Koji Ueda , Kaori Mogi
IPC分类号： C09K3/00
CPC分类号： C07B39/00 , C07B55/00 , C07B2200/07 , C07C17/16 , C07C67/307 , C07D207/16 , C07D209/48 , C07D405/04 , C07H19/09 , C07C19/08 , C07C69/63
摘要： There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.
摘要翻译：提供了含有硫酰氟（SO 2 F 2）和分子中不含游离羟基的有机碱的新型有用的脱羟基氟化剂。根据现有的脱羟基氟化剂，不需要使用全氟烷基磺酰氟，其在大规模使用中是不优选的，并且可以有利地制备作为药物，农药和光学的重要中间体的光学活性氟衍生物材料，例如4-氟脯氨酸衍生物，2'-脱氧-2'-氟尿苷衍生物，光学活性α-氟代羧酸酯衍生物和单氟甲基衍生物，甚至大规模。

32. 发明授权

US07393979B2 Process for producing optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine 有权
标题翻译：光学活性1-烷基取代的2,2,2-三氟乙胺的制备方法
公开(公告)号：US07393979B2
公开(公告)日：2008-07-01
申请号：US10560251
申请日：2004-06-08
申请人： Akihiro Ishii , Yokusu Kuriyama , Manabu Yasumoto , Masatomi Kanai , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
发明人： Akihiro Ishii , Yokusu Kuriyama , Manabu Yasumoto , Masatomi Kanai , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
IPC分类号： C07C209/62 , C07C211/05
CPC分类号： C07C209/62 , C07B2200/07 , C07C209/52 , C07C211/15 , C07C249/02 , C07C251/08
摘要： The present invention relates to a process for producing an optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine, which is an important intermediate of medicines and agricultural chemicals, and which is represented by the formula [3] [in the formula R represents a lower alkyl group of a carbon and * represents an asymmetric carbon], or its salt by subjecting an optically active imine represented by the formula [1] to an asymmetric reduction under hydrogen atmosphere using a metal catalyst of Group VIII to convert it into an optically active secondary amine represented by the formula [2] and then by subjecting the secondary amine or its salt to hydrogenolysis.[Chem. 23]
摘要翻译：本发明涉及一种制备光学活性的1-烷基取代的2,2,2-三氟乙基胺的方法，它是药物和农药的重要中间体，由式[3] [式 R表示碳的低级烷基，*表示不对称碳]或其盐，通过使用式（1）表示的光学活性亚胺在氢气氛下使用VIII族金属催化剂进行不对称还原，将其转化为由式[2]表示的光学活性仲胺，然后通过使仲胺或其盐进行氢解。 [Chem。 23]

33. 发明授权

US07388094B2 Processing for producing 2′-deoxy-2′-fluorouridine 失效
标题翻译： 2'-脱氧-2'-氟尿苷的制备方法
公开(公告)号：US07388094B2
公开(公告)日：2008-06-17
申请号：US10552463
申请日：2004-04-09
申请人： Akihiro Ishii , Takashi Ootsuka , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
发明人： Akihiro Ishii , Takashi Ootsuka , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
IPC分类号： C07H19/073
CPC分类号： C07H19/067 , Y02P20/55
摘要： 1-β-D-Arabinofuranosyluracil in 3′,5′-hydroxyl-protected form is reacted with a trifluoromethanesulfonylating agent in the presence of an organic base to convert it into a 2′-triflate form, and then it is reacted with a fluorinating agent containing “a salt or complex formed by an organic base and hydrofluoric acid” to produce 2′-deoxy-2′-fluorouridine in 3′,5′-hydroxyl-protected form. A deprotecting agent is further caused to act thereon to obtain 2′-deoxy-2′-fluorouridine. The 2′-deoxy-2′-fluorouridine obtained can efficiently be purified by temporarily converting it into a 3′,5′-diacetyl form, recrystallizing the 3′,5′-diacetyl form, and then deacetylating it. Thus, high-purity 2′-deoxy-2′-fluorouridine can be produced.
摘要翻译： 3'，5'-羟基保护形式的1-β-D-阿拉伯呋喃糖尿嘧啶在有机碱的存在下与三氟甲磺酰化剂反应，将其转化为2,3-三氟甲磺酸酯形式，然后与氟化含有“由有机碱和氢氟酸形成的盐或络合物”的试剂以产生3'，5'-羟基保护形式的2'-脱氧-2'-氟尿苷。进一步使脱保护剂作用于其上，得到2'-脱氧-2'-氟尿苷。所得到的2'-脱氧-2'-氟尿苷可以通过暂时转化为3'，5'-二乙酰基形式，重结晶3'，5'-二乙酰基形式，然后脱乙酰化而有效地纯化。因此，可以制备高纯度2'-脱氧-2'-氟尿苷。

34. 发明申请

US20060017517A1 Voltage controlled oscillator 审中-公开
标题翻译：压控振荡器
公开(公告)号：US20060017517A1
公开(公告)日：2006-01-26
申请号：US11188326
申请日：2005-07-25
申请人： Takashi Ootsuka , Hisato Takeuchi , Keigo Shingu
发明人： Takashi Ootsuka , Hisato Takeuchi , Keigo Shingu
IPC分类号： H03B5/32
CPC分类号： H03B5/366 , H03B5/04 , H03B2200/0012
摘要： A voltage controlled oscillator enables controlling the MOS transistor threshold voltage independently of the temperature compensation control signal and external voltage frequency control signal. The voltage controlled oscillator has a crystal oscillator and a load capacitance is parallel connected to a crystal oscillator. The load capacitance includes a first MOS transistor comprising a gate terminal and a source/drain terminal formed by shorting the source and drain, and a second MOS transistor comprising a gate terminal and a source/drain terminal formed by shorting the source and drain. First and second control signal generating circuits supply respective control signals to the source/drain terminals and gate terminals of the first and second MOS transistors.
摘要翻译：压控振荡器能够独立于温度补偿控制信号和外部电压频率控制信号来控制MOS晶体管阈值电压。压控振荡器具有晶体振荡器，并且负载电容并联连接到晶体振荡器。负载电容包括第一MOS晶体管，其包括通过使源极和漏极短路而形成的栅极端子和源极/漏极端子，以及包括通过短路源极和漏极形成的栅极端子和源极/漏极端子的第二MOS晶体管。第一和第二控制信号发生电路向第一和第二MOS晶体管的源极/漏极端子和栅极端子提供相应的控制信号。

35. 发明申请

US20060012445A1 Voltage controlled oscillator 有权
标题翻译：压控振荡器
公开(公告)号：US20060012445A1
公开(公告)日：2006-01-19
申请号：US11181129
申请日：2005-07-14
申请人： Hisato Takeuchi , Keigo Shingu , Takashi Ootsuka
发明人： Hisato Takeuchi , Keigo Shingu , Takashi Ootsuka
IPC分类号： H03B5/32
CPC分类号： H03L1/022 , H03B5/36 , H03K3/011 , H03K3/0307 , H03L1/023 , H03L1/028 , H03L7/099
摘要： In a voltage controlled oscillator including an amplifier, a feedback circuit and a crystal oscillator, two MOS transistors M1, M2 are connected for use as variable capacity elements for the frequency adjustment of the voltage controlled oscillator. Drains of the MOS transistors M1, M2 are respectively connected to an XT terminal and an XTB terminal of the crystal oscillator. Sources of the MOS transistors M1, M2 are made common and connected to a grounding terminal via a capacitor C3. Gates of the MOS transistors M1, M2 are made common, and an added voltage signal of a temperature compensating signal voltage and an external frequency control signal voltage is applied to the common gate terminals of the MOS transistors to thereby perform the frequency control of the oscillator.
摘要翻译：在包括放大器，反馈电路和晶体振荡器的压控振荡器中，两个MOS晶体管M 1，M 2连接用作用于压控振荡器的频率调整的可变电容元件。 MOS晶体管M 1，M 2的漏极分别连接到晶体振荡器的XT端子和XTB端子。 MOS晶体管M 1，M 2的源极共同，并通过电容器C 3连接到接地端子。 MOS晶体管M 1，M 2的栅极共同，并且将温度补偿信号电压和外部频率控制信号电压的附加电压信号施加到MOS晶体管的公共栅极端子，从而执行频率控制振荡器。

36. 发明申请

US20140194654A1 Process for Producing Alpha-Fluoroaldehydes 有权
标题翻译：生产α-氟醛的方法
公开(公告)号：US20140194654A1
公开(公告)日：2014-07-10
申请号：US14233629
申请日：2012-07-24
申请人： Akihiro Ishii , Takashi Ootsuka , Mari Imamura , Takayuki Nishimiya , Kazuto Kimura
发明人： Akihiro Ishii , Takashi Ootsuka , Mari Imamura , Takayuki Nishimiya , Kazuto Kimura
IPC分类号： C07C45/41
CPC分类号： C07C45/41 , B01J31/189 , B01J2231/641 , B01J2531/821 , C07C41/50 , C07C47/14 , C07C43/317
摘要： A production process of an α-fluoroaldehyde according to the present invention includes reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a ruthenium complex. It is possible in the present invention to allow relatively easy industrial production of the α-fluoroaldehyde and to directly obtain, as stable synthetic equivalents of the α-fluoroaldehyde, not only a hydrate (as obtained by conventional techniques) but also a hemiacetal that is easy to purify and is of high value in synthetic applications. The present invention provides solutions to all problems in the conventional techniques and establishes the significantly useful process for production of the α-fluoroaldehyde.
摘要翻译：根据本发明的α-氟代醛的制备方法包括在钌络合物的存在下α-氟酯与氢气（H 2）的反应。在本发明中，可以相对容易的工业生产α-氟代醛，并直接获得作为α-氟代醛的稳定的合成当量，而不仅仅是水合物（通过常规技术获得），而且还可以获得半缩醛易于净化，在合成应用中具有很高的价值。本发明提供了常规技术中所有问题的解决方案，并且建立了生产α-氟代醛的显着有用的方法。

37. 发明申请

US20130303774A1 Method For Producing Beta-Fluoroalcohol 有权
标题翻译：生产β-氟醇的方法
公开(公告)号：US20130303774A1
公开(公告)日：2013-11-14
申请号：US13990114
申请日：2012-01-27
申请人： Akihiro Ishii , Takashi Ootsuka , Takehisa Ishimaru , Mari Imamura
发明人： Akihiro Ishii , Takashi Ootsuka , Takehisa Ishimaru , Mari Imamura
IPC分类号： C07C29/149 , C07D213/30
CPC分类号： C07C29/149 , B01J31/189 , B01J2231/643 , B01J2531/0258 , B01J2531/821 , C07D213/30 , C07C31/38 , C07C31/42 , C07C33/46 , C07C33/423
摘要： A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.
摘要翻译： β-氟代醇的制备方法包括在特定的钌络合物（即通式[2]的钌络合物）存在下进行α-氟代酯与氢气（H 2）的反应，优选的是钌络合物通式[4]）。该制造方法可以通过使用这种特定的钌络合物来采用1MPa以下的合适的氢压，并且在投入工业实践中不需要高压气体生产设备。此外，与通常的α-氟代醇还原反应的底物/催化剂比例相比，该制造方法可以显着地减少其中使用的催化剂的用量（例如基质/催化剂比为20,000）。通过这些氢气压力和催化剂量的降低可以大大降低β-氟代醇的生产成本。

38. 发明授权

US08344187B2 Practical method for reducing esters or lactones 有权
标题翻译：减少酯或内酯的实用方法
公开(公告)号：US08344187B2
公开(公告)日：2013-01-01
申请号：US12991073
申请日：2009-06-26
申请人： Takao Ikariya , Masato Ito , Akira Shiibashi , Takashi Ootsuka
发明人： Takao Ikariya , Masato Ito , Akira Shiibashi , Takashi Ootsuka
IPC分类号： C07C29/136 , C07C29/149
CPC分类号： C07C29/149 , C07B31/00 , C07B2200/07 , C07C31/38 , C07C33/22 , C07C33/26 , C07C31/20
摘要： Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.
摘要翻译：在第8（VIII）族过渡金属络合物，碱和氢气（H2）的存在下，酯和内酯可以分别还原为醇和二醇。可以通过组8（VIII）过渡金属络合物，碱，碱的使用量，氢气的压力和反应温度的优选组合来提供非常实用的还原方法。该方法用于代替氢化物还原，并且是可以相对容易地制备高活性催化剂的设计的有用方法，同时可以预期高生产率。

39. 发明授权

US08278479B2 Method for producing optically active fluorine-containing carbonyl-ene product 有权
标题翻译：光学活性含氟羰基产物的制备方法
公开(公告)号：US08278479B2
公开(公告)日：2012-10-02
申请号：US12519959
申请日：2007-12-18
申请人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
发明人： Koichi Mikami , Kohsuke Aikawa , Akihiro Ishii , Kaori Mogi , Takashi Ootsuka
IPC分类号： C07C69/732
CPC分类号： C07C67/347 , C07B53/00 , C07B2200/07 , C07C67/343 , C07C69/732
摘要： An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing α-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of conducting this reaction in the absence of reaction solvent, Mode 2 of conducting this reaction in a solvent that is low in relative dielectric constant, and Mode 3 of conducting this reaction in a halogenated hydrocarbon-series solvent. In each of these three modes, it is possible to produce the optically active, fluorine-containing carbonyl-ene product with low cost.
摘要翻译：通过在具有光学活性配体的过渡金属络合物的存在下使含氟α-酮酯与烯烃反应来制备光学活性的含氟羰基产物。在没有反应溶剂的情况下进行该反应的方式1，在相对介电常数低的溶剂中进行该反应的方式2，以及在卤代烃系溶剂中进行该反应的方式3。在这三种模式中的每一种中，可以以低成本制造光学活性的含氟羰基产物。

40. 发明申请

US20120059187A1 Process for Preparation of 2-Fluoroacrylic Esters 有权
标题翻译： 2-氟丙烯酸酯的制备方法
公开(公告)号：US20120059187A1
公开(公告)日：2012-03-08
申请号：US13266008
申请日：2010-03-23
申请人： Akihiro Ishii , Takako Yamazaki , Hideyuki Tsuruta , Satoru Miyazawa , Michitaka Ootani , Takashi Ootsuka , Mikihiro Takahashi , Masataka Fujimoto
发明人： Akihiro Ishii , Takako Yamazaki , Hideyuki Tsuruta , Satoru Miyazawa , Michitaka Ootani , Takashi Ootsuka , Mikihiro Takahashi , Masataka Fujimoto
IPC分类号： C07C67/307
CPC分类号： C07C67/317 , C07C69/653
摘要： According to the present invention, there is provided a production process of a 2-fluoroacrylic ester including: a bromination step of converting a 2-fluoropropionic ester to a 2-bromo-2-fluoropropionic ester by reaction of the 2-fluoropropionic ester with a nitrogen-bromine bond-containing brominating agent in the presence of a radical initiator; and a dehydrobromination step of reacting the 2-bromo-2-fluoropropionic ester with a base. It is not necessary in this process to adopt very-low-temperature conditions and to use a stoichiometric amount of expensive reagent. The target 2-fluoroacrylic ester can be thus produced at low cost.
摘要翻译：根据本发明，提供了一种2-氟丙烯酸酯的制备方法，包括：通过2-氟代丙酸酯与2-氟丙酸酯的反应将2-氟丙酸酯转化为2-溴-2-氟丙酸酯的溴化步骤含有溴 - 溴键的溴化剂在自由基引发剂的存在下反应; 和使2-溴-2-氟丙酸酯与碱反应的脱溴氢化步骤。在这个过程中不需要采用非常低的温度条件和使用化学计量的昂贵的试剂。因此可以低成本制备目标2-氟丙烯酸酯。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式