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31. 发明授权

US09290804B2 Microparticle having single-molecule nucleic acid probe, method for producing same, method for analyzing nucleic acid using same, device for nucleic acid analysis, and apparatus for analyzing nucleic acid 有权
公开(公告)号：US09290804B2
公开(公告)日：2016-03-22
申请号：US13981983
申请日：2012-01-26
申请人： Toshiro Saito , Kazumichi Imai , Takayuki Obara , Eri Tarasawa
发明人： Toshiro Saito , Kazumichi Imai , Takayuki Obara , Eri Tarasawa
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6834 , C12Q1/6876 , C12Q2525/131 , C12Q2525/197 , C12Q2535/122 , C12Q2537/125 , C12Q2537/159 , C12Q2563/155
摘要： A microparticle having a probe molecule able to capture a specific nucleic acid group to be analyzed is used to extract only the specific nucleic acid group to be analyzed from a nucleic acid sample and the microparticle is thereafter directly immobilized on a smooth plate, whereby a device for nucleic acid analysis is rapidly prepared. Immobilizing a single capture probe molecule onto an individual microparticle in advance and forming, at regular positions on the smooth substrate, an adhesion pad on which a functional group that binds to the microparticle has been introduced makes it possible to readily and rapidly prepare the device for nucleic analysis, where the nucleic acid sample to be analyzed is arranged molecule by molecule in a lattice shape on the smooth substrate.

32. 发明申请

US20130316336A1 ANALYZER 有权
标题翻译：分析仪
公开(公告)号：US20130316336A1
公开(公告)日：2013-11-28
申请号：US13983340
申请日：2012-01-13
申请人： Takuya Matsui , Ryoji Inaba , Kazumichi Imai , Ryusuke Kimura
发明人： Takuya Matsui , Ryoji Inaba , Kazumichi Imai , Ryusuke Kimura
IPC分类号： C12Q1/68
CPC分类号： B01L3/502 , B01L3/0224 , B01L2300/026 , B01L2400/0406 , C12Q1/6869 , G01N35/0098 , G01N35/1002 , G01N35/1004 , G01N35/1095 , G01N2035/1039
摘要： Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.
摘要翻译：提供了能够减少试剂浪费量和溶液发送所需时间缩短的分析装置，从而提高分析用量。微量注射器将最小所需量的试剂吸收到与采样喷嘴相当的流动池的容量基本上相同的量。然后，将取样喷嘴插入流通池的注入口，通过驱动微量注射器将试剂注入到流通池中。通过将采样喷嘴移动到清洗槽并从采样喷嘴喷射清洗水来清洁采样喷嘴的内部，并且通过从清洗槽的内壁喷射清洁水来清洁采样喷嘴的外部。

33. 发明申请

US20120316087A1 Nucleic Acid Analyzer, Reaction Device for Nucleic Acid Analysis and Substrate of Reaction Device for Nucleic Acid Analysis 有权
标题翻译：核酸分析仪，用于核酸分析的反应装置和用于核酸分析的反应装置的底物
公开(公告)号：US20120316087A1
公开(公告)日：2012-12-13
申请号：US13575564
申请日：2010-12-01
申请人： Yoshiaki Sugimura , Masatoshi Narahara , Kazumichi Imai , Toshiro Saito , Ryoji Inaba , Takuya Matsui
发明人： Yoshiaki Sugimura , Masatoshi Narahara , Kazumichi Imai , Toshiro Saito , Ryoji Inaba , Takuya Matsui
IPC分类号： C40B60/10
CPC分类号： G01N33/54313 , B01L3/502715 , B01L2200/0668 , B01L2300/0609 , B01L2300/0877 , B01L2300/0883 , G01N21/6452 , G01N21/648 , G01N33/5308 , G01N33/54373 , G01N33/582 , G01N35/00 , G01N2035/00564
摘要： Provided is a reaction device for nucleic acid analysis wherein microparticles, which carry a nucleic acid to be detected having been immobilized thereon, are aligned in a lattice form on a substrate according to the pixel size of a two-dimensional sensor. By this reaction device for nucleic acid analysis which is provided with a channel-forming reaction chamber on the substrate (101), the nucleic acid having been immobilized on the microparticles (103) on the substrate (101) is detected. The microparticles (103), which carry the nucleic acid to be detected having been immobilized thereon, are arranged by microstructures (102) aligned on the substrate (101).
摘要翻译：提供了用于核酸分析的反应装置，其中携带已被固定在其上的被检测核酸的微粒根据二维传感器的像素尺寸以格子形式排列在基板上。通过在基板（101）上设置有通道形成反应室的核酸分析用反应装置，检测固定在基板（101）上的微粒（103）上的核酸。携带已被固定在其上的被检测核酸的微粒（103）通过在基板（101）上排列的微结构（102）布置。

34. 发明授权

US07883613B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US07883613B2
公开(公告)日：2011-02-08
申请号：US11806889
申请日：2007-06-05
申请人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
发明人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.
摘要翻译：本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。此外，在毛细管中有效地进行温度控制。在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。毛细管电泳装置包括可以同时存储样品和缓冲液的容器。毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

35. 发明申请

US20060231400A1 Electrophoretic apparatus and electrophoretic method 有权
公开(公告)号：US20060231400A1
公开(公告)日：2006-10-19
申请号：US11397890
申请日：2006-04-05
申请人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
发明人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
IPC分类号： B01D57/02 , G01N27/00
CPC分类号： G01N27/44721 , G01N27/44782
摘要： The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the electrophoretic paths in a direction approximately vertical to an electrophoretic direction. According to the invention, since an emission spectrum to be detected does not substantially change over time, it becomes possible to make observed emission spectrums completely correspond to various fluorescent dyes or various bases.

36. 发明授权

US06572752B1 Capillary electrophoretic instrument and capillary array assembly 有权
标题翻译：毛细管电泳仪和毛细管阵列组件
公开(公告)号：US06572752B1
公开(公告)日：2003-06-03
申请号：US09671818
申请日：2000-09-27
申请人： Muneo Maeshima , Kazumichi Imai , Masaya Kojima , Satoshi Takahashi , Hiromi Yamashita
发明人： Muneo Maeshima , Kazumichi Imai , Masaya Kojima , Satoshi Takahashi , Hiromi Yamashita
IPC分类号： G01N27453
CPC分类号： G01N27/44713 , G01N27/447 , G01N27/44704 , G01N27/44743 , G01N27/44782
摘要： The troublesomeness during the setting of a plurality of capillaries is eliminated by composing pairs of electrodes, which are electrically connected to the common electrode, and capillaries. By bringing electrodes installed in the vicinity of each capillary disposed at the pitch of wells on the side of sample plate (within the area of the wells) into electrical contact with a common electrode, the capillaries and electrodes are made integral in construction. When a voltage is applied to the electrophoretic instrument via a common electrode portion, the voltage is applied to the electrodes for each capillary. This enables an inexpensive microtiter plate, etc. to be used and a multiple of capillaries to be simultaneously inserted, attached and detached.
摘要翻译：通过构成电连接到公共电极的电极对和毛细管来消除在多个毛细管的设置期间的麻烦。通过将设置在每个毛细管附近的电极安装在位于样品板（在孔的区域内）与公共电极电接触，毛细管和电极在结构上是一体的。当通过公共电极部分向电泳仪施加电压时，对每个毛细管的电极施加电压。这使得可以使用廉价的微量滴定板等，同时插入，附着和分离多个毛细管。

37. 外观设计

USD430304S DNA detector 失效
公开(公告)号：USD430304S
公开(公告)日：2000-08-29
申请号：US100091
申请日：1999-02-03
申请人： Mitsuru Oonuma , Seiji Kamimura , Atsushi Ninomiya , Isamu Takekoshi , Kazumichi Imai
设计人： Mitsuru Oonuma , Seiji Kamimura , Atsushi Ninomiya , Isamu Takekoshi , Kazumichi Imai

38. 发明授权

US5938908A Capillary array electrophoresis system 失效
标题翻译：毛细管阵列电泳系统
公开(公告)号：US5938908A
公开(公告)日：1999-08-17
申请号：US847735
申请日：1997-04-22
申请人： Takashi Anazawa , Hideki Kambara , Satoshi Takahashi , Kazumichi Imai , Hisanori Nasu
发明人： Takashi Anazawa , Hideki Kambara , Satoshi Takahashi , Kazumichi Imai , Hisanori Nasu
IPC分类号： G01N21/64 , B01D57/02 , G01N27/447 , G01N35/00 , G01N27/26
CPC分类号： G01N27/44721 , G01N27/44782 , G01N2035/00237
摘要： A capillary electrophoresis system comprising a plurality of capillaries filled with a migration medium in which samples to which fluorephore labels are added migrate, a light source providing an excitation light exciting the fluorephore labels, a photo detector detecting a fluorescence radiated from the fluorephore labels, and light focusing means placed between the plurality of capillaries to which the excitation light is irradiated. The parts of the plurality of capillaries to which the excitation light is irradiated and the light focusing means are arranged in a plane shape. The excitation light is irradiated through the plurality of capillaries and the light focusing means, the capillaries and light focusing means alternatively placed in the parts where an excitation light is irradiated. The light focusing means consisting of cylindrical rod lenses. The axis of the cylindrical rod lenses is placed substantially parallel with the capillaries, which can detect the fluorescence from samples by irradiating a plurality of capillaries substantially at the same time in a batch without mechanical scanning of a plurality of capillaries or without optical scanning of a light beam, providing a highly sensitive detection of samples.
摘要翻译：一种毛细管电泳系统，包括填充有迁移介质的多个毛细管，其中添加有荧光标记的样品迁移，提供激发荧光标记的激发光的光源，检测从荧光标记物辐射的荧光的光电检测器，以及放置在激发光照射到的多个毛细管之间的光聚焦装置。照射激发光的多个毛细管的部分和光聚焦装置被布置成平面形状。激发光通过多个毛细管和光聚焦装置照射，毛细管和光聚焦装置交替地放置在照射激发光的部分中。光聚焦装置由圆柱形棒状透镜组成。圆柱形棒状透镜的轴线基本上与毛细管平行放置，其可以通过基本上同时照射多个毛细管而检测来自样品的荧光，而不需要对多个毛细管进行机械扫描，或者不进行光学扫描光束，提供高灵敏度的样品检测。

39. 发明授权

US5543292A Process for the measurement of nucleic acids 失效
标题翻译：核酸测量方法
公开(公告)号：US5543292A
公开(公告)日：1996-08-06
申请号：US76165
申请日：1993-06-14
申请人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
发明人： Kyoko Imai , Kazumichi Imai , Yasushi Nomura
IPC分类号： C12Q1/68 , G01N15/14 , G01N35/00 , G01N35/02
CPC分类号： G01N35/025 , C12Q1/6823 , C12Q1/6834 , G01N2015/1409 , G01N2035/00485
摘要： A process for detecting the existence of at least one sequence of oligonucleotide in a nucleic acid sample includes at least one performance of a step of mixing the sample witha labeled common polynucleotide, anda polynucleotide probe comprising a sequence complementary to at least a part of the sequence of oligonucleotide and a sequence complementary to at least a part of the labeled common polynucleotide. The existence of a sequence of oligonucleotide which is an analyte existing in a nucleic acid sample can be detected by the use of a common reagent and an unattached polynucleotide having a base sequence specific for the analyte to be measured.
摘要翻译：用于检测核酸样品中至少一个寡核苷酸序列的存在的方法包括将样品与标记的共同多核苷酸混合的步骤的至少一个性能，以及包含与至少一部分寡核苷酸序列和与标记的共同多核苷酸的至少一部分互补的序列。存在核酸样品中存在的分析物的寡核苷酸序列的存在可以通过使用具有对待测量的分析物特异的碱基序列的常见试剂和未附着的多核苷酸来检测。

40. 发明授权

US4628035A Immunoassay method 失效
标题翻译：免疫测定法
公开(公告)号：US4628035A
公开(公告)日：1986-12-09
申请号：US638423
申请日：1984-08-07
申请人： Daizo Tokinaga , Teruaki Kobayashi , Kazumichi Imai
发明人： Daizo Tokinaga , Teruaki Kobayashi , Kazumichi Imai
IPC分类号： A61K39/44 , G01N33/561 , G01N33/58 , G01N33/543
CPC分类号： G01N33/561
摘要： An immunoassay method for measuring a concentration of an antigen for a short period of time by immobilizing an antibody over the whole zone of an effective supporting matrix for electrophoresis and fixing an antigen in a sample to be measured by electrophoresis for the antigen-antibody reaction between said immobilized antibody and said antigen.
摘要翻译：一种免疫测定方法，用于通过将抗体固定在有效支持基质的整个区域上进行电泳和固定待测样品中的抗原，将抗体固定在短时间内的抗原浓度，以通过电泳进行抗原抗体反应所述固定化抗体和所述抗原。

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