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31. 发明申请

US20050049189A1 Protein iduced by homogeneous blood transfusion and dna encoding the same 失效
标题翻译：蛋白质均匀输血和dna编码相同
公开(公告)号：US20050049189A1
公开(公告)日：2005-03-03
申请号：US10344307
申请日：2001-08-01
申请人： Hiroo Uchida , Hirokazu Tanaka , Yasuhiko Kitoh , Akio Fujimura , Eiji Kobayashi
发明人： Hiroo Uchida , Hirokazu Tanaka , Yasuhiko Kitoh , Akio Fujimura , Eiji Kobayashi
IPC分类号： A61K38/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P27/16 , A61P29/00 , A61P37/06 , A61P37/08 , C07K14/81 , C12N1/21 , C12N15/12 , A61K38/17 , C07K14/47
CPC分类号： C07K14/8114 , A61K38/00 , C07K14/811
摘要： The present invention relates to a novel protein (MAY-I) which exhibits immunosuppressive activity in allogeneic mixed lymphocyte reaction, and provides a gene encoding that protein, a vector containing said gene, a transformant produced by said vector, a method of manufacturing the said protein with immune activity by culturing said transformant, and a medicinal composition and the like containing the said protein.
摘要翻译：本发明涉及在同种异体混合淋巴细胞反应中表现出免疫抑制活性的新型蛋白质（MAY-1），提供编码该蛋白质的基因，含有该基因的载体，由该载体产生的转化体，通过培养所述转化体的具有免疫活性的蛋白质和含有所述蛋白质的药物组合物等。

32. 发明授权

US06638377B2 Aluminum alloy piping material for automotive piping excelling in corrosion resistance and workability 有权
标题翻译：用于汽车管道的铝合金管道材料具有优异的耐腐蚀性和可加工性
公开(公告)号：US06638377B2
公开(公告)日：2003-10-28
申请号：US09954430
申请日：2001-09-17
申请人： Takahiro Koyama , Hirokazu Tanaka , Yoshifusa Shoji
发明人： Takahiro Koyama , Hirokazu Tanaka , Yoshifusa Shoji
IPC分类号： C22C2100
CPC分类号： C22F1/04 , C22C21/00 , F16L9/02
摘要： An aluminum alloy piping material for automotive piping excelling in corrosion resistance and workability and a method of fabricating the same. The aluminum alloy piping material is made of an aluminum alloy which contains 0.3-1.5% of Mn, 0.01-0.20% of Fe, and 0.01-0.20% of Si, wherein the content of Cu as impurities is limited to 0.05% or less, with the balance being Al and impurities, wherein, among Si compounds, Fe compounds, and Mn compounds present in the alloy's matrix, the number of compounds with a particle diameter (equivalent circle diameter, hereinafter the same) of 0.5 &mgr;m or more is 3×104 or less per mm2. The aluminum alloy piping material has a tensile strength of 70-130 MPa (temper: O material). An ingot of an aluminum alloy having the composition is hot extruded. The resulting extruded pipe is cold drawn at a working ratio of 30% or more and annealed.
摘要翻译：一种用于汽车管道的铝合金管道材料，其耐腐蚀性和加工性优良，且其制造方法。铝合金管材由铝合金制成，其含有0.3-1.5％的Mn，0.01-0.20％的Fe和0.01-0.20％的Si，其中作为杂质的Cu的含量被限制在0.05％以下，余量为Al和杂质，其中，在Si化合物中，Fe化合物和存在于合金基体中的Mn化合物中，粒径（当量圆直径，以下相同）为0.5μm以上的化合物的数量为3×10 <4>以下/ mm 2。铝合金管材的拉伸强度为70-130MPa（回火：O材料）。具有该组成的铝合金锭被热挤压。将得到的挤出管以30％以上的加工率进行冷拉伸并退火。

33. 发明授权

US06526086B1 Band narrowing laser 有权
标题翻译：乐队变窄的激光
公开(公告)号：US06526086B1
公开(公告)日：2003-02-25
申请号：US09423197
申请日：1999-11-04
申请人： Osamu Wakabayashi , Hirokazu Tanaka , Tatsuya Ariga
发明人： Osamu Wakabayashi , Hirokazu Tanaka , Tatsuya Ariga
IPC分类号： H01S309
CPC分类号： H01S3/1055 , H01S3/106 , H01S3/1305 , H01S3/136 , H01S3/139
摘要： A band narrowing laser having a band narrowing module which narrows by a band narrowing element a band of the laser beam generated from a laser medium, in which wavefront correction means (10) that corrects the wavefront of an incident laser beam and and projects the corrected beam is intalled in the band narrowing module (6) to produce a laser beam with a narrow and stable spectral line width.
摘要翻译：一种带式变窄激光器，其具有由带状窄化元件使由激光介质产生的激光束的波段变窄的波段变窄模块，其中波前校正装置（10）校正入射激光束的波前并且投影校正的波长光束在带狭窄模块（6）中被安置，以产生具有窄且稳定的光谱线宽度的激光束。

34. 发明授权

US06482419B1 Inorganic composite powder and cosmetic comprising the same 有权
标题翻译：无机复合粉末及其组合物
公开(公告)号：US06482419B1
公开(公告)日：2002-11-19
申请号：US09647498
申请日：2000-09-29
申请人： Takumi Miyazaki , Hirokazu Tanaka
发明人： Takumi Miyazaki , Hirokazu Tanaka
IPC分类号： A61K600
CPC分类号： A61Q1/12 , A61K8/11 , A61K8/19 , A61K8/23 , A61K8/25 , A61K8/26 , A61K8/28 , A61K8/29 , A61K2800/412 , A61Q1/02 , A61Q19/00 , A61Q19/08 , C01P2004/84 , C01P2006/12 , C01P2006/60 , C09C1/0015 , C09C1/0021 , C09C1/0024 , C09C1/0051 , C09C2200/1004 , C09C2200/102 , C09C2200/1087 , C09C2200/302 , C09C2200/303 , C09C2220/103 , C09C2220/106
摘要： An inorganic composite powder is formed of a scaled substrate, and at least three inorganic oxide layers having different refractive indexes respectively and sequentially laminated in an order of high refractive index to low refractive index from a surface of the scaled substrate to an utmost outer layer. A refractive index of an inorganic oxide used for forming the utmost outer layer is 1.73 or less, and a difference in the refractive indexes between the utmost layer and a layer adjacent thereto is 0.6 or less. Alternatively, the thickness of at least one of a second or higher inorganic oxide layer is within ±20% of a value d given by an equation: d=(&lgr;×X/4)/n, wherein &lgr; indicates a wavelength of visual light, X indicates an odd integer, and n indicates the refractive index of the inorganic oxide.
摘要翻译：无机复合粉末由比例基板和至少三个具有不同折射率的无机氧化物层分别按顺序层叠，从折射率低的折射率到低折射率的顺序从缩放基板的表面到最外层。用于形成最外层的无机氧化物的折射率为1.73以下，最上层与与其相邻的层的折射率差为0.6以下。或者，第二或更高无机氧化物层中的至少一个的厚度在由d =（lambdxX / 4）/ n给出的值d的±20％之内，其中lambd表示视觉光的波长，X 表示奇数整数，n表示无机氧化物的折射率。

35. 发明授权

US06201005B1 Method for inhibiting lymphokine production 失效
标题翻译：抑制淋巴细胞生成的方法
公开(公告)号：US06201005B1
公开(公告)日：2001-03-13
申请号：US09411630
申请日：1999-10-01
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N4338
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译：本发明涉及可用于治疗和预防移植抵抗力的三环化合物，通过髓质骨移植自身免疫性疾病，传染病等的移植物抗宿主病，其可以由下式表示：制备成含有该组合物的药物组合物及其用途。

36. 发明授权

US6129143A Brazing sheet having an excellent corrosion resistance for use in a heat exchanger, and a heat exchanger using the same 失效
标题翻译：在热交换器中使用具有优异的耐腐蚀性的钎焊片和使用其的热交换器
公开(公告)号：US6129143A
公开(公告)日：2000-10-10
申请号：US906455
申请日：1997-08-05
申请人： Yoshiharu Hasegawa , Haruhiko Miyachi , Yuji Suzuki , Hiroshi Ikeda , Hirokazu Tanaka , Takahiro Koyama , Koji Hirao
发明人： Yoshiharu Hasegawa , Haruhiko Miyachi , Yuji Suzuki , Hiroshi Ikeda , Hirokazu Tanaka , Takahiro Koyama , Koji Hirao
IPC分类号： B23K35/02 , B23K35/28 , B32B15/01 , F28F21/08 , B32B15/20
CPC分类号： B32B15/016 , B23K35/286 , F28F21/089 , B23K35/0238 , Y10S428/933 , Y10T428/12764
摘要： A brazing sheet which has an excellent corrosion resistance and cladding rolling property, and is formed from a four layer aluminum alloy cladding member, and a heat exchanger of aluminum alloy, in which the brazing sheet is used, are provided. The brazing sheet is suitable for use as a member in the fluid path of an aluminum heat exchange for a car, and particularly, as a core plate of a drawn cup type heat exchanger. In the brazing sheet, one side of a core member is cladded with an intermediate member less noble than a core member, and the other side of both the core member and the intermediate member are cladded with Al--Si--Mg type cladding member, wherein the core member is of an aluminum alloy containing 0.5 to 1.6% of Mn, 0.15 to 0.35% of Cu, 0.05 to 0.50% of Mg, 0.06 to 0.30% of Ti, and the remainder being Al and unavoidable impurities, and the intermediate member contains 0.5 to 1.2% of Mn and the remainder being aluminum and unavoidable impurities, and 0.05 to 1.2% of Mg, if desired, and has a 70 to 130% deformation resistance. The intermediate member may be composed of an aluminum alloy containing 1 to 5% of Zn, 0.5 to 1.2% of Mg, and the remainder being Al and unavoidable impurities.
摘要翻译：提供具有优异的耐腐蚀性和包层轧制性的钎焊板，由四层铝合金包覆部件和使用钎焊板的铝合金热交换器形成。钎焊片适合用作汽车铝热交换器的流体路径中的部件，特别是作为拉拔式热交换器的芯板。在钎焊片中，芯构件的一侧被覆有中心构件，其中心构件比芯构件的贵度低，并且芯构件和中间构件的另一侧被Al-Si-Mg型包覆构件包覆，其中芯构件是含有Mn：0.5〜1.6％，Cu：0.15〜0.35％，Mg：0.05〜0.50％，Ti：0.06〜0.30％，余量：Al和不可避免的杂质的铝合金，中间构件含有0.5〜1.2％的Mn，其余为铝和不可避免的杂质，如果需要，含有0.05〜1.2％的Mg，并且具有70〜130％的变形抗力。中间构件可以由含有1至5％的Zn，0.5至1.2％的Mg，其余为Al和不可避免的杂质的铝合金构成。

37. 发明授权

US5888972A Peptide compounds, their preparation and uses 失效
标题翻译：肽化合物，其制备和用途
公开(公告)号：US5888972A
公开(公告)日：1999-03-30
申请号：US564271
申请日：1997-06-24
申请人： Keiji Hemmi, deceased , Masahiro Neya , Naoki Fukami , Natsuko Kayakiri , Hirokazu Tanaka
发明人： Keiji Hemmi, deceased , Masahiro Neya , Naoki Fukami , Natsuko Kayakiri , Hirokazu Tanaka
IPC分类号： A61K38/00 , A61P9/12 , C07K5/02 , C07K5/03 , C07K5/062 , C07K5/08 , C07K5/083 , A61K38/06 , A61K38/07
CPC分类号： C07K5/0808 , C07K5/0207 , C07K5/0827 , A61K38/00 , Y02P20/55
摘要： A compound of the formula: ##STR1## in which R.sup.4 is acyl,R.sup.5 is lower alkyl,R.sup.6 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl,R.sup.7 is lower alkyl or lower alkylthio(lower)alkyl,R.sup.8 is carboxy or protected carboxy,A is lower alkylene,Z is a group of the formula: ##STR2## wherein R.sup.1 is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl,R.sup.2 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, andR.sup.3 is optionally substituted heterocyclic(lower)alkyl, andm is an integer of 0 to 2,or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.
摘要翻译： PCT No.PCT / JP94 / 01042 Sec。 371日期1996年6月24日 102（e）1996年6月24日PCT 1994年6月28日PCT公布。公开号WO95 / 00537 日期1995年1月5日具有下式的化合物：其中R 4为酰基，R 5为低级烷基，R 6为任选取代的芳（低级）烷基或任选取代的杂环 - （低级）烷基，R 7为低级烷基或低级烷硫基（低级）烷基，R 8为羧基或被保护的羧基，A为低级亚烷基，Z为下式基团：其中R 1为氢，低级烷基，普通氨基保护基或任选取代的芳（低级）烷基（低级）烷基，任选取代的杂环 - （低级）烷基，任选取代的环（低级）烷基（低级）烷基，常用氨基保护基，氨基（或被保护的氨基）（低级烷基，任选取代的杂环羰基或环（低级）烷基，R 3为任选取代的杂环（低级）烷基，m为0-2的整数，或其药学上可接受的盐，可用作内皮素拮抗剂。

38. 发明授权

US5861771A Regulator circuit and semiconductor integrated circuit device having the same 失效
标题翻译：调节器电路和具有其的半导体集成电路器件
公开(公告)号：US5861771A
公开(公告)日：1999-01-19
申请号：US871954
申请日：1997-06-10
申请人： Atsushi Matsuda , Hirokazu Tanaka , Kunihiko Gotoh
发明人： Atsushi Matsuda , Hirokazu Tanaka , Kunihiko Gotoh
IPC分类号： G05F1/56 , G05F1/46 , G11C11/407 , H02M3/156 , G05F3/16
CPC分类号： H02M3/1563 , G05F1/465
摘要： A regulator circuit includes an output circuit outputting an output voltage based on a control voltage, a reference voltage generating circuit generating a reference voltage, an output voltage control circuit comparing the reference voltage with a voltage depending on the output voltage and producing the control voltage based on a comparison result, and a power supply circuit which supplies the reference voltage generating circuit and the output voltage control circuit with a first power supply voltage which is different from a second power supply voltage supplied to the output circuit.
摘要翻译：调节器电路包括输出基于控制电压的输出电压的输出电路，产生参考电压的参考电压产生电路，将参考电压与取决于输出电压的电压进行比较并输出基于控制电压的输出电压控制电路以及电源电路，其向基准电压产生电路和输出电压控制电路提供与提供给输出电路的第二电源电压不同的第一电源电压。

39. 发明授权

US5663673A Output circuit having at least one external transistor 失效
标题翻译：输出电路具有至少一个外部晶体管
公开(公告)号：US5663673A
公开(公告)日：1997-09-02
申请号：US413947
申请日：1995-03-30
申请人： Hirokazu Tanaka , Tatsuo Kumano , Tetsuji Funaki , Takahiro Watai
发明人： Hirokazu Tanaka , Tatsuo Kumano , Tetsuji Funaki , Takahiro Watai
IPC分类号： H03G5/16 , H03F1/30 , H03F3/30 , H03F3/45 , H04M19/00 , H03F3/26 , H03K17/16
CPC分类号： H03F3/3071 , H03F1/307
摘要： An output circuit, for minimizing output idle current fluctuations and improve the output voltage range, has first and second transistors connected to first and second power sources, with a plurality of diodes connected to control terminals of the first and second transistors. The output circuit further includes a third transistor having a first terminal connected to the second power source and a second terminal connected to a predetermined position among the plurality of diodes. A predetermined voltage is applied from the diodes to the control terminal of the first transistor when the third transistor is saturated, to bring a level of an output of said output circuit close to a level of the second power source. A fourth transistor, a fifth transistor, a first resistor, and a capacitor are also provided. The forth transistor has a control terminal connected to an output of a differential circuit, and a first terminal connected to the second power source through the first resistor as well as to the control terminals of the third and fifth transistors. A second terminal is connected to the first power source, with the fifth transistor having a first terminal connected to the second power source and a second terminal connected to the control terminal of the second transistor. The capacitor is connected between the control terminal of the fourth transistor and the second terminal of the fifth transistor. This output circuit also limits the output voltage without changing the impedance of the high-impedance input.
摘要翻译：用于最小化输出空闲电流波动并改善输出电压范围的输出电路具有连接到第一和第二电源的第一和第二晶体管，多个二极管连接到第一和第二晶体管的控制端子。输出电路还包括具有连接到第二电源的第一端子和连接到多个二极管中的预定位置的第二端子的第三晶体管。当第三晶体管饱和时，从二极管向第一晶体管的控制端施加预定电压，以使所述输出电路的输出电平接近第二电源的电平。还提供第四晶体管，第五晶体管，第一电阻器和电容器。第四晶体管具有连接到差分电路的输出的控制端子，以及通过第一电阻器连接到第二电源的第一端子以及第三和第五晶体管的控制端子。第二端子连接到第一电源，第五晶体管具有连接到第二电源的第一端子和连接到第二晶体管的控制端子的第二端子。电容器连接在第四晶体管的控制端和第五晶体管的第二端之间。该输出电路还限制输出电压，而不改变高阻抗输入的阻抗。

40. 发明授权

US5624842A Strain of Streptomyces for the production of tricyclo compounds 失效
标题翻译：用于生产三环化合物的链霉菌菌株
公开(公告)号：US5624842A
公开(公告)日：1997-04-29
申请号：US450412
申请日：1995-05-25
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译：本发明涉及可用于治疗和预防移植抵抗的三环类化合物，通过髓质移植移植物抗宿主病，自身免疫性疾病，感染性疾病等，其可以由下式表示：（ I）涉及其制备方法，含有该方法的药物组合物及其用途。

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