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31. 发明授权

US08636929B2 Nanoporous foamed active compound-containing preparations based on pharmaceutically acceptable thermoplastically workable polymers 失效
标题翻译：基于药学上可接受的热塑性可加工聚合物的纳米多孔泡沫活性成分制剂
公开(公告)号：US08636929B2
公开(公告)日：2014-01-28
申请号：US13111999
申请日：2011-05-20
申请人： Jan Kurt Walter Sandler , Ingo Bellin , Dejan Djuric , Karl Kolter , Holger Ruckdäschel
发明人： Jan Kurt Walter Sandler , Ingo Bellin , Dejan Djuric , Karl Kolter , Holger Ruckdäschel
IPC分类号： B29C67/20
CPC分类号： A61K31/235 , A61K9/146 , A61K31/496 , B82Y5/00
摘要： Process for the production of nanoporous foamed active substance-containing preparations, wherein the active substance is present embedded in a pharmaceutically acceptable polymer, wherein, in stage a) loading of a polymeric molding composition or a polymer melt with a propellant is effected at a pressure and at a temperature at which the propellant is in the supercritical state, in stage b) heating of the laden polymer molding compound or melt is carried out under pressure at a temperature which lies in the range from −40 to +60° C., preferably −20 to +55° C., and especially preferably 0 to +50° C. around the glass transition temperature of the unladen (prior to loading) polymeric molding compound and in stage c) a depressurization of the polymeric molding compound or melt laden in stage a) and heated under pressure in stage b) is effected out with a depressurization rate in the range from 15,000 to 200,000 MPa/sec.
摘要翻译：制备纳米多孔泡沫活性物质制剂的方法，其中活性物质包含在药学上可接受的聚合物中，其中在阶段a）聚合物模塑组合物或聚合物熔体与推进剂的加载在压力并且在推进剂处于超临界状态的温度下，在阶段b）加载聚合物模塑料或熔体在加压下在-40至+ 60℃的温度下进行，优选为-20至+ 55℃，特别优选为0至+ 50℃，并且在阶段c）将聚合物模塑料或熔体的减压在步骤a）中负载并且在阶段b）中加压，以15,000至200,000MPa /秒的减压速率进行。

32. 发明授权

US08623978B2 Process for the preparation of low-peroxide crosslinked vinyllactam polymer 有权
标题翻译：制备低过氧化物交联乙烯基内酰胺聚合物的方法
公开(公告)号：US08623978B2
公开(公告)日：2014-01-07
申请号：US13303275
申请日：2011-11-23
申请人： Frank Fischer , Erik Bohrer , Angelika Maschke , Karl Kolter , Michael Kerber
发明人： Frank Fischer , Erik Bohrer , Angelika Maschke , Karl Kolter , Michael Kerber
IPC分类号： C08F26/10 , C08F26/06
CPC分类号： C08F2/44 , C08J3/24 , C08J2339/06 , C08K5/0025 , C08K5/005 , C08L39/06
摘要： Process for the preparation of low-peroxide crosslinked vinyllactam polymer by free-radical polymerization in the presence of at least one organic substance acting as antioxidant, low-peroxide crosslinked vinyllactam polymer obtainable by this process, and its use.
摘要翻译：在至少一种作为抗氧化剂的有机物质，通过该方法获得的低过氧化物交联的乙烯基内酰胺聚合物的存在下，通过自由基聚合制备低过氧化物交联的乙烯基内酰胺聚合物的方法及其用途。

33. 发明授权

US08268350B2 Binders for tablets with high strength based on finely divided vinyllactam polymers, the production and use thereof 有权
标题翻译：基于精细分散的乙烯基内酰胺聚合物的具有高强度的片剂的粘合剂，其生产和使用
公开(公告)号：US08268350B2
公开(公告)日：2012-09-18
申请号：US11406320
申请日：2006-04-19
申请人： Karl Kolter , Hermann Ascherl , Bernhard Fussnegger
发明人： Karl Kolter , Hermann Ascherl , Bernhard Fussnegger
IPC分类号： A61K9/20
CPC分类号： A61K47/32 , A61K9/2027 , C08F226/06 , C08F226/10
摘要： Finely divided binders in powder form composed of vinyllactam polymers, where the binders have an average particle size of up to 35 μm and an apparent density of less than 0.2 g/ml.
摘要翻译：由乙烯基内酰胺聚合物组成的粉末形式的细分粘合剂，其中粘合剂的平均粒度高达35μm，表观密度小于0.2g / ml。

34. 发明申请

US20120183623A1 Pellets Coated With Coatings Containing Active Substances 有权
标题翻译：含有活性物质涂层的颗粒
公开(公告)号：US20120183623A1
公开(公告)日：2012-07-19
申请号：US13496533
申请日：2010-09-13
申请人： Karl Kolter , Dejan Djuric , Stefan Fischer , Matthias Karl
发明人： Karl Kolter , Dejan Djuric , Stefan Fischer , Matthias Karl
IPC分类号： A61K9/14 , B05D1/02
CPC分类号： A61K9/1676 , A61K9/1641 , C08F218/08 , C08F226/06 , C08F283/06 , C08L1/02 , C08L5/00 , C08L51/08 , C09D151/08 , C09D171/02
摘要： Formulations of sparingly water-soluble active ingredients, consisting of carrier particles provided with active ingredient-containing coatings, the sparingly soluble active ingredients being embedded in coatings composed of amphiphilic copolymers.
摘要翻译：由具有含活性成分的涂层的载体颗粒组成的微水溶性活性成分的制剂，将微溶于水的活性成分包埋在由两亲性共聚物组成的涂层中。

35. 发明申请

US20120053303A1 Branched Polyesters Based On Citric Acid, Their Preparation And Use 审中-公开
标题翻译：基于柠檬酸的分支聚酯，其制备和使用
公开(公告)号：US20120053303A1
公开(公告)日：2012-03-01
申请号：US13221245
申请日：2011-08-30
申请人： Dejan Djuric , Monika Haberecht , Karl Kolter , Bernd Bruchmann
发明人： Dejan Djuric , Monika Haberecht , Karl Kolter , Bernd Bruchmann
IPC分类号： C08G63/12
CPC分类号： C08G63/133 , A61K9/146 , A61K9/1641 , A61K9/1676 , A61K9/2031 , A61K9/7007 , C08G63/12 , C08G63/85
摘要： Branched polyesters obtained by polycondensation of citric acid with at least one polyalcohol having at least two hydroxyl groups and, if desired, further polycarboxylic acid components, the molar ratio of citric acid to polyalcohol being 2.4:1 to 1:3.
摘要翻译：通过柠檬酸与至少一种具有至少两个羟基的多元醇缩聚得到的支化聚酯，如果需要，还可以含有其它多元羧酸成分，柠檬酸与多元醇的摩尔比为2.4:1至1:3。

36. 发明申请

US20100178306A1 PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF RAPIDLY DISINTEGRATING TABLETS 有权
标题翻译：用于生产快速消毒片的制药配方
公开(公告)号：US20100178306A1
公开(公告)日：2010-07-15
申请号：US12663417
申请日：2008-06-02
申请人： Karl Kolter , Michael Schönherr , Silke Gebert , Kathrin Meyer-Böhm , Angelika Maschke
发明人： Karl Kolter , Michael Schönherr , Silke Gebert , Kathrin Meyer-Böhm , Angelika Maschke
IPC分类号： A61K31/70 , A61K9/14
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： Pharmaceutical formulation in the form of agglomerates comprisingA) an excipient content composed of a) 60-97% by weight of sugar or sugar alcohols, b) 1-25% by weight of a disintegrant, selected from the group consisting of croscarmellose, sodium carboxymethylstarch and L-hydroxypropoylcellulose, c) 1-15% by weight of water-insoluble, film-forming polymers d) 0-15% by weight of water-soluble polymers and e) 0-15% by weight of further pharmaceutically customary excipients the total of the components a) to e) being 100% by weight.
摘要翻译：附聚物形式的药物制剂，其包含A）由a）60-97重量％的糖或糖醇组成的赋形剂含量，b）1-25重量％的崩解剂，其选自交联羧甲纤维素，钠羧甲基淀粉和L-羟丙酰基纤维素，c）1-15重量％的不溶于水的成膜聚合物d）0-15重量％的水溶性聚合物和e）0-15重量％的其它药学上常规的赋形剂组分a）至e）的总量为100重量％。

37. 发明申请

US20080194708A1 Cationic Polymers as Thickeners for Aqueous and Alcoholic Compositions 审中-公开
标题翻译：阳离子聚合物作为水性和醇类组合物的增稠剂
公开(公告)号：US20080194708A1
公开(公告)日：2008-08-14
申请号：US11909034
申请日：2006-03-16
申请人： Peter Hossel , Klemens Mathauer , Claudia Wood , Matthias Laubender , Wolfgang Jahnel , Ivette Garcia Castro , Volker Wendel , Karl Kolter
发明人： Peter Hossel , Klemens Mathauer , Claudia Wood , Matthias Laubender , Wolfgang Jahnel , Ivette Garcia Castro , Volker Wendel , Karl Kolter
IPC分类号： A61K8/81 , C08L39/04 , C08L33/24 , C08F220/52 , C08F226/06
CPC分类号： C08F226/06 , A61K8/817 , A61K8/8182 , A61K8/86 , A61K8/90 , A61K2800/48 , A61K2800/5426 , A61Q5/06 , A61Q19/00 , C08F220/18 , C08F283/06 , C08F287/00 , C08L39/04 , C08L51/006 , C08L51/08 , C08L53/00 , C08L71/00 , C08L2666/14 , C08L2666/22 , C08L2666/02
摘要： The present invention relates to the use of a water-soluble or water-dispersible crosslinked polymer obtainable by the polymerization of a mixture comprising 99.99 to 10% by weight of at least one α,β-ethylenically unsaturated compound having at least one cationogenic and/or cationic group per molecule, 0 to 90% by weight of at least one monoethylenically unsaturated compound containing amide groups which differs from a), and 0.01 to 5% by weight of a crosslinking agent for modifying the rheology of aqueous compositions.
摘要翻译：本发明涉及通过聚合包含99.99-10％（重量）至少一种具有至少一种阳离子和/或碱性的α，β-烯属不饱和化合物的混合物的水溶性或水分散性交联聚合物的用途，或阳离子基团，0至90重量％的至少一种含有不同于a）的酰胺基的单烯键式不饱和化合物和0.01至5重量％的用于改变含水组合物流变性的交联剂。

38. 发明申请

US20050106252A1 Combination of polyvinyl acetate with water-insoluble, acid-insoluble, or alkali-insoluble polymers used for the production of film coatings with highly controlled release and high stability 有权
标题翻译：聚乙酸乙烯酯与水不溶性，酸不溶性或碱不溶性聚合物的组合，用于生产具有高度控制释放和高稳定性的薄膜涂料
公开(公告)号：US20050106252A1
公开(公告)日：2005-05-19
申请号：US10507607
申请日：2003-03-11
申请人： Karl Kolter , Roland Bodmeier , Andriy Dashevskiy
发明人： Karl Kolter , Roland Bodmeier , Andriy Dashevskiy
IPC分类号： A61K9/22 , A61K9/32 , A61K9/50 , A61K9/26
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5078
摘要： The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which agents are released in a controlled manner, and methods for the production thereof. The controlled-release properties can be specifically adjusted by means of said combinations, resulting in films having excellent mechanical stability and storage stability. In particular, agents are released independent of the pH by means of the inventive forms of administration.
摘要翻译：本发明涉及聚乙酸乙烯酯和水不溶性，酸不溶性或碱不溶性聚合物的组合，其用于生产用于以受控方式释放试剂的给药形式的膜包衣及其生产方法。可以通过所述组合特异性地调节控释特性，从而得到具有优异的机械稳定性和储存稳定性的膜。特别地，通过本发明的给药形式，释放与pH无关的药剂。

39. 发明授权

US06635279B2 Active ingredient-containing floating forms comprising polyvinyl acetate and polyvinylpyrrolidone, their use and production 有权
标题翻译：包含聚乙酸乙烯酯和聚乙烯吡咯烷酮的含活性成分浮选形式，其用途和生产
公开(公告)号：US06635279B2
公开(公告)日：2003-10-21
申请号：US09811434
申请日：2001-03-20
申请人： Karl Kolter , Michael Schönherr , Hermann Ascherl
发明人： Karl Kolter , Michael Schönherr , Hermann Ascherl
IPC分类号： A61K922
CPC分类号： A61K9/0065 , A61K9/2027
摘要： The present invention relates to oral dosage forms comprising a) one or more active ingredients b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone c) where appropriate other excipients customary for producing the dosage form, wherein they float on gastric fluid and display delayed release of active ingredient, and to the use and production thereof.
摘要翻译：本发明涉及包含a）一种或多种活性成分的b）一种或多种活性成分b）配制的聚乙酸乙烯酯和聚乙烯吡咯烷酮的混合物），其中适用于制备剂型的常规的其它赋形剂，其中它们漂浮在胃液上并显示活性成分的延迟释放，以及其使用和生产。

40. 发明授权

US6107397A Aqueous copolymer dispersions of water-soluble monomers with N-vinyl groups and hydrophobic monomers 失效
标题翻译：水溶性单体与N-乙烯基和疏水性单体的水共聚物分散体
公开(公告)号：US6107397A
公开(公告)日：2000-08-22
申请号：US42744
申请日：1998-03-17
申请人： Rainer Blankenburg , Volker Schehlmann , Karl Kolter
发明人： Rainer Blankenburg , Volker Schehlmann , Karl Kolter
IPC分类号： C08F2/22 , A61K9/50 , C08F4/04 , C08F4/28 , C08F4/30 , C08F226/00 , C08L39/04 , C08L39/06
CPC分类号： A61K9/5026 , C08F226/00
摘要： An aqueous copolymer dispersion is prepared by free-radical emulsion co-polymerization of a monomer mixture ofi) from 10 to 70% by weight of at least one nonionic monomer A having a water-solubility of more than 60 g/l at 25.degree. C., and being selected from the group consisting of N-vinyllactams having from 6 to 8 carbon atoms, N-vinylformamide and N-methyl-N-vinylacetamide,ii) from 30 to 90% by weight of at least one monoethylenically unsaturated hydrophobic monomer B having a water-solubility of less than 60 g/l at 25.degree. C.,and optionally further comprisingiii) up to 5% by weight of at least one monoethylenically unsaturated monomer C which has at least one ionic and/or ionizable functional group,iv) up to 10% by weight of at least one monomer D which has at least 2 ethylenically unsaturated bonds,v) up to 20% by weight of at least one further monoethylenically unsaturated monomer E, which is different from the monomers A and C, and has a water-solubility of >60 g/l at 25.degree. C.,in the presence of a water-soluble polymerization initiator in water or an aqueous solvent.
摘要翻译：通过自由基乳液共聚制备水性共聚物分散体，该单体混合物为i）10至70重量％的至少一种在25℃下具有大于60g / l的水溶性的非离子单体A 并且选自具有6至8个碳原子的N-乙烯基内酰胺，N-乙烯基甲酰胺和N-甲基-N-乙烯基乙酰胺，ii）30至90重量％的至少一种单烯属不饱和疏水性单体B在25℃具有小于60g / l的水溶性，并且任选地还包含iii）至多5重量％的至少一种具有至少一个离子和/或可离子化的单烯属不饱和单体C 官能团，iv）至多10重量％的至少一种具有至少2个烯键式不饱和键的单体D，v）至多20重量％的至少一种另外的单烯属不饱和单体E，其不同于单体 A和C，并且在25℃下的水溶解度> 60g / l 在水或水溶剂中存在水溶性聚合引发剂的情况下。

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