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31. 发明授权

US07771922B2 Biomolecule diagnostic device 有权
标题翻译：生物分子诊断装置
公开(公告)号：US07771922B2
公开(公告)日：2010-08-10
申请号：US10139025
申请日：2002-05-03
申请人： David Cohen , Rosann Kaylor , Curtis Sayre
发明人： David Cohen , Rosann Kaylor , Curtis Sayre
IPC分类号： C12Q1/00
CPC分类号： G01N33/54373
摘要： A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activated in a masking process. The receptive material is specific for an analyte of interest.
摘要翻译：生物传感器包括具有接受材料的活性区域图案和阻挡材料层图案的基底构件。接受材料和阻挡材料通过在掩蔽过程中活化的光反应性交联剂附着到基底构件上。受体材料对于感兴趣的分析物是特异性的。

32. 发明授权

US07169550B2 Diffraction-based diagnostic devices 有权
$Diffraction-based diagnostic devices$
标题翻译：基于衍射的诊断装置
公开(公告)号：US07169550B2
公开(公告)日：2007-01-30
申请号：US10256278
申请日：2002-09-26
申请人： Curtis Sayre , Rosann Kaylor , David Cohen
发明人： Curtis Sayre , Rosann Kaylor , David Cohen
IPC分类号： C12Q1/00
CPC分类号： G03H1/182 , G01N21/4788 , G01N33/54373 , Y10S436/805 , Y10S436/815 , Y10S436/82 , Y10S436/901
摘要： A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process wherein areas are exposed through a mask with a light source to induce deactivation.
摘要翻译：生物传感器包括具有设置在其上的辐射吸收部件（RAM）标记的生物分子的受体材料层的基板。受体材料对于感兴趣的分析物是特异性的。受体材料的活性和去活化区域的图案通过掩蔽过程限定在接受材料层中，其中通过具有光源的掩模暴露区域以诱导失活。

33. 发明授权

US08110349B2 Method for producing biomolecule diagnostic devices 有权
标题翻译：生物分子诊断装置的生产方法
公开(公告)号：US08110349B2
公开(公告)日：2012-02-07
申请号：US12853776
申请日：2010-08-10
申请人： David Cohen , Rosann Kaylor , Curtis Sayre
发明人： David Cohen , Rosann Kaylor , Curtis Sayre
IPC分类号： C12Q1/00
CPC分类号： G01N33/54373
摘要： A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to the substrate member with a photo-reactive crosslinking agent activated in a masking process. The receptive material is specific for an analyte of interest.
摘要翻译：生物传感器包括具有接受材料的活性区域图案和阻挡材料层图案的基底构件。接受材料和阻挡材料通过在掩蔽过程中活化的光反应性交联剂附着到基底构件上。受体材料对于感兴趣的分析物是特异性的。

34. 发明申请

US20090142826A1 Diffraction-Based Diagnostic Devices 有权
$Diffraction-Based Diagnostic Devices$
标题翻译：基于衍射的诊断设备
公开(公告)号：US20090142826A1
公开(公告)日：2009-06-04
申请号：US12363987
申请日：2009-02-02
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
IPC分类号： C12M1/00 , G01N21/00
CPC分类号： G01N33/54373 , C12Q1/003
摘要： A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process.
摘要翻译：生物传感器包括其上设置有活性接受材料区域的基底。受体材料对于感兴趣的分析物是特异性的。通过氧化光掩模工艺在衬底上限定有源区的图案。

35. 发明授权

US07223368B2 Diffraction-based diagnostic devices 有权
$Diffraction-based diagnostic devices$
标题翻译：基于衍射的诊断装置
公开(公告)号：US07223368B2
公开(公告)日：2007-05-29
申请号：US10138677
申请日：2002-05-03
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
IPC分类号： G01N21/29
CPC分类号： G01N21/4788 , G01N33/543
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process.
摘要翻译：生物传感器包括具有设置在其上的接受材料层的基板。受体材料对于感兴趣的分析物是特异性的。受体材料的活性和非活性区域的图案通过掩蔽过程限定在接受材料层中。

36. 发明授权

US07214530B2 Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices 有权
标题翻译：生物分子诊断装置及生物分子诊断装置的制造方法
公开(公告)号：US07214530B2
公开(公告)日：2007-05-08
申请号：US10139013
申请日：2002-05-03
申请人： Curtis Sayre , David Cohen , Rosann Kaylor
发明人： Curtis Sayre , David Cohen , Rosann Kaylor
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , G03H1/182
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process wherein the photo-reactive agent is activated in the exposed regions of the mask.
摘要翻译：生物传感器包括具有覆盖在含有光反应剂的层的层上的接受材料层的基板。受体材料对于感兴趣的分析物是特异性的。受体材料的活性和非活性区域的图案通过掩模过程在接受材料层中限定，其中光敏反应剂在掩模的暴露区域中被活化。

37. 发明授权

US07118855B2 Diffraction-based diagnostic devices 有权
$Diffraction-based diagnostic devices$
公开(公告)号：US07118855B2
公开(公告)日：2006-10-10
申请号：US10138882
申请日：2002-05-03
申请人： David Cohen , Rosann Kaylor
发明人： David Cohen , Rosann Kaylor
IPC分类号： C12Q1/00
CPC分类号： G01N33/543 , G01N21/4788
摘要： A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a masking process.

38. 发明申请

US20060068500A1 Detecting yeast infections using a lateral flow assay 审中-公开
标题翻译：使用侧流测定法检测酵母菌感染
公开(公告)号：US20060068500A1
公开(公告)日：2006-03-30
申请号：US10951367
申请日：2004-09-28
申请人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
发明人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N2333/40
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in liquid communication with a conjugate pad and a wicking pad. The conjugate pad has a gold colloid-containing detection probe. The porous membrane has a detection zone where an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A sample containing an analyte is deposited on the conjugate pad, interacts with the detection probes, and moves toward the control zone for detection.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与结合垫和芯吸垫液体连通的多孔膜。共轭垫具有含金胶体的检测探针。多孔膜具有检测区，其中固定的第一捕获试剂被配置为结合至少一部分分析物和分析物 - 共轭复合物以产生检测信号。控制区位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。将含有分析物的样品沉积在共轭垫上，与检测探针相互作用，并朝向控制区移动进行检测。

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