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31. 发明专利

JPS6039688B2 失效
公开(公告)号：JPS6039688B2
公开(公告)日：1985-09-07
申请号：JP8511175
申请日：1975-07-11
申请人： KURARAY CO
发明人： NAKAJIMA TOSHIHIDE , TAKAKURA KOICHI
IPC分类号： C08F291/00 , A61L33/00 , C08F290/00 , C08F293/00 , C08F297/00 , C08F299/00 , C08G85/00

32. 发明专利

JPS59184134A Production of carrier for immobilizing physiologically active substance 失效
标题翻译：生产用于固定生理活性物质的载体
公开(公告)号：JPS59184134A
公开(公告)日：1984-10-19
申请号：JP5690983
申请日：1983-03-31
申请人： Kuraray Co Ltd
发明人： TANIHARA MASAO , NAKAJIMA TOSHIHIDE , TAKAKURA KOUICHI
IPC分类号： A61K47/30 , A61K47/00 , A61K47/02
摘要： PURPOSE: To obtain the titled carrier without deteriorating nor inactivating by wet heat sterilization, by immobilizing a physiologically active substance on a porous carrier having a defined linear expansion coefficient, Young's modulus and a constituent material within specific ranges, and sterilizing the resultant immobilized substance in wet heat.
CONSTITUTION: A physiologically active substance is immobilized on a porous carrier having ≤3×10
-5 deg
-1 at room temperature, ≥1×10
11 dynes cm
-2 Young's modulus at room temperature and ≤20% absorption ratio of the constituent material, and then sterilized in wet heat to give the aimed carrier. A metal, glass or alumina, etc. is used as the above-mentioned constituent material and has preferably ≥1,000Å average pore diameter and ≥0.3mlg
-1 pore volume and chemically bondable active groups in ≥1×10
-8 mol m
-2 concentration on the surface of the porous carrier. The physiologically active substance is immobilized through the above-mentioned active groups. Thus, the deformation of the carrier by the sterilization in wet heat is suppressed under the above-mentioned conditions.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过将生理活性物质固定在具有规定的线膨胀系数，杨氏模量和构成材料的多孔载体上的特定范围内，通过湿热灭菌获得标题载体而不劣化或灭活，并将所得固定化物质灭菌湿热。构成：将生理活性物质固定在具有<= 3×10 -5 -5℃的多孔载体上，在室温下，> = 1×10 11达因厘米-2在室温下的杨氏模量和<= 20 ％构成材料的吸收率，然后在湿热中灭菌，得到目标载体。使用金属，玻璃或氧化铝等作为上述构成材料，优选> = 1000A平均孔径和> = 0.3mlg -1孔体积，并且化学键合活性基团> 1×10 < 8> mol m -2浓度在多孔载体的表面上。通过上述活性基团固定生理活性物质。因此，在上述条件下，通过湿热中的灭菌来抑制载体的变形。

33. 发明专利

JPS599565B2 JPS599565B2 - 失效
公开(公告)号：JPS599565B2
公开(公告)日：1984-03-03
申请号：JP5301474
申请日：1974-05-13
申请人： Kuraray Co
发明人： NAKAJIMA TOSHIHIDE , TAKAKURA KOICHI
IPC分类号： G02C7/04 , A61L29/00 , C08F2/00 , C08F2/44 , C08F265/00 , C08F271/00 , C08F290/00 , C08F291/00 , C08F299/00

34. 发明专利

JPS5844685B2 失效
公开(公告)号：JPS5844685B2
公开(公告)日：1983-10-05
申请号：JP11979674
申请日：1974-10-17
申请人： KURARAY CO
发明人： NAKAJIMA TOSHIHIDE , TAKAKURA KOICHI
IPC分类号： G02C7/04 , A61L27/00 , A61L29/00 , C08F2/00 , C08F2/10 , C08F4/00 , C08F4/06 , C08F20/00 , C08F20/26 , C08F265/00 , C08F265/04 , C12N11/08

35. 发明专利

JPS5888320A PURIFICATION OF IMMUNOSUPPRESSIVE FACTOR 失效
公开(公告)号：JPS5888320A
公开(公告)日：1983-05-26
申请号：JP18752881
申请日：1981-11-20
申请人： KURARAY CO
发明人： TANIHARA MASAO , NAKAJIMA TOSHIHIDE , TAKAKURA KOUICHI , OOTA KAZUO , HAYASAKA YUUTAROU
IPC分类号： A61K35/14 , A61K35/16 , A61K35/26 , A61K38/16 , A61P37/06
摘要： PURPOSE:A porous body with a specific average pore size and void volume, further negative charge on its surface is brought into contact with a solution containing soluble immune factors to remove immunestimulative factors selectively, thus purifying the titled factor. CONSTITUTION:A porous body with an average pore diameter (D) of 30-1,000Angstrom , with a void volume of pores measuring 0.8-1.2D, exceeding 80% of the total void volume and with a negative charge on its surface, such as porous glass or porous silica or porous alumina, is brought into contact with a solution containing soluble immune factors such as blood, serum and other humors or supernatant of cultured lymphocytes to purify immunosuppressive factors. The factors are used for autoimmune diseases of rejection after organ transplantation. The above porous body has a void volume of 01-2cc/g, preferably 0.5-2cc/g. The porous body can be reused by washing, subjecting to desoption treatment and cleaning with a surface active agent.

36. 发明专利

JPS5861753A BLOOD TREATING APPARATUS 失效
公开(公告)号：JPS5861753A
公开(公告)日：1983-04-12
申请号：JP16177781
申请日：1981-10-09
申请人： KURARAY CO
发明人： TANIHARA MASAO , NAKAJIMA TOSHIHIDE , TAKAKURA KOUICHI
IPC分类号： A61M1/36

37. 发明专利

JPS5289584A BASE MATERIAL FOR HYDROGEL 失效
公开(公告)号：JPS5289584A
公开(公告)日：1977-07-27
申请号：JP678776
申请日：1976-01-22
申请人： KURARAY CO
发明人： NAKAJIMA TOSHIHIDE , TAKAKURA KOUICHI
IPC分类号： C09K3/00 , B01J13/00 , C08G59/00 , C08G59/18 , C08G59/20 , C08G59/40 , C08L33/00 , C08L33/02 , C08L63/00 , G02C7/04
摘要： PURPOSE:To obtain a hydrogel base material with water absorbing rate almost equal to that of a conventional one and greatly improved mechanical strength when impregnated with water, by polymerizing hydrophilic acrylic acid esters while adding bisepoxy compounds.

38. 发明专利

JP2002248671A ENDOTRACHEAL TUBE 审中-公开
公开(公告)号：JP2002248671A
公开(公告)日：2002-09-03
申请号：JP2001363916
申请日：2001-11-29
申请人： KURARAY CO
发明人： OGUSHI MASAYASU , FUKUDA MOTOHIRO , ZENTO TOSHIYUKI , KIRITA TAIZO , NAKAJIMA TOSHIHIDE , FUJIEDA YUKIHIRO
IPC分类号： A61M16/04 , B29C48/32 , B29C49/04 , B29K9/06 , B29K23/00 , B29K25/00 , B29K55/02 , B29K105/16 , B29L23/00 , B29L23/24 , C08J5/00 , C08K3/00 , C08K5/103 , C08K5/20 , C08L23/00 , C08L53/02 , B29C47/20
摘要： PROBLEM TO BE SOLVED: To provide an endotracheal tube having excellent kink resistance, slidableness and gluing preventiveness. SOLUTION: The endotracheal tube is made of a tube obtained by extrusion molding a resin composition containing a styrene elastomer and a polyolefin resin. The composition has a storage elastic modulus (MD) of an extruding direction at 25 deg.C of 5.0×10 to 8.0×10 dyne/cm and a ratio (MD/TD) of the storage elastic modulus of the extruding direction to the storage elastic modulus (TD) of a circumferential direction of 1.3 or less. The tube is obtained by blow molding a resin composition containing a styrene elastomer and a polyolefin resin and having a melt tension at 230 deg.C of 1 g or more and the storage elastic modulus of 5.0×10 dyne/cm or less.

39. 发明专利

JP2001019605A ADHESIVE FOR DENTAL IMPLANT 失效
公开(公告)号：JP2001019605A
公开(公告)日：2001-01-23
申请号：JP19517999
申请日：1999-07-09
申请人： KURARAY CO
发明人： YAMADA HIDEAKI , NAKAJIMA TOSHIHIDE , HINO KENICHI , NISHIMURA TANSEI
IPC分类号： A61K6/083
摘要： PROBLEM TO BE SOLVED: To obtain an adhesive for dental implant which shows a firm adhesiveness to both of alveolar bone and implant denture, possesses no toxicity and exhibits excellent operativity in the oral cavity by mixing a paste containing a calcium phosphate-based inorganic powder, a specific polymeric monomer mixture and a polymerization initiator with a paste containing the above powder, the above mixture and a polymerization promoter. SOLUTION: The adhesive for dental implant is obtained by mixing (A) a paste containing (i) a calcium phosphate-based inorganic powder (e.g. tricalcium α-phosphate, hydroxyapatite or the like), (ii) a polymeric monomer mixture and (iii) a polymerization initiator with (B) a paste containing (i) the calcium phosphate-based inorganic powder, (ii) the polymeric monomer mixture and (iii) a polymerization promoter. The above component ii contains a monomer of formula I [R1 and R2 are each H or methyl; (p) is 1-4] and a monomer of formula II [R3 and R4 are each H or methyl; (m) and (n) are each 1-5; m+n=2-6]. It is favorable that the content of the component i contained in the component A or B is 75-85 wt.%.

40. 发明专利

JP2000239635A ADHESIVE 失效
公开(公告)号：JP2000239635A
公开(公告)日：2000-09-05
申请号：JP4574499
申请日：1999-02-24
申请人： KURARAY CO
发明人： KIRITA TAIZO , NAKAJIMA TOSHIHIDE , UDAGAWA NOBUYUKI , WADA KOICHI , JOGO YOSUKE , MAEDA MIZUHO
IPC分类号： C09J153/02
摘要： PROBLEM TO BE SOLVED: To provide an adhesive which keeps its adhesion even when subjected to various sterilization treatments when used to bond polyvinyl chloride substitutes in medical devices, sanitary products and medical supplies and which can be used easily. SOLUTION: An adhesive comprises a solution obtained by dissolving at least one of those selected from block copolymers comprising (A) polymer blocks comprising aromatic vinyl compound units and (B) polymer blocks comprising conjugated diene units, the content of the aromatic vinyl compound units being 5-40 wt.%, and hydrogenated products thereof in an organic solvent. The polymer block (B) is preferably at least one polymer block selected from the group consisting of (b1) polyisoprene blocks having 1,2-linkage and 3,4-linkage content of 3 mol% or more, (b2) polymer blocks comprising 5-95 wt.% of isoprene unit and 95-5 wt.% of butadiene unit having a 1,2-linkage and 3,4-linkage content of 20 mol% or more and (b3) polybutadiene blocks having a 1,2-linkage content of 35 mol% or more.

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