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31. 发明申请

US20060269544A1 Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
公开(公告)号：US20060269544A1
公开(公告)日：2006-11-30
申请号：US11496357
申请日：2006-07-31
申请人： John Feder , Shujian Wu , Thomas Nelson
发明人： John Feder , Shujian Wu , Thomas Nelson
IPC分类号： A61K39/395 , C07H21/04 , C12N9/00 , C12P21/06
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

32. 发明申请

US20060246051A1 Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
标题翻译：编码新型睾丸特异性微管蛋白酪氨酸连接酶样蛋白的多核苷酸BGS42
公开(公告)号：US20060246051A1
公开(公告)日：2006-11-02
申请号：US11445988
申请日：2006-06-02
申请人： John Feder , Shujian Wu , Thomas Nelson
发明人： John Feder , Shujian Wu , Thomas Nelson
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , A61K38/48 , C12N9/64 , G01N33/53 , C07K16/40
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

33. 发明授权

US06232441B1 PIGR-1, a member of immunoglobulin gene superfamily 失效
标题翻译： PIGR-1是免疫球蛋白基因超家族的成员
公开(公告)号：US06232441B1
公开(公告)日：2001-05-15
申请号：US09300985
申请日：1999-04-28
申请人： Shujian Wu , Raymond W Sweet , Alemseged Truneh , Mark Robert Hurle
发明人： Shujian Wu , Raymond W Sweet , Alemseged Truneh , Mark Robert Hurle
IPC分类号： C07K14435
CPC分类号： C07K14/70503 , A61K38/00
摘要： PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.
摘要翻译：公开了PIGR-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗类风湿性关节炎（RA），多发性硬化症（MS），牛皮癣，系统性红斑狼疮（SLE）和炎症性肠病（IBD））的方案中使用PIGR-1多肽和多核苷酸的方法，其中其他和诊断测定这些条件。

34. 发明授权

US07541434B2 Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants 有权
标题翻译：用于TRP通道家族成员的多肽，TRP-PLIK2和剪接变体
公开(公告)号：US07541434B2
公开(公告)日：2009-06-02
申请号：US11726234
申请日：2007-03-21
申请人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
发明人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
IPC分类号： C07K14/47 , C12N15/07 , C12N15/64 , C12P21/02
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段及其同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

35. 发明申请

US20070172880A1 Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体
公开(公告)号：US20070172880A1
公开(公告)日：2007-07-26
申请号：US11726234
申请日：2007-03-21
申请人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Han Chang , Liana Lee , Michael Blanar , David Bol
发明人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Han Chang , Liana Lee , Michael Blanar , David Bol
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

36. 发明申请

US20070071743A1 Novel human cell surface protein with immunoglobulin folds, BGS-19 审中-公开
标题翻译：具有免疫球蛋白折叠的新型人细胞表面蛋白BGS-19
公开(公告)号：US20070071743A1
公开(公告)日：2007-03-29
申请号：US11601407
申请日：2006-11-17
申请人： Liana Lee , John Feder , Shujian Wu , Jian Chen
发明人： Liana Lee , John Feder , Shujian Wu , Jian Chen
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/705 , C07K16/42
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503
摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

37. 发明申请

US20060105379A1 Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 有权
公开(公告)号：US20060105379A1
公开(公告)日：2006-05-18
申请号：US11313356
申请日：2005-12-21
申请人： Shujian Wu , Jian Chen , John Feder , Liana Lee , Stanley Krystek
发明人： Shujian Wu , Jian Chen , John Feder , Liana Lee , Stanley Krystek
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

38. 发明申请

US20050048620A1 Polynucleotides encoding a novel human neuronal cell adhesion protein, BGS-28, and variants thereof 审中-公开
标题翻译：编码新型人神经元细胞粘附蛋白的多核苷酸，BGS-28及其变体
公开(公告)号：US20050048620A1
公开(公告)日：2005-03-03
申请号：US10926386
申请日：2004-08-25
申请人： Shujian Wu , John Feder
发明人： Shujian Wu , John Feder
IPC分类号： C07H21/04 , C07K14/705 , C12P21/04
CPC分类号： C07K14/70503 , C07H21/04
摘要： The present invention provides novel polynucleotides encoding BGS-28 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-28 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-28多肽，其片段和同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-28多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

39. 发明授权

US6114515A PIGRL-1, a member of immunoglobulin gene superfamily 失效
标题翻译： PIGRL-1是免疫球蛋白基因超家族的成员
公开(公告)号：US6114515A
公开(公告)日：2000-09-05
申请号：US961564
申请日：1997-10-30
申请人： Shujian Wu , Raymond W. Sweet , Alemseged Truneh
发明人： Shujian Wu , Raymond W. Sweet , Alemseged Truneh
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P17/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/15 , G01N33/50 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70503 , A61K39/00
摘要： PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.
摘要翻译：公开了PIGRL-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗超IgM免疫缺陷（HIM），X连锁严重联合免疫缺陷（XSCID）和IgA缺乏（IgA-D）的方案中使用PIGRL-1多肽和多核苷酸的方法等和这些病症的诊断测定。

40. 发明授权

US06046030A Human LIG-1 homolog (HLIG-1) 失效
标题翻译：人LIG-1同源物（HLIG-1）
公开(公告)号：US06046030A
公开(公告)日：2000-04-04
申请号：US986485
申请日：1997-12-08
申请人： Shujian Wu , Raymond W Sweet , Alemseged Truneh
发明人： Shujian Wu , Raymond W Sweet , Alemseged Truneh
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/02 , A61P25/00 , A61P25/28 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/68 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/70503 , A61K39/00
摘要： HLIG-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLIG-1 polypeptides and polynucleotides in the design of protocols for the treatment of neurological disorders such as Alzheimer's disease, multiple sclerosis and abnormal neural development; endocrine disorders such as diabetes; and heart disease, among others and diagnostic assays for such conditions.
摘要翻译：公开了HLIG-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗诸如阿尔茨海默病，多发性硬化和异常神经发育的神经障碍的方案中使用HLIG-1多肽和多核苷酸的方法; 内分泌疾病如糖尿病; 和心脏病等，以及这些病症的诊断测定。

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