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31. 发明申请

US20050186616A1 Human cystatin F 审中-公开
标题翻译：人类半胱氨酸蛋白酶抑制剂F
公开(公告)号：US20050186616A1
公开(公告)日：2005-08-25
申请号：US11088093
申请日：2005-03-24
申请人： Haodong Li , Guo-Liang Yu , Reiner Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner Gentz , Jian Ni
IPC分类号： G01N33/53 , A61K38/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P43/00 , C07K14/81 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , C07H21/04 , C12N9/99
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

32. 发明授权

US06338948B1 Human endometrial specific steroid-binding factor I, II and III 失效
公开(公告)号：US06338948B1
公开(公告)日：2002-01-15
申请号：US09583169
申请日：2000-05-30
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
IPC分类号： C07K1618
CPC分类号： C07K14/4702
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

33. 发明授权

US06294164B1 Natural killer cell enhancing factor C 失效
标题翻译：自然杀伤细胞增强因子C
公开(公告)号：US06294164B1
公开(公告)日：2001-09-25
申请号：US09407891
申请日：1999-09-29
申请人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jiar Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： A61K3819
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

34. 发明申请

US20060240036A1 I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 审中-公开
标题翻译： I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡
公开(公告)号：US20060240036A1
公开(公告)日：2006-10-26
申请号：US11445311
申请日：2006-06-02
申请人： Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
发明人： Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
IPC分类号： A61K39/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06
CPC分类号： C12N9/6475 , A61K38/00
摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
摘要翻译：本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

35. 发明申请

US20060142199A1 CD-44 like protein 审中-公开
标题翻译： CD-44像蛋白质
公开(公告)号：US20060142199A1
公开(公告)日：2006-06-29
申请号：US11359509
申请日：2006-02-23
申请人： Jian Ni , Reiner Gentz , Patrick Dillon
发明人： Jian Ni , Reiner Gentz , Patrick Dillon
IPC分类号： A61K38/17 , C07K14/74 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70585 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
摘要翻译：本发明涉及一种新型的CD44样蛋白受体。特别地，提供编码CD44样蛋白质的分离的核酸分子。还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。

36. 发明授权

US07049402B2 Tumor necrosis factor receptor-5 失效
标题翻译：肿瘤坏死因子受体-5
公开(公告)号：US07049402B2
公开(公告)日：2006-05-23
申请号：US09826212
申请日：2001-04-05
申请人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
发明人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
IPC分类号： C07K14/00
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

37. 发明申请

US20050176044A1 Polynucleotides and polypeptides encoding receptors 审中-公开
标题翻译：编码受体的多核苷酸和多肽
公开(公告)号：US20050176044A1
公开(公告)日：2005-08-11
申请号：US11041419
申请日：2005-01-25
申请人： Jian Ni , Craig Rosen , Reiner Gentz
发明人： Jian Ni , Craig Rosen , Reiner Gentz
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/735 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/50 , A61K38/17 , C07H21/04
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译：公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

38. 发明申请

US20050112090A9 Death domain containing receptor 4 有权
标题翻译：死亡域含受体4
公开(公告)号：US20050112090A9
公开(公告)日：2005-05-26
申请号：US10648786
申请日：2003-08-27
申请人： Jian Ni , Craig Rosen , Reiner Gentz
发明人： Jian Ni , Craig Rosen , Reiner Gentz
IPC分类号： A61K38/00 , A61K39/395 , C07K14/705 , C07K14/715 , C07K16/28 , A61K38/19
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/39541 , C07K14/70578 , C07K14/7151 , C07K2319/30 , C12N2799/026 , Y02A50/412 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

39. 发明申请

US20080058247A1 Polynucleotides and Polypeptides Encoding Receptors 审中-公开
标题翻译：编码受体的多核苷酸和多肽
公开(公告)号：US20080058247A1
公开(公告)日：2008-03-06
申请号：US11832019
申请日：2007-08-01
申请人： Jian Ni , Craig Rosen , Reiner Gentz
发明人： Jian Ni , Craig Rosen , Reiner Gentz
IPC分类号： A61K31/70 , A61K38/00 , A61P43/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N5/00 , G01N33/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译：公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。

40. 发明申请

US20060045878A1 Pancreas-derived plasminogen activator inhibitor 审中-公开
标题翻译：胰腺来源的纤溶酶原激活物抑制剂
公开(公告)号：US20060045878A1
公开(公告)日：2006-03-02
申请号：US11048774
申请日：2005-02-03
申请人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
发明人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
IPC分类号： C07H21/04 , A61K39/395 , C07K16/44 , C12N5/06
CPC分类号： C07K14/81 , A61K38/00 , A61K48/00 , C07K14/8132 , C07K2319/00 , Y02A50/463
摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
摘要翻译：本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于治疗生理和病理疾病状况的方法以及用于检测病理学疾病的诊断方法。

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