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31. 发明授权

US06794148B2 High speed, automated, continuous flow, multi-dimensional molecular selection and analysis 有权
标题翻译：高速，自动化，连续流动，多维分子选择和分析
公开(公告)号：US06794148B2
公开(公告)日：2004-09-21
申请号：US10006630
申请日：2001-12-05
申请人： Satish Jindal , Fred Regnier , Kevin Williams , Noubar Afeyan , Sandeep Paliwal , David Evans , Aruna Pingali
发明人： Satish Jindal , Fred Regnier , Kevin Williams , Noubar Afeyan , Sandeep Paliwal , David Evans , Aruna Pingali
IPC分类号： G01N3350
CPC分类号： G01N30/463 , G01N30/7233 , G01N30/88 , G01N2030/027 , G01N2030/8813 , G01N2030/8831
摘要： The invention provides novel methods for screening a sample to select a ligand to a target of interest and for obtaining information about the ligand and its binding characteristics. Specifically, the claimed multi-dimensional methods involve combining a solution of heterogeneous ligands with the target of interest to screen the ligands on the basis of one or more binding characteristics. Ligands having the first binding characteristic bind to the target of interest thereby to form a target/ligand complex. The complex then optionally is separated from the unbound components using any of a variety of separation techniques, e.g., size exclusion. At least one of the complex or unbound components then is introduced to a second “dimension”. The second dimension is capable of separating components based upon a second binding characteristic. One then elutes the ligand having the desired binding characteristics.
摘要翻译：本发明提供了筛选样品以选择目的靶标的配体并获得关于配体及其结合特征的信息的新方法。具体地，所要求保护的多维方法包括将异构配体的溶液与感兴趣的靶结合在一个或多个结合特征的基础上筛选配体。具有第一结合特征的配体与感兴趣的靶结合，从而形成靶/配体复合物。然后任选地使用各种分离技术（例如尺寸排阻）中的未结合组分分离复合物。然后将至少一个复杂的或未结合的组件引入第二个“维度”。第二维能够基于第二结合特征分离组分。然后，然后将具有所需结合特征的配体洗脱出来。

32. 外观设计

USD335562S Trash container 失效
公开(公告)号：USD335562S
公开(公告)日：1993-05-11
申请号：US738287
申请日：1991-07-30
申请人： David Evans
设计人： David Evans

33. 发明授权

US4415070A Hose connector 失效
标题翻译：软管接头
公开(公告)号：US4415070A
公开(公告)日：1983-11-15
申请号：US268240
申请日：1981-05-29
申请人： John F. Pickering , David Evans
发明人： John F. Pickering , David Evans
IPC分类号： B60T17/04 , F16D55/22 , F16D65/28 , F16D65/78 , F16D65/84 , F16L33/30
CPC分类号： F16D65/84 , B60T17/04 , F16D55/22 , F16L33/30 , F16D2065/782
摘要： A hose connector has a body having a first portion adapted to receive a flexible hydraulic hose and a second portion adatped for connection to a brake actuator. A bore portion of the second body portion is arranged to provide a space large enough to contain at least a major part of any heated brake fluid returning from the actuator upon brake retraction thereby minimizing the amount of heated fluid reaching the hose.
摘要翻译：软管连接器具有主体，该主体具有适于容纳柔性液压软管的第一部分和适于连接到制动致动器的第二部分。第二主体部分的孔部分布置成提供足够大的空间，以容纳至少大部分在制动回缩时从致动器返回的任何加热的制动流体，从而最小化到达软管的加热流体的量。

34. 发明申请

US20210260182A1 RECOMBINANT POXVIRUS BASED VACCINE AGAINST SARS-CoV-2 VIRUS 有权
公开(公告)号：US20210260182A1
公开(公告)日：2021-08-26
申请号：US17187678
申请日：2021-02-26
申请人： Scott J. Goebel , David Evans , Ryan Noyce , Tonix Pharmaceuticals Holding Corp. , The Governors of the University of Alberta
发明人： Seth Lederman , Scott J. Goebel , David Evans , Ryan Noyce
IPC分类号： A61K39/215 , C12N7/00 , C12N15/85
摘要： The invention relates in various aspects to a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing such viruses and the use of such viruses. The recombinant poxviruses are well suited, among others, as protective virus vaccines against SARS-CoV-2 virus.

35. 发明授权

US09718768B2 System for purifying, producing and storing biomolecules 有权
公开(公告)号：US09718768B2
公开(公告)日：2017-08-01
申请号：US14111305
申请日：2012-04-12
申请人： David Evans
发明人： David Evans
IPC分类号： C07K9/00 , C07C319/28 , A61K47/48 , B01J20/287 , B01J20/32 , C07K1/22 , C07C59/347 , C07C323/58 , C07K17/02
CPC分类号： C07C319/28 , A61K47/6817 , A61K47/6855 , B01J20/287 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3274 , C07C59/347 , C07C323/58 , C07K1/22 , C07K17/02 , Y10T428/2982
摘要： The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.

36. 发明授权

US09150574B2 Enzyme inhibitor compounds 有权
公开(公告)号：US09150574B2
公开(公告)日：2015-10-06
申请号：US14344417
申请日：2011-09-14
申请人： David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
发明人： David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
IPC分类号： C07D471/02 , A61K31/55 , C07D471/04
CPC分类号： C07D471/04
摘要： 2-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}ethan-1-amine; 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate; 1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}-4-(dimethylamino)butan-1-one; 5-amino-1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}pentan-1-one; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; N-(3-aminopropyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-N-[3-(dimethylamino)propyl]piperidine-1-carboxamide; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)piperazine; 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-1,4-diazepane; ethyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; ethyl 1-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylic acid; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxamide; 4-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4yl}carbonyl)morpholine; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4-yl}carbonyl)piperazine; {4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}methanol; {4-[1-(4-methyl-phenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methanol; [(3R)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl]methanol; methyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxylate; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxamide; 2-{4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}ethan-1-ol; methyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxylate; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxamide; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-2-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]morpholine; 1-(4-chlorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-4-ol; N-butyl-1-(4-chlorophenyl)-N-methyl-1H-pyrazolo[3,4-c]pyridin-3-amine; 1-[4-(fluoromethyl)phenyl]-3-(oxan-4-yl)-1H-pyrazolo[3,4-c]pyridine; and 3-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-1-yl}methyl)pyridine are useful for the inhibition of SSAO activity.

37. 发明授权

US09005926B2 Methods of preventing and removing trisulfide bonds 有权
标题翻译：防止和去除三硫键的方法
公开(公告)号：US09005926B2
公开(公告)日：2015-04-14
申请号：US13499858
申请日：2010-10-01
申请人： David Evans , R. Blake Pepinsky , Dingyi Wen , Rashmi Rohit Kshirsagar , Karin Lucas
发明人： David Evans , R. Blake Pepinsky , Dingyi Wen , Rashmi Rohit Kshirsagar , Karin Lucas
IPC分类号： C07K1/04 , C07K1/113 , C07K16/00 , C07K1/26 , G01N30/02 , G01N33/534 , G01N33/563
CPC分类号： C07K16/00 , C07K1/1133
摘要： The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.
摘要翻译：本发明涉及在蛋白质如抗体中预防和消除三硫键的方法。在一个实施方案中，作为色谱纯化方法的一部分，将蛋白质中的三硫键转化为二硫键。在另一个实施方案中，通过在这些蛋白质的细胞培养生产期间实施本文所述的方法来抑制蛋白质中三硫键的形成。在另一个实施方案中，通过本文所述的方法产生单克隆抗体。

38. 发明申请

US20140304906A1 Pool Construction Method 审中-公开
标题翻译：池施工方法
公开(公告)号：US20140304906A1
公开(公告)日：2014-10-16
申请号：US13859818
申请日：2013-04-10
申请人： Walter Judson Bennett , David Evans
发明人： Walter Judson Bennett , David Evans
IPC分类号： E04H4/14 , E02D3/00
CPC分类号： E02D3/00 , E04H4/0037 , E04H4/0056 , E04H2004/146 , Y10T29/49801
摘要： The present invention relates to a new construction method for swimming pools, surfing pools, body boarding pools, wave pools, water park pools, kayaking and white water rafting courses and pools, wake boarding pools, water skiing pools and jet skiing pools, static surfing simulators, deep water river standing wave attractions. The present invention construction method can also be used in lagoons, ponds, lakes, and rivers. The invention will save construction costs, and save pool construction time.
摘要翻译：本发明涉及游泳池，冲浪池，身体游泳池，波浪池，水上公园游泳池，皮划艇和白水漂流课程和游泳池，唤醒游泳池，滑水游泳池和喷气式滑雪游泳池的新的施工方法，静态冲浪模拟器，深水河站立波浪景点。本发明的施工方法也可用于泻湖，池塘，湖泊和河流。本发明可节省施工成本，节约施工时间。

39. 外观设计

USD711059S1 Draining mat 有权
标题翻译：排水垫
公开(公告)号：USD711059S1
公开(公告)日：2014-08-12
申请号：US29405714
申请日：2011-11-04
申请人： David Evans , Ashley May
设计人： David Evans , Ashley May

40. 发明授权

US08367921B2 Method and system for assessing a musical performance 失效
标题翻译：用于评估音乐表演的方法和系统
公开(公告)号：US08367921B2
公开(公告)日：2013-02-05
申请号：US11568265
申请日：2005-01-31
申请人： David Evans , Benjamin Ruciak , William Thorpe
发明人： David Evans , Benjamin Ruciak , William Thorpe
IPC分类号： G04B13/00
CPC分类号： G09B15/00 , G09B5/04
摘要： The invention relates to a method and system for assessing a performance of a musical composition in relation to a model performance of the same composition. In particular, as even a model performance does not follow a score of a composition precisely, the present invention initially correlates the model performance to a score of the performed composition. This allows for an accurate assessment of the timing of the assessable performance, relative to the timing of the model performance. The invention is of particular use where the assessable performance is performed along with the model performance, but the two performances are remote from each other.
摘要翻译：本发明涉及一种用于评估与相同构图的模型演奏相关的乐曲的演奏的方法和系统。特别地，即使模型性能也不能精确地跟随组合得分，本发明最初将模型性能与所执行的组合的得分相关联。这样可以准确地评估可评估绩效的时间，相对于模型绩效的时间。本发明在评估性能与模型性能一起执行时具有特别的用途，但两种性能彼此远离。

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