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31. 发明授权

US08998929B2 Medical device system and apparatus for guiding the placement of a subcutaneous device 有权
标题翻译：用于引导皮下装置的放置的医疗装置系统和装置
公开(公告)号：US08998929B2
公开(公告)日：2015-04-07
申请号：US12432028
申请日：2009-04-29
申请人： William J. Havel , Vladimir P. Nikolski
发明人： William J. Havel , Vladimir P. Nikolski
IPC分类号： A61B19/00 , A61B17/34 , A61N1/04 , A61B17/00 , A61B17/30 , A61B17/32 , A61N1/05
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： A medical device system for advancing a subcutaneous device to a desired implant site that includes a strap extending along a length from a proximal end to a distal end, a first flange and a second flange extending along a portion of the length of the strap, a base portion extending along a portion of the length of the strap between the first flange and the second flange, and an indentation extending from the proximal end to the distal end of the strap, the indentation formed by the first flange, the second flange, and the base portion, wherein the first flange and the second flange include curved bottom portions that make contact with and compress a tissue layer to position the tissue layer within the indentation during the placement of the subcutaneous device.
摘要翻译：一种用于将皮下装置推进到期望的植入部位的医疗装置系统，所述植入部位包括沿着从近端到远端的长度延伸的带，沿着带的长度的一部分延伸的第一凸缘和第二凸缘，所述基部沿着所述带的所述长度的第一凸缘和所述第二凸缘之间的部分延伸，以及从所述带的近端延伸到所述远端，所述凹陷由所述第一凸缘，所述第二凸缘和所述基部部分，其中所述第一凸缘和所述第二凸缘包括弯曲的底部部分，所述弯曲的底部部分在所述皮下装置的放置期间与所述组织层接触并将所述组织层定位在所述凹陷内。

32. 发明授权

US08918171B2 Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权
标题翻译：使用组织氧合测量进行休克后评估的方法和装置
公开(公告)号：US08918171B2
公开(公告)日：2014-12-23
申请号：US12845843
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365 , A61N1/39 , A61B5/1455 , A61B5/00 , A61B5/1459
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

33. 发明申请

US20140058402A1 ENDOLUMINAL PROSTHESIS AND DELIVERY DEVICE 有权
标题翻译：内分泌出血和输送装置
公开(公告)号：US20140058402A1
公开(公告)日：2014-02-27
申请号：US13595636
申请日：2012-08-27
申请人： William J. Havel
发明人： William J. Havel
IPC分类号： A61B17/00
CPC分类号： A61F2/954 , A61F2/07 , A61F2/966 , A61F2002/065 , A61F2002/067
摘要： A system for treating a body vessel may include a delivery device and a prosthesis retained on the delivery device. The prosthesis may include a main body and first and second legs each extending from the main body. The main body may include a lumen, and the first leg may include a lumen in fluid communication with the lumen of the main body. The second leg may include a tubular graft body and a stent attached to the graft body. The prosthesis may have a predeployment configuration in which the graft body of the second leg is inverted into and positioned within the lumen of the first leg, and the stent is positioned outside of the inverted graft body. The prosthesis may have a deployed configuration in which the second leg extends outward from the main body, and the stent is positioned within a lumen of the graft body.
摘要翻译：用于治疗身体血管的系统可以包括输送装置和保留在输送装置上的假体。假体可以包括主体以及从主体延伸的第一和第二腿。主体可以包括腔，并且第一腿可以包括与主体的内腔流体连通的内腔。第二腿部可以包括管状移植体和附接到移植物体的支架。假体可以具有预部署构造，其中第二腿的移植物体被倒置并位于第一腿的内腔中，并且支架位于倒置的移植物体的外侧。假体可以具有展开构造，其中第二腿从主体向外延伸，并且支架位于移植物主体的内腔内。

34. 发明授权

US08639332B2 Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权
标题翻译：使用组织氧合测量进行休克后评估的方法和装置
公开(公告)号：US08639332B2
公开(公告)日：2014-01-28
申请号：US12845830
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

35. 发明授权

US08391973B2 Apparatus and method for non-invasive induction of ventricular fibrillation 有权
公开(公告)号：US08391973B2
公开(公告)日：2013-03-05
申请号：US11969663
申请日：2008-01-04
申请人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
发明人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3943 , A61N1/3962
摘要： An apparatus and method for delivering an external shock pulse receive pacing pulses generated by a first device and a shock pulse generated by a second device. An output of the apparatus is coupled to patient electrodes and the apparatus controls delivery of the received pacing pulses to the output and delivery of the received shock pulse to the output. A control module, pacing control and shock control included in the apparatus cooperatively control delivery of the received shock pulse to the output at a predetermined delay after one of the received pacing pulses.

36. 发明申请

US20110066198A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 有权
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：US20110066198A1
公开(公告)日：2011-03-17
申请号：US12845830
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/36
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

37. 发明申请

US20100030291A1 SUBCUTANEOUS IMPLANTABLE LEAD 有权
标题翻译：不可替代的领先
公开(公告)号：US20100030291A1
公开(公告)日：2010-02-04
申请号：US12183568
申请日：2008-07-31
申请人： William J. Havel , Markus J.C. Lazeroms , Jean J.G. Rutten , Karel F.A.A. Smits
发明人： William J. Havel , Markus J.C. Lazeroms , Jean J.G. Rutten , Karel F.A.A. Smits
IPC分类号： A61N1/39 , A61N1/05
CPC分类号： A61N1/0504 , A61N1/3962
摘要： A subcutaneous implantable device is provided that includes a defibrillation electrode disposed along a portion of a lead, and a lead tip connected to the lead. The lead tip includes a trailing end coupled to a distal end of the lead, and first and second non-parallel sides extending from the trailing end that converge to a leading end that is configured to wedge between tissue layers as the lead is advanced subcutaneously.
摘要翻译：提供了一种皮下可植入装置，其包括沿引线的一部分设置的除颤电极和连接到引线的引线头。引导尖端包括联接到引线的远端的尾端以及从后端延伸的第一和第二非平行侧，所述后端会聚到前端，当引导皮下进行时，构造成楔入组织层之间。

38. 发明申请

US20100030228A1 MEDICAL DEVICE SYSTEM AND APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 审中-公开
标题翻译：医疗装置系统及用于指导装置的装置
公开(公告)号：US20100030228A1
公开(公告)日：2010-02-04
申请号：US12432014
申请日：2009-04-29
申请人： William J. Havel
发明人： William J. Havel
IPC分类号： A61B17/32
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： An apparatus for guiding advancing of a subcutaneous medical device to a desired implant site that includes a strap extending along a length from a proximal end to a distal end, a handle orientation member positioned at the proximal end of the strap, and a handle capable of being selectively positioned at one of a plurality of orientations along the handle member.
摘要翻译：一种用于将皮下医疗装置引导到期望的植入部位的装置，所述植入部位包括沿着从近端到远端的长度延伸的带，位于带的近端的手柄定向构件和能够被选择性地定位在沿手柄构件的多个取向中的一个方向上。

39. 发明申请

US20100030147A1 APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 有权
标题翻译：用于指导设备的布置的装置
公开(公告)号：US20100030147A1
公开(公告)日：2010-02-04
申请号：US12431926
申请日：2009-04-29
申请人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
发明人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
IPC分类号： A61M5/42
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： An apparatus for guiding the placement of a subcutaneous device that includes a strap having an indentation configured for a fold of skin and fat layer to be positioned within the indentation as the subcutaneous device is advanced to a desired implantation site.
摘要翻译：一种用于引导皮下装置的放置的装置，所述装置包括当皮下装置前进到期望的植入部位时，所述带具有构造成用于皮肤和脂肪层折叠的凹陷，以定位在凹陷内。

40. 发明授权

US07277757B2 Respiratory nerve stimulation 有权
标题翻译：呼吸神经刺激
公开(公告)号：US07277757B2
公开(公告)日：2007-10-02
申请号：US10284899
申请日：2002-10-31
申请人： David A. Casavant , William J. Havel
发明人： David A. Casavant , William J. Havel
IPC分类号： A61N1/00
CPC分类号： A61N1/3601 , A61N1/365 , A61N2001/0585
摘要： The invention is directed to an implantable medical device that stimulates a nerve associated with respiration. The nerve may, for example be a phrenic nerve, and the stimulation may cause a diaphragm of the patient to contract. The implantable medical device receives a signal that indicates a need for increased cardiac output and stimulates the nerve in response to the signal. The implantable medical device may receive such a signal by, for example, detecting a ventricular tachyarrhythmia, sensing a pressure that indicates a need for increased cardiac output, or receiving a signal from a patient via a patient activator. Stimulation of the nerve may increase cardiac output of a beating or defibrillating heart.
摘要翻译：本发明涉及一种刺激与呼吸相关的神经的可植入医疗装置。神经可能例如是膈神经，并且刺激可能导致患者的隔膜收缩。可植入医疗装置接收指示需要增加心输出量并响应信号刺激神经的信号。可植入医疗装置可以通过例如检测心室快速性心律失常，感测指示增加心输出量的需要的压力或经由患者激活器从患者接收信号来接收这种信号。刺激神经可能会增加心脏输出的跳动或除颤心脏。

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