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31. 发明专利

CA2840818C AN IMPROVED PROCESS FOR THE PREPARATION OF AZILSARTAN MEDOXOMIL 未知
公开(公告)号：CA2840818C
公开(公告)日：2018-12-11
申请号：CA2840818
申请日：2012-01-24
申请人： JUBILANT LIFE SCIENCES LTD
发明人： BANSAL DEEPAK , MISHRA HIMANCHAL , DUBEY SHAILENDR KUMAR , CHOUDHARY ALKA SRIVASTAVA , VIR DHARAM , AGARWAL ASHUTOSH
IPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2'-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3- yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7 -carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2'-(4,5-dihydro- 5-oxo-4H-1,2,4-oxadiazol-3-yl) biphenyl-4-yl] methyl]-2-ethoxy-1H-benzirnidazole-7- carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.

32. 发明专利

SG11201801065PA AN IMPROVED PROCESS FOR THE PREPARATION OF TETROFOSMIN OR ACID ADDITION SALT THEREOF 未知
公开(公告)号：SG11201801065PA
公开(公告)日：2018-10-30
申请号：SG11201801065P
申请日：2017-11-20
申请人： JUBILANT GENERICS LTD FORMERLY A DIVISION OF JUBILANT LIFE SCIENCES LTD
发明人： PRASAD M UMAMAHESHWAR , KUMAR ANJUL , SINGH SHISHUPAL , VIR DHARAM
IPC分类号： C07D403/06
摘要： The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.

33. 发明专利

IN1800DE2012A PROCESS FOR THE PREPARATION OF TADALAFIL 未知
公开(公告)号：IN1800DE2012A
公开(公告)日：2015-10-16
申请号：IN1800DE2012
申请日：2012-06-12
申请人： JUBILANT LIFE SCIENCES LTD
发明人： MEHTA JATIN , SINGH KUMBER , SRIVASTAVA ALKA CHAUDHARY , VIR DHARAM , AGARWAL ASHUTOSH
IPC分类号： A61K20060101
摘要： The present invention provides an improved, simple, commercially viable and economic process for the preparation of tadalafil. Further, the process of present invention provides tadalafil particulate having DsO between 50 and 190 micron.

34. 发明专利

IN862DE2012A "PROCESS FOR PREPARATION OF EPROSARTAN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF VIA A NOVEL INTERMEDIATE" 未知
公开(公告)号：IN862DE2012A
公开(公告)日：2015-08-28
申请号：IN862DE2012
申请日：2012-03-23
申请人： JUBILANT LIFE SCIENCES LTD
发明人： HOLKAR ANIL GANPATRAO , PATEL CHETAN B , SURESH C H , POOJARI SANTHOSHA S , CHANDRASHEKHAR Y , VIR DHARAM , AGARWAL ASHUTOSH
IPC分类号： A61K20060101
摘要： The invention relates to a novel intermediate of Eprosartan, process for producing the same and employing the same for producing Eprosartan or pharmaceutically acceptable salts thereof in high yield and purity in an industrial friendly manner.

35. 发明专利

IN241DE2013A Improved Process for the Preparation of Bosentan, Its salts or hydrates thereof 未知
公开(公告)号：IN241DE2013A
公开(公告)日：2015-06-19
申请号：IN241DE2013
申请日：2013-01-29
申请人： JUBILANT LIFE SCIENCES LTD
发明人： HOLKAR ANIL GANPATRAO , PATEL CHETAN B , RADHESHYAM A , RAO M N V SRINIVASA , ULLAS B J , BHAT SUBRAY , VIR DHARAM , AGARWAL ASHUTOSH
IPC分类号： C30B20060101
摘要： The present invention relates to an improved process for the preparation of bosentan compound of formula-I or its hydrates. Further aspect of invention provides polymorph of bosentan, process for its preparation and pharmaceutical composition containing it. The present invention also provides the preparation of bosentan lithium salt and its novel crystalline forms. The obtained crystalline bosentan lithium salt can be subsequently converted into the bosentan or its hydrates. It also provides bosentan with high yield and high chemical purity without the use of tedious, complicated purification steps, such as chromatography.

36. 发明专利

IN3591DE2013A PROCESS FOR THE PREPARATION OF TRANS (-) PINAVERIUM BROMIDE AND INTERMEDIATES THEREOF 未知
公开(公告)号：IN3591DE2013A
公开(公告)日：2015-06-12
申请号：IN3591DE2013
申请日：2013-12-11
申请人： JUBILANT LIFE SCIENCES LTD
发明人： BISWAS SUJAY , KANERIA ANKITKUMAR RAMNIKLAL , HAWALDAR MAURYA , VIR DHARAM
IPC分类号： C07D20060101
摘要： The invention relates to the process for the preparation of substantially pure trans pinaverium bromide, compound of formula-11, having HPLC purity more than 99%. In one more aspect of the present invention provides the improved process for the preparation of trans (-)

37. 发明专利

CA2840818A1 AN IMPROVED PROCESS FOR THE PREPARATION OF AZILSARTAN MEDOXOMIL 未知
公开(公告)号：CA2840818A1
公开(公告)日：2012-08-16
申请号：CA2840818
申请日：2012-01-24
申请人： JUBILANT LIFE SCIENCES LTD
发明人： BANSAL DEEPAK , MISHRA HIMANCHAL , DUBEY SHAILENDR KUMAR , CHOUDHARY ALKA SRIVASTAVA , VIR DHARAM , AGARWAL ASHUTOSH
IPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to an improved process for the preparation of azilsartan or its esters or salts thereof. Specifically, the invention provides a method for the preparation of highly pure methyl 1-[[2'-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3- yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7 -carboxylate an intermediate compound of formula (4) for azilsartan medoxomil with reduced content of desethyl impurity. The invention also involves the use of highly pure methyl 1-[[2'-(4,5-dihydro- 5-oxo-4H-1,2,4-oxadiazol-3-yl) biphenyl-4-yl] methyl]-2-ethoxy-1H-benzirnidazole-7- carboxylate in the preparation of azilsartan or its esters or salts thereof, preferably medoxomil with reduced content of desethyl impurity.

38. 发明申请

WO2011030213A1 IMPROVED PROCESS FOR THE PREPARATION OF 7.(4-BROMOBUTOXY) 3,4-DIHYDROCARBOSTYRIL, A PRECURSOR OF ARIPIPRAZOLE 审中-公开
标题翻译：改进的制备7（4-溴代氧代）3,4-二氯碳硅烷的方法，阿维哌唑的前体
公开(公告)号：WO2011030213A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010002276
申请日：2010-09-14
申请人： JUBILANT ORGANOSYS LTD , SRIVASTAVA JAYANT , GUPTA VIJAY SHANKAR , VARU BHARAT VITHALBHAL , KUMAR PARMOD , VIR DHARAM
发明人： SRIVASTAVA JAYANT , GUPTA VIJAY SHANKAR , VARU BHARAT VITHALBHAL , KUMAR PARMOD , VIR DHARAM
IPC分类号： C07D215/227
CPC分类号： C07D215/227
摘要： Disclosed herein is an improved process for the preparation of 7-(4-bromobutoxy) 3,4-dihydrocarbostyril, a key intermediate used in the preparation of Aripiprazole.
摘要翻译：本文公开了一种用于制备用于制备阿立哌唑的关键中间体7-（4-溴丁氧基）3,4-二氢喹诺酮的改进方法。

39. 发明申请

WO2005100331A3 ANTIDIABETIC AGENTS 审中-公开
标题翻译：抗真菌剂
公开(公告)号：WO2005100331A3
公开(公告)日：2006-04-06
申请号：PCT/IB2005000998
申请日：2005-04-14
申请人： RANBAXY LAB LTD , SALMAN MOHAMMAD , SATTIGERI JITENDRA , VIR DHARAM , GANGAN VIJA DATTATRAYA
发明人： SALMAN MOHAMMAD , SATTIGERI JITENDRA , VIR DHARAM , GANGAN VIJA DATTATRAYA
IPC分类号： A61K31/427 , A61P3/10 , C07D277/20 , C07D277/34 , C07D417/10 , C07D417/12
CPC分类号： C07D277/20 , C07D277/34 , C07D417/10 , C07D417/12
摘要： The present invention relates to alkynyl derivatives, which have PPAR agonist activity and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used for the treatment of diabetes and diabetes-associated complications, for the treatment of diseases and conditions in which insulin resistance is the central pathophysiological mechanism, for the treatment of diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndorme, hypertensive nephrosclerosis, polycystic ovarian syndrome, eating disorders, psoriasis, obesity, for improving cognitive functions in dementia and as aldose reductase inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diabetes mellitus and the diseases and conditions mediated through insulin resistance are provided.
摘要翻译：本发明涉及具有PPAR激动剂活性的炔基衍生物，因此可用作抗糖尿病化合物。本文公开的化合物可用于治疗糖尿病和糖尿病相关并发症，用于治疗其中胰岛素抵抗是中枢病理机制的疾病和病症，用于治疗疾病或病症如II型糖尿病，血脂异常，高血压冠心病，心血管疾病，动脉粥样硬化，糖尿病肾病，肾小球肾炎，肾小球硬化症，肾病综合征，高血压性肾硬化，多囊卵巢综合征，进食障碍，牛皮癣，肥胖症，用于改善痴呆症中的认知功能和作为醛糖还原酶抑制剂。提供了制备所公开化合物的方法，含有所公开化合物的药物组合物，以及治疗糖尿病的方法以及通过胰岛素抵抗介导的疾病和病症。

40. 发明申请

WO2011042804A2 AN IMPROVED PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE FORM I 审中-公开
标题翻译：一种改进的氯吡格雷硫酸氢盐制备方法Ⅰ
公开(公告)号：WO2011042804A2
公开(公告)日：2011-04-14
申请号：PCT/IB2010002553
申请日：2010-10-08
申请人： JUBLIANT LIFE SCIENCES LTD , ACHARYA HRISHIKESH DILIP , SRIVASTAVA JAYANT , KUMAR SATISH , AWASTHI ARUN KUMAR , KUMAR PRAMOD , VIR DHARAM
发明人： ACHARYA HRISHIKESH DILIP , SRIVASTAVA JAYANT , KUMAR SATISH , AWASTHI ARUN KUMAR , KUMAR PRAMOD , VIR DHARAM
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Disclosed herein an improved process for the preparation of polymorphic Form I of clopidogrel hydrogen sulfate.
摘要翻译：本文公开了制备氯吡格雷硫酸氢盐的多晶型I的改进方法。

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