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31. 发明授权

US4738122A Refrigerant expansion device with means for capturing condensed contaminants to prevent blockage 失效
标题翻译：具有用于捕获浓缩污染物以防止堵塞的装置的制冷剂膨胀装置
公开(公告)号：US4738122A
公开(公告)日：1988-04-19
申请号：US947526
申请日：1986-12-29
申请人： Graham Walker
发明人： Graham Walker
IPC分类号： F16K31/64 , F17D1/075 , F25B9/00 , F25B9/02 , F25B19/00 , G05D23/02
CPC分类号： G05D23/024 , F25B9/02 , F25B2309/022 , Y10T137/8013 , Y10T137/87981
摘要： A refrigerant expansion device such as a Joule-Thomson expander has a surface with grooves or recesses which capture contaminants that condense from the refrigerant flow in the device, thereby avoiding blockage of the device by the condensed contaminants.
摘要翻译：诸如焦耳 - 汤姆逊膨胀机的制冷剂膨胀装置具有凹槽或凹槽的表面，其捕获从装置中的制冷剂流冷凝的污染物，从而避免由冷凝的污染物阻塞装置。

32. 发明授权

US08288413B2 Benzimidazolones which have activity at M1 receptor 失效
标题翻译：具有M1受体活性的苯并咪唑酮
公开(公告)号：US08288413B2
公开(公告)日：2012-10-16
申请号：US12088489
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D405/04
CPC分类号： C07D401/04 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 6选自氢，卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基， C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基和氰基，Q是氢或C 1-6烷基。化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

33. 再颁专利

USRE43398E1 Methods and apparatus to generate liquid ambulatory oxygen from an oxygen concentrator 有权
标题翻译：从氧气浓缩器产生液体动态氧气的方法和装置
公开(公告)号：USRE43398E1
公开(公告)日：2012-05-22
申请号：US11366986
申请日：2006-03-01
申请人： Scott C. Honkonen , Theodore B. Hill , Charles C. Hill , Graham Walker , Ann Valentine Walker, legal representative
发明人： Scott C. Honkonen , Theodore B. Hill , Charles C. Hill , Graham Walker
IPC分类号： A62B7/06 , A62B7/00
CPC分类号： B01D5/0039 , B01D53/047 , B01D53/053 , B01D53/261 , B01D2253/108 , B01D2253/116 , B01D2256/12 , B01D2257/102 , B01D2257/404 , B01D2257/502 , B01D2257/504 , B01D2257/80 , B01D2259/40001 , B01D2259/40009 , B01D2259/416 , B01D2259/4525 , B01D2259/4533 , B01D2259/4541 , B01D2259/455 , F17C6/00 , F17C2221/011 , F17C2223/0161 , F17C2227/0353 , F17C2265/015 , F17C2270/0509 , F25B9/006 , F25B9/145 , F25J1/0017 , F25J1/0052 , F25J1/0212 , F25J1/0225 , F25J1/0244 , F25J1/0276 , F25J2205/40 , F25J2205/60 , F25J2205/80 , F25J2210/40 , F25J2220/50 , F25J2270/90 , F25J2270/91 , Y02C10/08 , Y02P70/34
摘要： The present invention is directed to a much safer and less expensive way of providing portable oxygen from a gas concentrator for patients who do not want to be tied to a stationary machine or restricted by present oxygen technology. The present invention involves a home liquid oxygen ambulatory system for supplying a portable supply of oxygen, where a portion of the gaseous oxygen output obtained from an oxygen concentrator is condensed into liquid oxygen. The system includes an oxygen concentrator which separates oxygen gas from the ambient air, a condenser in communication with the oxygen concentrator for receiving and liquefying the oxygen gas flow, a cryocooler associated with the condenser, and a first storage dewar in fluid communication with the condenser and adapted to store the oxygen liquefied by the condenser, the first storage dewar including means for transferring liquid oxygen from the first dewar to a second dewar for storing a quantity of oxygen suitable for moveable oxygen treatment.
摘要翻译：本发明涉及一种从气体浓缩器提供便携式氧气的安全性和价格较低的方法，用于不希望被固定式机器束缚或受现有氧气技术限制的患者。本发明涉及用于提供便携式氧气供应的家用液体氧气移动系统，其中从氧气浓缩器获得的部分气态氧气输出被冷凝成液氧。该系统包括将氧气与环境空气分离的氧浓缩器，与氧浓缩器连通的用于接收和液化氧气流的冷凝器，与冷凝器相关的低温冷却器，以及与冷凝器流体连通的第一储存杜瓦瓶并且适于存储由冷凝器液化的氧气，第一储存杜瓦包括用于将液氧从第一杜瓦转移到第二杜瓦瓶的装置，用于储存适于可移动氧处理的氧气量。

34. 发明申请

US20080306112A1 Benzimidazolones Which Have Activity at M1 Receptor 失效
标题翻译：在M1受体上具有活性的苯并咪唑酮
公开(公告)号：US20080306112A1
公开(公告)日：2008-12-11
申请号：US12088489
申请日：2006-09-27
申请人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
发明人： Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Jian Jin , Dongchuan Shi , Paul William Smith , Graham Walker
IPC分类号： A61K31/454 , C07D211/06 , A61P25/00
CPC分类号： C07D401/04 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）和盐的化合物：其中R 6选自氢，卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基， C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基和氰基，Q是氢或C 1-6烷基。化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

35. 发明授权

US4631928A Joule-Thomson apparatus with temperature sensitive annular expansion passageway 失效
标题翻译：焦耳汤姆森设备带有温度敏感的环形膨胀通道
公开(公告)号：US4631928A
公开(公告)日：1986-12-30
申请号：US793268
申请日：1985-10-31
申请人： Graham Walker
发明人： Graham Walker
IPC分类号： F16K31/64 , F17D1/075 , F25B9/00 , F25B9/02 , F25B19/00 , G05D23/02
CPC分类号： G05D23/024 , F25B9/02 , F25B2309/022 , Y10T137/8013 , Y10T137/87981
摘要： A self-regulated Joule-Thomson expansion valve and cryostat useful in miniaturized cryogenic gas liquefaction systems include a substantially frustroconical valve member having a base portion supported at the end of first means such as an elongate shaft and a tapered valve seat generally complementary to the valve member and supported circumferentially adjacent a lengthwise portion of the valve member by second means such as a sheath slidably received upon the shaft. The valve member and valve seat taper down toward a free extremity of the valve member, whereby opposing peripheral surfaces of the valve member and valve seat define a converging annular passageway terminating at an annular expansion opening. The first means is constructed with an effective coefficient of thermal expansion lower than that of the second means so that the valve seat moves axially toward and away from the valve member by differential contraction and expansion between the first and second means in response respectively to decreases and increases in the temperature of expanded coolant gas, thus regulating the effective flow area of the converging annular passageway. The valve member may advantageously include labyrinth flow spoilers in the form of circumferential grooves which serve additionally as catchment reservoirs for capturing contaminants contained in the coolant gas, thus rendering the expansion valve highly resistant to blockage by such contaminants. Means may also be provided for adjusting the relative axial positions of the valve member and valve seat in order to calibrate the effective flow area of the converging passageway.
摘要翻译：用于小型化低温气体液化系统的自调节焦耳 - 汤姆森膨胀阀和低温恒温器包括基本上截头圆锥形的阀构件，其具有支撑在诸如细长轴的第一装置的端部处的基部部分和通常与阀门互补的锥形阀座并且通过诸如可滑动地容纳在轴上的护套的第二装置周向地邻近阀构件的纵向部分。阀构件和阀座朝向阀构件的自由端向下锥形，由此阀构件和阀座的相对的外围表面限定了终止于环形膨胀开口的会聚环形通道。第一装置被构造成具有低于第二装置的有效热膨胀系数，使得阀座分别通过第一和第二装置之间的差分收缩和膨胀而轴向地朝向和远离阀构件移动，以响应于减小和膨胀的冷却剂气体的温度升高，从而调节会聚环形通道的有效流动面积。阀构件可以有利地包括圆周凹槽形式的迷宫式流动扰流器，其另外用作用于捕获包含在冷却剂气体中的污染物的集水池，从而使膨胀阀高度抵抗这种污染物的堵塞。还可以提供用于调节阀构件和阀座的相对轴向位置以便校准会聚通道的有效流动面积的装置。

36. 发明授权

US4362743A Antibacterial monic acid esters 失效
标题翻译：抗菌单酸酯
公开(公告)号：US4362743A
公开(公告)日：1982-12-07
申请号：US289103
申请日：1981-07-31
申请人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker
发明人： Norman H. Rogers , Peter J. O'Hanlon , Graham Walker
IPC分类号： A61K31/35 , A61K31/351 , A61P31/04 , C07D309/10 , C07D407/06 , C07D309/06
CPC分类号： C07D407/06 , C07D309/10
摘要： Compounds of formula (II): ##STR1## in which Y represents ##STR2## and R.sub.0 represents a C.sub.2-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.4-20 alkenyl, arakyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl group, which is substituted by a hydroxyiminohydrazono- or semicarbazono group, have activity against human and veterinary bacteria and mycoplasma. They may be produced by conventional methods and are used in conventional formulations.
摘要翻译：式（II）的化合物：其中Y代表<！ - SIPO - >和R 0代表C2-20烷基，C3-8环烷基，C4-20烯基，芳烷基，环烷基烷基，杂环基或芳基被羟亚氨基腙或氨基咔唑基取代的杂环基烷基具有抗人和兽医细菌和支原体的活性。它们可以通过常规方法制备并且用于常规制剂中。

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