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31. 发明申请

US20160303132A1 PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS 审中-公开
标题翻译： PYRAZOLO [3,4-D]吡嗪衍生物有助于治疗呼吸道疾病
公开(公告)号：US20160303132A1
公开(公告)日：2016-10-20
申请号：US15194373
申请日：2016-06-27
申请人： Ian Bruce , Judy Fox Hayler , Graham Charles Bloomfield , Lee Edwards , Brian Cox , Catherine Howsham
发明人： Ian Bruce , Judy Fox Hayler , Graham Charles Bloomfield , Lee Edwards , Brian Cox , Catherine Howsham
IPC分类号： A61K31/519 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/5377 , C07D487/04
摘要： The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.
摘要翻译：或其药学上可接受的盐或溶剂化物，其中R1-R3和Y在说明书中定义，及其用于治疗其中涉及pi3激酶的病症。

32. 发明授权

US09193118B2 Ophthalmic lens molds, ophthalmic lenses molded therein, and related methods 有权
标题翻译：眼镜片，其中模制的眼镜片及相关方法
公开(公告)号：US09193118B2
公开(公告)日：2015-11-24
申请号：US13805524
申请日：2011-07-29
申请人： A. K. M. Shahab Siddiqui , David Robert Morsley , Sarah L. Almond , Richard C. Rogers , Ian Bruce , Lee Darren Norris , Edyta S. Bialek , Benjamin S. Sheader
发明人： A. K. M. Shahab Siddiqui , David Robert Morsley , Sarah L. Almond , Richard C. Rogers , Ian Bruce , Lee Darren Norris , Edyta S. Bialek , Benjamin S. Sheader
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： B29D11/00038 , B29D11/0048 , G02B1/043 , C08L101/14 , C08L51/085
摘要： Methods of manufacturing contact lenses using ophthalmic lens molds having a molding surface comprising a thermoplastic polymer, the molding surface having a percent polarity from 3% to 20% and a surface energy from about 25 mN/m to about 40 mN/m to cast mold a polymerizable composition having a surface tension from about 20 mN/m to about 25 mN/m, wherein a surface energy differential of the surface tension of the polymerizable composition less the surface energy of the molding surface less than or equal to zero (0); and silicone hydrogel contact lens bodies so manufactured are described.
摘要翻译：使用具有包含热塑性聚合物的模制表面的眼镜模具制造隐形眼镜的方法，所述模制表面具有3％至20％的百分比极性和约25mN / m至约40mN / m的表面能，具有约20mN / m至约25mN / m的表面张力的可聚合组合物，其中可聚合组合物的表面张力的表面能量差使模制表面的表面能小于或等于零（0） ; 并描述如此制造的硅氧水凝胶隐形眼镜体。

33. 发明授权

US08835444B2 Cyclohexyl amide derivatives as CRF receptor antagonists 有权
标题翻译：环己基酰胺衍生物作为CRF受体拮抗剂
公开(公告)号：US08835444B2
公开(公告)日：2014-09-16
申请号：US13576040
申请日：2011-01-31
申请人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
发明人： David Beattie , Ian Bruce , Anny-Odile Colson , Andrew James Culshaw , Thomas Sharp
IPC分类号： C07C233/79 , C07D213/82 , C07D231/12 , C07D231/38 , C07D249/08 , C07D401/12 , C07D231/16 , C07D473/00 , C07D231/54 , C07D231/14 , C07D405/04 , C07D491/052 , C07D231/20 , C07D231/56 , C07D401/04 , C07D471/04 , C07D401/14
CPC分类号： C07D213/82 , C07C233/79 , C07C2601/14 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/54 , C07D231/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/04 , C07D473/00 , C07D491/052
摘要： There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists Formula (I).
摘要翻译：描述了可用作促肾上腺皮质激素释放因子（CRF）受体拮抗剂式（I）的环己基酰胺衍生物。

34. 发明申请

US20130237519A1 BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
公开(公告)号：US20130237519A1
公开(公告)日：2013-09-12
申请号：US13599267
申请日：2012-08-30
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

35. 发明申请

US20130169927A1 Vinyl Alcohol Ophthalmic Lens Molds, Ophthalmic Lenses Molded Therein, And Related Methods 有权
标题翻译：乙烯醇眼科镜片模具及其相关方法
公开(公告)号：US20130169927A1
公开(公告)日：2013-07-04
申请号：US13810677
申请日：2011-06-13
申请人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
发明人： Neil Goodenough , David Robert Morsley , Ian Bruce , Edyta S. Bialek , Lee Darren Norris
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： G02C7/04 , A45C11/005 , B29C33/40 , B29C45/26 , B29D11/00009 , B29D11/00038 , B29D11/00134 , B29D11/00192 , B29D11/00413 , B29D11/0048 , B29K2083/00 , B29K2823/12 , B29K2829/04 , B29K2995/0025 , B29K2995/006 , B29K2995/0062 , B29L2011/0041 , B65D75/36 , B65D81/22 , C08L83/04 , C08L2201/50 , C08L2203/02 , G02B1/043 , G02B2207/109 , C08L33/26 , C08L33/10 , C08L39/06 , C08L101/14
摘要： Ophthalmic lens molds made from at least one vinyl alcohol copolymers with high amorphous content, ophthalmic lenses including silicone hydrogel contact lenses formed using these molds, packaged ophthalmic lenses present in a solution comprising the at least one vinyl alcohol copolymer with high amorphous content, and related methods are described. The methods of manufacturing ophthalmic lenses can use wet demolding, delensing or demolding and delensing processes involving dissolving the molds in water or an aqueous solution.
摘要翻译：由至少一种具有高无定形含量的乙烯醇共聚物制成的眼镜片模具，包括使用这些模具形成的硅酮水凝胶隐形眼镜的眼科镜片，包含至少一种具有高无定形含量的至少一种乙烯醇共聚物的溶液的包装眼镜片，以及相关描述方法。制造眼镜片的方法可以使用湿式脱模，脱模或脱模和脱模过程，包括将模具溶解在水或水溶液中。

36. 发明申请

US20120302531A1 beta-2-Adrenoreceptor Agonists 有权
标题翻译： β-2-肾上腺素受体激动剂
公开(公告)号：US20120302531A1
公开(公告)日：2012-11-29
申请号：US13555536
申请日：2012-07-23
申请人： Bernard Cuenoud , Ian Bruce , Robin Alec Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin Alec Fairhurst , David Beattie
IPC分类号： A61K31/56 , A61P11/06 , A61P11/00 , A61P29/00 , A61K31/58 , A61K31/573
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, whereAr is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译：其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

37. 发明申请

US20120214800A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20120214800A1
公开(公告)日：2012-08-23
申请号：US13460504
申请日：2012-04-30
申请人： Ian Bruce , Emma Budd , Lee Edwards , Catherine Howsham
发明人： Ian Bruce , Emma Budd , Lee Edwards , Catherine Howsham
IPC分类号： A61K31/551 , A61K31/497 , C07D413/14 , A61K31/5377 , C07D401/06 , C07D413/12 , C07D241/20 , A61K31/4965 , C07D265/36 , A61K31/536 , A61P11/00 , A61P37/08 , A61P19/02 , A61P17/06 , A61P1/04 , A61P1/00 , A61P35/00 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/04 , C07D401/14
CPC分类号： C07D401/06 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.
摘要翻译：本发明涉及式（I）化合物或其盐，其合适的药学上可接受的盐或溶剂合物，其中R 1，R 2，Ar'，A和Y基团在说明书中定义为组合物和用途化合物治疗炎症和过敏症状。

38. 发明授权

US08147727B2 Methods and systems for forming ophthalmic lens mold assemblies 有权
标题翻译：用于形成眼镜片模具组件的方法和系统
公开(公告)号：US08147727B2
公开(公告)日：2012-04-03
申请号：US12763543
申请日：2010-04-20
申请人： Ian Bruce , Robert Oag , Stuart Bailey , Stephen Saunders
发明人： Ian Bruce , Robert Oag , Stuart Bailey , Stephen Saunders
IPC分类号： B29D11/00
CPC分类号： B29D11/005 , B29C33/202 , B29L2011/0041 , Y10S425/808
摘要： Methods and systems are provided for making an ophthalmic lens. The present methods and systems are effecting in coupling two mold sections together at two or more discrete regions. Embodiments of the methods and systems form a bore that extends completely through one of the mold sections and only partially through the other mold section. During formation of the bore, the mold material in proximity to the bore being foamed becomes molten and diffuses from the bore. A portion of the molten mold material is provided at a contact point between the two mold sections and when the molten material cools, the material foams a spot weld between the mold sections. By foaming multiple hollow spot welds in a mold assembly, the two mold sections can be securely coupled to each other during the manufacture of an ophthalmic lens, such as a silicone hydrogel contact lens.
摘要翻译：提供了用于制造眼科镜片的方法和系统。目前的方法和系统正在两个或更多个离散区域将两个模具部分联接在一起。方法和系统的实施例形成了一个完全穿过其中一个模具部分并且仅部分地穿过另一个模具部分的孔。在孔的形成期间，靠近所形成的孔的模具材料变得熔化并且从孔扩散。熔融模具材料的一部分设置在两个模具部分之间的接触点处，并且当熔融材料冷却时，该材料在模具部分之间形成点焊。通过在模具组件中形成多个中空点焊，在制造眼用透镜（例如硅酮水凝胶隐形眼镜）期间，两个模具部分可以彼此牢固地联接。

39. 发明申请

US20100197682A1 Organic Compounds 失效
标题翻译：有机化合物
公开(公告)号：US20100197682A1
公开(公告)日：2010-08-05
申请号：US12669536
申请日：2008-07-16
申请人： Ian Bruce , Darren Mark Legrand , James Dale , Thomas Anthony Hunt
发明人： Ian Bruce , Darren Mark Legrand , James Dale , Thomas Anthony Hunt
IPC分类号： A61K31/5377 , A61K31/5025 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/437 , C07D471/04 , C07D487/04 , A61P35/00 , C12N5/02
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

40. 发明申请

US20080280871A1 5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases 失效
标题翻译： 5-苯基-4-甲基 - 噻唑-2-基胺衍生物作为磷脂酰肌醇蛋白的抑制剂Ositol 3激酶（PI13）用于治疗炎性疾病
公开(公告)号：US20080280871A1
公开(公告)日：2008-11-13
申请号：US10568053
申请日：2004-08-27
申请人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
发明人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
IPC分类号： A61K31/426 , C07D277/42 , C07D417/12 , A61K31/5377 , A61P17/06 , A61P11/00
CPC分类号： C07D451/04 , C07D277/48 , C07D417/12 , C07D471/04
摘要： in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：游离或盐形式，其中R a，R b，R b，R 3，R 3，R SUP > 4和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的病症。还描述了含有化合物的药物组合物和制备该化合物的方法。

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