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31. 发明公开

EP1740604A2 TD ANTIGENS 审中-公开
标题翻译： TD抗原
公开(公告)号：EP1740604A2
公开(公告)日：2007-01-10
申请号：EP05733499.7
申请日：2005-04-26
申请人： Intercell AG
发明人： MEINKE, Andreas , TRISKA, Christine , HENICS, Tamas , MINH BUI, Duc , NAGY, Eszter , PRUSTOMERSKY, Sonja
IPC分类号： C07K14/195
CPC分类号： C07K14/245 , A61K39/00 , A61K2039/53 , C07K14/205 , C07K14/25 , Y02A50/47 , Y02A50/476
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from enteroaggregative E. coli, enterotexigenic E. coli, S. flexneri and C. jejuni, methods for isolating such antigens and specific uses thereof.

32. 发明公开

EP1633777A2 CHLAMYDIA PNEUMONIAE ANTIGENS 审中-公开
标题翻译： CHLAMYDIA PNEUMONIAE ANTIGENE
公开(公告)号：EP1633777A2
公开(公告)日：2006-03-15
申请号：EP04739928.2
申请日：2004-06-16
申请人： Intercell AG
发明人： MEINKE, Andreas , NAGY, Eszter , WINKLER, Birgit
IPC分类号： C07K14/295 , A61K39/118
CPC分类号： C07K14/295 , A61K39/00
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from C. pneumoniae, methods for isolating such antigens and specific uses thereof.

33. 发明公开

EP1620460A2 STREPTOCOCCUS AGALACTIAE ANTIGENS I + II 审中-公开
标题翻译： STREPTOCOCCUS AGALACTIAE-ANTIGENE I + II
公开(公告)号：EP1620460A2
公开(公告)日：2006-02-01
申请号：EP04731346.5
申请日：2004-05-06
申请人： Intercell AG
发明人： MEINKE, Andreas , NAGY, Eszter , HANNER, Markus , HORKY, Markus , KALLENDA, Sabine , PRUSTOMERSKY, Sonja
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C07K16/12 , C12Q1/68 , C12N15/11 , G01N33/50
CPC分类号： C07K16/1275 , C07K14/315 , C07K2317/00
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, methods for isolating such antigens and specific uses thereof.

34. 发明公开

EP2265634A2 PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE AND COMPOSITIONS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：对肺炎链球菌和组合物中，有连接过程和应用程序肽防护剂
公开(公告)号：EP2265634A2
公开(公告)日：2010-12-29
申请号：EP09723484.3
申请日：2009-03-17
申请人： Intercell AG
发明人： MEINKE, Andreas , TEUBENBACHER, Astrid , SENN, Beatrice , ZERBS, Manuel , HANNER, Markus , PIKALO, Jutta , NAGY, Eszter , GIEFING, Carmen , VON GABAIN, Alexander
IPC分类号： C07K14/315 , C07K16/12 , G01N33/68 , A61K39/09
CPC分类号： A61K39/092 , C07K14/3156 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to a protective peptide of Streptococcus pneumoniae (S. pneumoniae) or a functionally active variant of the protective peptide; a composition comprising at least two protective peptides or functionally active variants thereof; a composition comprising at least two proteins selected from the group consisting of i) a first type of protective peptide or functionally active variant thereof, ii) a second type of protective peptide or functionally active variant thereof and iii) a supportive peptide or a functionally active variant thereof; one or more nucleic acid(s) encoding the protective peptide or functionally active variant thereof or the at least two proteins comprised in the composition; a pharmaceutical composition comprising the protective peptide or functionally active variant thereof, the composition, or the nucleic acid(s); a method of producing an antibody using the protective peptide or functionally active variant thereof or the composition; the use of the protective peptide or functionally active variant thereof and/or the composition and/or the nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; a method of diagnosing a S. pneumoniae infection using the protective peptide or a functionally active variant thereof, the composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to a protective peptide or functionally active variant thereof; and the use of a protective peptide or functionally active variant thereof for the isolation and/or purification and/or identification of an interaction partner of the peptide.

35. 发明公开

EP2167530A2 CHLAMYDIA ANTIGENS 审中-公开
标题翻译： CHLAMYDIA抗原
公开(公告)号：EP2167530A2
公开(公告)日：2010-03-31
申请号：EP08760988.9
申请日：2008-06-13
申请人： Intercell AG
发明人： MEINKE, Andreas , NAGY, Eszter , NOIGES, Birgit , ASKLIN, Johanna , VON GABAIN, Alexander
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , A61K39/118 , G01N33/56927 , G01N2469/20
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia.
摘要翻译：本发明涉及编码来自衣原体属物种的抗原的分离的核酸分子，包含此类核酸分子的载体和包含此类载体的宿主细胞。此外，本发明提供了来自衣原体属的抗原及其片段和变体，生产这种抗原的方法，以及生产表达此类抗原的细胞的方法。更具体地说，这样的抗原由肺炎衣原体引起的细菌感染产生或与之相关。此外，本发明提供了与这样的抗原结合的抗体，产生这种抗体的杂交瘤细胞，产生这种抗体的方法，包含这种核酸分子，抗原，载体或抗体的药物组合物，这种核酸分子，抗原，载体或抗体用于制备药物组合物的方法，用于鉴定能够结合此类抗原的拮抗剂或减少或抑制此类抗原的相互作用活性的方法，用于诊断衣原体感染的方法以及用于治疗或预防感染的方法与披衣菌。

36. 发明公开

EP2152731A2 KLEBSIELLA ANTIGENS 审中-公开
标题翻译：克雷伯菌抗原
公开(公告)号：EP2152731A2
公开(公告)日：2010-02-17
申请号：EP08736618.3
申请日：2008-04-29
申请人： Intercell AG
发明人： BAKSHI, Sharmila , CIPPS, Thomas , HANNER, Markus , PIKALO, Jutta , SATKE, Christina , NAGY, Eszter , LUNDBERG, Urban , ZIERER,Dagmar , MEINKE, Andreas , NOIGES, Birgit , STIERSCHNEIDER, Ulrike , VON GABAIN, Alexander
IPC分类号： C07K14/26 , C07K16/12 , A61K39/395 , A61P31/04
CPC分类号： C07K14/26 , A61K39/00 , A61K39/0266 , A61K45/06 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , C07K16/1228 , C07K2317/21
摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Klebsiella species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection and methods for the treatment or prevention of an infection. More specifically such antigens are produced by or associated with bacterial pathogens causing nosocomial infections or bacterial infections caused by Klebsiella pneumoniae.

37. 发明公开

EP2120984A2 PROTECTIVE PROTEINS OF S. AGALACTIAE, COMBINATIONS THEREOF AND METHODS OF USING THE SAME 审中-公开
标题翻译：无乳链球菌的保护蛋白质，其组合以及其使用方法
公开(公告)号：EP2120984A2
公开(公告)日：2009-11-25
申请号：EP08701380.1
申请日：2008-01-10
申请人： Intercell AG
发明人： SENN, Beatrice , NAGY, Eszter , MEINKE, Andreas , VON GABAIN, Alexander , MAIERHOFER, Barbara , STIERSCHNEIDER, Ulrike , BERGER, Manfred , NEUBAUER, Christina , COHEN, Katherine
IPC分类号： A61K38/00
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.

38. 发明公开

EP2059526A2 BORRELIA ANTIGENS 审中-公开
标题翻译：疏螺旋体抗原
公开(公告)号：EP2059526A2
公开(公告)日：2009-05-20
申请号：EP07815120.6
申请日：2007-09-14
申请人： Intercell AG
发明人： LUNDBERG, Urban , MEINKE, Andreas , NAGY, Eszter , VON GABAIN, Alexander , NOIGES, Birgit , GELBMANN, Dieter , POLJAK, Albina , TRISKA, Christine
IPC分类号： C07K14/20
CPC分类号： C07K7/08 , A61K39/00 , A61K2039/53 , C07K7/06 , C07K14/20 , Y02A50/401
摘要： The present invention relates to isolated nucleic acid molecules which encode a protein, isolated nucleic acid molecules which encode a hyperimmune serum reactive antigen, a vector which comprises such nucleic acid molecule, a host cell comprising such vector, a hyperimmune reactive antigen from Borrelia species, proteins which are preferably hyperimmune serum reactive antigens, hyperimmune serum reactive antigens, antigens, a process for producing such proteins, hyperimmune serum reactive antigens or antigens, a process for producing a cell which expresses such protein, hyperimmune serum reactive antigen or antigen, an antibody binding to such protein, hyperimmune serum reactive antigen or antigen, a hybridoma cell producing such antibody, methods for producing such antibody, a pharmaceutical composition comprising such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody, the use of such nucleic acid molecule, protein, hyperimmune serum reactive antigen, antigen or antibody for the manufacture of a medicament, methods for identifying an antagonist capable of reducing or inhibiting the interaction activity of such protein, hyperimmune serum reactive antigen or antigen, methods for diagnosing an infection and methods for the treatment of an infection. More specifically such proteins, hyperimmune serum reactive antigens or antigens are produced by or associated with bacterial pathogens causing Lyme disease or bacterial infections caused by Borrelia burgdorferi s.1.

39. 发明公开

EP1608756A2 STAPHYLOCOCCUS EPIDERMIDIS ANTIGENS 有权
标题翻译：表皮葡萄球菌抗原
公开(公告)号：EP1608756A2
公开(公告)日：2005-12-28
申请号：EP04724557.6
申请日：2004-03-31
申请人： Intercell AG
发明人： MEINKE, Andreas , MIN BUI, Duc , NAGY, Eszter
IPC分类号： C12N15/31 , C07K14/31 , C12R1/44 , C07K16/12 , C12Q1/68 , A61K39/085 , G01N33/68
CPC分类号： A61K39/00 , A61K2039/505 , A61K2039/53 , A61K2039/55516 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/31
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. epidermidis, methods for isolating such antigens and specific uses thereof.

40. 发明授权

EP1601770B1 STREPTOCOCCUS PYOGENES ANTIGENS 有权
标题翻译： STREPTOCOCCUS PYOGENES ANTIGENE
公开(公告)号：EP1601770B1
公开(公告)日：2009-09-02
申请号：EP04716233.4
申请日：2004-03-02
申请人： Intercell AG
发明人： MEINKE, Andreas , NAGY, Eszter , WINKLER, Birgit , GELBMANN, Dieter
IPC分类号： C12N15/31 , C07K14/315 , C07K16/12 , C12Q1/68 , A61K39/09 , G01N33/68
CPC分类号： A61K39/0208 , A61K39/00 , C07K14/315 , C07K16/1275 , C07K2317/21
摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pyogenes, methods for isolating such antigens and specific uses therefor
摘要翻译：本发明公开了编码超免疫血清反应性抗原或其片段的分离的核酸分子，以及来自化脓性链球菌的超免疫血清反应性抗原或其片段，分离此类抗原的方法及其特异性用途。

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