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31. 发明专利

SG10201809900PA Hybrid Nanopore Sensors 未知
公开(公告)号：SG10201809900PA
公开(公告)日：2018-12-28
申请号：SG10201809900P
申请日：2015-07-29
申请人： ILLUMINA INC
发明人： BOYANOV BOYAN , MANDELL JEFFREY G , GUNDERSON KEVIN L , BAI JINGWEI , QIANG LIANGLIANG , BAAS BRADLEY
摘要： HYBRID NANOPORE SENSORS In one aspect, a detection apparatus comprises a solid support with an array of solid- state nanopores and a plurality of lipid nanodiscs with protein nanopores, wherein the lipid nanodiscs are disposed on the solid support such that they form seals at the solid-state 5 nanopores. In another aspect, a detection apparatus comprises one or more nanopores that are surrounded by a membrane, wherein each nanopore is tethered to an electrode. Figure 2A

32. 发明专利

AU2014364926B2 Preserving genomic connectivity information in fragmented genomic DNA samples 未知
公开(公告)号：AU2014364926B2
公开(公告)日：2017-12-14
申请号：AU2014364926
申请日：2014-12-16
申请人： ILLUMINA INC
发明人： FISHER JEFFREY S , STEEMERS FRANK J , AMINI SASAN , GUNDERSON KEVIN L
IPC分类号： C12Q1/68
摘要： A method of sequencing a target nucleic acid polymer by (a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing fragments of the modified nucleic acid polymer, wherein the fragments are attached to locations on a solid support surface (c) determining nucleotide sequences from the fragments at the locations; and (d) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the relative distances between the locations on the solid support surface.

33. 发明专利

AU2016261850A1 Field-effect apparatus and methods for sequencing nucelic acids 未知
公开(公告)号：AU2016261850A1
公开(公告)日：2017-11-16
申请号：AU2016261850
申请日：2016-05-11
申请人： ILLUMINA INC , UNIV CALIFORNIA
发明人： GUNDERSON KEVIN L , BAI JINGWEI , CHEN CHENG-YAO , MANDELL JEFFREY G , PEISAJOVICH SERGIO , BOYANOV BOYAN , COLLINS PHILIP G , WEISS GREGORY A
IPC分类号： C12Q1/68
摘要： The present disclosure provides a method for sequencing nucleic acids. The method can include polymerase catalyzed incorporation of nucleotides into a nascent nucleic acid strand against a nucleic acid template, wherein the polymerase is attached to a charge sensor that detects nucleotide incorporation events. One or more non-natural nucleotide types that each produce a unique signatures at the charge sensor can be used to uniquely identify different nucleotides in the template nucleic acid.

34. 发明专利

CA2986074A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR SEQUENCING POLYNUCLEOTIDES USING TETHERS ANCHORED TO POLYMERASES ADJACENT TO NANOPORES 未知
公开(公告)号：CA2986074A1
公开(公告)日：2016-12-08
申请号：CA2986074
申请日：2016-06-02
申请人： ILLUMINA INC
发明人： GUNDERSON KEVIN L , MANDELL JEFFREY G
摘要： A composition includes a nanopore including first and second sides and an aperture, nucleotides each including an elongated tag, and a first polynucleotide that is complementary to a second polynucleotide. A polymerase can be disposed adjacent to the first side of the nanopore and configured to add nucleotides to the first polynucleotide based on a sequence of the second polynucleotide. A permanent tether can include a head region anchored to the polymerase, a tail region, and an elongated body disposed therebetween that occurs in the aperture of the nanopore. A first moiety can be disposed on the elongated body that binds to the elongated tag of a first nucleotide upon which the polymerase is acting. A reporter region can be disposed on the elongated body that indicates when the first nucleotide is complementary or is not complementary to a next nucleotide in the sequence of the second polynucleotide.

35. 发明专利

CA2967525A1 METHODS AND ARRAYS FOR PRODUCING AND SEQUENCING MONOCLONAL CLUSTERS OF NUCLEIC ACID 未知
公开(公告)号：CA2967525A1
公开(公告)日：2016-05-19
申请号：CA2967525
申请日：2015-11-11
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： GUNDERSON KEVIN L , BAI JINGWEI , KELLINGER MATTHEW WILLIAM , BEIERLE JOHN M , BOUTELL JONATHAN MARK , RIGATTI ROBERTO , ROGERT BACIGALUPO MARIA CANDELARIA , BOYANOV BOYAN , MAISINGER KLAUS
IPC分类号： C12Q1/68 , B01J19/00 , C40B40/06 , C40B50/14
摘要： Methods for capturing and amplifying target polynucleotides on a solid surface, in particular in a well in a microarray, wherein the microarray may comprise a) a substrate comprising at least one well, a surface surrounding the well and an inner well surface; b) a first layer covering the inner well surface and comprising at least one first capture primer pair; and c) a second layer covering the first layer and the surface surrounding the well. Alternatively, the microarray may comprise a) a substrate comprising at least one well, a surface surrounding the well and an inner well surface; and b) a layer covering the inner well surface and comprising at least one first capture primer pair and at least one second capture primer pair. In particular kinetic exclusion amplification is used in creating monoclonal populations of the nucleic acids in the wells. The application also discloses a method for modifying an immobilized capture primer comprising: a) contacting a substrate comprising a plurality of immobilized capture primers with a plurality of template nucleic acids to produce one or more immobilized template nucleic acids,wherein the plurality of immobilized capture primers comprises a first plurality of primers comprising a 3'-terminal universal capture region Y, e.g. primer P5, and a second plurality of primers comprising a 3'-terminal universal capture region Z, e.g. primer P7; and wherein each template nucleic acid is flanked by a 5'-terminal and a 3'-terminal universal capture region Y or Z and comprises one or more, e.g. SapI, restriction sites and a target-specific capture region between the one or more restriction sites and the 3'-terminal universal capture region; and b) extending one or more immobilized capture primer. Finally, the application discloses a method for modifying an immobilized capture primer comprising: a) contacting a substrate comprising a plurality of immobilized capture primers with a plurality of different seed nucleic acids to produce a plurality of different immobilized seed nucleic acids; b) extending two or more of the immobilized capture primers to produce a plurality of different immobilized extension products complementary to two or more of the plurality of different immobilized seed nucleic acids; and c) activating one immobilized extension product of the plurality of different immobilized extension products, to form an activated capture primer.

36. 发明专利

CA2955356A1 BIOCHEMICALLY ACTIVATED ELECTRONIC DEVICE 未知
公开(公告)号：CA2955356A1
公开(公告)日：2016-01-21
申请号：CA2955356
申请日：2015-07-14
申请人： ILLUMINA INC
发明人： BOYANOV BOYAN , MANDELL JEFFREY G , BAI JINGWEI , GUNDERSON KEVIN L , CHEN CHENG-YAO , PERBOST MICHEL
IPC分类号： C12Q1/68
摘要： A method of nucleic acid sequencing. The method can include the steps of (a) providing a polymerase tethered to a solid support charge sensor; (b) providing one or more nucleotides, whereby the presence of the nucleotide can be detected by the charge sensor; and (c) detecting incorporation of the nucleotide into a nascent strand complementary to a template nucleic acid.

37. 发明专利

AU2012328662B2 Microarray fabrication system and method 未知
公开(公告)号：AU2012328662B2
公开(公告)日：2015-12-17
申请号：AU2012328662
申请日：2012-10-26
申请人： ILLUMINA INC
发明人： BOWEN M SHANE , GUNDERSON KEVIN L , LIN SHENGRONG , BACIGALUPO MARIA CANDELARIA ROGERT , VIJAYAN KANDASWAMY , WU YIR-SHYUAN , VENKATESAN BALA MURALI , TSAY JAMES , BEIERLE JOHN M , BERTI LORENZO , PARK SANG RYUL
IPC分类号： B01J19/00
摘要： A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites.

38. 发明专利

AU2014228958A1 Super resolution imaging 未知
公开(公告)号：AU2014228958A1
公开(公告)日：2015-08-06
申请号：AU2014228958
申请日：2014-03-14
申请人： ILLUMINA INC
发明人： KHURANA TARUN , GUNDERSON KEVIN L , WU YIR-SHYUAN , KAIN ROBERT C
IPC分类号： C12Q1/68 , G01N21/64 , G01N27/02 , G01N33/543
摘要： A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad.

39. 发明专利

CA3003082A1 MICROARRAY FABRICATION SYSTEM AND METHOD 未知
公开(公告)号：CA3003082A1
公开(公告)日：2013-05-02
申请号：CA3003082
申请日：2012-10-26
申请人： ILLUMINA INC
发明人： BOWEN M SHANE , GUNDERSON KEVIN L , LIN SHENGRONG , BACIGALUPO MARIA CANDELARIA ROGERT , VIJAYAN KANDASWAMY , WU YIR-SHYUAN , VENKATESAN BALA MURALI , TSAY JAMES , BEIERLE JOHN M , BERTI LORENZO , PARK SANG RYUL
IPC分类号： C12Q1/6834 , C12Q1/6837 , C12Q1/6844 , C40B40/06 , C40B50/06 , C40B50/18 , G01N33/543
摘要： A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the 14 sites.

40. 发明专利

CA2975739C METHODS AND COMPOSITIONS FOR ANALYZING CELLULAR COMPONENTS 未知
公开(公告)号：CA2975739C
公开(公告)日：2022-12-06
申请号：CA2975739
申请日：2016-02-10
申请人： ILLUMINA INC
发明人： GUNDERSON KEVIN L , STEEMERS FRANK J , FISHER JEFFREY S , RIGATTI ROBERTO
IPC分类号： C12Q1/68 , C12Q1/00 , C12Q1/6869 , G01N33/50
摘要： Embodiments of the present invention relate to analyzing components of a cell. In some embodiments, the present invention relate to analyzing components of a single cell. In some embodiments, the methods and compositions relate to sequencing nucleic acids. In some embodiments, the methods and compositions relate to identifying and/or quantitating nucleic acid, proteins, organelles, and/or cellular metabolites.

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